Autor: "Xavier, Ramnik J." - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Integrated annotation prioritizes metabolites with bioactivity in inflammatory bowel disease.
Autorzy:: Bhosle A; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Harvard Chan Microbiome in Public Health Center, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Bae S; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Zhang Y; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Harvard Chan Microbiome in Public Health Center, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Chun E; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Avila-Pacheco J; Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Geistlinger L; Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York, NY, USA.; Center for Computational Biomedicine, Harvard Medical School, Boston, MA, USA.
Pishchany G; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Glickman JN; Beth Israel Deaconess Medical Center, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA.
Michaud M; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Waldron L; Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York, NY, USA.
Clish CB; Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Xavier RJ; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Vlamakis H; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Franzosa EA; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Harvard Chan Microbiome in Public Health Center, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Garrett WS; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Chan Microbiome in Public Health Center, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Huttenhower C; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. .; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA. .; Harvard Chan Microbiome in Public Health Center, Harvard T. H. Chan School of Public Health, Boston, MA, USA. .; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA. .; Pokaż więcej
Źródło:: Molecular systems biology [Mol Syst Biol] 2024 Apr; Vol. 20 (4), pp. 338-361. Date of Electronic Publication: 2024 Mar 11.
Typ publikacji:: Journal Article
MeSH Terms:: Inflammatory Bowel Diseases*/drug therapy
Inflammatory Bowel Diseases*/metabolism
Colitis*
Humans ; Animals ; Mice ; Metabolome ; Bile Acids and Salts

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Skocz do pozycji: 2.

Tytuł:: Comparison of vaginal microbiota between women with inflammatory bowel disease and healthy controls.
Autorzy:: Bar O; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, United States of America.; Department of Microbiology and Molecular Genetics, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Sudhof LS; Harvard Medical School, Boston, MA, United States of America.; Department of Obstetrics & Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, United States of America.
Yockey LJ; Departments of Medicine, Massachusetts General Hospital, Boston, MA, United States of America.
Bergerat A; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, United States of America.
Moriel N; Department of Microbiology and Molecular Genetics, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Andrews E; Departments of Gastroenterology, Massachusetts General Hospital, Boston, MA, United States of America.
Ananthakrishnan AN; Harvard Medical School, Boston, MA, United States of America.; Departments of Gastroenterology, Massachusetts General Hospital, Boston, MA, United States of America.
Xavier RJ; Harvard Medical School, Boston, MA, United States of America.; Departments of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, United States of America.; Broad Institute, Boston MA, United States of America.
Yassour M; The Rachel and Selim Benin School of Computer Science and Engineering, Hebrew University of Jerusalem, Jerusalem, Israel.
Mitchell CM; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, United States of America.; Harvard Medical School, Boston, MA, United States of America.; Departments of Obstetrics & Gynecology, Massachusetts General Hospital, Boston, MA, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2023 Nov 29; Vol. 18 (11), pp. e0284709. Date of Electronic Publication: 2023 Nov 29 (Print Publication: 2023).
Typ publikacji:: Journal Article
MeSH Terms:: Colitis, Ulcerative*
Microbiota*/genetics
Inflammatory Bowel Diseases*
Humans ; Female ; RNA, Ribosomal, 16S/genetics ; Longitudinal Studies ; Vagina ; Lactobacillus/genetics

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Skocz do pozycji: 3.

Tytuł:: Functional screen of inflammatory bowel disease genes reveals key epithelial functions.
Autorzy:: Ntunzwenimana JC; Montreal Heart Institute Research Centre, 5000 rue Bélanger, S-6201, Montreal, Quebec, Canada.; Université de Montréal, Montreal, Quebec, Canada.
Boucher G; Montreal Heart Institute Research Centre, 5000 rue Bélanger, S-6201, Montreal, Quebec, Canada.
Paquette J; Montreal Heart Institute Research Centre, 5000 rue Bélanger, S-6201, Montreal, Quebec, Canada.
Gosselin H; Montreal Heart Institute Research Centre, 5000 rue Bélanger, S-6201, Montreal, Quebec, Canada.
Alikashani A; Montreal Heart Institute Research Centre, 5000 rue Bélanger, S-6201, Montreal, Quebec, Canada.
Morin N; Montreal Heart Institute Research Centre, 5000 rue Bélanger, S-6201, Montreal, Quebec, Canada.
Beauchamp C; Montreal Heart Institute Research Centre, 5000 rue Bélanger, S-6201, Montreal, Quebec, Canada.
Thauvette L; Montreal Heart Institute Research Centre, 5000 rue Bélanger, S-6201, Montreal, Quebec, Canada.
Rivard MÈ; Montreal Heart Institute Research Centre, 5000 rue Bélanger, S-6201, Montreal, Quebec, Canada.
Dupuis F; Montreal Heart Institute Research Centre, 5000 rue Bélanger, S-6201, Montreal, Quebec, Canada.
Deschênes S; Montreal Heart Institute Research Centre, 5000 rue Bélanger, S-6201, Montreal, Quebec, Canada.
Foisy S; Montreal Heart Institute Research Centre, 5000 rue Bélanger, S-6201, Montreal, Quebec, Canada.
Latour F; Montreal Heart Institute Research Centre, 5000 rue Bélanger, S-6201, Montreal, Quebec, Canada.
Lavallée G; Montreal Heart Institute Research Centre, 5000 rue Bélanger, S-6201, Montreal, Quebec, Canada.
Daly MJ; Massachusetts General Hospital, Boston, MA, USA.; The Broad Institute, Cambridge, MA, USA.
Xavier RJ; Massachusetts General Hospital, Boston, MA, USA.; The Broad Institute, Cambridge, MA, USA.
Charron G; Montreal Heart Institute Research Centre, 5000 rue Bélanger, S-6201, Montreal, Quebec, Canada.
Goyette P; Montreal Heart Institute Research Centre, 5000 rue Bélanger, S-6201, Montreal, Quebec, Canada.
Rioux JD; Montreal Heart Institute Research Centre, 5000 rue Bélanger, S-6201, Montreal, Quebec, Canada. .; Université de Montréal, Montreal, Quebec, Canada. .; Pokaż więcej
Corporate Authors:: iGenoMed Consortium
Źródło:: Genome medicine [Genome Med] 2021 Nov 11; Vol. 13 (1), pp. 181. Date of Electronic Publication: 2021 Nov 11.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Inflammatory Bowel Diseases/*genetics
Inflammatory Bowel Diseases/*metabolism
Butyrate Response Factor 1/genetics ; Carrier Proteins/genetics ; Dual-Specificity Phosphatases/genetics ; Epithelial Cells/metabolism ; Gastrointestinal Microbiome ; HEK293 Cells ; Humans ; Immunoglobulins ; Interferon Regulatory Factor-1/genetics ; Intestinal Mucosa/metabolism ; Intestines ; Mitogen-Activated Protein Kinase Phosphatases/genetics ; Paired Box Transcription Factors/genetics ; Protein Kinases/genetics ; Transcription Factors/genetics ; Transcriptome ; Ubiquitin-Specific Proteases/genetics ; AIRE Protein

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Skocz do pozycji: 4.

Tytuł:: Exome sequencing in patient-parent trios suggests new candidate genes for early-onset primary sclerosing cholangitis.
Autorzy:: Haisma SM; Department of Paediatric Gastroenterology Hepatology and Nutrition, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Weersma RK; Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Joosse ME; Department of Paediatric Gastroenterology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
de Koning BAE; Department of Paediatric Gastroenterology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
de Meij T; Department of Pediatric Gastroenterology, VU University Medical Center, Amsterdam, The Netherlands.
Koot BGP; Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Wolters V; Department of Pediatric Gastroenterology, University Medical Center Utrecht - Wilhelmina Children's Hospital, Utrecht, The Netherlands.
Norbruis O; Department of Pediatrics, Isala Hospital, Zwolle, The Netherlands.
Daly MJ; Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, MA, USA.
Stevens C; Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, MA, USA.
Xavier RJ; Massachusetts General Hospital, Gastroenterology, Boston, MA, USA.
Koskela J; Massachusetts General Hospital, Gastroenterology, Boston, MA, USA.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Clinic of Gastroenterology Helsinki, Helsinki University and Helsinki University Hospital, Helsinki, Finland.
Rivas MA; Stanford University, Stanford, CA, United States.
Visschedijk MC; Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Verkade HJ; Department of Paediatric Gastroenterology Hepatology and Nutrition, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Barbieri R; Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jansen DBH; Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Festen EAM; Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
van Rheenen PF; Department of Paediatric Gastroenterology Hepatology and Nutrition, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
van Diemen CC; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Pokaż więcej
Źródło:: Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2021 May; Vol. 41 (5), pp. 1044-1057. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji:: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms:: Cholangitis, Sclerosing*/genetics
Inflammatory Bowel Diseases*/genetics
Exome ; Humans ; Parents ; Exome Sequencing

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Skocz do pozycji: 5.

Tytuł:: C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.
Autorzy:: Mohanan V; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Nakata T; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Desch AN; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Lévesque C; Montreal Heart Institute Research Center, Montreal, Quebec H1T 1C8, Canada.
Boroughs A; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Guzman G; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Cao Z; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Creasey E; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Yao J; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Boucher G; Montreal Heart Institute Research Center, Montreal, Quebec H1T 1C8, Canada.
Charron G; Montreal Heart Institute Research Center, Montreal, Quebec H1T 1C8, Canada.
Bhan AK; Pathology Department, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.; Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA.
Schenone M; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Carr SA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Reinecker HC; Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA.; Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Daly MJ; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Rioux JD; Montreal Heart Institute Research Center, Montreal, Quebec H1T 1C8, Canada.; Department of Medicine, Université de Montréal, Montreal, Quebec H1T 1C8, Canada.
Lassen KG; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. xavier@molbio.mgh.harvard.edu.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Xavier RJ; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. xavier@molbio.mgh.harvard.edu.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA.; Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA.; Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2018 Mar 09; Vol. 359 (6380), pp. 1161-1166. Date of Electronic Publication: 2018 Feb 01.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Adherens Junctions/*genetics
Guanine Nucleotide Exchange Factors/*metabolism
Inflammatory Bowel Diseases/*genetics
Phosphoproteins/*metabolism
ADP-Ribosylation Factor 6 ; ADP-Ribosylation Factors/metabolism ; Animals ; Caco-2 Cells ; HEK293 Cells ; Humans ; Immunoprecipitation ; Intestinal Mucosa/pathology ; Mice ; Mice, Mutant Strains ; Phosphoproteins/genetics ; Polymorphism, Genetic ; Proteolysis ; Risk ; Ubiquitination/genetics

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Skocz do pozycji: 6.

Tytuł:: A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients.
Autorzy:: Hall AB; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Yassour M; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Sauk J; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Current address: Vatche and Tamar Manoukian Division of Digestive Disease, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA.
Garner A; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Jiang X; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Arthur T; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Lagoudas GK; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; MIT Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.
Vatanen T; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Fornelos N; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Wilson R; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Bertha M; Emory University School of Medicine, Emory University, Atlanta, GA, 30322, USA.
Cohen M; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Garber J; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Khalili H; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Gevers D; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Current address: Janssen Human Microbiome Institute, Janssen Research & Development, Cambridge, MA, 02142, USA.
Ananthakrishnan AN; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Kugathasan S; Emory University School of Medicine, Emory University, Atlanta, GA, 30322, USA.
Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; MIT Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, 02114, USA.
Blainey P; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; MIT Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.
Vlamakis H; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. xavier@molbio.mgh.harvard.edu.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA. xavier@molbio.mgh.harvard.edu.; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA. xavier@molbio.mgh.harvard.edu.; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. xavier@molbio.mgh.harvard.edu.
Huttenhower C; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. .; Department of Biostatistics, Harvard School of Public Health, Boston, MA, 02115, USA. .; Pokaż więcej
Źródło:: Genome medicine [Genome Med] 2017 Nov 28; Vol. 9 (1), pp. 103. Date of Electronic Publication: 2017 Nov 28.
Typ publikacji:: Journal Article
MeSH Terms:: Inflammatory Bowel Diseases/*microbiology
Ruminococcus/*isolation & purification
Adult ; Aged ; Feces/microbiology ; Gastrointestinal Microbiome/genetics ; Genome, Bacterial ; Humans ; Middle Aged ; Oxidative Stress ; Phylogeny ; Ruminococcus/genetics ; Species Specificity ; Young Adult

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Skocz do pozycji: 7.

