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Tytuł :
PO-440 Development and characterisation of pre-clinical in vitro/in vivo models from disseminated tumour cells of melanoma patients
Autorzy :
Treitschke, S.
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Źródło :
In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June - 3 July 2018, ESMO Open 30 June-3 July 2018 3 Supplement 2:A404-A404
Czasopismo naukowe
Tytuł :
14 - Proffered Paper: Cell density, Her2 and progesterone signaling regulate dissemination of breast cancer cells
Autorzy :
Hosseini, H.
Harper, K.
Obradovic, M.
Sosa, M. Soledad
Nanduri, L.K.
Hoffmann, M.
Werno, C.
Aguirre-Ghiso, J.A.
Klein, C.A.
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Źródło :
In 24th Biennial Congress of the European Association for Cancer Research, 9-12 July 2016, Manchester, UK, European Journal of Cancer July 2016 61 Supplement 1:S6-S7
Czasopismo naukowe
Tytuł :
Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency.
Autorzy :
Werner-Klein M; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany. .
Grujovic A; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.; Telexos GmbH, Weilheim, Germany.
Irlbeck C; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Obradović M; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.; Wellmera AG, Basel, Switzerland.
Hoffmann M; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Koerkel-Qu H; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
Lu X; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Treitschke S; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Köstler C; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Botteron C; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Weidele K; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Werno C; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Polzer B; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Kirsch S; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Gužvić M; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
Warfsmann J; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Honarnejad K; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Czyz Z; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
Feliciello G; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.
Blochberger I; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
Grunewald S; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
Schneider E; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
Haunschild G; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
Patwary N; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
Guetter S; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
Huber S; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
Rack B; Department OB&GYN and CCCLMU, Breast Center, LMU University Hospital, 80337, Munich, Germany.; Department of Gynecology, Ulm University Hospital, Ulm, Germany.
Harbeck N; Department OB&GYN and CCCLMU, Breast Center, LMU University Hospital, 80337, Munich, Germany.
Buchholz S; Clinic of Gynecology and Obstetrics, University Medical Center Regensburg, 93053, Regensburg, Germany.
Rümmele P; Department of Pathology, University of Regensburg, 93053, Regensburg, Germany.; Institute of Pathology, University Hospital, Friedrich-Alexander-University Erlangen-Nürnberg, 91054, Erlangen, Germany.
Heine N; University Center of Plastic-, Aesthetic, Hand- and Reconstructive Surgery, University of Regensburg, Regensburg, Germany.
Rose-John S; Institute of Biochemistry, Christian-Albrechts-Universität Kiel, Kiel, Germany.
Klein CA; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany. .; Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 05; Vol. 11 (1), pp. 4977. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
Interleukin-6/*metabolism
Neoplastic Stem Cells/*metabolism
Neoplastic Stem Cells/*pathology
Bone Marrow/pathology ; Breast/cytology ; Breast Neoplasms/pathology ; Class I Phosphatidylinositol 3-Kinases/genetics ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Cytokine Receptor gp130/metabolism ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Female ; Humans ; Interleukin-6/genetics ; Mutation ; Neoplasm Metastasis/genetics ; Receptors, Interleukin-6/deficiency ; Receptors, Interleukin-6/metabolism ; Stromal Cells/metabolism ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma.
Autorzy :
Werner-Klein M; Experimental Medicine and Therapy Research, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany.; Regensburg Center for Interventional Immunology (RCI) and University Medical Center of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany.
Scheitler S; Experimental Medicine and Therapy Research, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany.; Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine, Regensburg, Am Biopark 9, 93053, Germany.
Hoffmann M; Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine, Regensburg, Am Biopark 9, 93053, Germany.
Hodak I; Experimental Medicine and Therapy Research, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany.
Dietz K; Department of Medical Biometry, University of Tübingen, Silcherstr. 5, 72076, Tübingen, Germany.
Lehnert P; Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076, Tübingen, Germany.
Naimer V; Experimental Medicine and Therapy Research, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany.
Polzer B; Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine, Regensburg, Am Biopark 9, 93053, Germany.
Treitschke S; Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine, Regensburg, Am Biopark 9, 93053, Germany.
Werno C; Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine, Regensburg, Am Biopark 9, 93053, Germany.
Markiewicz A; Experimental Medicine and Therapy Research, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany.
Weidele K; Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine, Regensburg, Am Biopark 9, 93053, Germany.
Czyz Z; Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine, Regensburg, Am Biopark 9, 93053, Germany.
Hohenleutner U; Department of Dermatology, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany.
Hafner C; Department of Dermatology, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany.
Haferkamp S; Department of Dermatology, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany.
Berneburg M; Department of Dermatology, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany.
Rümmele P; Department of Pathology, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany.; Institute of Pathology, University Hospital, Friedrich-Alexander-University Erlangen-Nürnberg, Krankenhausstr. 8-10, 91054, Erlangen, Germany.
Ulmer A; Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076, Tübingen, Germany.
Klein CA; Experimental Medicine and Therapy Research, University of Regensburg, Franz-Josef Strauß Allee 11, 93053, Regensburg, Germany. .; Division of Personalized Tumor Therapy, Fraunhofer-Institute for Toxicology and Experimental Medicine, Regensburg, Am Biopark 9, 93053, Germany. .
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Źródło :
Nature communications [Nat Commun] 2018 Feb 09; Vol. 9 (1), pp. 595. Date of Electronic Publication: 2018 Feb 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Melanoma/*genetics
Skin/*metabolism
Skin Neoplasms/*genetics
Animals ; Cell Line, Tumor ; Comparative Genomic Hybridization/methods ; Female ; GTP Phosphohydrolases/genetics ; Humans ; Lymph Nodes/metabolism ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Male ; Melanoma/pathology ; Membrane Proteins/genetics ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Proto-Oncogene Proteins p21(ras)/genetics ; Skin/pathology ; Skin Neoplasms/pathology ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł :
Early dissemination seeds metastasis in breast cancer.
Autorzy :
Hosseini H; Experimental Medicine and Therapy Research, University of Regensburg, 93053 Regensburg, Germany.
Obradović MMS; Experimental Medicine and Therapy Research, University of Regensburg, 93053 Regensburg, Germany.
Hoffmann M; Project group 'Personalized Tumour Therapy', Fraunhofer Institute for Toxicology und Experimental Medicine, 93053 Regensburg, Germany.
Harper KL; Division of Hematology and Oncology, Department of Medicine, Department of Otolaryngology, Department of Oncological Sciences, Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York 10029, USA.
Sosa MS; Division of Hematology and Oncology, Department of Medicine, Department of Otolaryngology, Department of Oncological Sciences, Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York 10029, USA.
Werner-Klein M; Institute of Immunology, University of Regensburg, 93053 Regensburg, Germany.
Nanduri LK; Experimental Medicine and Therapy Research, University of Regensburg, 93053 Regensburg, Germany.
Werno C; Project group 'Personalized Tumour Therapy', Fraunhofer Institute for Toxicology und Experimental Medicine, 93053 Regensburg, Germany.
Ehrl C; Experimental Medicine and Therapy Research, University of Regensburg, 93053 Regensburg, Germany.
Maneck M; Experimental Medicine and Therapy Research, University of Regensburg, 93053 Regensburg, Germany.
Patwary N; Experimental Medicine and Therapy Research, University of Regensburg, 93053 Regensburg, Germany.
Haunschild G; Experimental Medicine and Therapy Research, University of Regensburg, 93053 Regensburg, Germany.
Gužvić M; Experimental Medicine and Therapy Research, University of Regensburg, 93053 Regensburg, Germany.
Reimelt C; Experimental Medicine and Therapy Research, University of Regensburg, 93053 Regensburg, Germany.
Grauvogl M; Department of Statistical Bioinformatics, Institute of Functional Genomics, University of Regensburg, 93053 Regensburg, Germany.
Eichner N; Biochemistry Center Regensburg (BZR), Laboratory for RNA Biology, University of Regensburg, 93053 Regensburg, Germany.
Weber F; Institute of Pathology, University of Regensburg, 93053 Regensburg, Germany.
Hartkopf AD; Department of Gynecology and Obstetrics, University of Tübingen, 72076 Tübingen, Germany.
Taran FA; Department of Gynecology and Obstetrics, University of Tübingen, 72076 Tübingen, Germany.
Brucker SY; Department of Gynecology and Obstetrics, University of Tübingen, 72076 Tübingen, Germany.
Fehm T; Department of Gynecology and Obstetrics, University of Düsseldorf, 40225 Düsseldorf, Germany.
Rack B; Department of Gynecology and Obstetrics, University Munich, 80337 Munich, Germany.
Buchholz S; Department of Gynecology and Obstetrics, University Medical Center Regensburg, 93053 Regensburg, Germany.
Spang R; Department of Statistical Bioinformatics, Institute of Functional Genomics, University of Regensburg, 93053 Regensburg, Germany.
Meister G; Biochemistry Center Regensburg (BZR), Laboratory for RNA Biology, University of Regensburg, 93053 Regensburg, Germany.
Aguirre-Ghiso JA; Division of Hematology and Oncology, Department of Medicine, Department of Otolaryngology, Department of Oncological Sciences, Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York 10029, USA.
Klein CA; Experimental Medicine and Therapy Research, University of Regensburg, 93053 Regensburg, Germany.; Project group 'Personalized Tumour Therapy', Fraunhofer Institute for Toxicology und Experimental Medicine, 93053 Regensburg, Germany.
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Źródło :
Nature [Nature] 2016 Dec 22; Vol. 540 (7634), pp. 552-558. Date of Electronic Publication: 2016 Dec 14.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Immune humanization of immunodeficient mice using diagnostic bone marrow aspirates from carcinoma patients.
Autorzy :
Werner-Klein M; Institute of Immunology, University of Regensburg, Regensburg, Germany.
Proske J; Institute of Immunology, University of Regensburg, Regensburg, Germany.
Werno C; Project Group Personalized Tumor Therapy, Fraunhofer Institute of Toxicology and Experimental Medicine, Regensburg, Germany.
Schneider K; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
Hofmann HS; Department of Thoracic Surgery, University Regensburg, Regensburg, Germany.
Rack B; Department of Gynecology and Obstetrics, Ludwig-Maximilians-Universität München, Munich, Germany.
Buchholz S; Department of Gynecology and Obstetrics, University Medical Center Regensburg, Regensburg, Germany.
Ganzer R; Department of Urology, University of Leipzig, Leipzig, Germany.
Blana A; Department of Urology, Fuerth Hospital, Fuerth, Germany.
Seelbach-Göbel B; Clinic of Gynecology and Obstetrics St. Hedwig, University of Regensburg, Regensburg, Germany.
Nitsche U; Department of Surgery, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
Männel DN; Institute of Immunology, University of Regensburg, Regensburg, Germany.
Klein CA; Project Group Personalized Tumor Therapy, Fraunhofer Institute of Toxicology and Experimental Medicine, Regensburg, Germany; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.
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Źródło :
PloS one [PLoS One] 2014 May 15; Vol. 9 (5), pp. e97860. Date of Electronic Publication: 2014 May 15 (Print Publication: 2014).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hematopoietic Stem Cell Transplantation*
Animals ; Antigens, CD34/metabolism ; Bone Marrow/immunology ; Bone Marrow/pathology ; Breast Neoplasms/immunology ; Breast Neoplasms/pathology ; Disease Models, Animal ; Esophageal Neoplasms/immunology ; Esophageal Neoplasms/pathology ; Female ; Hematopoietic Stem Cells/immunology ; Hematopoietic Stem Cells/metabolism ; Humans ; Lung Neoplasms/immunology ; Lung Neoplasms/pathology ; Male ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, SCID ; Prostatic Neoplasms/immunology ; Prostatic Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Knockout of HIF-1α in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses.
Autorzy :
Werno C; Institute of Biochemistry I--Pathobiochemistry/Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit, Faculty of Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Menrad H
Weigert A
Dehne N
Goerdt S
Schledzewski K
Kzhyshkowska J
Brüne B
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Źródło :
Carcinogenesis [Carcinogenesis] 2010 Oct; Vol. 31 (10), pp. 1863-72. Date of Electronic Publication: 2010 Apr 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Polarity*
Hypoxia-Inducible Factor 1, alpha Subunit/*physiology
Macrophages/*physiology
Neoplasms/*blood supply
Neovascularization, Pathologic/*etiology
Animals ; Cell Adhesion Molecules, Neuronal/analysis ; Cell Line, Tumor ; Humans ; Interferon-gamma/pharmacology ; Interleukin-6/biosynthesis ; Lectins, C-Type/analysis ; Lipopolysaccharides/pharmacology ; Mannose-Binding Lectins/analysis ; Mice ; Neoplasm Invasiveness ; Neoplasms/pathology ; Nitric Oxide Synthase Type II/biosynthesis ; Platelet Endothelial Cell Adhesion Molecule-1/analysis ; Receptors, Cell Surface/analysis ; Receptors, Lymphocyte Homing/analysis ; Spheroids, Cellular/pathology ; Tumor Necrosis Factor-alpha/biosynthesis
Czasopismo naukowe
Tytuł :
A combination of hypoxia and lipopolysaccharide activates tristetraprolin to destabilize proinflammatory mRNAs such as tumor necrosis factor-alpha.
Autorzy :
Werno C; Goethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry, Frankfurt, Germany.
Schmid T
Schnitzer SE
Peters K
Milke L
Brüne B
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Źródło :
The American journal of pathology [Am J Pathol] 2010 Sep; Vol. 177 (3), pp. 1104-12. Date of Electronic Publication: 2010 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hypoxia/*metabolism
Inflammation/*metabolism
Lipopolysaccharides/*pharmacology
Macrophages/*metabolism
RNA Stability/*physiology
Tristetraprolin/*metabolism
Tumor Necrosis Factor-alpha/*metabolism
3' Untranslated Regions ; Animals ; Blotting, Western ; Cell Line ; Cells, Cultured ; Hypoxia/genetics ; Immunohistochemistry ; Inflammation/genetics ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Lipopolysaccharides/metabolism ; Macrophage Colony-Stimulating Factor/genetics ; Macrophage Colony-Stimulating Factor/metabolism ; Macrophages/cytology ; Macrophages/drug effects ; Mice ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Small Interfering ; Reverse Transcriptase Polymerase Chain Reaction ; Transfection ; Tristetraprolin/genetics ; Tumor Necrosis Factor-alpha/genetics
Czasopismo naukowe
Tytuł :
Roles of hypoxia-inducible factor-1alpha (HIF-1alpha) versus HIF-2alpha in the survival of hepatocellular tumor spheroids.
Autorzy :
Menrad H; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.
Werno C
Schmid T
Copanaki E
Deller T
Dehne N
Brüne B
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Źródło :
Hepatology (Baltimore, Md.) [Hepatology] 2010 Jun; Vol. 51 (6), pp. 2183-92.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Autophagy*
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Carcinoma, Hepatocellular/*metabolism
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Liver Neoplasms/*metabolism
Basic Helix-Loop-Helix Transcription Factors/genetics ; Caspase 3/metabolism ; Cell Enlargement ; Cell Survival ; Gene Knockdown Techniques ; Hep G2 Cells ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Membrane Proteins/metabolism ; Proto-Oncogene Proteins/metabolism ; Spheroids, Cellular/metabolism ; Tumor Cells, Cultured ; Up-Regulation ; bcl-2-Associated X Protein/metabolism ; bcl-X Protein/metabolism
Czasopismo naukowe

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