Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Welch BD"" wg kryterium: Autor


Wyświetlanie 1-20 z 20
Tytuł :
Prevention and treatment of SHIVAD8 infection in rhesus macaques by a potent d-peptide HIV entry inhibitor.
Autorzy :
Nishimura Y; Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Francis JN; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112.; Navigen, Inc., Salt Lake City, UT 84108.
Donau OK; Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Jesteadt E; Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Sadjadpour R; Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Smith AR; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112.
Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Welch BD; Navigen, Inc., Salt Lake City, UT 84108.
Martin MA; Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892; .
Kay MS; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112; .
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 08; Vol. 117 (36), pp. 22436-22442. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-HIV Agents*/chemistry
Anti-HIV Agents*/pharmacology
Anti-HIV Agents*/therapeutic use
HIV*/drug effects
HIV*/genetics
HIV Infections*/drug therapy
HIV Infections*/prevention & control
HIV Infections*/virology
Simian Immunodeficiency Virus*/drug effects
Simian Immunodeficiency Virus*/genetics
Virus Internalization/*drug effects
Animals ; Drug Evaluation, Preclinical ; Female ; HIV Envelope Protein gp41/antagonists & inhibitors ; Macaca mulatta ; Male
Czasopismo naukowe
Tytuł :
Pharmacokinetic and Chemical Synthesis Optimization of a Potent d-Peptide HIV Entry Inhibitor Suitable for Extended-Release Delivery.
Autorzy :
Redman JS; Department of Biochemistry , University of Utah School of Medicine , Salt Lake City , Utah 84132 , United States.
Francis JN; Department of Biochemistry , University of Utah School of Medicine , Salt Lake City , Utah 84132 , United States.; Navigen Inc. , Salt Lake City , Utah 84108 , United States.
Marquardt R; Department of Biochemistry , University of Utah School of Medicine , Salt Lake City , Utah 84132 , United States.
Papac D; Navigen Inc. , Salt Lake City , Utah 84108 , United States.
Mueller AL; Navigen Inc. , Salt Lake City , Utah 84108 , United States.
Eckert DM; Department of Biochemistry , University of Utah School of Medicine , Salt Lake City , Utah 84132 , United States.
Welch BD; Navigen Inc. , Salt Lake City , Utah 84108 , United States.
Kay MS; Department of Biochemistry , University of Utah School of Medicine , Salt Lake City , Utah 84132 , United States.
Pokaż więcej
Źródło :
Molecular pharmaceutics [Mol Pharm] 2018 Mar 05; Vol. 15 (3), pp. 1169-1179. Date of Electronic Publication: 2018 Feb 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
HIV Fusion Inhibitors/*pharmacokinetics
HIV Infections/*drug therapy
HIV-1/*drug effects
Peptide Fragments/*pharmacokinetics
Animals ; Cholesterol/chemistry ; Delayed-Action Preparations ; Drug Carriers/chemistry ; Drug Design ; Drug Evaluation, Preclinical ; HIV Fusion Inhibitors/administration & dosage ; HIV Fusion Inhibitors/chemical synthesis ; HIV Infections/prevention & control ; HIV Infections/virology ; HIV-1/physiology ; Half-Life ; Macaca fascicularis ; Male ; Models, Animal ; Peptide Fragments/administration & dosage ; Peptide Fragments/chemical synthesis ; Rats ; Rats, Sprague-Dawley ; Stereoisomerism
Czasopismo naukowe
Tytuł :
Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets.
Autorzy :
Clinton TR; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, 84112-5650.
Weinstock MT
Jacobsen MT
Szabo-Fresnais N
Pandya MJ
Whitby FG
Herbert AS
Prugar LI
McKinnon R
Hill CP
Welch BD
Dye JM
Eckert DM
Kay MS
Pokaż więcej
Źródło :
Protein science : a publication of the Protein Society [Protein Sci] 2015 Apr; Vol. 24 (4), pp. 446-63. Date of Electronic Publication: 2014 Oct 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Ebolavirus/*chemistry
Viral Envelope Proteins/*chemistry
Viral Envelope Proteins/*metabolism
Amino Acid Sequence ; Drug Delivery Systems ; Models, Molecular ; Molecular Sequence Data ; Protein Conformation ; Sequence Alignment ; Viral Envelope Proteins/genetics
Czasopismo naukowe
Tytuł :
On the stability of parainfluenza virus 5 F proteins.