Tytuł:: Ectopic colonization of oral bacteria in the intestine drives T H 1 cell induction and inflammation.
Autorzy:: Atarashi K; Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.; RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Suda W; Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.; Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan.; Cooperative Major in Advanced Health Science, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.
Luo C; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Kawaguchi T; Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.; RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Motoo I; RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Narushima S; RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Kiguchi Y; Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan.
Yasuma K; Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Watanabe E; RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Tanoue T; Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.; RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Thaiss CA; Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel.
Sato M; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Toyooka K; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Said HS; Cooperative Major in Advanced Health Science, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.; Department of Microbiology and Immunology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Yamagami H; Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Rice SA; The Singapore Centre for Environmental Life Sciences Engineering, The School of Biological Sciences, Nanyang Technological University, Singapore.
Gevers D; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Johnson RC; Microbial Genomics Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Segre JA; Microbial Genomics Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Chen K; Richard King Mellon Foundation Institute for Pediatric Research, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.
Kolls JK; Richard King Mellon Foundation Institute for Pediatric Research, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.
Elinav E; Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel.
Morita H; Graduate School of Environmental and Life Science, Okayama University, Okayama, Japan.
Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Hattori M; Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan. .; Cooperative Major in Advanced Health Science, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.
Honda K; Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. .; RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2017 Oct 20; Vol. 358 (6361), pp. 359-365.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Inflammatory Bowel Diseases/*immunology
Inflammatory Bowel Diseases/*microbiology
Intestines/*immunology
Klebsiella/*immunology
Microbiota/*immunology
Mouth/*microbiology
Th1 Cells/*immunology
Animals ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial ; Dysbiosis/immunology ; Dysbiosis/microbiology ; Germ-Free Life ; Intestines/microbiology ; Klebsiella/drug effects ; Klebsiella/isolation & purification ; Klebsiella/pathogenicity ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Saliva/microbiology

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Skocz do pozycji: 8.

Tytuł:: Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease.
Autorzy:: Chu H; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. .
Khosravi A; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Kusumawardhani IP; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Kwon AH; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Vasconcelos AC; Center for Veterinary Sciences and Comparative Medicine, University of California, San Diego, San Diego, CA 92093, USA.
Cunha LD; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Mayer AE; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Shen Y; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Wu WL; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Kambal A; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Targan SR; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Xavier RJ; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Ernst PB; Center for Veterinary Sciences and Comparative Medicine, University of California, San Diego, San Diego, CA 92093, USA.
Green DR; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
McGovern DP; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Virgin HW; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Mazmanian SK; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. .; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2016 May 27; Vol. 352 (6289), pp. 1116-20. Date of Electronic Publication: 2016 May 05.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene-Environment Interaction*
Bacteroides fragilis/*immunology
Carrier Proteins/*genetics
Gastrointestinal Microbiome/*immunology
Inflammatory Bowel Diseases/*genetics
Inflammatory Bowel Diseases/*microbiology
Nod2 Signaling Adaptor Protein/*genetics
Adult ; Aged ; Animals ; Autophagy/immunology ; Autophagy-Related Proteins ; Dendritic Cells/immunology ; Extracellular Vesicles/immunology ; Female ; Genetic Predisposition to Disease ; Genome, Human ; Humans ; Inflammatory Bowel Diseases/immunology ; Intestinal Mucosa/immunology ; Intestinal Mucosa/microbiology ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Polymorphism, Genetic ; T-Lymphocytes, Regulatory/immunology

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Tytuł:: Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Autorzy:: Jostins L; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.
Ripke S
Weersma RK
Duerr RH
McGovern DP
Hui KY
Lee JC
Schumm LP
Sharma Y
Anderson CA
Essers J
Mitrovic M
Ning K
Cleynen I
Theatre E
Spain SL
Raychaudhuri S
Goyette P
Wei Z
Abraham C
Achkar JP
Ahmad T
Amininejad L
Ananthakrishnan AN
Andersen V
Andrews JM
Baidoo L
Balschun T
Bampton PA
Bitton A
Boucher G
Brand S
Büning C
Cohain A
Cichon S
D'Amato M
De Jong D
Devaney KL
Dubinsky M
Edwards C
Ellinghaus D
Ferguson LR
Franchimont D
Fransen K
Gearry R
Georges M
Gieger C
Glas J
Haritunians T
Hart A
Hawkey C
Hedl M
Hu X
Karlsen TH
Kupcinskas L
Kugathasan S
Latiano A
Laukens D
Lawrance IC
Lees CW
Louis E
Mahy G
Mansfield J
Morgan AR
Mowat C
Newman W
Palmieri O
Ponsioen CY
Potocnik U
Prescott NJ
Regueiro M
Rotter JI
Russell RK
Sanderson JD
Sans M
Satsangi J
Schreiber S
Simms LA
Sventoraityte J
Targan SR
Taylor KD
Tremelling M
Verspaget HW
De Vos M
Wijmenga C
Wilson DC
Winkelmann J
Xavier RJ
Zeissig S
Zhang B
Zhang CK
Zhao H
Silverberg MS
Annese V
Hakonarson H
Brant SR
Radford-Smith G
Mathew CG
Rioux JD
Schadt EE
Daly MJ
Franke A
Parkes M
Vermeire S
Barrett JC
Cho JH; Pokaż więcej
Corporate Authors:: International IBD Genetics Consortium (IIBDGC)
Źródło:: Nature [Nature] 2012 Nov 01; Vol. 491 (7422), pp. 119-24.
Typ publikacji:: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Genome-Wide Association Study*
Host-Pathogen Interactions*/genetics
Host-Pathogen Interactions*/immunology
Genetic Predisposition to Disease/*genetics
Inflammatory Bowel Diseases/*genetics
Inflammatory Bowel Diseases/*microbiology
Mycobacterium/*immunology
Colitis, Ulcerative/genetics ; Colitis, Ulcerative/immunology ; Colitis, Ulcerative/microbiology ; Colitis, Ulcerative/physiopathology ; Crohn Disease/genetics ; Crohn Disease/immunology ; Crohn Disease/microbiology ; Crohn Disease/physiopathology ; Genome, Human/genetics ; Haplotypes/genetics ; Humans ; Inflammatory Bowel Diseases/immunology ; Inflammatory Bowel Diseases/physiopathology ; Mycobacterium/pathogenicity ; Mycobacterium Infections/genetics ; Mycobacterium Infections/microbiology ; Mycobacterium tuberculosis/immunology ; Mycobacterium tuberculosis/pathogenicity ; Phenotype ; Polymorphism, Single Nucleotide/genetics ; Reproducibility of Results

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Tytuł:: Non-invasive mapping of the gastrointestinal microbiota identifies children with inflammatory bowel disease.
Autorzy:: Papa E; Harvard/MIT Health Science and Technology Institute, Cambridge, Massachusetts, United States of America.
Docktor M
Smillie C
Weber S
Preheim SP
Gevers D
Giannoukos G
Ciulla D
Tabbaa D
Ingram J
Schauer DB
Ward DV
Korzenik JR
Xavier RJ
Bousvaros A
Alm EJ; Pokaż więcej
Źródło:: PloS one [PLoS One] 2012; Vol. 7 (6), pp. e39242. Date of Electronic Publication: 2012 Jun 29.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Metagenome*/genetics
Gastrointestinal Tract/*microbiology
Gastrointestinal Tract/*pathology
Inflammatory Bowel Diseases/*diagnosis
Inflammatory Bowel Diseases/*microbiology
Adolescent ; Adult ; Anti-Bacterial Agents/therapeutic use ; Biodiversity ; Child ; Child, Preschool ; Cohort Studies ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/microbiology ; Colitis, Ulcerative/pathology ; Crohn Disease/diagnosis ; Crohn Disease/microbiology ; Crohn Disease/pathology ; Demography ; Diagnosis, Differential ; Feces/microbiology ; Female ; Humans ; Inflammatory Bowel Diseases/classification ; Inflammatory Bowel Diseases/drug therapy ; Leukocyte L1 Antigen Complex/metabolism ; Male ; Remission Induction ; Reproducibility of Results ; Severity of Illness Index ; Software ; Young Adult

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Tytuł:: Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.
Autorzy:: Rivas MA; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA. />Beaudoin M
Gardet A
Stevens C
Sharma Y
Zhang CK
Boucher G
Ripke S
Ellinghaus D
Burtt N
Fennell T
Kirby A
Latiano A
Goyette P
Green T
Halfvarson J
Haritunians T
Korn JM
Kuruvilla F
Lagacé C
Neale B
Lo KS
Schumm P
Törkvist L
Dubinsky MC
Brant SR
Silverberg MS
Duerr RH
Altshuler D
Gabriel S
Lettre G
Franke A
D'Amato M
McGovern DP
Cho JH
Rioux JD
Xavier RJ
Daly MJ; Pokaż więcej
Corporate Authors:: National Institute of Diabetes and Digestive Kidney Diseases Inflammatory Bowel Disease Genetics Consortium (NIDDK IBDGC)
United Kingdom Inflammatory Bowel Disease Genetics Consortium
International Inflammatory Bowel Disease Genetics Consortium
Źródło:: Nature genetics [Nat Genet] 2011 Oct 09; Vol. 43 (11), pp. 1066-73. Date of Electronic Publication: 2011 Oct 09.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Genome-Wide Association Study*
Sequence Analysis, DNA*
Inflammatory Bowel Diseases/*genetics
Case-Control Studies ; Cell Line ; Genetic Predisposition to Disease ; Humans ; Nod2 Signaling Adaptor Protein/genetics ; RNA Splicing ; Receptors, Interleukin/genetics

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Tytuł:: Genetics and pathogenesis of inflammatory bowel disease.
Autorzy:: Khor B; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
Gardet A
Xavier RJ; Pokaż więcej
Źródło:: Nature [Nature] 2011 Jun 15; Vol. 474 (7351), pp. 307-17. Date of Electronic Publication: 2011 Jun 15.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Genetic Predisposition to Disease*
Inflammatory Bowel Diseases/*genetics
Inflammatory Bowel Diseases/*physiopathology
Animals ; Autophagy ; Epithelium/immunology ; Epithelium/metabolism ; Epithelium/microbiology ; Humans ; Immunity, Innate/immunology ; Inflammatory Bowel Diseases/immunology ; Inflammatory Bowel Diseases/microbiology

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Tytuł:: Common variants at five new loci associated with early-onset inflammatory bowel disease.
Autorzy:: Imielinski M; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Baldassano RN
Griffiths A
Russell RK
Annese V
Dubinsky M
Kugathasan S
Bradfield JP
Walters TD
Sleiman P
Kim CE
Muise A
Wang K
Glessner JT
Saeed S
Zhang H
Frackelton EC
Hou C
Flory JH
Otieno G
Chiavacci RM
Grundmeier R
Castro M
Latiano A
Dallapiccola B
Stempak J
Abrams DJ
Taylor K
McGovern D
Silber G
Wrobel I
Quiros A
Barrett JC
Hansoul S
Nicolae DL
Cho JH
Duerr RH
Rioux JD
Brant SR
Silverberg MS
Taylor KD
Barmuda MM
Bitton A
Dassopoulos T
Datta LW
Green T
Griffiths AM
Kistner EO
Murtha MT
Regueiro MD
Rotter JI
Schumm LP
Steinhart AH
Targan SR
Xavier RJ
Libioulle C
Sandor C
Lathrop M
Belaiche J
Dewit O
Gut I
Heath S
Laukens D
Mni M
Rutgeerts P
Van Gossum A
Zelenika D
Franchimont D
Hugot JP
de Vos M
Vermeire S
Louis E
Cardon LR
Anderson CA
Drummond H
Nimmo E
Ahmad T
Prescott NJ
Onnie CM
Fisher SA
Marchini J
Ghori J
Bumpstead S
Gwillam R
Tremelling M
Delukas P
Mansfield J
Jewell D
Satsangi J
Mathew CG
Parkes M
Georges M
Daly MJ
Heyman MB
Ferry GD
Kirschner B
Lee J
Essers J
Grand R
Stephens M
Levine A
Piccoli D
Van Limbergen J
Cucchiara S
Monos DS
Guthery SL
Denson L
Wilson DC
Grant SF
Daly M
Silverberg MS
Satsangi J
Hakonarson H; Pokaż więcej
Corporate Authors:: Western Regional Alliance for Pediatric IBD
International IBD Genetics Consortium
NIDDK IBD Genetics Consortium
Belgian-French IBD Consortium
Wellcome Trust Case Control Consortium
Źródło:: Nature genetics [Nat Genet] 2009 Dec; Vol. 41 (12), pp. 1335-40. Date of Electronic Publication: 2009 Nov 15.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Genetic Variation*
Inflammatory Bowel Diseases/*genetics
Age of Onset ; Chromosome Mapping ; Colitis, Ulcerative/genetics ; Genome, Human ; Genome-Wide Association Study ; Humans ; Inflammatory Bowel Diseases/epidemiology

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Tytuł:: Translating the human microbiome: a path to improving health.
Autorzy:: Xavier, Ramnik J. (AUTHOR) xavier@molbio.mgh.harvard.edu; Pokaż więcej
Źródło:: Genome Medicine. 5/5/2021, Vol. 13 Issue 1, p1-4. 4p.