Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Wu, Tian"" wg kryterium: Autor


Tytuł :
A drug-like imidazole-benzothiazole conjugate inhibits malignant melanoma by stabilizing the c-MYC G-quadruplex.
Autorzy :
Wu TY; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Huang Q; School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China.
Huang ZS; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Hu MH; School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China. Electronic address: .
Tan JH; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. Electronic address: .
Pokaż więcej
Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Jun; Vol. 99, pp. 103866. Date of Electronic Publication: 2020 Apr 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Benzothiazoles/*pharmacology
G-Quadruplexes/*drug effects
Imidazoles/*pharmacology
Melanoma/*drug therapy
Proto-Oncogene Proteins c-myc/*antagonists & inhibitors
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Benzothiazoles/chemistry ; Cell Cycle Checkpoints/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Female ; Imidazoles/chemistry ; Melanoma/genetics ; Melanoma/pathology ; Melanoma, Experimental/drug therapy ; Melanoma, Experimental/genetics ; Melanoma, Experimental/pathology ; Mice ; Mice, Inbred C57BL ; Molecular Structure ; Proto-Oncogene Proteins c-myc/genetics ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
New substituted quinoxalines inhibit triple-negative breast cancer by specifically downregulating the c-MYC transcription.
Autorzy :
Hu MH; School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China.
Wu TY; School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China.
Huang Q; School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China.
Jin G; School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China.; International Cancer Center, Shenzhen University Health Science Center, Shenzhen 518060, China.
Pokaż więcej
Źródło :
Nucleic acids research [Nucleic Acids Res] 2019 Nov 18; Vol. 47 (20), pp. 10529-10542.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*
Antineoplastic Agents/*therapeutic use
Mammary Neoplasms, Experimental/*drug therapy
Proto-Oncogene Proteins c-myc/*genetics
Quinoxalines/*chemistry
Triple Negative Breast Neoplasms/*drug therapy
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Female ; G-Quadruplexes ; Mice ; Mice, Inbred BALB C ; Promoter Regions, Genetic/drug effects ; Proto-Oncogene Proteins c-myc/metabolism
Czasopismo naukowe
Tytuł :
Constituents and Anti-Multidrug Resistance Activity of Taiwanofungus camphoratus on Human Cervical Cancer Cells.
Autorzy :
Hung HY; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. .
Hung CC; Department of Pharmacy, College of Pharmacy, China Medical University, Taichung 402, Taiwan.
Liang JW; Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan. .
Chen CF; Department of Life Sciences, National Cheng Kung University, Tainan 701, Taiwan. .
Chen HY; Department of Pharmacy, College of Pharmacy, China Medical University, Taichung 402, Taiwan. .
Shieh PC; Department of Pharmacy, College of Pharmacy and Health Care, Tajen University, Pingtung 907, Taiwan. .
Kuo PC; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. .
Wu TS; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. .; Department of Pharmacy, College of Pharmacy and Health Care, Tajen University, Pingtung 907, Taiwan. .
Pokaż więcej
Źródło :
Molecules (Basel, Switzerland) [Molecules] 2019 Oct 16; Vol. 24 (20). Date of Electronic Publication: 2019 Oct 16.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Basidiomycota/*chemistry
Biological Products/*pharmacology
Drug Resistance, Multiple/*drug effects
Drug Resistance, Neoplasm/*drug effects
ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/isolation & purification ; Biological Products/chemistry ; Biological Products/isolation & purification ; Female ; HeLa Cells ; Humans ; Molecular Structure
Czasopismo naukowe
Tytuł :
Carnosic acid enhances the anti-lung cancer effect of cisplatin by inhibiting myeloid-derived suppressor cells.
Autorzy :
Liu W; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, China.
Wu TC; Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Hong DM; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, China.
Hu Y; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, China.
Fan T; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, China.
Guo WJ; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, China. Electronic address: .
Xu Q; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, China. Electronic address: .
Pokaż więcej
Źródło :
Chinese journal of natural medicines [Chin J Nat Med] 2018 Dec; Vol. 16 (12), pp. 907-915.
Typ publikacji :
Journal Article
MeSH Terms :
Abietanes/*administration & dosage
Antineoplastic Agents/*administration & dosage
Carcinoma, Lewis Lung/*drug therapy
Cisplatin/*administration & dosage
Lung Neoplasms/*drug therapy
Myeloid-Derived Suppressor Cells/*drug effects
Plant Extracts/*administration & dosage
Rosmarinus/*chemistry
Animals ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; Carcinoma, Lewis Lung/genetics ; Carcinoma, Lewis Lung/immunology ; Cell Line, Tumor ; Drug Synergism ; Humans ; Interferon-gamma/genetics ; Interferon-gamma/immunology ; Lung Neoplasms/genetics ; Lung Neoplasms/immunology ; Matrix Metalloproteinase 9/genetics ; Mice ; Mice, Inbred C57BL ; Myeloid-Derived Suppressor Cells/immunology
Czasopismo naukowe
Tytuł :
Chemical constituents from the fruiting bodies of Phellinus igniarius.
Autorzy :
Thanh NT; a School of Chemistry, Biology and Environment , Vinh University , Vinh City , Vietnam.
Tuan NN; b Institute of Biotechnology and Food Technology , Industrial University of Ho Chi Minh City , Ho Chi Minh City, Vietnam.
Kuo PC; c School of Pharmacy, College of Medicine , National Cheng Kung University , Tainan , Taiwan.
Dung DM; d Hue University of Science - Hue University , Hue City , Vietnam.
Phuong DL; e Institute of Natural Products Chemistry , Vietnam Academy of Science and Technology , Cau Giay , Viet Nam.
Giang DTT; f School of Natural Sciences Education , Vinh University , Vinh City , Vietnam.
Wu TS; c School of Pharmacy, College of Medicine , National Cheng Kung University , Tainan , Taiwan.; g Department of Pharmacy, College of Pharmacy and Health Care , Tajen University , Pingtung Taiwan.
Thang TD; a School of Chemistry, Biology and Environment , Vinh University , Vinh City , Vietnam.
Pokaż więcej
Źródło :
Natural product research [Nat Prod Res] 2018 Oct; Vol. 32 (20), pp. 2392-2397. Date of Electronic Publication: 2017 Dec 13.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Basidiomycota/*chemistry
Triterpenes/*pharmacology
Antineoplastic Agents/isolation & purification ; Cell Line, Tumor ; Ergosterol/analogs & derivatives ; Ergosterol/isolation & purification ; Fruiting Bodies, Fungal/chemistry ; Hep G2 Cells ; Humans ; MCF-7 Cells ; Molecular Structure ; Triterpenes/isolation & purification ; Vietnam
Czasopismo naukowe
Tytuł :
Anti-cell proliferation effect of naphthoquinone dimers isolated from Plumbago zeylanica.
Autorzy :
Ito C; a Faculty of Pharmacy , Meijo University , Tempaku , Japan.
Matsui T; a Faculty of Pharmacy , Meijo University , Tempaku , Japan.; b Department of Physiology , Aichi Medical University , Nagakute , Japan.
Takano M; a Faculty of Pharmacy , Meijo University , Tempaku , Japan.
Wu TS; c Department of Chemistry , National Cheng Kung University , Tainan , Taiwan.
Itoigawa M; d School of Sport and Health Science , Tokai Gakuen University , Miyoshi , Japan.
Pokaż więcej
Źródło :
Natural product research [Nat Prod Res] 2018 Sep; Vol. 32 (18), pp. 2127-2132. Date of Electronic Publication: 2017 Aug 20.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*isolation & purification
Cell Proliferation/*drug effects
Naphthoquinones/*pharmacology
Plumbaginaceae/*chemistry
Antineoplastic Agents/pharmacology ; Cell Cycle/drug effects ; Cell Line, Tumor ; Dimerization ; Humans ; Naphthoquinones/chemistry ; Naphthoquinones/isolation & purification ; Plant Roots/chemistry ; Taiwan
Czasopismo naukowe
Tytuł :
Synthesis and antitumor activity of bis(hydroxymethyl)propionate analogs of pterostilbene in cisplatin-resistant human oral cancer cells.
Autorzy :
Hsieh MT; School of Pharmacy, China Medical University, Taichung 404, Taiwan; Chinese Medicinal Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan.
Huang LJ; School of Pharmacy, China Medical University, Taichung 404, Taiwan.
Wu TS; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Lin HY; School of Pharmacy, China Medical University, Taichung 404, Taiwan.
Morris-Natschke SL; Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, United States.
Lee KH; Chinese Medicinal Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan; Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, United States. Electronic address: .
Kuo SC; School of Pharmacy, China Medical University, Taichung 404, Taiwan; Chinese Medicinal Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. Electronic address: .
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2018 Aug 07; Vol. 26 (14), pp. 3909-3916. Date of Electronic Publication: 2018 Jun 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Cisplatin/*pharmacology
Drug Resistance, Neoplasm/*drug effects
Mouth Neoplasms/*drug therapy
Propionates/*pharmacology
Stilbenes/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Cisplatin/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Mouth Neoplasms/pathology ; Propionates/chemistry ; Stilbenes/chemical synthesis ; Stilbenes/chemistry ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Toxicological effects of NCKU-21, a phenanthrene derivative, on cell growth and migration of A549 and CL1-5 human lung adenocarcinoma cells.
Autorzy :
Liao HF; Cancer Biology and Drug Discovery, China Medical University and Academia Sinica, Taichung, Taiwan.; Department of Pharmacy, Yuanli Lee's General Hospital, Lee's Medical Corporation, Miaoli, Taiwan.
Pan CH; School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Chou PY; Department of Nursing, Hung Kuang University, Taichung, Taiwan.; Sports Recreation and Health Management Continuing Studies-Bachelor's Degree Completion Program, Tung Hai University, Taichung, Taiwan.
Chen YF; Cancer Biology and Drug Discovery, China Medical University and Academia Sinica, Taichung, Taiwan.
Wu TS; Department of Chemistry, National Cheng Kung University, Tainan, Taiwan.; Department of Pharmacy, National Cheng Kung University, Tainan, Taiwan.
Sheu MJ; School of Pharmacy, China Medical University, Taichung, Taiwan.
Wu CH; School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Pokaż więcej
Źródło :
PloS one [PLoS One] 2017 Sep 25; Vol. 12 (9), pp. e0185021. Date of Electronic Publication: 2017 Sep 25 (Print Publication: 2017).
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma/*drug therapy
Antineoplastic Agents/*therapeutic use
Cell Movement/*drug effects
Cell Proliferation/*drug effects
Lung Neoplasms/*drug therapy
Phenanthrenes/*therapeutic use
A549 Cells ; Blotting, Western ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Caspase 3/metabolism ; Cell Line, Tumor ; Humans ; Matrix Metalloproteinase 9/metabolism ; Mitochondria/drug effects ; Molecular Docking Simulation
Czasopismo naukowe
Tytuł :
The synthesis, structure-toxicity relationship of cisplatin derivatives for the mechanism research of cisplatin-induced nephrotoxicity.
Autorzy :
Hu J; Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China.
Wu TM; Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China.
Li HZ; Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China.
Zuo ZP; Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China.
Zhao YL; Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China. Electronic address: .
Yang L; Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China. Electronic address: .
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Aug 01; Vol. 27 (15), pp. 3591-3594. Date of Electronic Publication: 2017 Apr 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*toxicity
Cisplatin/*analogs & derivatives
Cisplatin/*toxicity
Kidney/*drug effects
Kidney Diseases/*chemically induced
Animals ; Biotin/chemistry ; Cell Line ; Cell Survival/drug effects ; Humans ; Kidney/cytology ; Kidney/pathology ; Kidney Diseases/pathology ; LLC-PK1 Cells ; Proteomics ; Swine
Czasopismo naukowe
Tytuł :
Mechanistic Study of Tetrahydrofuran- acetogenins In Triggering Endoplasmic Reticulum Stress Response-apotoposis in Human Nasopharyngeal Carcinoma.
Autorzy :
Juang SH; Department of Pharmacy, Tajen University, Pingtung 907, Taiwan.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan.
Chiang CY; School of Pharmacy, China Medical University, Taichung 404, Taiwan.
Liang FP; Department of Pharmacy, Tajen University, Pingtung 907, Taiwan.
Chan HH; Department of Pharmacy, National Cheng Kung University, Tainan 701, Taiwan.
Yang JS; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan.
Wang SH; School of Pharmacy, China Medical University, Taichung 404, Taiwan.
Lin YC; School of Pharmacy, China Medical University, Taichung 404, Taiwan.
Kuo PC; Department of Pharmacy, National Cheng Kung University, Tainan 701, Taiwan.
Shen MR; Department of Pharmacology, Obstetrics &Gynecology, National Cheng Kung University, Tainan 701, Taiwan.
Thang TD; Department of Chemistry, Vinh University, Vinh City, Nghean province, Vietnam.
Nguyet BT; Department of Chemistry, Vinh University, Vinh City, Nghean province, Vietnam.
Kuo SC; School of Pharmacy, China Medical University, Taichung 404, Taiwan.
Wu TS; Department of Pharmacy, National Cheng Kung University, Tainan 701, Taiwan.
Pokaż więcej
Źródło :
Scientific reports [Sci Rep] 2016 Dec 21; Vol. 6, pp. 39251. Date of Electronic Publication: 2016 Dec 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetogenins/*toxicity
Antineoplastic Agents/*toxicity
Apoptosis/*drug effects
Endoplasmic Reticulum Stress/*drug effects
Furans/*chemistry
Acetogenins/chemistry ; Acetogenins/isolation & purification ; Acetogenins/therapeutic use ; Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Carcinoma/drug therapy ; Carcinoma/metabolism ; Carcinoma/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; G2 Phase Cell Cycle Checkpoints/drug effects ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Humans ; M Phase Cell Cycle Checkpoints/drug effects ; Male ; Membrane Potential, Mitochondrial/drug effects ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Nasopharyngeal Carcinoma ; Nasopharyngeal Neoplasms/drug therapy ; Nasopharyngeal Neoplasms/metabolism ; Nasopharyngeal Neoplasms/pathology ; Protein Phosphatase 1/antagonists & inhibitors ; Protein Phosphatase 1/genetics ; Protein Phosphatase 1/metabolism ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł :
Suppression of phospho-p85α-GTP-Rac1 lipid raft interaction by bichalcone analog attenuates cancer cell invasion.
Autorzy :
Lu HL; Division of Laboratory, Armed Force Taichung General Hospital, Taichung, Taiwan.
Chen SS; Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan.
Hsu WT; Division of Laboratory, Armed Force Taichung General Hospital, Taichung, Taiwan.
Lu YC; Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan.
Lee CC; Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan.
Wu TS; Department of Chemistry, National Cheng Kung University, Tainan, Taiwan.
Lin ML; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan.
Pokaż więcej
Źródło :
Molecular carcinogenesis [Mol Carcinog] 2016 Dec; Vol. 55 (12), pp. 2106-2120. Date of Electronic Publication: 2016 Jan 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Chalcones/*pharmacology
Class Ia Phosphatidylinositol 3-Kinase/*metabolism
Membrane Microdomains/*metabolism
Neoplasm Invasiveness/*prevention & control
Piperazines/*pharmacology
rac1 GTP-Binding Protein/*metabolism
Cell Line, Tumor ; Cell Movement/drug effects ; Down-Regulation ; Guanosine Triphosphate/metabolism ; Humans ; Matrix Metalloproteinase 2/genetics ; NF-kappa B/metabolism ; Neoplasm Invasiveness/genetics ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors.
Autorzy :
Pettus LH; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Andrews KL; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Booker SK; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Chen J; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Cee VJ; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Chavez F Jr; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Chen Y; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Eastwood H; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Guerrero N; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Herberich B; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Hickman D; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Lanman BA; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Laszlo J 3rd; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Lee MR; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Lipford JR; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Mattson B; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Mohr C; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Nguyen Y; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Norman MH; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Powers D; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Reed AB; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Rex K; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Sastri C; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Tamayo N; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Wang P; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Winston JT; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Wu B; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Wu T; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Wurz RP; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Xu Y; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Zhou Y; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Tasker AS; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Wang HL; Department of Therapeutic Discovery-Medicinal Chemistry, ‡Molecular Structure, §Pharmacokinetics and Drug Metabolism, ∥Oncology Research, ⊥Pharmaceutics, #Discovery Technologies, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2016 Jul 14; Vol. 59 (13), pp. 6407-30. Date of Electronic Publication: 2016 Jun 22.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Antineoplastic Agents/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Proto-Oncogene Proteins c-pim-1/*antagonists & inhibitors
Pyrroles/*pharmacology
Quinazolinones/*pharmacology
Administration, Oral ; Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Humans ; Mice ; Models, Molecular ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/pathology ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/chemistry ; Proto-Oncogene Proteins c-pim-1/metabolism ; Pyrroles/administration & dosage ; Pyrroles/chemistry ; Quinazolinones/administration & dosage ; Quinazolinones/chemistry ; Structure-Activity Relationship ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Design and synthesis of new 2-arylnaphthyridin-4-ones as potent antitumor agents targeting tumorigenic cell lines.
Autorzy :
Liu CY; Graduate Institute of Pharmaceutical Chemistry, China Medical University, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan.
Cheng YY; Graduate Institute of Pharmaceutical Chemistry, China Medical University, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan.
Chang LC; Graduate Institute of Pharmaceutical Chemistry, China Medical University, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan.
Huang LJ; Graduate Institute of Pharmaceutical Chemistry, China Medical University, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan.
Chou LC; Graduate Institute of Pharmaceutical Chemistry, China Medical University, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan; Graduate School of Biotechnology, Hung Kuang University, No. 1018, Sec. 6 Taiwan Boulevard, Shalu District, Taichung 43302, Taiwan.
Huang CH; Graduate School of Biotechnology, Hung Kuang University, No. 1018, Sec. 6 Taiwan Boulevard, Shalu District, Taichung 43302, Taiwan.
Tsai MT; Graduate Institute of Pharmaceutical Chemistry, China Medical University, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan.
Liao CC; Graduate Institute of Pharmaceutical Chemistry, China Medical University, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan.
Hsu MH; Graduate Institute of Pharmaceutical Chemistry, China Medical University, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan.
Lin HY; Graduate Institute of Pharmaceutical Chemistry, China Medical University, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan.
Wu TS; Department of Chemistry, National Cheng Kung University, No. 1 Dasyue Road, Tainan 70101, Taiwan.
Wen YF; Industrial Technology Research Institute, No. 195, Sec. 4 Chung Hsing Rd., Chutung, Hsinchu 31040, Taiwan.
Zhao Y; Kunming Institute of Botany, Chinese Academy of Sciences, No. 132 Lanhei Road, Heilongtan, Kunming, Yunnan 650201, China; Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
Kuo SC; Graduate Institute of Pharmaceutical Chemistry, China Medical University, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan; Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: .
Lee KH; Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA; Chinese Medicine Research and Development Center, China Medical University and Hospital, 2 Yuh-Der Road, Taichung 40447, Taiwan. Electronic address: .
Pokaż więcej
Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2015 Jan 27; Vol. 90, pp. 775-87. Date of Electronic Publication: 2014 Dec 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Antineoplastic Agents/*pharmacology
Liver Neoplasms, Experimental/*drug therapy
Naphthyridines/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; HL-60 Cells ; Humans ; Liver Neoplasms, Experimental/pathology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Models, Molecular ; Molecular Structure ; Naphthyridines/chemical synthesis ; Naphthyridines/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Suppression of PI3K/Akt signaling by synthetic bichalcone analog TSWU-CD4 induces ER stress- and Bax/Bak-mediated apoptosis of cancer cells.
Autorzy :
Lin ML; Department of Medical Laboratory Science and Biotechnology, China Medical University, No. 91, Hsueh-Shih Road, Taichung, 40402, Taiwan, .
Chen SS
Huang RY
Lu YC
Liao YR
Reddy MV
Lee CC
Wu TS
Pokaż więcej
Źródło :
Apoptosis : an international journal on programmed cell death [Apoptosis] 2014 Nov; Vol. 19 (11), pp. 1637-53.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Chalcones/*pharmacology
Endoplasmic Reticulum Stress/*drug effects
Phosphatidylinositol 3-Kinases/*metabolism
Piperazines/*pharmacology
Proto-Oncogene Proteins c-akt/*metabolism
bcl-2 Homologous Antagonist-Killer Protein/*metabolism
bcl-2-Associated X Protein/*metabolism
Calcium/metabolism ; Calcium Channel Blockers/pharmacology ; Caspase 12/metabolism ; Cell Line ; Dantrolene/pharmacology ; Heat-Shock Proteins/metabolism ; Humans ; Mitochondria/metabolism ; Phosphoinositide-3 Kinase Inhibitors ; Protein Multimerization ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Signal Transduction ; eIF-2 Kinase/metabolism
Czasopismo naukowe
Tytuł :
The novel pterostilbene derivative ANK-199 induces autophagic cell death through regulating PI3 kinase class III/beclin 1/Atg‑related proteins in cisplatin‑resistant CAR human oral cancer cells.
Autorzy :
Hsieh MT; School of Pharmacy, China Medical University, Taichung 404, Taiwan, R.O.C.
Chen HP; Department of Biochemistry, Tzu Chi University, Hualien 970, Taiwan, R.O.C.
Lu CC; Department of Food Science and Biotechnology, National Chung Hsing University, Taichung 402, Taiwan, R.O.C.
Chiang JH; Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan, R.O.C.
Wu TS; Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan, R.O.C.
Kuo DH; Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan, R.O.C.
Huang LJ; Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan, R.O.C.
Kuo SC; Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan, R.O.C.
Yang JS; Department of Pharmacology, China Medical University, Taichung 404, Taiwan, R.O.C.
Pokaż więcej
Źródło :
International journal of oncology [Int J Oncol] 2014 Aug; Vol. 45 (2), pp. 782-94. Date of Electronic Publication: 2014 Jun 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Autophagy/*drug effects
Drug Resistance, Neoplasm/*drug effects
Mouth Neoplasms/*metabolism
Stilbenes/*pharmacokinetics
Stilbenes/*pharmacology
Apoptosis Regulatory Proteins/metabolism ; Beclin-1 ; Blotting, Western ; Cell Line, Tumor ; Cell Survival/drug effects ; Cisplatin/pharmacology ; Humans ; Membrane Proteins/metabolism ; Mouth Neoplasms/pathology ; Oligonucleotide Array Sequence Analysis ; Phosphatidylinositol 3-Kinases/metabolism ; Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
The constituents of Michelia compressa var. formosana and their bioactivities.
Autorzy :
Chan YY; Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan. .
Juang SH; Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 40402, Taiwan. .
Huang GJ; Department of Pharmacy, China Medical University, Taichung 40402, Taiwan. .
Liao YR; Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan. .
Chen YF; Department of Life Sciences, National Cheng Kung University, Tainan 70101, Taiwan. .
Wu CC; School of Forestry and Resource Conservation, National Taiwan University, Taipei 10617, Taiwan. .
Chang HT; School of Forestry and Resource Conservation, National Taiwan University, Taipei 10617, Taiwan. .
Wu TS; Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan. .
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2014 Jun 17; Vol. 15 (6), pp. 10926-35. Date of Electronic Publication: 2014 Jun 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Inflammatory Agents/*chemistry
Antineoplastic Agents/*chemistry
Aporphines/*chemistry
Magnoliaceae/*chemistry
Anti-Inflammatory Agents/isolation & purification ; Anti-Inflammatory Agents/pharmacology ; Antineoplastic Agents/isolation & purification ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/toxicity ; Aporphines/isolation & purification ; Aporphines/pharmacology ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Screening Assays, Antitumor ; Humans ; Jurkat Cells ; Magnoliaceae/metabolism ; Nitric Oxide/metabolism ; Plant Extracts/chemistry ; Plant Extracts/pharmacology
Czasopismo naukowe
Tytuł :
Cytotoxic cardiac glycosides and coumarins from Antiaris toxicaria.
Autorzy :
Shi LS; Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan; Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan.
Kuo SC; Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 401, Taiwan.
Sun HD; Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204, Yunnan, China.
Morris-Natschke SL; Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA.
Lee KH; Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA; Department of Pharmacy and Chinese Medicine Research and Development Center, China Medical University, Taichung 401, Taiwan.
Wu TS; Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan; Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA. Electronic address: .
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2014 Mar 15; Vol. 22 (6), pp. 1889-98. Date of Electronic Publication: 2014 Feb 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiaris/*chemistry
Antineoplastic Agents/*pharmacology
Cardiac Glycosides/*pharmacology
Coumarins/*pharmacology
Antineoplastic Agents/chemistry ; Antineoplastic Agents/isolation & purification ; Cardiac Glycosides/chemistry ; Cardiac Glycosides/isolation & purification ; Cell Line, Tumor ; Coumarins/chemistry ; Coumarins/isolation & purification ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; MCF-7 Cells ; Molecular Conformation ; Plant Bark/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead.
Autorzy :
Cheng YY; Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 40402, Taiwan, ROC.
Liu CY
Tsai MT
Lin HY
Yang JS
Wu TS
Kuo SC
Huang LJ
Lee KH
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Sep 15; Vol. 23 (18), pp. 5223-7. Date of Electronic Publication: 2013 Jul 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Antineoplastic Agents/*pharmacology
Pyrrolidines/*pharmacology
Quinolones/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Pyrrolidines/chemical synthesis ; Pyrrolidines/chemistry ; Quinolones/chemical synthesis ; Quinolones/chemistry ; Structure-Activity Relationship
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies