Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Xanthine oxidase"" wg kryterium: Temat


Tytuł :
Effects of lobetyolin on xanthine oxidase activity in vitro and in vivo : weak and mixed inhibition.
Autorzy :
Yoon IS; Department of Manufacturing Pharmacy, College of Pharmacy, Pusan National University, Busan, South Korea.
Cho SS; Department of Pharmacy, College of Pharmacy, Mokpo National University, Jeonnam, South Korea.
Pokaż więcej
Źródło :
Natural product research [Nat Prod Res] 2021 May; Vol. 35 (10), pp. 1667-1670. Date of Electronic Publication: 2019 May 29.
Typ publikacji :
Journal Article
MeSH Terms :
Enzyme Inhibitors/*pharmacology
Polyynes/*pharmacology
Xanthine Oxidase/*metabolism
Administration, Oral ; Animals ; Dose-Response Relationship, Drug ; Hyperuricemia/chemically induced ; Hyperuricemia/drug therapy ; Male ; Mice ; Oxonic Acid/toxicity ; Uric Acid/metabolism ; Xanthine Oxidase/antagonists & inhibitors ; Xanthine Oxidase/blood
Czasopismo naukowe
Tytuł :
Exploring the potential of novel xanthine oxidase inhibitory peptide (ACECD) derived from Skipjack tuna hydrolysates using affinity-ultrafiltration coupled with HPLC-MALDI-TOF/TOF-MS.
Autorzy :
Zhong H; Ningbo Research Institute, Zhejiang University, Ningbo 315100, China; College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China.
Abdullah; College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China.
Zhang Y; Ningbo Research Institute, Zhejiang University, Ningbo 315100, China; College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China.
Deng L; College of Biological Science and Technology, Hubei Minzu University, Enshi 445000, China.
Zhao M; Ningbo Research Institute, Zhejiang University, Ningbo 315100, China; College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China.
Tang J; Ningbo Research Institute, Zhejiang University, Ningbo 315100, China; College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China.
Zhang H; Ningbo Research Institute, Zhejiang University, Ningbo 315100, China; College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China.
Feng F; Ningbo Research Institute, Zhejiang University, Ningbo 315100, China; College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China. Electronic address: .
Wang J; Ningbo Research Institute, Zhejiang University, Ningbo 315100, China; College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China. Electronic address: .
Pokaż więcej
Źródło :
Food chemistry [Food Chem] 2021 Jun 15; Vol. 347, pp. 129068. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article
MeSH Terms :
Enzyme Inhibitors/*chemistry
Peptides/*chemistry
Tuna/*metabolism
Xanthine Oxidase/*antagonists & inhibitors
Amino Acid Sequence ; Animals ; Antioxidants/chemistry ; Binding Sites ; Chromatography, High Pressure Liquid ; Enzyme Inhibitors/isolation & purification ; Enzyme Inhibitors/metabolism ; Molecular Docking Simulation ; Peptides/isolation & purification ; Peptides/metabolism ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Ultrafiltration ; Xanthine Oxidase/metabolism
Czasopismo naukowe
Tytuł :
Characterization of xanthine oxidase from Cellulosimicrobium funkei possessing hypoxanthine-metabolizing activity.
Autorzy :
Kozono I; Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Takeuchi M; Industrial Microbiology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Kozono S; Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Satomura A; Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Aoki W; Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Hibi M; Industrial Microbiology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.; Department of Biotechnology, Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan.
Ogawa J; Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Pokaż więcej
Źródło :
Journal of applied microbiology [J Appl Microbiol] 2021 Jun; Vol. 130 (6), pp. 2132-2140. Date of Electronic Publication: 2020 Nov 22.
Typ publikacji :
Journal Article
MeSH Terms :
Actinobacteria/*enzymology
Hypoxanthine/*metabolism
Purines/*metabolism
Rhodococcus/*metabolism
Xanthine Oxidase/*chemistry
Actinobacteria/genetics ; Amino Acid Sequence ; Bacterial Proteins ; DNA, Bacterial ; Oxidation-Reduction ; Recombinant Proteins/metabolism ; Rhodococcus/genetics ; Uric Acid/metabolism ; Whole Genome Sequencing ; Xanthine/metabolism ; Xanthine Dehydrogenase/metabolism ; Xanthine Oxidase/genetics
SCR Organism :
Cellulosimicrobium funkei; Rhodococcus erythropolis
Czasopismo naukowe
Tytuł :
Xanthine oxidase inhibitory peptides derived from tuna protein: virtual screening, inhibitory activity, and molecular mechanisms.
