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Wyświetlanie 1-20 z 29
Tytuł:
Local negative feedback of Rac activity at the leading edge underlies a pilot pseudopod-like program for amoeboid cell guidance.
Autorzy:
Town JP; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, United States of America.; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America.
Weiner OD; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, United States of America.; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America.
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Źródło:
PLoS biology [PLoS Biol] 2023 Sep 25; Vol. 21 (9), pp. e3002307. Date of Electronic Publication: 2023 Sep 25 (Print Publication: 2023).
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cell confinement reveals a branched-actin independent circuit for neutrophil polarity.
Autorzy:
Graziano BR; Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, California, United States of America.
Town JP; Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, California, United States of America.
Sitarska E; Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Nagy TL; Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, California, United States of America.
Fošnarič M; Laboratory of Clinical Biophysics, Faculty of Medicine, University of Ljubljana, Slovenia.
Penič S; Department of Theoretical Electrotechnics, Mathematics and Physics, Faculty of Electrical Engineering, University of Ljubljana, Slovenia.
Iglič A; Laboratory of Clinical Biophysics, Faculty of Medicine, University of Ljubljana, Slovenia.; Department of Theoretical Electrotechnics, Mathematics and Physics, Faculty of Electrical Engineering, University of Ljubljana, Slovenia.
Kralj-Iglič V; Faculty of Health Sciences, University of Ljubljana, Slovenia.
Gov NS; Department of Chemical and Biological Physics, Weizmann Institute, Rehovot, Israel.
Diz-Muñoz A; Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Weiner OD; Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, California, United States of America.
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Źródło:
PLoS biology [PLoS Biol] 2019 Oct 10; Vol. 17 (10), pp. e3000457. Date of Electronic Publication: 2019 Oct 10 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Actin-Related Protein 2-3 Complex/*genetics
Actins/*genetics
Cell Polarity/*genetics
Chemotaxis/*genetics
Wiskott-Aldrich Syndrome Protein Family/*genetics
Actin-Related Protein 2-3 Complex/metabolism ; Actins/metabolism ; Biomechanical Phenomena ; CRISPR-Cas Systems ; Cell Adhesion/drug effects ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Cell Membrane/ultrastructure ; Cell Polarity/drug effects ; Chemotactic Factors/pharmacology ; Chemotaxis/drug effects ; Gene Editing ; Gene Expression Regulation ; HEK293 Cells ; HL-60 Cells ; Humans ; Microscopy, Atomic Force ; N-Formylmethionine Leucyl-Phenylalanine/pharmacology ; Pseudopodia/drug effects ; Pseudopodia/metabolism ; Pseudopodia/ultrastructure ; Signal Transduction ; Surface Properties ; Wiskott-Aldrich Syndrome Protein Family/deficiency
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A size-invariant bud-duration timer enables robustness in yeast cell size control.
Autorzy:
Allard CAH; Marine Biological Laboratory, Woods Hole, MA, United States of America.; Dept. of Biochemistry and Cell Biology, The Geisel School of Medicine at Dartmouth, Hanover, NH, United States of America.
Decker F; Marine Biological Laboratory, Woods Hole, MA, United States of America.; Max Planck Institute for the Physics of Complex Systems, Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden, Dresden, Germany.
Weiner OD; Marine Biological Laboratory, Woods Hole, MA, United States of America.; Cardiovascular Research Institute and Dept. of Biochemistry and Biophysics, UC San Francisco, San Francisco, United States of America.
Toettcher JE; Marine Biological Laboratory, Woods Hole, MA, United States of America.; Department of Molecular Biology, Princeton University, Princeton, NJ, United States of America.
Graziano BR; Marine Biological Laboratory, Woods Hole, MA, United States of America.; Cardiovascular Research Institute and Dept. of Biochemistry and Biophysics, UC San Francisco, San Francisco, United States of America.
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Źródło:
PloS one [PLoS One] 2018 Dec 21; Vol. 13 (12), pp. e0209301. Date of Electronic Publication: 2018 Dec 21 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Saccharomyces cerevisiae/*cytology
Adaptor Proteins, Signal Transducing/genetics ; Cell Cycle ; Cell Growth Processes/genetics ; G1 Phase ; Homeostasis ; Optogenetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/growth & development ; Saccharomyces cerevisiae Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration.
