Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders.
Autorzy:
Schaser AJ; Department of Neurology & Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, 97239, USA. Osterberg VR; Department of Neurology & Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, 97239, USA. Dent SE; Department of Neurology & Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, 97239, USA. Stackhouse TL; Department of Neurology & Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, 97239, USA. Wakeham CM; Neuroscience Graduate Program, Vollum Institute, Oregon Health & Science University, Portland, OR, 97239, USA. Boutros SW; Departments of Behavioral Neuroscience, Neurology, and Radiation Medicine and Division of Neuroscience, ONPRC, Oregon Health & Science University, Portland, Oregon, 97239, USA. Weston LJ; Department of Neurology & Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, 97239, USA. Owen N; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, 97239, USA. WeissmanTA; Department of Biology, Lewis & Clark College, Portland, OR, 97219, USA. Luna E; Department of Pathology and Laboratory Medicine and Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. Raber J; Departments of Behavioral Neuroscience, Neurology, and Radiation Medicine and Division of Neuroscience, ONPRC, Oregon Health & Science University, Portland, Oregon, 97239, USA. Luk KC; Department of Pathology and Laboratory Medicine and Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. McCullough AK; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, 97239, USA.; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, 97239, USA. Woltjer RL; Department of Pathology, Division of Neuropathology, Oregon Health & Science University, Portland, OR, 97239, USA. Unni VK; Department of Neurology & Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, 97239, USA. .; OHSU Parkinson Center, Oregon Health & Science University, Portland, OR, 97239, USA. .
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Źródło:
Scientific reports [Sci Rep] 2019 Jul 29; Vol. 9 (1), pp. 10919. Date of Electronic Publication: 2019 Jul 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
In vivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility.
Autorzy:
Unni VK; Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America. WeissmanTA Rockenstein E Masliah E McLean PJ Hyman BT
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Źródło:
PloS one [PLoS One] 2010 May 11; Vol. 5 (5), pp. e10589. Date of Electronic Publication: 2010 May 11.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
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