Autorzy :
Yu Z; College of Food Science and Engineering, Bohai University, Jinzhou, P.R. China.; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing, P.R. China.
Kan R; College of Food Science and Engineering, Bohai University, Jinzhou, P.R. China.
Wu S; College of Food Science and Engineering, Bohai University, Jinzhou, P.R. China.
Guo H; College of Food Science and Engineering, Bohai University, Jinzhou, P.R. China.
Zhao W; College of Food Science and Engineering, Bohai University, Jinzhou, P.R. China.
Ding L; College of Food Science and Engineering, Northwest A&F University, Yangling, P.R. China.
Zheng F; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing, P.R. China.
Liu J; Laboratory of Nutrition and Functional Food, Jilin University, Changchun, P.R. China.
Pokaż więcej
Źródło :
Journal of the science of food and agriculture [J Sci Food Agric] 2021 Mar 15; Vol. 101 (4), pp. 1349-1354. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji :
Journal Article
MeSH Terms :
Enzyme Inhibitors/*chemistry
Fish Proteins/*chemistry
Peptides/*chemistry
Xanthine Oxidase/*antagonists & inhibitors
Animals ; Catalytic Domain ; Enzyme Inhibitors/pharmacology ; Fish Proteins/pharmacology ; Gout/drug therapy ; Gout/enzymology ; Humans ; Hydrogen Bonding ; Hyperuricemia/drug therapy ; Hyperuricemia/enzymology ; Kinetics ; Molecular Docking Simulation ; Peptides/pharmacology ; Tuna ; Xanthine Oxidase/chemistry ; Xanthine Oxidase/metabolism
Czasopismo naukowe
Tytuł :
Xanthine Oxidase Drives Hemolysis and Vascular Malfunction in Sickle Cell Disease.
Autorzy :
Schmidt HM; Department of Pharmacology and Chemical Biology (H.M.S., D.A.V., A.C.S.), University of Pittsburgh, PA.
Wood KC; Heart, Lung, Blood and Vascular Medicine Institute (K.C.W., S.A.H., B.M., J.J.B., S.Y., T.N.B., S.G., S.F.O.-A., D.A.V., A.C.S.), University of Pittsburgh, PA.
Lewis SE; Department of Physiology and Pharmacology, Health Sciences Center (S.E.L., X.M.W., E.E.K.), West Virginia University, Morgantown.
Hahn SA; Heart, Lung, Blood and Vascular Medicine Institute (K.C.W., S.A.H., B.M., J.J.B., S.Y., T.N.B., S.G., S.F.O.-A., D.A.V., A.C.S.), University of Pittsburgh, PA.
Williams XM; Department of Physiology and Pharmacology, Health Sciences Center (S.E.L., X.M.W., E.E.K.), West Virginia University, Morgantown.
McMahon B; Heart, Lung, Blood and Vascular Medicine Institute (K.C.W., S.A.H., B.M., J.J.B., S.Y., T.N.B., S.G., S.F.O.-A., D.A.V., A.C.S.), University of Pittsburgh, PA.
Baust JJ; Heart, Lung, Blood and Vascular Medicine Institute (K.C.W., S.A.H., B.M., J.J.B., S.Y., T.N.B., S.G., S.F.O.-A., D.A.V., A.C.S.), University of Pittsburgh, PA.
Yuan S; Heart, Lung, Blood and Vascular Medicine Institute (K.C.W., S.A.H., B.M., J.J.B., S.Y., T.N.B., S.G., S.F.O.-A., D.A.V., A.C.S.), University of Pittsburgh, PA.
Bachman TN; Heart, Lung, Blood and Vascular Medicine Institute (K.C.W., S.A.H., B.M., J.J.B., S.Y., T.N.B., S.G., S.F.O.-A., D.A.V., A.C.S.), University of Pittsburgh, PA.
Wang Y; Department of Ophthalmology (Y.W., J.D.), West Virginia University, Morgantown.; Department of Biochemistry (Y.W., J.D.), West Virginia University, Morgantown.
Oh JY; Center for Free Radical Biology (J.-Y.O., R.P.P.), University of Alabama at Birmingham.
Ghosh S; Heart, Lung, Blood and Vascular Medicine Institute (K.C.W., S.A.H., B.M., J.J.B., S.Y., T.N.B., S.G., S.F.O.-A., D.A.V., A.C.S.), University of Pittsburgh, PA.; Division of Hematology/Oncology, Department of Medicine, School of Medicine (S.G., S.F.O.-A.), University of Pittsburgh, PA.
Ofori-Acquah SF; Heart, Lung, Blood and Vascular Medicine Institute (K.C.W., S.A.H., B.M., J.J.B., S.Y., T.N.B., S.G., S.F.O.-A., D.A.V., A.C.S.), University of Pittsburgh, PA.; Division of Hematology/Oncology, Department of Medicine, School of Medicine (S.G., S.F.O.-A.), University of Pittsburgh, PA.; School of Biomedical and Allied Health Sciences, University of Ghana, Accra (S.F.O.-A.).
Lebensburger JD; Department of Pediatrics (J.D.L.), University of Alabama at Birmingham.
Patel RP; Center for Free Radical Biology (J.-Y.O., R.P.P.), University of Alabama at Birmingham.; Department of Pathology (R.P.P.), University of Alabama at Birmingham.
Du J; Department of Ophthalmology (Y.W., J.D.), West Virginia University, Morgantown.; Department of Biochemistry (Y.W., J.D.), West Virginia University, Morgantown.
Vitturi DA; Department of Pharmacology and Chemical Biology (H.M.S., D.A.V., A.C.S.), University of Pittsburgh, PA.; Heart, Lung, Blood and Vascular Medicine Institute (K.C.W., S.A.H., B.M., J.J.B., S.Y., T.N.B., S.G., S.F.O.-A., D.A.V., A.C.S.), University of Pittsburgh, PA.
Kelley EE; Department of Physiology and Pharmacology, Health Sciences Center (S.E.L., X.M.W., E.E.K.), West Virginia University, Morgantown.
Straub AC; Department of Pharmacology and Chemical Biology (H.M.S., D.A.V., A.C.S.), University of Pittsburgh, PA.; Heart, Lung, Blood and Vascular Medicine Institute (K.C.W., S.A.H., B.M., J.J.B., S.Y., T.N.B., S.G., S.F.O.-A., D.A.V., A.C.S.), University of Pittsburgh, PA.
Pokaż więcej
Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Feb; Vol. 41 (2), pp. 769-782. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anemia, Sickle Cell/*drug therapy
Enzyme Inhibitors/*pharmacology
Erythrocytes/*drug effects
Febuxostat/*pharmacology
Hemodynamics/*drug effects
Hemolysis/*drug effects
Pulmonary Artery/*drug effects
Xanthine Oxidase/*antagonists & inhibitors
Anemia, Sickle Cell/blood ; Anemia, Sickle Cell/enzymology ; Anemia, Sickle Cell/physiopathology ; Animals ; Disease Models, Animal ; Erythrocytes/enzymology ; Liver/enzymology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Pulmonary Artery/enzymology ; Pulmonary Artery/physiopathology ; Ventricular Function/drug effects ; Xanthine Oxidase/genetics ; Xanthine Oxidase/metabolism
Czasopismo naukowe
Tytuł :
Fast dereplication of xanthine oxidase-inhibiting compounds in alfalfa using comparative metabolomics.
Autorzy :
Hsu SJ; Department of Food Science, National Chiayi University, Chiayi City, Taiwan.
Verpoorte R; Natural Products Laboratory, Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333BE Leiden, the Netherlands.
Lin SM; Department of Food Science, National Chiayi University, Chiayi City, Taiwan. Electronic address: .
Lee CK; School of Pharmacy, Taipei Medical University, Taipei City, Taiwan; School of Food Safety, Taipei Medical University, Taipei City, Taiwan. Electronic address: .
Pokaż więcej
Źródło :
Food research international (Ottawa, Ont.) [Food Res Int] 2021 Mar; Vol. 141, pp. 110170. Date of Electronic Publication: 2021 Jan 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Medicago sativa*
Xanthine Oxidase*
Metabolomics ; Molecular Docking Simulation ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
Xanthine oxidase inhibition attenuates doxorubicin-induced cardiotoxicity in mice.
Autorzy :
Tanaka Y; Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Japan.
Nagoshi T; Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Japan. Electronic address: .
Yoshii A; Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Japan.
Oi Y; Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Japan.
Takahashi H; Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Japan.
Kimura H; Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Japan.
Ito K; Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Japan.
Kashiwagi Y; Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Japan.
Tanaka TD; Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Japan.
Yoshimura M; Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Japan.
Pokaż więcej
Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2021 Jan; Vol. 162, pp. 298-308. Date of Electronic Publication: 2020 Oct 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Uric Acid*
Xanthine Oxidase*
Animals ; Cardiotoxicity/drug therapy ; Doxorubicin/toxicity ; Febuxostat ; Mice
Czasopismo naukowe
Tytuł :
Xanthine Oxidoreductase Inhibitors.
Autorzy :
Vickneson K; Ninewells Hospital, Dundee, Scotland, UK.
George J; Ninewells Hospital, Dundee, Scotland, UK. .
Pokaż więcej
Źródło :
Handbook of experimental pharmacology [Handb Exp Pharmacol] 2021; Vol. 264, pp. 205-228.
Typ publikacji :
Journal Article
MeSH Terms :
Xanthine Dehydrogenase*
Xanthine Oxidase*
Allopurinol ; Enzyme Inhibitors/pharmacology ; Humans ; Reactive Oxygen Species
Czasopismo naukowe
Tytuł :
The Crucial Role of Xanthine Oxidase in CKD Progression Associated with Hypercholesterolemia.
Autorzy :
Kim YJ; Division of Nephrology, Kyungpook National University Hospital, Daegu 41944, Korea.; Cell and Matrix Research Institute, Kyungpook National University, Daegu 41944, Korea.
Oh SH; Division of Nephrology, Kyungpook National University Hospital, Daegu 41944, Korea.; Cell and Matrix Research Institute, Kyungpook National University, Daegu 41944, Korea.
Ahn JS; Division of Nephrology, Kyungpook National University Hospital, Daegu 41944, Korea.
Yook JM; Division of Nephrology, Kyungpook National University Hospital, Daegu 41944, Korea.
Kim CD; Division of Nephrology, Kyungpook National University Hospital, Daegu 41944, Korea.; Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
Park SH; Division of Nephrology, Kyungpook National University Hospital, Daegu 41944, Korea.; Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
Cho JH; Division of Nephrology, Kyungpook National University Hospital, Daegu 41944, Korea.; Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
Kim YL; Division of Nephrology, Kyungpook National University Hospital, Daegu 41944, Korea.; Cell and Matrix Research Institute, Kyungpook National University, Daegu 41944, Korea.; Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 09; Vol. 21 (20). Date of Electronic Publication: 2020 Oct 09.
Typ publikacji :
Journal Article
MeSH Terms :
Hypercholesterolemia/*complications
Hypercholesterolemia/*metabolism
Renal Insufficiency, Chronic/*etiology
Renal Insufficiency, Chronic/*metabolism
Xanthine Oxidase/*metabolism
Cholesterol/metabolism ; Disease Progression ; Disease Susceptibility ; Fibrosis ; Humans ; Lipid Metabolism ; Lipoproteins, LDL/metabolism ; Oxidative Stress ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/pathology ; Signal Transduction ; Xanthine Oxidase/genetics
Czasopismo naukowe
Tytuł :
Xanthine oxidase inhibitors: patent landscape and clinical development (2015-2020).
Autorzy :
Singh JV; Department of Pharmaceutical Sciences, Guru Nanak Dev University , Amritsar, Punjab, India.
Bedi PMS; Department of Pharmaceutical Sciences, Guru Nanak Dev University , Amritsar, Punjab, India.
Singh H; Department of Pharmaceutical Sciences, Guru Nanak Dev University , Amritsar, Punjab, India.
Sharma S; Department of Pharmaceutical Sciences, Guru Nanak Dev University , Amritsar, Punjab, India.
Pokaż więcej
Źródło :
Expert opinion on therapeutic patents [Expert Opin Ther Pat] 2020 Oct; Vol. 30 (10), pp. 769-780. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Enzyme Inhibitors/*pharmacology
Gout/*drug therapy
Xanthine Oxidase/*antagonists & inhibitors
Animals ; Drug Development ; Gout/enzymology ; Humans ; Hyperuricemia/drug therapy ; Hyperuricemia/enzymology ; Patents as Topic ; Reactive Oxygen Species/metabolism ; Uric Acid/metabolism ; Xanthine Oxidase/metabolism
Czasopismo naukowe
Tytuł :
Switching a Xanthine Oxidase Inhibitor to a Dual-Target Antagonist of P2Y 1 and P2Y 12 as an Oral Antiplatelet Agent with a Wider Therapeutic Window in Rats than Ticagrelor.
Autorzy :
Lei Y; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang 110016, China.
Zhang B; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang 110016, China.
Liu D; Shenyang Hinewy Pharmaceutical Technology Co., Ltd., 41 Liutang Road, Shenhe District, Shenyang 110016, China.
Zhao J; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang 110016, China.
Dai X; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang 110016, China.
Gao J; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang 110016, China.
Mao Q; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang 110016, China.
Feng Y; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang 110016, China.
Zhao J; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang 110016, China.
Lin F; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang 110016, China.
Duan Y; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang 110016, China.
Zhang Y; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang 110016, China.
Bao Z; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang 110016, China.
Yang Y; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang 110016, China.
Mou Y; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang 110016, China.
Wang S; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang 110016, China.
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Dec 24; Vol. 63 (24), pp. 15752-15772. Date of Electronic Publication: 2020 Dec 12.
Typ publikacji :
Journal Article
MeSH Terms :
Enzyme Inhibitors/*chemistry
Platelet Aggregation Inhibitors/*chemistry
Purinergic P2Y Receptor Antagonists/*chemistry
Receptors, Purinergic P2Y1/*chemistry
Receptors, Purinergic P2Y12/*chemistry
Xanthine Oxidase/*antagonists & inhibitors
Animals ; Binding Sites ; Cytochrome P-450 Enzyme System/chemistry ; Cytochrome P-450 Enzyme System/metabolism ; Drug Stability ; Enzyme Inhibitors/metabolism ; Enzyme Inhibitors/pharmacology ; Half-Life ; Humans ; Imidazoles/chemistry ; Imidazoles/metabolism ; Imidazoles/pharmacology ; Mice ; Microsomes, Liver/metabolism ; Molecular Docking Simulation ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/metabolism ; Platelet Aggregation Inhibitors/pharmacology ; Purinergic P2Y Receptor Antagonists/metabolism ; Rats ; Receptors, Purinergic P2Y1/metabolism ; Receptors, Purinergic P2Y12/metabolism ; Structure-Activity Relationship ; Ticagrelor/pharmacology ; Xanthine Oxidase/metabolism
Czasopismo naukowe
Tytuł :
Evaluation of xanthine oxidase inhibitory activity of flavonoids by an online capillary electrophoresis-based immobilized enzyme microreactor.
Autorzy :
Wu ZY; School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, P. R. China.
Zhang H; School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, P. R. China.
Li F; Australian Centre for Research on Separation Science (ACROSS), School of Natural Sciences, Chemistry, University of Tasmania, Hobart, Tasmania, Australia.
Yang FQ; School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, P. R. China.
Pokaż więcej
Źródło :
Electrophoresis [Electrophoresis] 2020 Aug; Vol. 41 (15), pp. 1326-1332. Date of Electronic Publication: 2020 May 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bioreactors*
Flavonoids*/analysis
Flavonoids*/pharmacology
Electrophoresis, Capillary/*methods
Enzymes, Immobilized/*antagonists & inhibitors
Xanthine Oxidase/*antagonists & inhibitors
Enzymes, Immobilized/chemistry ; Enzymes, Immobilized/metabolism ; Humans ; Kinetics ; Molecular Docking Simulation ; Xanthine Oxidase/chemistry ; Xanthine Oxidase/metabolism
Czasopismo naukowe
Tytuł :
Xanthine Oxidase Inhibition and Anti-LDL Oxidation by Prenylated Isoflavones from Flemingia philippinensis Root.
Autorzy :
Kim JY; Division of Applied Life Science (BK21 Plus), IALS, Gyeongsang National University, Jinju 52828, Korea.
Wang Y; College of Food and Biological Engineering, Qiqihar University, Qiqihar 161006, China.
Li ZP; Division of Applied Life Science (BK21 Plus), IALS, Gyeongsang National University, Jinju 52828, Korea.
Baiseitova A; Division of Applied Life Science (BK21 Plus), IALS, Gyeongsang National University, Jinju 52828, Korea.
Ban YJ; Division of Applied Life Science (BK21 Plus), IALS, Gyeongsang National University, Jinju 52828, Korea.
Park KH; Division of Applied Life Science (BK21 Plus), IALS, Gyeongsang National University, Jinju 52828, Korea.
Pokaż więcej
Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Jul 06; Vol. 25 (13). Date of Electronic Publication: 2020 Jul 06.
Typ publikacji :
Journal Article
MeSH Terms :
Fabaceae/*chemistry
Isoflavones/*analysis
Isoflavones/*pharmacology
Lipoproteins, LDL/*metabolism
Plant Roots/*chemistry
Thiobarbiturates/*chemistry
Xanthine Oxidase/*antagonists & inhibitors
Chromatography, Liquid ; Copper/chemistry ; Enzyme Inhibitors/chemistry ; Fluorescence ; Inhibitory Concentration 50 ; Isoflavones/chemistry ; Isoflavones/isolation & purification ; Kinetics ; Mass Spectrometry ; Oxidation-Reduction ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Prenylation ; Xanthine Oxidase/metabolism
Czasopismo naukowe
Tytuł :
3'-Methyl-4-thio-1H-tetrahydropyranspiro-5'-hydantoin platinum complex as a novel potent anticancer agent and xanthine oxidase inhibitor.
Autorzy :
Cherneva E; Department of Chemistry, Faculty of Pharmacy, Medical University-Sofia, Sofia, Bulgaria.; Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Atanasova M; Department of Chemistry, Faculty of Pharmacy, Medical University-Sofia, Sofia, Bulgaria.
Buyukliev R; Department of Chemistry, Faculty of Pharmacy, Medical University-Sofia, Sofia, Bulgaria.
Tomovic K; Department of Pharmacy, Faculty of Medicine, University of Nis, Nis, Serbia.
Smelcerovic Z; Center for Biomedicinal Science, Faculty of Medicine, University of Nis, Nis, Serbia.
Bakalova A; Department of Chemistry, Faculty of Pharmacy, Medical University-Sofia, Sofia, Bulgaria.
Smelcerovic A; Department of Chemistry, Faculty of Medicine, University of Nis, Nis, Serbia.
Pokaż więcej
Źródło :
Archiv der Pharmazie [Arch Pharm (Weinheim)] 2020 Jul; Vol. 353 (7), pp. e2000039. Date of Electronic Publication: 2020 Apr 24.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Organoplatinum Compounds/*pharmacology
Xanthine Oxidase/*antagonists & inhibitors
Adolescent ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Female ; Humans ; K562 Cells ; Middle Aged ; Molecular Docking Simulation ; Molecular Structure ; Organoplatinum Compounds/chemical synthesis ; Organoplatinum Compounds/chemistry ; Tumor Cells, Cultured ; Xanthine Oxidase/metabolism
Czasopismo naukowe
Tytuł :
Xanthine oxidase-lactoperoxidase system and innate immunity: Biochemical actions and physiological roles.
Autorzy :
Al-Shehri SS; College of Applied Medical Sciences, Taif University, Taif, 21944, Saudi Arabia. Electronic address: .
Duley JA; School of Pharmacy, The University of Queensland, St Lucia, 4102, Australia.
Bansal N; School of Pharmacy, The University of Queensland, St Lucia, 4102, Australia; School of Agriculture and Food Science, The University of Queensland, St Lucia, 4102, Australia.
Pokaż więcej
Źródło :
Redox biology [Redox Biol] 2020 Jul; Vol. 34, pp. 101524. Date of Electronic Publication: 2020 Apr 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Lactoperoxidase*
Xanthine Oxidase*
Animals ; Humans ; Hydrogen Peroxide ; Immunity, Innate ; Infant, Newborn ; Superoxides ; Xanthine
Czasopismo naukowe
Tytuł :
High Salt Intake-Increased (Pro)renin Receptor Expression Is Exaggerated in the Kidney of Dahl Salt-Sensitive Rats.
Autorzy :
Yamakoshi S; From the Department of Internal Medicine and Rehabilitation Science (S.Y., O.I., R.R., T.N., M.K.), Tohoku University Graduate School of Medicine, Japan.
Ito O; From the Department of Internal Medicine and Rehabilitation Science (S.Y., O.I., R.R., T.N., M.K.), Tohoku University Graduate School of Medicine, Japan.; Division of General Medicine and Rehabilitation (O.I.), Tohoku Medical and Pharmaceutical University Faculty of Medicine, Japan.
Rong R; From the Department of Internal Medicine and Rehabilitation Science (S.Y., O.I., R.R., T.N., M.K.), Tohoku University Graduate School of Medicine, Japan.
Ohsaki Y; Division of Nephrology, Endocrinology, and Vascular Medicine (Y.O.), Tohoku University Graduate School of Medicine, Japan.
Nakamura T; From the Department of Internal Medicine and Rehabilitation Science (S.Y., O.I., R.R., T.N., M.K.), Tohoku University Graduate School of Medicine, Japan.
Hirose T; Division of Nephrology and Endocrinology (T.H., T.M.), Tohoku Medical and Pharmaceutical University Faculty of Medicine, Japan.
Takahashi K; Division of Endocrinology and Applied Medical Science (K. Takahashi), Tohoku University Graduate School of Medicine, Japan.
Mori T; Division of Nephrology and Endocrinology (T.H., T.M.), Tohoku Medical and Pharmaceutical University Faculty of Medicine, Japan.
Totsune K; Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Japan (K. Totsune).
Kohzuki M; From the Department of Internal Medicine and Rehabilitation Science (S.Y., O.I., R.R., T.N., M.K.), Tohoku University Graduate School of Medicine, Japan.
Pokaż więcej
Źródło :
Hypertension (Dallas, Tex. : 1979) [Hypertension] 2020 Jun; Vol. 75 (6), pp. 1447-1454. Date of Electronic Publication: 2020 Apr 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nephrons*/drug effects
Nephrons*/metabolism
Xanthine Oxidase*/antagonists & inhibitors
Xanthine Oxidase*/metabolism
Febuxostat/*pharmacology
Hypertension/*metabolism
Receptors, Cell Surface/*metabolism
Sodium Chloride, Dietary/*pharmacology
Spironolactone/*pharmacology
Animals ; Blood Pressure/drug effects ; Blood Pressure/physiology ; Flavoring Agents/pharmacology ; Gene Expression Regulation/drug effects ; Mineralocorticoid Receptor Antagonists/pharmacology ; Rats ; Rats, Inbred Dahl ; Renin-Angiotensin System/drug effects ; Renin-Angiotensin System/physiology
Czasopismo naukowe
Tytuł :
Functional mononuclear molybdenum enzymes: challenges and triumphs in molecular cloning, expression, and isolation.
Autorzy :
Mintmier B; Department of Chemistry and Chemical Biology, Indiana University-Purdue University Indianapolis, 402 N Blackford St, Indianapolis, IN, 46202, USA.
Nassif S; Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, PA, USA.
Stolz JF; Department of Biological Sciences, Duquesne University, Pittsburgh, PA, USA.
Basu P; Department of Chemistry and Chemical Biology, Indiana University-Purdue University Indianapolis, 402 N Blackford St, Indianapolis, IN, 46202, USA. .
Pokaż więcej
Źródło :
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry [J Biol Inorg Chem] 2020 Jun; Vol. 25 (4), pp. 547-569. Date of Electronic Publication: 2020 Apr 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Iron-Sulfur Proteins/*metabolism
Metalloproteins/*metabolism
Molybdenum/*metabolism
Oxidoreductases/*metabolism
Sulfite Oxidase/*metabolism
Xanthine Oxidase/*metabolism
Cloning, Molecular ; Iron-Sulfur Proteins/chemistry ; Iron-Sulfur Proteins/genetics ; Metalloproteins/chemistry ; Metalloproteins/genetics ; Molecular Structure ; Molybdenum/chemistry ; Oxidoreductases/chemistry ; Oxidoreductases/genetics ; Sulfite Oxidase/chemistry ; Sulfite Oxidase/genetics ; Xanthine Oxidase/chemistry ; Xanthine Oxidase/genetics
Czasopismo naukowe
Tytuł :
Codeine exerts cardiorenal injury via upregulation of adenine deaminase/xanthine oxidase and caspase 3 signaling.
Autorzy :
Akhigbe RE; Department of Physiology, College of Medicine, Ladoke Akintola University of Technology, Ogbomoso, Oyo, Nigeria; Reproductive Biology and Toxicology Research Laboratories, Oasis of Grace Hospital, Osogbo, Nigeria.
Ajayi LO; Department of Biochemistry, Adeleke University, Ede, Osun State, Nigeria.
Ajayi AF; Department of Physiology, College of Medicine, Ladoke Akintola University of Technology, Ogbomoso, Oyo, Nigeria. Electronic address: .
Pokaż więcej
Źródło :
Life sciences [Life Sci] 2021 May 15; Vol. 273, pp. 118717. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Kidney Injury/*pathology
Adenosine Deaminase/*metabolism
Caspase 3/*metabolism
Codeine/*toxicity
Gene Expression Regulation, Enzymologic/*drug effects
Heart/*physiopathology
Xanthine Oxidase/*metabolism
Acute Kidney Injury/chemically induced ; Acute Kidney Injury/metabolism ; Animals ; Apoptosis ; Gene Expression ; Glucose/metabolism ; Heart/drug effects ; Insulin Resistance ; Male ; Narcotics/toxicity ; Rabbits ; Triglycerides/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
[Study on drug-target binding kinetics profiles of flavonoids in Chrysanthemum morifolium and xanthine oxidase].
Autorzy :
Li XY; School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.
Liu Y; School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.
Liu F; School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.
Chen HJ; School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.
Yang WN; School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.
Yang HY; School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.
Jiang XQ; School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.
Sen ML; School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.
Wang GP; Zhongcai Health(Beijing) Biological Technology Development Co., Ltd. Beijing 101503, China.
Wang J; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Beijing 100191, China.
Pan YL; Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences Beijing 100700, China.
Pokaż więcej
Źródło :
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2021 Apr; Vol. 46 (7), pp. 1822-1831.
Typ publikacji :
Journal Article
MeSH Terms :
Chrysanthemum*
Pharmaceutical Preparations*
Chromatography, Liquid ; Flavonoids ; Kinetics ; Tandem Mass Spectrometry ; Xanthine Oxidase/metabolism
Czasopismo naukowe
Tytuł :
Xanthine Oxidase Inhibitory Activity, Chemical Composition, Antioxidant Properties and GC-MS Analysis of Keladi Candik ( Alocasia longiloba Miq).
Autorzy :
Abdulhafiz F; Faculty of Agro-Based Industry, University Malaysia Kelantan, Jeli Campus, Jeli 17600, Kelantan, Malaysia.
Mohammed A; Faculty of Agro-Based Industry, University Malaysia Kelantan, Jeli Campus, Jeli 17600, Kelantan, Malaysia.; Institute of Food Security and Sustainable Agriculture (IFSSA), University Malaysia Kelantan, Jeli 17600, Kelantan, Malaysia.
Kayat F; Faculty of Agro-Based Industry, University Malaysia Kelantan, Jeli Campus, Jeli 17600, Kelantan, Malaysia.
Bhaskar M; Division of Animal Biotechnology, Department of Zoology, Sri Venkateswara University, Tirupati, Andhra Pradesh 517502, India.
Hamzah Z; Faculty of Earth Science, University Malaysia Kelantan, Jeli 17600, Kelantan, Malaysia.
Podapati SK; Faculty of Agro-Based Industry, University Malaysia Kelantan, Jeli Campus, Jeli 17600, Kelantan, Malaysia.
Reddy LV; Department of Microbiology, Yogi Vemana University, Kadapa, Andhra Pradesh 516003, India.
Pokaż więcej
Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Jun 08; Vol. 25 (11). Date of Electronic Publication: 2020 Jun 08.
Typ publikacji :
Journal Article
MeSH Terms :
Alocasia/*chemistry
Antioxidants/*pharmacology
Enzyme Inhibitors/*pharmacology
Gas Chromatography-Mass Spectrometry/*methods
Phytochemicals/*pharmacology
Plant Extracts/*pharmacology
Xanthine Oxidase/*antagonists & inhibitors
Phytochemicals/chemistry ; Phytochemicals/isolation & purification ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Xanthine Oxidase/metabolism
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies