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Wyszukujesz frazę ""X Chromosome"" wg kryterium: Temat


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Tytuł :
The X chromosome dosage compensation program during the development of cynomolgus monkeys.
Autorzy :
Okamoto I; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Nakamura T; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.; Hakubi Center for Advanced Research, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Sasaki K; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Yabuta Y; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Iwatani C; Research Center for Animal Life Science, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.
Tsuchiya H; Research Center for Animal Life Science, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.
Nakamura SI; Research Center for Animal Life Science, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.
Ema M; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.; Research Center for Animal Life Science, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.
Yamamoto T; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.; Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.; AMED-CREST, AMED, 1-7-1 Otemachi, Chiyoda-ku, Tokyo 100-0004, Japan.; Medical-Risk Avoidance Based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), Kyoto 606-8507, Japan.
Saitou M; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.; Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Nov 19; Vol. 374 (6570), pp. eabd8887. Date of Electronic Publication: 2021 Nov 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dosage Compensation, Genetic*
X Chromosome Inactivation*
Blastocyst/*physiology
Macaca fascicularis/*embryology
Macaca fascicularis/*genetics
Trophoblasts/*physiology
X Chromosome/*genetics
Animals ; Embryonic Development ; Female ; Gene Expression Regulation, Developmental ; Genes, X-Linked ; Germ Cells/physiology ; Histones/metabolism ; Methylation ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Up-Regulation ; X Chromosome/metabolism ; X Chromosome/ultrastructure
Czasopismo naukowe
Tytuł :
Four-dimensional chromosome reconstruction elucidates the spatiotemporal reorganization of the mammalian X chromosome.
Autorzy :
Lappala A; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545.; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Genetics, The Blavatnik Institute, Harvard Medical School, Boston, MA 02114.
Wang CY; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Genetics, The Blavatnik Institute, Harvard Medical School, Boston, MA 02114.
Kriz A; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Genetics, The Blavatnik Institute, Harvard Medical School, Boston, MA 02114.
Michalk H; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545.
Tan K; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Genetics, The Blavatnik Institute, Harvard Medical School, Boston, MA 02114.
Lee JT; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114; .; Department of Genetics, The Blavatnik Institute, Harvard Medical School, Boston, MA 02114.
Sanbonmatsu KY; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545; .; New Mexico Consortium, Los Alamos, NM 87545.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Oct 19; Vol. 118 (42).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
X Chromosome*
Mammals/*genetics
Animals ; X Chromosome Inactivation
Czasopismo naukowe
Tytuł :
Xist nucleates local protein gradients to propagate silencing across the X chromosome.
Autorzy :
Markaki Y; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: .
Gan Chong J; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Wang Y; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jacobson EC; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Luong C; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Tan SYX; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jachowicz JW; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Strehle M; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Maestrini D; Department of Computational Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Banerjee AK; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Mistry BA; Department of Computational Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Claremont McKenna College, Claremont, CA 91711, USA.
Dror I; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Dossin F; European Molecular Biology Laboratory, Director's Unit, Heidelberg 69117, Germany.
Schöneberg J; Departments of Pharmacology & Chemistry and Biochemistry, University of California San Diego, San Diego, CA 92093, USA.
Heard E; European Molecular Biology Laboratory, Director's Unit, Heidelberg 69117, Germany.
Guttman M; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Chou T; Department of Computational Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: .
Plath K; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: .
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Źródło :
Cell [Cell] 2021 Dec 09; Vol. 184 (25), pp. 6174-6192.e32. Date of Electronic Publication: 2021 Nov 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis Regulatory Proteins/*metabolism
Mitochondrial Proteins/*metabolism
RNA, Long Noncoding/*metabolism
X Chromosome/*metabolism
Animals ; Cell Line ; Embryonic Stem Cells ; Fibroblasts ; Gene Silencing ; Humans ; Mice ; Protein Binding ; X Chromosome Inactivation
Czasopismo naukowe
Tytuł :
Contribution of genetic and epigenetic changes to escape from X-chromosome inactivation.
Autorzy :
Balaton BP; Department of Medical Genetics, The University of British Columbia, Vancouver, Canada.
Brown CJ; Department of Medical Genetics, The University of British Columbia, Vancouver, Canada. .
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Źródło :
Epigenetics & chromatin [Epigenetics Chromatin] 2021 Jun 29; Vol. 14 (1), pp. 30. Date of Electronic Publication: 2021 Jun 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic*
X Chromosome Inactivation*
Animals ; CpG Islands ; DNA Methylation ; Histones ; X Chromosome/genetics
Czasopismo naukowe
Tytuł :
Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution.
Autorzy :
Pacini G; Otto Warburg Laboratories, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Dunkel I; Otto Warburg Laboratories, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Mages N; Sequencing core facility, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Mutzel V; Otto Warburg Laboratories, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Timmermann B; Sequencing core facility, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Marsico A; Institute for Computational Biology, Helmholtz Center, München, Germany. .
Schulz EG; Otto Warburg Laboratories, Max Planck Institute for Molecular Genetics, Berlin, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 15; Vol. 12 (1), pp. 3638. Date of Electronic Publication: 2021 Jun 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Up-Regulation*
X Chromosome Inactivation*/genetics
X Chromosome Inactivation*/physiology
RNA, Long Noncoding/*genetics
RNA, Long Noncoding/*metabolism
Alleles ; Animals ; Dosage Compensation, Genetic ; Female ; Gene Silencing ; Mice ; Mice, Inbred C57BL ; Mouse Embryonic Stem Cells ; Sequence Analysis, RNA ; X Chromosome
Czasopismo naukowe
Tytuł :
Time-resolved structured illumination microscopy reveals key principles of Xist RNA spreading.
Autorzy :
Rodermund L; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
Coker H; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
Oldenkamp R; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
Wei G; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
Bowness J; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
Rajkumar B; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
Nesterova T; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
Susano Pinto DM; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
Schermelleh L; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK. .
Brockdorff N; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK. .
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Źródło :
Science (New York, N.Y.) [Science] 2021 Jun 11; Vol. 372 (6547).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
X Chromosome Inactivation*
DNA-Binding Proteins/*metabolism
Nuclear Proteins/*metabolism
RNA, Long Noncoding/*metabolism
RNA-Binding Proteins/*metabolism
Animals ; Cell Line ; Cell Nucleus/metabolism ; Chromatin/metabolism ; DNA-Binding Proteins/genetics ; Embryonic Stem Cells ; Gene Silencing ; Mice ; Microscopy ; Nuclear Proteins/genetics ; RNA Stability ; RNA, Long Noncoding/biosynthesis ; RNA-Binding Proteins/genetics ; Spatial Analysis ; Transcription, Genetic ; X Chromosome/metabolism
Czasopismo naukowe
Tytuł :
Cross-species examination of X-chromosome inactivation highlights domains of escape from silencing.
Autorzy :
Balaton BP; Department of Medical Genetics, The University of British Columbia, Vancouver, Canada.
Fornes O; Department of Medical Genetics, The University of British Columbia, Vancouver, Canada.; BC Children's Hospital Research Institute, Vancouver, Canada.; Centre for Molecular Medicine and Therapeutics, The University of British Columbia, Vancouver, Canada.
Wasserman WW; Department of Medical Genetics, The University of British Columbia, Vancouver, Canada.; BC Children's Hospital Research Institute, Vancouver, Canada.; Centre for Molecular Medicine and Therapeutics, The University of British Columbia, Vancouver, Canada.
Brown CJ; Department of Medical Genetics, The University of British Columbia, Vancouver, Canada. .
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Źródło :
Epigenetics & chromatin [Epigenetics Chromatin] 2021 Feb 17; Vol. 14 (1), pp. 12. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation*
X Chromosome Inactivation*
Animals ; Cattle ; CpG Islands ; Dogs ; Female ; Genes, X-Linked ; Horses ; Male ; Mice ; Sheep ; Swine ; X Chromosome/genetics
Czasopismo naukowe
Tytuł :
Does XIST safeguard against sex-biased human diseases?
Autorzy :
Sado T; Department of Advanced Bioscience, Graduate School of Agriculture, and Agricultural Technology and Innovation Research Institute, Kindai University, 3327-204, Nakamachi, Nara, 631-8505, Japan. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Apr 15; Vol. 81 (8), pp. 1598-1600.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
RNA, Long Noncoding*/genetics
X Chromosome Inactivation*/genetics
B-Lymphocytes ; Cell Differentiation ; Female ; Humans ; X Chromosome/genetics
Czasopismo naukowe
Tytuł :
Dynamic Behavior of Inactive X Chromosome Territory During the Cell Cycle as Revealed by H3K27me3-Specific Intracellular Antibody.
Autorzy :
Sato Y; Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan.
Kimura H; Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2329, pp. 237-247.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
X Chromosome Inactivation*
Fluorescent Dyes/*chemistry
Histones/*metabolism
X Chromosome/*genetics
Animals ; Cell Cycle ; Cell Line, Tumor ; HeLa Cells ; Histone Code ; Histones/chemistry ; Humans ; Methylation ; Mice ; Microscopy, Confocal ; Time-Lapse Imaging ; X Chromosome/chemistry
Czasopismo naukowe
Tytuł :
Sex chromosome transformation and the origin of a male-specific X chromosome in the creeping vole.
Autorzy :
Couger MB; Department of Thoracic Surgery, Brigham and Women's Hospital, Boston MA, 02115, USA.
Roy SW; Department of Biology, San Francisco State University, San Francisco, CA 94117, USA.; Department of Molecular and Cell Biology, University of California, Merced, Merced, CA 95343, USA.
Anderson N; Department of Molecular and Cell Biology, University of California, Merced, Merced, CA 95343, USA.
Gozashti L; Department of Organismic and Evolutionary Biology and Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, USA.
Pirro S; Iridian Genomes, Inc., Bethesda, MD 20817, USA.
Millward LS; Department of Fisheries and Wildlife, Oregon State University, Corvallis, OR 97330, USA.
Kim M; Circulomics Inc., Baltimore, MD 21202, USA.
Kilburn D; Circulomics Inc., Baltimore, MD 21202, USA.
Liu KJ; Circulomics Inc., Baltimore, MD 21202, USA.
Wilson TM; US Forest Service, PNW Research Station, Corvallis, OR 97331, USA.
Epps CW; Department of Fisheries and Wildlife, Oregon State University, Corvallis, OR 97330, USA.
Dizney L; Department of Biology, University of Portland, Portland, OR 97203, USA.
Ruedas LA; Department of Biology and Museum of Natural History, Portland State University, Portland, OR 97207, USA.
Campbell P; Department of Evolution, Ecology, and Organismal Biology, University of California, Riverside, Riverside, CA 92521, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2021 May 07; Vol. 372 (6542), pp. 592-600.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Abnormal Karyotype*
Arvicolinae/*genetics
Sex Determination Processes/*genetics
X Chromosome/*genetics
Animals ; Base Sequence ; Female ; Gene Amplification ; Genes, sry ; Haplotypes ; Male ; Maternal Inheritance ; X Chromosome Inactivation ; Y Chromosome/genetics
Czasopismo naukowe
Tytuł :
Overcoming Autocrine FGF Signaling-Induced Heterogeneity in Naive Human ESCs Enables Modeling of Random X Chromosome Inactivation.
Autorzy :
An C; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
Feng G; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
Zhang J; University of Chinese Academy of Sciences, Beijing 100049, China; Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
Cao S; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
Wang Y; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
Wang N; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
Lu F; University of Chinese Academy of Sciences, Beijing 100049, China; Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
Zhou Q; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
Wang H; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: .
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Źródło :
Cell stem cell [Cell Stem Cell] 2020 Sep 03; Vol. 27 (3), pp. 482-497.e4. Date of Electronic Publication: 2020 Jul 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Human Embryonic Stem Cells*
X Chromosome Inactivation*/genetics
Cell Differentiation ; Chromosomes, Human, X/genetics ; Humans ; Signal Transduction ; X Chromosome
Czasopismo naukowe
Tytuł :
Molecular Mechanisms of Facultative Heterochromatin Formation: An X-Chromosome Perspective.
Autorzy :
Żylicz JJ; Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR 3215, INSERM U934, PSL University, 75248 Paris Cedex 05, France.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EL, United Kingdom.
Heard E; Directors' Research, EMBL Heidelberg, 69117 Heidelberg, Germany; email: .
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Źródło :
Annual review of biochemistry [Annu Rev Biochem] 2020 Jun 20; Vol. 89, pp. 255-282. Date of Electronic Publication: 2020 Jul 07.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Gene Expression Regulation, Developmental*
Genomic Imprinting*
X Chromosome Inactivation*
Heterochromatin/*metabolism
Polycomb-Group Proteins/*genetics
X Chromosome/*metabolism
Animals ; Chromatin Assembly and Disassembly ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Embryo, Mammalian ; Female ; Gene Silencing ; Heterochromatin/chemistry ; Histone Deacetylases/genetics ; Histone Deacetylases/metabolism ; Histones/genetics ; Histones/metabolism ; Humans ; Male ; Oocytes/cytology ; Oocytes/growth & development ; Oocytes/metabolism ; Polycomb-Group Proteins/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Spermatozoa/cytology ; Spermatozoa/growth & development ; Spermatozoa/metabolism ; X Chromosome/chemistry
Czasopismo naukowe
Tytuł :
SPEN is required for Xist upregulation during initiation of X chromosome inactivation.
Autorzy :
Robert-Finestra T; Department of Developmental Biology, Erasmus University Medical Center, Oncode Institute, 3015GD, Rotterdam, The Netherlands.
Tan BF; Department of Developmental Biology, Erasmus University Medical Center, Oncode Institute, 3015GD, Rotterdam, The Netherlands.
Mira-Bontenbal H; Department of Developmental Biology, Erasmus University Medical Center, Oncode Institute, 3015GD, Rotterdam, The Netherlands.
Timmers E; Department of Developmental Biology, Erasmus University Medical Center, Oncode Institute, 3015GD, Rotterdam, The Netherlands.
Gontan C; Department of Developmental Biology, Erasmus University Medical Center, Oncode Institute, 3015GD, Rotterdam, The Netherlands.
Merzouk S; Department of Developmental Biology, Erasmus University Medical Center, Oncode Institute, 3015GD, Rotterdam, The Netherlands.
Giaimo BD; Institute of Biochemistry, University of Giessen, 35392, Giessen, Germany.
Dossin F; European Molecular Biology Laboratory, Director's Research, 69117, Heidelberg, Germany.
van IJcken WFJ; Center for Biomics, Erasmus University Medical Center, 3015CN, Rotterdam, The Netherlands.
Martens JWM; Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center, 3015CN, Rotterdam, The Netherlands.
Borggrefe T; Institute of Biochemistry, University of Giessen, 35392, Giessen, Germany.
Heard E; European Molecular Biology Laboratory, Director's Research, 69117, Heidelberg, Germany.
Gribnau J; Department of Developmental Biology, Erasmus University Medical Center, Oncode Institute, 3015GD, Rotterdam, The Netherlands. .
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Źródło :
Nature communications [Nat Commun] 2021 Dec 01; Vol. 12 (1), pp. 7000. Date of Electronic Publication: 2021 Dec 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
X Chromosome Inactivation*
DNA-Binding Proteins/*genetics
DNA-Binding Proteins/*metabolism
RNA, Long Noncoding/*genetics
RNA, Long Noncoding/*metabolism
RNA-Binding Proteins/*genetics
RNA-Binding Proteins/*metabolism
Animals ; Cell Differentiation ; Chromatin Assembly and Disassembly ; Female ; Gene Expression Regulation, Developmental ; Genes, X-Linked ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mouse Embryonic Stem Cells ; Promoter Regions, Genetic ; Transcriptional Activation ; Transcriptome ; Up-Regulation
Czasopismo naukowe
Tytuł :
Digging into X chromosome inactivation.
Autorzy :
Heard E; Director's Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
Rougeulle C; Department of Epigenetics and Cell Fate, Université de Paris, CNRS, F-75006 Paris, France.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Nov 19; Vol. 374 (6570), pp. 942-943. Date of Electronic Publication: 2021 Nov 18.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
X Chromosome Inactivation*
Czasopismo naukowe
Tytuł :
The lupus autoantigen La/Ssb is an Xist-binding protein involved in Xist folding and cloud formation.
Autorzy :
Ha N; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551.
Ding N; Institute of Translational Medicine, Tianjin Union Medical Center, State Key Laboratory of Medicinal Chemical Biology, Collaborative Innovation Center for Biotherapy, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Protein Sciences, National Demonstration Center for Experimental Biology Education and College of Life Sciences, Nankai University, Tianjin 300071, China.
Hong R; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551.
Liu R; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551.
Roca X; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551.
Luo Y; Institute of Translational Medicine, Tianjin Union Medical Center, State Key Laboratory of Medicinal Chemical Biology, Collaborative Innovation Center for Biotherapy, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Protein Sciences, National Demonstration Center for Experimental Biology Education and College of Life Sciences, Nankai University, Tianjin 300071, China.
Duan X; Institute of Translational Medicine, Tianjin Union Medical Center, State Key Laboratory of Medicinal Chemical Biology, Collaborative Innovation Center for Biotherapy, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Protein Sciences, National Demonstration Center for Experimental Biology Education and College of Life Sciences, Nankai University, Tianjin 300071, China.
Wang X; Institute of Translational Medicine, Tianjin Union Medical Center, State Key Laboratory of Medicinal Chemical Biology, Collaborative Innovation Center for Biotherapy, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Protein Sciences, National Demonstration Center for Experimental Biology Education and College of Life Sciences, Nankai University, Tianjin 300071, China.
Ni P; Institute of Translational Medicine, Tianjin Union Medical Center, State Key Laboratory of Medicinal Chemical Biology, Collaborative Innovation Center for Biotherapy, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Protein Sciences, National Demonstration Center for Experimental Biology Education and College of Life Sciences, Nankai University, Tianjin 300071, China.
Wu H; TCRCure Biological Technology Co Ltd., Guangdong, China.
Zhang LF; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551.; TCRCure Biological Technology Co Ltd., Guangdong, China.
Chen L; Institute of Translational Medicine, Tianjin Union Medical Center, State Key Laboratory of Medicinal Chemical Biology, Collaborative Innovation Center for Biotherapy, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Protein Sciences, National Demonstration Center for Experimental Biology Education and College of Life Sciences, Nankai University, Tianjin 300071, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Nov 18; Vol. 49 (20), pp. 11596-11613.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Folding*
X Chromosome Inactivation*
RNA, Long Noncoding/*chemistry
RNA-Binding Proteins/*metabolism
Animals ; Autoantigens/chemistry ; Autoantigens/metabolism ; Binding Sites ; Cell Line ; Mice ; Protein Binding ; RNA, Long Noncoding/metabolism ; RNA-Binding Proteins/chemistry ; RNA-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression.
Autorzy :
Cerase A; EMBL-Rome, Epigenetics and Neurobiology Unit, Monterotondo, Italy. .; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. .
Young AN; EMBL-Rome, Epigenetics and Neurobiology Unit, Monterotondo, Italy.; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Ruiz NB; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Buness A; EMBL-Rome, Epigenetics and Neurobiology Unit, Monterotondo, Italy.; Core Unit for Bioinformatics Data Analysis Universitätsklinikum Bonn, Bonn, Germany.
Sant GM; EMBL-Rome, Epigenetics and Neurobiology Unit, Monterotondo, Italy.; Institute of Molecular Biology gGmbH (IMB), Mainz, Germany.
Arnold M; EMBL-Rome, Epigenetics and Neurobiology Unit, Monterotondo, Italy.; Max Planck Institute for Molecular Genetics, Otto Warburg Laboratory, Berlin, Germany.
Di Giacomo M; EMBL-Rome, Epigenetics and Neurobiology Unit, Monterotondo, Italy.
Ascolani M; EMBL-Rome, Epigenetics and Neurobiology Unit, Monterotondo, Italy.
Kumar M; EMBL-Rome, Epigenetics and Neurobiology Unit, Monterotondo, Italy.; Department of Allied Health Science, Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE, Vijaypura, Karnataka, India.
Hierholzer A; EMBL-Rome, Epigenetics and Neurobiology Unit, Monterotondo, Italy.; Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.
Trigiante G; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Marzi SJ; UK Dementia Research Institute, Imperial College London, London, UK.
Avner P; EMBL-Rome, Epigenetics and Neurobiology Unit, Monterotondo, Italy. .
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Źródło :
Communications biology [Commun Biol] 2021 Apr 15; Vol. 4 (1), pp. 485. Date of Electronic Publication: 2021 Apr 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
X Chromosome Inactivation*
DNA-Binding Proteins/*genetics
X Chromosome/*genetics
Animals ; DNA-Binding Proteins/metabolism ; Dosage Compensation, Genetic ; Female ; Mice ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism
Czasopismo naukowe
Tytuł :
Xist Repeats A and B Account for Two Distinct Phases of X Inactivation Establishment.
Autorzy :
Colognori D; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Sunwoo H; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Wang D; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Wang CY; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Lee JT; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: .
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Źródło :
Developmental cell [Dev Cell] 2020 Jul 06; Vol. 54 (1), pp. 21-32.e5. Date of Electronic Publication: 2020 Jun 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
X Chromosome Inactivation*
Polycomb-Group Proteins/*metabolism
RNA, Long Noncoding/*metabolism
Animals ; Cells, Cultured ; Mice ; Polycomb-Group Proteins/genetics ; RNA, Long Noncoding/chemistry ; RNA, Long Noncoding/genetics ; X Chromosome/genetics
Czasopismo naukowe
Tytuł :
X-Chromosome Insight for Targeting Gene Therapy.
Autorzy :
Parmeggiani F; Department of Morphology, Experimental Medicine and Surgery, University of Ferrara & Ferrara University Hospital, Ferrara, Italy. Electronic address: .
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Źródło :
Ophthalmology. Retina [Ophthalmol Retina] 2020 May; Vol. 4 (5), pp. 521-522.
Typ publikacji :
Editorial; Comment
MeSH Terms :
Retinitis Pigmentosa*
X Chromosome*
Biomarkers ; Female ; Genetic Therapy ; Humans ; X Chromosome Inactivation
Opinia redakcyjna
Tytuł :
[Latest insights on X-chromosome inactivation: When general principles should be revisited].
Autorzy :
Moscatelli M; Université de Paris, Épigénétique et Destin Cellulaire, CNRS, F-75006 Paris, France.
Rougeulle C; Université de Paris, Épigénétique et Destin Cellulaire, CNRS, F-75006 Paris, France.
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Transliterated Title :
Dernières nouvelles du chromosome X - Des principes généraux nuancés.
Źródło :
Medecine sciences : M/S [Med Sci (Paris)] 2021 Feb; Vol. 37 (2), pp. 152-158. Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
X Chromosome Inactivation/*physiology
Animals ; Female ; Gene Silencing/physiology ; Genetics/trends ; Humans ; Mammals/genetics ; X Chromosome/genetics
Czasopismo naukowe
Tytuł :
Integrated functional genomic analyses of Klinefelter and Turner syndromes reveal global network effects of altered X chromosome dosage.
Autorzy :
Zhang X; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305.
Hong D; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305; .
Ma S; Department of Statistics, Stanford University, Stanford, CA 94305.; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305.
Ward T; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305.
Ho M; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305.
Pattni R; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305.
Duren Z; Department of Statistics, Stanford University, Stanford, CA 94305.; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305.
Stankov A; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.
Bade Shrestha S; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.
Hallmayer J; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.
Wong WH; Department of Statistics, Stanford University, Stanford, CA 94305; .; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305.
Reiss AL; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305; .
Urban AE; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305; .; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 03; Vol. 117 (9), pp. 4864-4873. Date of Electronic Publication: 2020 Feb 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Dosage*
Gene Expression Regulation*
Genomics*
X Chromosome*
Klinefelter Syndrome/*genetics
Turner Syndrome/*genetics
Animals ; Chromatin/chemistry ; Chromosomes, Human, X ; DNA Methylation ; Female ; Filamins ; Humans ; Karyotype ; Male ; Mammals/genetics ; N-Terminal Acetyltransferase A ; N-Terminal Acetyltransferase E ; Protein Serine-Threonine Kinases/genetics ; Receptor, PAR-2 ; Repressor Proteins/genetics ; Septins ; Transcriptome/genetics ; X Chromosome Inactivation
Czasopismo naukowe

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