- Tytuł:
- Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody.
- Autorzy:
- Źródło:
- Science (New York, N.Y.) [Science] 2021 Feb 19; Vol. 371 (6531), pp. 823-829. Date of Electronic Publication: 2021 Jan 25.
- Typ publikacji:
- Journal Article; Research Support, N.I.H., Extramural
- MeSH Terms:
-
Antibodies, Monoclonal/*immunology
Antibodies, Viral/*immunology
Betacoronavirus/*immunology
Broadly Neutralizing Antibodies/*immunologySARS-CoV-2 /*immunology
Spike Glycoprotein, Coronavirus/*immunology
Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Antibodies, Monoclonal/genetics ; Antibodies, Monoclonal/metabolism ; Antibodies, Viral/genetics ; Antibodies, Viral/metabolism ; Antibody Affinity ; Binding Sites ; Binding Sites, Antibody ; Broadly Neutralizing Antibodies/genetics ; Broadly Neutralizing Antibodies/metabolism ; COVID-19/prevention & control ; COVID-19/therapy ; Cell Surface Display Techniques ; Directed Molecular Evolution ; Epitopes/immunology ; Humans ; Immunization, Passive ; Immunoglobulin Fc Fragments/immunology ; Mice, Inbred BALB C ; Protein Domains ; Protein Engineering ; Receptors, Coronavirus/metabolism ; Severe acute respiratory syndrome-related coronavirus/immunology ; Severe Acute Respiratory Syndrome/immunology ; Severe Acute Respiratory Syndrome/prevention & control ; Severe Acute Respiratory Syndrome/therapy ; Spike Glycoprotein, Coronavirus/metabolism ; COVID-19 Serotherapy ; Mice
Czasopismo naukowe