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    Wyświetlanie 1-14 z 14
    Tytuł:
    Non-small-cell lung cancer: molecular targeted therapy and personalized medicine – drug resistance, mechanisms, and strategies
    Autorzy:
    Sechler M
    Cizmic AD
    Avasarala S
    Van Scoyk M
    Brzezinski C
    Kelley N
    Bikkavilli RK
    Winn RA
    Pokaż więcej
    Temat:
    Therapeutics. Pharmacology
    RM1-950
    Źródło:
    Pharmacogenomics and Personalized Medicine, Vol 2013, Iss default, Pp 25-36 (2013)
    Opis pliku:
    electronic resource
    Relacje:
    http://www.dovepress.com/non-small-cell-lung-cancer-molecular-targeted-therapy-and-personalized-a12654; https://doaj.org/toc/1178-7066
    Dostęp URL:
    https://doaj.org/article/8b0b2ddeb49e4be6bd39eab835a8c665  Link otwiera się w nowym oknie
    Czasopismo naukowe
    Szczegóły
    Tytuł:
    The National Heart Lung and Blood Institute Disparities Elimination through Coordinated Interventions to Prevent and Control Heart and Lung Disease Alliance.
    Autorzy:
    Kho A; Center for Health Information Partnerships (CHiP), Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
    Daumit GL; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Truesdale KP; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
    Brown A; Department of Internal Medicine, University of Los Angeles School of Medicine, Los Angeles, CA, USA.
    Kilbourne AM; Department of Learning Health Sciences, University of Michigan Medicine, Ann Arbor, Michigan, USA.; Quality Enhancement Research Initiative (QUERI), U.S. Department of Veterans Affairs, Washington, D.C., USA.
    Ladapo J; Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.
    Wali S; Department of Internal Medicine, University of Los Angeles School of Medicine, Los Angeles, CA, USA.
    Cicutto L; Department of Medicine, National Jewish Health, Community Outreach and Research, Denver, Colorado, USA.
    Matthews AK; College of Nursing, University of Illinois at Chicago, Chicago, Illinois, USA.
    Smith JD; Department of Population Health Sciences, University of Utah Health, Salt Lake City, Utah, USA.
    Davis PD; Total Resource Community Development Organization, Northwestern University, Chicago, Illinois, USA.
    Schoenthaler A; Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.
    Ogedegbe G; Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.
    Islam N; Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.
    Mills KT; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
    He J; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
    Watson KS; NIH All of Us Bethesda, MD; Formerly, University of Illinois in Chicago Hospital and Health Sciences System, Mile Square Health Center Chicago, Illinois, USA.
    Winn RA; Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, USA.
    Stevens J; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
    Huebschmann AG; Department of Medicine, Division of General Internal Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado, USA.
    Szefler SJ; Department of Pediatrics, University of Colorado Denver School of Medicine, Denver, Colorado, USA.
    Pokaż więcej
    Źródło:
    Health services research [Health Serv Res] 2022 Jun; Vol. 57 Suppl 1, pp. 20-31.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Health Equity*
    Hypertension*
    Lung Diseases*/prevention & control
    Child ; Humans ; Poverty ; Racial Groups
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Wnt7a induces a unique phenotype of monocyte-derived macrophages with lower phagocytic capacity and differential expression of pro- and anti-inflammatory cytokines.
    Autorzy:
    Wallace J; Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL, USA.
    Lutgen V; Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL, USA.
    Avasarala S; University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, IL, USA.
    St Croix B; Center for Cancer Research (CCR), National Cancer Institute (NCI), Frederick, MD, USA.
    Winn RA; University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, IL, USA.
    Al-Harthi L; Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL, USA.
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    Źródło:
    Immunology [Immunology] 2018 Feb; Vol. 153 (2), pp. 203-213. Date of Electronic Publication: 2017 Oct 12.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
    MeSH Terms:
    Phagocytosis*
    Cytokines/*immunology
    Gene Expression Regulation/*immunology
    Macrophages/*immunology
    Monocytes/*immunology
    Wnt Proteins/*immunology
    Animals ; Antigens, CD/genetics ; Antigens, CD/immunology ; Brain/immunology ; Cytokines/genetics ; Female ; Humans ; Macrophages/cytology ; Male ; Mice ; Mice, Knockout ; Monocytes/cytology ; Spleen/immunology ; Wnt Proteins/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    The histone demethylase KDM3A is a microRNA-22-regulated tumor promoter in Ewing Sarcoma.
    Autorzy:
    Parrish JK; Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
    Sechler M; Cancer Biology Graduate Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
    Winn RA; Department of Medicine, University of Illinois, Chicago, IL, USA.
    Jedlicka P; 1] Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA [2] Cancer Biology Graduate Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
    Pokaż więcej
    Źródło:
    Oncogene [Oncogene] 2015 Jan 08; Vol. 34 (2), pp. 257-62. Date of Electronic Publication: 2013 Dec 23.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Bone Neoplasms/*enzymology
    Bone Neoplasms/*genetics
    Jumonji Domain-Containing Histone Demethylases/*genetics
    MicroRNAs/*genetics
    Sarcoma, Ewing/*enzymology
    Sarcoma, Ewing/*genetics
    Animals ; Cell Line, Tumor ; Cell Transformation, Neoplastic/genetics ; Down-Regulation ; Epigenomics ; Heterografts ; Humans ; Jumonji Domain-Containing Histone Demethylases/metabolism ; Mice ; Mice, Nude ; MicroRNAs/metabolism ; Sarcoma, Ewing/pathology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Heterotrimeric G-protein, Gα16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer.
    Autorzy:
    Avasarala S; Department of Pulmonary, Critical Care, Sleep and Allergy, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America.
    Bikkavilli RK
    Van Scoyk M
    Zhang W
    Lapite A
    Hostetter L
    Byers JT
    Heasley LE
    Sohn JW
    Winn RA
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2013 Oct 18; Vol. 8 (10), pp. e76895. Date of Electronic Publication: 2013 Oct 18 (Print Publication: 2013).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Cell Proliferation*
    Wnt Signaling Pathway*
    GTP-Binding Protein alpha Subunits, Gq-G11/*metabolism
    Growth Inhibitors/*metabolism
    Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line ; Cell Line, Tumor ; Enzyme Activation ; Frizzled Receptors/genetics ; Frizzled Receptors/metabolism ; GTP-Binding Protein alpha Subunits, Gq-G11/genetics ; Growth Inhibitors/genetics ; Humans ; Immunoblotting ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Mitogen-Activated Protein Kinase 7/metabolism ; Mutation ; PPAR gamma/metabolism ; RNA Interference ; Receptor Tyrosine Kinase-like Orphan Receptors/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Wnt Proteins/genetics ; Wnt Proteins/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Tumours with elevated levels of the Notch and Wnt pathways exhibit efficacy to PF-03084014, a γ-secretase inhibitor, in a preclinical colorectal explant model.
    Autorzy:
    Arcaroli JJ; Department of Medicine, University of Colorado Cancer Center, University of Colorado Denver, Aurora, CO, USA.
    Quackenbush KS
    Purkey A
    Powell RW
    Pitts TM
    Bagby S
    Tan AC
    Cross B
    McPhillips K
    Song EK
    Tai WM
    Winn RA
    Bikkavilli K
    Vanscoyk M
    Eckhardt SG
    Messersmith WA
    Pokaż więcej
    Źródło:
    British journal of cancer [Br J Cancer] 2013 Aug 06; Vol. 109 (3), pp. 667-75. Date of Electronic Publication: 2013 Jul 18.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Amyloid Precursor Protein Secretases/*antagonists & inhibitors
    Colorectal Neoplasms/*drug therapy
    Colorectal Neoplasms/*metabolism
    Receptors, Notch/*metabolism
    Tetrahydronaphthalenes/*pharmacology
    Valine/*analogs & derivatives
    Wnt Signaling Pathway/*drug effects
    Adenocarcinoma/drug therapy ; Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Adult ; Aged ; Animals ; Cell Growth Processes/drug effects ; Colorectal Neoplasms/pathology ; Enzyme Inhibitors/pharmacology ; Female ; Gene Knockdown Techniques ; HCT116 Cells ; Humans ; Mice ; Mice, Nude ; Middle Aged ; Random Allocation ; Valine/pharmacology ; Xenograft Model Antitumor Assays
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Methylation of Wnt7a is modulated by DNMT1 and cigarette smoke condensate in non-small cell lung cancer.
    Autorzy:
    Tennis MA; Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America. />Vanscoyk MM
    Wilson LA
    Kelley N
    Winn RA
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2012; Vol. 7 (3), pp. e32921. Date of Electronic Publication: 2012 Mar 05.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Carcinoma, Non-Small-Cell Lung/*pathology
    DNA (Cytosine-5-)-Methyltransferases/*metabolism
    DNA Methylation/*drug effects
    Lung Neoplasms/*pathology
    Smoke/*adverse effects
    Smoking/*adverse effects
    Wnt Proteins/*genetics
    Azacitidine/analogs & derivatives ; Azacitidine/pharmacology ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; DNA (Cytosine-5-)-Methyltransferase 1 ; Decitabine ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Lung/pathology ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Phenotype ; Promoter Regions, Genetic/drug effects ; Promoter Regions, Genetic/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    The many faces of wnt and pancreatic ductal adenocarcinoma oncogenesis.
    Autorzy:
    Weekes CD; Division of Medical Oncology, Department of Medicine, University of Colorado Cancer Center, University of Colorado Denver Anschutz Medical Campus, 12801 E. 17th Avenue, Aurora, CO 80045, USA. .
    Winn RA
    Pokaż więcej
    Źródło:
    Cancers [Cancers (Basel)] 2011 Sep 21; Vol. 3 (3), pp. 3676-86. Date of Electronic Publication: 2011 Sep 21.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Gamma-catenin expression is reduced or absent in a subset of human non-small cell lung cancers, and its re-expression inhibits cell growth.
    Autorzy:
    Winn RA; Veterans Administration Medical Center, Denver, Denver, CO 80262, USA. robert.winn@uchsc.edu
    Heasley LE
    Pokaż więcej
    Źródło:
    Chest [Chest] 2004 May; Vol. 125 (5 Suppl), pp. 122S-3S.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Azacitidine/*analogs & derivatives
    Carcinoma, Non-Small-Cell Lung/*metabolism
    Cytoskeletal Proteins/*metabolism
    Lung Neoplasms/*metabolism
    Azacitidine/pharmacology ; Cell Division/physiology ; Cell Line, Tumor ; DNA Modification Methylases/antagonists & inhibitors ; Decitabine ; Desmoplakins ; Humans ; Hydroxamic Acids/pharmacology ; Neoplasm Proteins/metabolism ; Trans-Activators/metabolism ; beta Catenin ; gamma Catenin
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-14 z 14

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