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Wyszukujesz frazę ""Winkler, Johannes"" wg kryterium: Autor


Wyświetlanie 1-9 z 9
Tytuł :
Targeted delivery and endosomal cellular uptake of DARPin-siRNA bioconjugates: Influence of linker stability on gene silencing.
Autorzy :
Lorenzer C; Department of Pharmaceutical Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.
Streußnig S; Department of Pharmaceutical Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.
Tot E; Department of Pharmaceutical Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.
Winkler AM; Department of Pharmaceutical Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.
Merten H; Department of Biochemistry, University of Zurich, Winterthurerstraße 190, 8057 Zurich, Switzerland.
Brandl F; Department of Biochemistry, University of Zurich, Winterthurerstraße 190, 8057 Zurich, Switzerland.
Sayers EJ; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, Wales CF10 3NB, United Kingdom.
Watson P; School of Biosciences, Cardiff University, Cardiff, Wales CF10 3AX, United Kingdom.
Jones AT; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, Wales CF10 3NB, United Kingdom.
Zangemeister-Wittke U; Department of Biochemistry, University of Zurich, Winterthurerstraße 190, 8057 Zurich, Switzerland; Institute of Pharmacology, University of Bern, Inselspital INO-F, 3010 Bern, Switzerland.
Plückthun A; Department of Biochemistry, University of Zurich, Winterthurerstraße 190, 8057 Zurich, Switzerland.
Winkler J; Department of Pharmaceutical Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria; Department of Cardiology, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. Electronic address: johannes.winkler@univie.ac.at.
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Źródło :
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2019 Aug; Vol. 141, pp. 37-50. Date of Electronic Publication: 2019 May 16.
Typ publikacji :
Journal Article
MeSH Terms :
Endosomes/*metabolism
Gene Silencing/*physiology
Muscle Proteins/*metabolism
Nuclear Proteins/*metabolism
RNA, Small Interfering/*metabolism
Alanine/analogs & derivatives ; Alanine/metabolism ; Cell Line, Tumor ; Click Chemistry/methods ; Epithelial Cell Adhesion Molecule/metabolism ; HeLa Cells ; Humans ; MCF-7 Cells ; Maleimides/metabolism ; Sulfhydryl Compounds/metabolism ; Triazoles/metabolism
Czasopismo naukowe
Tytuł :
Chemically defined polyethylene glycol siRNA conjugates with enhanced gene silencing effect.
Autorzy :
Gaziova Z; University of Vienna, Department of Medicinal Chemistry, Althanstraße 14, 1090 Vienna, Austria.
Baumann V; University of Vienna, Department of Medicinal Chemistry, Althanstraße 14, 1090 Vienna, Austria.
Winkler AM; University of Vienna, Department of Medicinal Chemistry, Althanstraße 14, 1090 Vienna, Austria.
Winkler J; University of Vienna, Department of Medicinal Chemistry, Althanstraße 14, 1090 Vienna, Austria. Electronic address: johannes.winkler@univie.ac.at.
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2014 Apr 01; Vol. 22 (7), pp. 2320-6. Date of Electronic Publication: 2014 Feb 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Silencing/*drug effects
Genes, Reporter/*drug effects
Luciferases/*antagonists & inhibitors
Polyethylene Glycols/*pharmacology
Proto-Oncogene Proteins c-bcl-2/*antagonists & inhibitors
RNA, Small Interfering/*pharmacology
Receptors, CXCR4/*antagonists & inhibitors
Humans ; Luciferases/genetics ; Luciferases/metabolism ; MCF-7 Cells ; Molecular Structure ; Polyethylene Glycols/chemical synthesis ; Polyethylene Glycols/chemistry ; Proto-Oncogene Proteins c-bcl-2/genetics ; RNA, Messenger/drug effects ; RNA, Messenger/genetics ; RNA, Small Interfering/chemical synthesis ; RNA, Small Interfering/chemistry ; Receptors, CXCR4/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Influence of diverse chemical modifications on the ADME characteristics and toxicology of antisense oligonucleotides.
Autorzy :
Dirin M; University of Vienna, Department of Medicinal Chemistry, Althanstrasse 14, 1090 Vienna, Austria.
Winkler J
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Źródło :
Expert opinion on biological therapy [Expert Opin Biol Ther] 2013 Jun; Vol. 13 (6), pp. 875-88. Date of Electronic Publication: 2013 Mar 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Gene Silencing*
Genetic Therapy/*methods
Oligonucleotides, Antisense/*pharmacokinetics
Animals ; Cell Membrane Permeability ; Genetic Therapy/adverse effects ; Humans ; Molecular Structure ; Oligonucleotides, Antisense/administration & dosage ; Oligonucleotides, Antisense/adverse effects ; Oligonucleotides, Antisense/chemistry ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Oligonucleotide-polyamine conjugates: influence of length and position of 2'-attached polyamines on duplex stability and antisense effect.
Autorzy :
Winkler J; Department of Medicinal Chemistry, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria. johannes.winkler@univie.ac.at
Saadat K
Díaz-Gavilán M
Urban E
Noe CR
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2009 Feb; Vol. 44 (2), pp. 670-7. Date of Electronic Publication: 2008 May 27.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Silencing/*drug effects
Oligonucleotides/*chemistry
Polyamines/*chemistry
Antineoplastic Agents ; Cations ; Down-Regulation/genetics ; Humans ; Melanoma/drug therapy ; Nucleic Acid Hybridization ; Oligonucleotides/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Targeted delivery and endosomal cellular uptake of DARPin-siRNA bioconjugates: Influence of linker stability on gene silencing.
Autorzy :
Lorenzer, Cornelia (AUTHOR)
Streußnig, Sonja (AUTHOR)
Tot, Emilia (AUTHOR)
Winkler, Anna-Maria (AUTHOR)
Merten, Hannes (AUTHOR)
Brandl, Fabian (AUTHOR)
Sayers, Edward J. (AUTHOR)
Watson, Peter (AUTHOR)
Jones, Arwyn T. (AUTHOR)
Zangemeister-Wittke, Uwe (AUTHOR)
Plückthun, Andreas (AUTHOR)
Winkler, Johannes (AUTHOR) johannes.winkler@univie.ac.at
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Źródło :
European Journal of Pharmaceutics & Biopharmaceutics. Aug2019, Vol. 141, p37-50. 14p.
Czasopismo naukowe
    Wyświetlanie 1-9 z 9

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