Autorzy:
Diz-Muñoz A; Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America.; Bioengineering Department and Biophysics Program, University of California Berkeley, Berkeley, California, United States of America.
Thurley K; Dept. of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America.
Chintamen S; Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America.
Altschuler SJ; Dept. of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America.
Wu LF; Dept. of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America.
Fletcher DA; Bioengineering Department and Biophysics Program, University of California Berkeley, Berkeley, California, United States of America.
Weiner OD; Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America.
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Źródło:
PLoS biology [PLoS Biol] 2016 Jun 09; Vol. 14 (6), pp. e1002474. Date of Electronic Publication: 2016 Jun 09 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Cell Movement*
Actin Cytoskeleton/*metabolism
Cell Membrane/*metabolism
Multiprotein Complexes/*metabolism
Neutrophils/*metabolism
Phospholipase D/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Actins/metabolism ; Blotting, Western ; Cell Polarity ; HEK293 Cells ; HL-60 Cells ; Humans ; Mechanistic Target of Rapamycin Complex 2 ; Mechanotransduction, Cellular ; Microscopy, Fluorescence/methods ; Models, Biological ; Multiprotein Complexes/genetics ; Phospholipase D/genetics ; Polymerization ; RNA Interference ; TOR Serine-Threonine Kinases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Gβ Regulates Coupling between Actin Oscillators for Cell Polarity and Directional Migration.
Autorzy:
Hoeller O; Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America.
Toettcher JE; Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America.
Cai H; Department of Cell Biology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
Sun Y; Institute for Regenerative Cures, Department of Dermatology, University of California Davis School of Medicine, Sacramento, California, United States of America.
Huang CH; Department of Cell Biology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
Freyre M; Swarthmore College, Swarthmore, Pennsylvania, United States of America.
Zhao M; Institute for Regenerative Cures, Department of Dermatology, University of California Davis School of Medicine, Sacramento, California, United States of America.
Devreotes PN; Department of Cell Biology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
Weiner OD; Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America.
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Źródło:
PLoS biology [PLoS Biol] 2016 Feb 18; Vol. 14 (2), pp. e1002381. Date of Electronic Publication: 2016 Feb 18 (Print Publication: 2016).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Cell Movement*
Cell Polarity*
Models, Biological*
Actins/*metabolism
GTP-Binding Protein beta Subunits/*metabolism
Biological Clocks ; Cytoskeleton/metabolism ; Dictyostelium ; Signal Transduction ; Sirolimus
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A naturally monomeric infrared fluorescent protein for protein labeling in vivo.
Autorzy:
Yu D; 1] Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, USA. [2] Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.
Baird MA; 1] National High Magnetic Field Laboratory, The Florida State University, Tallahassee, Florida, USA. [2] Department of Biological Science, The Florida State University, Tallahassee, Florida, USA.
Allen JR; 1] National High Magnetic Field Laboratory, The Florida State University, Tallahassee, Florida, USA. [2] Department of Biological Science, The Florida State University, Tallahassee, Florida, USA.
Howe ES; 1] National High Magnetic Field Laboratory, The Florida State University, Tallahassee, Florida, USA. [2] Department of Biological Science, The Florida State University, Tallahassee, Florida, USA.
Klassen MP; 1] Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA. [2] Department of Physiology, University of California, San Francisco, San Francisco, California, USA. [3] Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California, USA.
Reade A; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.
Makhijani K; 1] Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, USA. [2] Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.
Song Y; 1] Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA. [2] Department of Physiology, University of California, San Francisco, San Francisco, California, USA. [3] Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California, USA.
Liu S; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.
Murthy Z; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.
Zhang SQ; 1] Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, USA. [2] Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA. [3] Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Weiner OD; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.
Kornberg TB; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.
Jan YN; 1] Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA. [2] Department of Physiology, University of California, San Francisco, San Francisco, California, USA. [3] Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California, USA.
Davidson MW; 1] National High Magnetic Field Laboratory, The Florida State University, Tallahassee, Florida, USA. [2] Department of Biological Science, The Florida State University, Tallahassee, Florida, USA.
Shu X; 1] Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, USA. [2] Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.
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Źródło:
Nature methods [Nat Methods] 2015 Aug; Vol. 12 (8), pp. 763-5. Date of Electronic Publication: 2015 Jun 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Infrared Rays*
Green Fluorescent Proteins/*chemistry
Amino Acid Sequence ; Animals ; Animals, Genetically Modified ; DNA/chemistry ; Developmental Biology ; Drosophila melanogaster ; Fluorescent Dyes/chemistry ; HeLa Cells ; Histidine/chemistry ; Humans ; Luminescent Proteins/chemistry ; Mice ; Molecular Sequence Data ; Mutation ; Neurons/metabolism ; Plasmids/metabolism ; Protein Conformation ; Protein Multimerization ; Recombinant Fusion Proteins/chemistry ; Transfection ; Zebrafish
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Illuminating cell signalling with optogenetic tools.
Autorzy:
Tischer D; Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94158-9001, USA.
Weiner OD; Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94158-9001, USA.
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Źródło:
Nature reviews. Molecular cell biology [Nat Rev Mol Cell Biol] 2014 Aug; Vol. 15 (8), pp. 551-8. Date of Electronic Publication: 2014 Jul 16.
Typ publikacji:
Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Signal Transduction*
Lighting/*methods
Optogenetics/*methods
Animals ; Arabidopsis/metabolism ; Cryptochromes/physiology ; Humans ; Ion Channels/chemistry ; Ion Channels/physiology ; Phytochrome B/physiology ; Protein Structure, Tertiary
Recenzja
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
An optogenetic gene expression system with rapid activation and deactivation kinetics.
Autorzy:
Motta-Mena LB; 1] Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas, USA. [2] Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Reade A; 1] Cardiovascular Research Institute, University of California-San Francisco, San Francisco, California, USA. [2] Department of Biochemistry and Biophysics, University of California-San Francisco, San Francisco, California, USA.
Mallory MJ; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Glantz S; Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Weiner OD; 1] Cardiovascular Research Institute, University of California-San Francisco, San Francisco, California, USA. [2] Department of Biochemistry and Biophysics, University of California-San Francisco, San Francisco, California, USA.
Lynch KW; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Gardner KH; 1] Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas, USA. [2] Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA. [3] Structural Biology Initiative, Advanced Science Research Center, City University of New York, New York, New York, USA.
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Źródło:
Nature chemical biology [Nat Chem Biol] 2014 Mar; Vol. 10 (3), pp. 196-202. Date of Electronic Publication: 2014 Jan 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Light*
Optogenetics*
Activating Transcription Factors/*radiation effects
Bacterial Proteins/*genetics
Gene Expression/*genetics
Animals ; Cell Line ; Kinetics ; Models, Biological ; Promoter Regions, Genetic ; RNA-Binding Proteins/metabolism ; T-Lymphocytes/metabolism ; Zebrafish/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Light-based feedback for controlling intracellular signaling dynamics.
Autorzy:
Toettcher JE; Cardiovascular Research Institute and Department of Biochemistry, University of California San Francisco, San Francisco, California, USA.
Gong D
Lim WA
Weiner OD
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Źródło:
Nature methods [Nat Methods] 2011 Sep 11; Vol. 8 (10), pp. 837-9. Date of Electronic Publication: 2011 Sep 11.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Light*
Feedback, Physiological/*radiation effects
Signal Transduction/*radiation effects
Animals ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Computational Biology ; Humans ; Models, Biological ; Phosphatidylinositol 3-Kinases/chemistry ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphoinositide-3 Kinase Inhibitors ; Protein Binding
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The promise of optogenetics in cell biology: interrogating molecular circuits in space and time.
Autorzy:
Toettcher JE; Department of Cellular and Molecular Pharmacology and the Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA.
Voigt CA
Weiner OD
Lim WA
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Źródło:
Nature methods [Nat Methods] 2011 Jan; Vol. 8 (1), pp. 35-8. Date of Electronic Publication: 2010 Dec 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Cell Biology*
Genetic Techniques*
Light*
Photic Stimulation*
Cytological Techniques/*methods
Luminescent Proteins/*genetics
Gene Expression Regulation/radiation effects ; Luminescent Proteins/metabolism ; Signal Transduction/genetics ; Signal Transduction/radiation effects ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 29

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