Autorzy :
Poor TA; Department of Molecular Biosciences Northwestern University, Evanston, Illinois, USA.
Song AS; Department of Molecular Biosciences Northwestern University, Evanston, Illinois, USA.
Welch BD; Department of Molecular Biosciences Northwestern University, Evanston, Illinois, USA Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois, USA.
Kors CA; Department of Molecular Biosciences Northwestern University, Evanston, Illinois, USA Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois, USA.
Jardetzky TS; Department of Structural Biology, Stanford University, Stanford, California, USA.
Lamb RA; Department of Molecular Biosciences Northwestern University, Evanston, Illinois, USA Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois, USA .
Pokaż więcej
Źródło :
Journal of virology [J Virol] 2015 Mar; Vol. 89 (6), pp. 3438-41. Date of Electronic Publication: 2015 Jan 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Parainfluenza Virus 5/*metabolism
Viral Fusion Proteins/*chemistry
Amino Acid Motifs ; Crystallography, X-Ray ; Humans ; Mutation ; Parainfluenza Virus 5/chemistry ; Parainfluenza Virus 5/genetics ; Protein Stability ; Protein Structure, Tertiary ; Rubulavirus Infections/virology ; Viral Fusion Proteins/genetics ; Viral Fusion Proteins/metabolism
Czasopismo naukowe
Tytuł :
Probing the functions of the paramyxovirus glycoproteins F and HN with a panel of synthetic antibodies.
Autorzy :
Welch BD; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois, USA.
Paduch M; Department of Biochemistry and Molecular Biology and the Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois, USA.
Leser GP; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois, USA.
Bergman Z; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA.
Kors CA; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois, USA.
Paterson RG; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA.
Jardetzky TS; Department of Structural Biology, Stanford University School of Medicine, Stanford, California, USA.
Kossiakoff AA; Department of Biochemistry and Molecular Biology and the Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois, USA .
Lamb RA; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois, USA .
Pokaż więcej
Źródło :
Journal of virology [J Virol] 2014 Oct; Vol. 88 (20), pp. 11713-25. Date of Electronic Publication: 2014 Aug 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies/*immunology
Glycoproteins/*physiology
Paramyxoviridae/*physiology
Viral Proteins/*physiology
Animals ; Antibody Specificity ; Antigens, Viral/immunology ; Cell Line ; Electrophoresis, Polyacrylamide Gel ; Enzyme-Linked Immunosorbent Assay ; Glycoproteins/immunology ; Humans ; Microscopy, Electron ; Viral Proteins/immunology
Czasopismo naukowe
Tytuł :
Structure of the parainfluenza virus 5 (PIV5) hemagglutinin-neuraminidase (HN) ectodomain.
Autorzy :
Welch BD; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA.
Yuan P
Bose S
Kors CA
Lamb RA
Jardetzky TS
Pokaż więcej
Źródło :
PLoS pathogens [PLoS Pathog] 2013; Vol. 9 (8), pp. e1003534. Date of Electronic Publication: 2013 Aug 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Models, Molecular*
HN Protein/*chemistry
Parainfluenza Virus 5/*chemistry
Animals ; Chlorocebus aethiops ; Crystallography, X-Ray ; HN Protein/genetics ; HN Protein/immunology ; Humans ; Parainfluenza Virus 5/genetics ; Parainfluenza Virus 5/immunology ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Structure-Activity Relationship ; Vero Cells
Czasopismo naukowe
Tytuł :
Structure of the cleavage-activated prefusion form of the parainfluenza virus 5 fusion protein.
Autorzy :
Welch BD; Howard Hughes Medical Institute and Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Liu Y
Kors CA
Leser GP
Jardetzky TS
Lamb RA
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2012 Oct 09; Vol. 109 (41), pp. 16672-7. Date of Electronic Publication: 2012 Sep 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Membrane Fusion*
Protein Conformation*
Paramyxovirinae/*metabolism
Viral Fusion Proteins/*chemistry
Animals ; Arginine/chemistry ; Arginine/genetics ; Arginine/metabolism ; Binding Sites/genetics ; Cells, Cultured ; Crystallography, X-Ray ; HN Protein/metabolism ; Models, Molecular ; Paramyxovirinae/genetics ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Sf9 Cells ; Trypsin/metabolism ; Viral Fusion Proteins/genetics ; Viral Fusion Proteins/metabolism
Czasopismo naukowe
Tytuł :
Fusion activation by a headless parainfluenza virus 5 hemagglutinin-neuraminidase stalk suggests a modular mechanism for triggering.
Autorzy :
Bose S; Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Zokarkar A
Welch BD
Leser GP
Jardetzky TS
Lamb RA
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2012 Sep 25; Vol. 109 (39), pp. E2625-34. Date of Electronic Publication: 2012 Sep 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Folding*
HN Protein/*chemistry
Rubulavirus/*enzymology
Animals ; Chlorocebus aethiops ; Cricetinae ; Crystallography, X-Ray ; HN Protein/genetics ; HN Protein/metabolism ; Humans ; Protein Structure, Tertiary ; Rubulavirus/genetics ; Vero Cells ; Viral Fusion Proteins/genetics ; Viral Fusion Proteins/metabolism ; Virus Internalization
Czasopismo naukowe
Tytuł :
Structure and mutagenesis of the parainfluenza virus 5 hemagglutinin-neuraminidase stalk domain reveals a four-helix bundle and the role of the stalk in fusion promotion.
Autorzy :
Bose S; Department of Molecular Biosciences, Northwestern University, 2205 Tech Drive, Evanston, IL 60208-3500, USA.
Welch BD
Kors CA
Yuan P
Jardetzky TS
Lamb RA
Pokaż więcej
Źródło :
Journal of virology [J Virol] 2011 Dec; Vol. 85 (24), pp. 12855-66. Date of Electronic Publication: 2011 Oct 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Internalization*
HN Protein/*chemistry
HN Protein/*genetics
Paramyxoviridae/*physiology
Amino Acid Substitution ; Animals ; Cell Line ; Crystallography, X-Ray ; Glycosylation ; HN Protein/metabolism ; Humans ; Models, Molecular ; Mutagenesis, Site-Directed ; Mutant Proteins/chemistry ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Paramyxoviridae/chemistry ; Paramyxoviridae/genetics ; Protein Binding ; Protein Conformation ; Protein Multimerization
Czasopismo naukowe
Tytuł :
One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates.
Autorzy :
Denton PW; Division of Infectious Diseases, Department of Internal Medicine, Center for AIDS Research, University of North Carolina, Chapel Hill, North Carolina 27510, USA.
Othieno F
Martinez-Torres F
Zou W
Krisko JF
Fleming E
Zein S
Powell DA
Wahl A
Kwak YT
Welch BD
Kay MS
Payne DA
Gallay P
Appella E
Estes JD
Lu M
Garcia JV
Pokaż więcej
Źródło :
Journal of virology [J Virol] 2011 Aug; Vol. 85 (15), pp. 7582-93. Date of Electronic Publication: 2011 May 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms :
Disease Models, Animal*
Vagina*
Adenine/*analogs & derivatives
HIV Infections/*prevention & control
Organophosphonates/*administration & dosage
Reverse Transcriptase Inhibitors/*administration & dosage
Adenine/administration & dosage ; Administration, Topical ; Animals ; Base Sequence ; CD4-Positive T-Lymphocytes/immunology ; Chimera ; DNA Primers ; Drug Evaluation, Preclinical ; Female ; HIV Infections/immunology ; HIV Infections/transmission ; Humans ; Mice ; Receptors, CCR5/immunology ; Tenofovir
Czasopismo naukowe
Tytuł :
Design of a potent D-peptide HIV-1 entry inhibitor with a strong barrier to resistance.
Autorzy :
Welch BD; Department of Biochemistry, University of Utah School of Medicine, 15 N. Medical Drive East, Rm. 4100, Salt Lake City, UT 84112-5650, USA.
Francis JN
Redman JS
Paul S
Weinstock MT
Reeves JD
Lie YS
Whitby FG
Eckert DM
Hill CP
Root MJ
Kay MS
Pokaż więcej
Źródło :
Journal of virology [J Virol] 2010 Nov; Vol. 84 (21), pp. 11235-44. Date of Electronic Publication: 2010 Aug 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Drug Design*
Drug Resistance, Viral*
HIV Fusion Inhibitors/*chemistry
Peptides/*pharmacology
Binding Sites ; HIV Envelope Protein gp41/antagonists & inhibitors ; Peptide Hydrolases/metabolism ; Peptides/chemistry ; Peptides/therapeutic use
Czasopismo naukowe
Tytuł :
Characterization of the steric defense of the HIV-1 gp41 N-trimer region.
Autorzy :
Eckert DM; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84112-5650, USA.
Shi Y
Kim S
Welch BD
Kang E
Poff ES
Kay MS
Pokaż więcej
Źródło :
Protein science : a publication of the Protein Society [Protein Sci] 2008 Dec; Vol. 17 (12), pp. 2091-100. Date of Electronic Publication: 2008 Sep 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
HIV Envelope Protein gp41/*chemistry
HIV Envelope Protein gp41/*metabolism
Humans ; Kinetics ; Membrane Fusion ; Peptide Fragments/antagonists & inhibitors ; Protein Binding ; Protein Conformation ; Protein Interaction Domains and Motifs ; Protein Stability ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/pharmacology ; Surface Plasmon Resonance
Czasopismo naukowe
Tytuł :
Potent D-peptide inhibitors of HIV-1 entry.
Autorzy :
Welch BD; Department of Biochemistry, University of Utah, Emma Eccles Jones Medical Research Building, 15 North Medical Drive East, Salt Lake City, UT 84112-5650, USA.
VanDemark AP
Heroux A
Hill CP
Kay MS
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2007 Oct 23; Vol. 104 (43), pp. 16828-33. Date of Electronic Publication: 2007 Oct 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Anti-HIV Agents/*pharmacology
HIV-1/*drug effects
Peptides/*pharmacology
Virus Internalization/*drug effects
Amino Acid Sequence ; Cell Line ; Crystallography, X-Ray ; HIV Envelope Protein gp41/chemistry ; Humans ; Models, Molecular ; Molecular Sequence Data ; Peptide Library ; Peptides/chemistry ; Protein Structure, Quaternary ; Sequence Alignment ; Surface Plasmon Resonance
Czasopismo naukowe
Tytuł :
P2Y2 receptor-stimulated release of prostaglandin E2 by rat inner medullary collecting duct preparations.
Autorzy :
Welch BD; Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City 84132, USA.
Carlson NG
Shi H
Myatt L
Kishore BK
Pokaż więcej
Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2003 Oct; Vol. 285 (4), pp. F711-21. Date of Electronic Publication: 2003 Jun 10.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Adenosine Triphosphate/*analogs & derivatives
Dinoprostone/*metabolism
Kidney Tubules, Collecting/*metabolism
Receptors, Purinergic P2/*physiology
Adenosine Triphosphate/administration & dosage ; Adenosine Triphosphate/pharmacology ; Animals ; Cell Separation/methods ; Cell Survival ; Cyclooxygenase 1 ; Cyclooxygenase 2 ; Cyclooxygenase 2 Inhibitors ; Cyclooxygenase Inhibitors/pharmacology ; Dose-Response Relationship, Drug ; In Vitro Techniques ; Isoenzymes/antagonists & inhibitors ; Kidney Medulla ; Kidney Tubules, Collecting/cytology ; Kidney Tubules, Collecting/physiology ; Male ; Membrane Proteins ; Osmolar Concentration ; Phospholipases A/physiology ; Prostaglandin-Endoperoxide Synthases ; Purinergic P2 Receptor Agonists ; Rats ; Rats, Sprague-Dawley ; Receptors, Purinergic P2Y2
Czasopismo naukowe
    Wyświetlanie 1-20 z 20

    Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies