Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Xenobiotica"" wg kryterium: JN


Tytuł :
Expression of cytochrome P450 isozyme transcripts and activities in human livers.
Autorzy :
Liu J; Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.; Center for Computational Toxicology and Exposure, US EPA, Durham, NC, USA.
Lu YF; Key Lab of Pharmacology of Ministry of Education, Zunyi Medical University, Zunyi, PR China.
Corton JC; Center for Computational Toxicology and Exposure, US EPA, Durham, NC, USA.
Klaassen CD; Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Mar; Vol. 51 (3), pp. 279-286. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article
MeSH Terms :
Cytochrome P-450 Enzyme System*/genetics
Liver/*enzymology
African Americans ; Aged ; Child ; European Continental Ancestry Group ; Female ; Hispanic Americans ; Humans ; Isoenzymes/genetics ; Male
Czasopismo naukowe
Tytuł :
Plasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling.
Autorzy :
Toda A; Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd., Wakayama , Japan.
Shimizu M; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University , Tokyo , Japan.
Uehara S; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University , Tokyo , Japan.; Laboratory Animal Research Department, Central Institute for Experimental Animals , Kawasaki , Japan.
Sasaki T; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University , Tokyo , Japan.
Miura T; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University , Tokyo , Japan.
Mogi M; Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd., Wakayama , Japan.; Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., Kagoshima , Japan.
Utoh M; Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd., Wakayama , Japan.; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University , Tokyo , Japan.; Scientific Affairs Division, Shin Nippon Biomedical Laboratories, Ltd., Tokyo , Japan.
Suemizu H; Laboratory Animal Research Department, Central Institute for Experimental Animals , Kawasaki , Japan.
Yamazaki H; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University , Tokyo , Japan.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Mar; Vol. 51 (3), pp. 316-323. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article
MeSH Terms :
Acetaminophen/*pharmacokinetics
Liver/*chemistry
Plasma/*chemistry
Administration, Oral ; Animals ; Callithrix ; Humans ; Macaca fascicularis ; Mice ; Rats ; Swine ; Swine, Miniature
Czasopismo naukowe
Tytuł :
Kinetics of metabolism of deltamethrin and cis - and trans -permethrin in vitro . Studies using rat and human liver microsomes, isolated rat hepatocytes and rat liver cytosol.
Autorzy :
Price RJ; Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK.
Scott MP; Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK.
Cantrill C; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK.
Higgins LG; Concept Life Sciences (formerly CXR Biosciences Ltd.), Dundee, UK.
Moreau M; ScitoVation, LLC, Research Triangle Park, NC, USA.
Yoon M; ScitoVation, LLC, Research Triangle Park, NC, USA.
Clewell HJ; Ramboll, Research Triangle Park, NC, USA.
Creek MR; Moire Creek Toxicology Consulting Services, Lincoln, CA, USA.
Osimitz TG; Science Strategies, LLC, Charlottesville, VA, USA.
Houston JB; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK.
Lake BG; Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Jan; Vol. 51 (1), pp. 40-50. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article
MeSH Terms :
Cytosol/*metabolism
Liver/*metabolism
Permethrin/*metabolism
Animals ; Carboxylesterase/metabolism ; Cytochrome P-450 Enzyme System/metabolism ; Hepatocytes/metabolism ; Humans ; Kinetics ; Male ; Microsomes, Liver/metabolism ; Nitriles/metabolism ; Pyrethrins/metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: integration with hepatic drug metabolism.
Autorzy :
Sanoh S; Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.; School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan.
Naritomi Y; Analysis and Pharmacokinetics Research Laboratories, Astellas Pharma Inc, Tsukuba, Japan.
Kitamura S; Analysis and Pharmacokinetics Research Laboratories, Astellas Pharma Inc, Tsukuba, Japan.
Shinagawa A; School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan.
Kakuni M; Study Service Dept, PhoenixBio, Co., Ltd, Tsukuba, Japan.
Tateno C; R&D Dept, PhoenixBio, Co., Ltd, Higashi-Hiroshima, Japan.; Research Center for Hepatology and Gastroenterology, Hiroshima University, Higashi-Hiroshima, Japan.
Ohta S; Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.; School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan.; Wakayama Medical University, Wakayama, Japan.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Nov; Vol. 50 (11), pp. 1370-1379. Date of Electronic Publication: 2020 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Liver/*metabolism
Organic Anion Transporters/*metabolism
Pharmaceutical Preparations/*metabolism
Animals ; Humans ; Inactivation, Metabolic ; Metabolic Clearance Rate ; Mice ; Pharmacokinetics
Czasopismo naukowe
Tytuł :
Quantitative evaluation of hepatic and intestinal induction of CYP3A in clinical practice.
Autorzy :
Tsutsui H; Research division, Chugai Pharmaceutical Co., Ltd, Gotemba, Shizuoka, Japan.
Kato M; Research division, Chugai Pharmaceutical Co., Ltd, Gotemba, Shizuoka, Japan.
Kuramoto S; Research division, Chugai Pharmaceutical Co., Ltd, Gotemba, Shizuoka, Japan.
Sekiguchi N; Research division, Chugai Pharmaceutical Co., Ltd, Gotemba, Shizuoka, Japan.
Shindoh H; Research division, Chugai Pharmaceutical Co., Ltd, Gotemba, Shizuoka, Japan.
Ozeki K; Research division, Chugai Pharmaceutical Co., Ltd, Gotemba, Shizuoka, Japan.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Aug; Vol. 50 (8), pp. 875-884. Date of Electronic Publication: 2020 Jan 07.
Typ publikacji :
Journal Article
MeSH Terms :
Cytochrome P-450 CYP3A/*metabolism
Intestines/*physiology
Liver/*metabolism
Alfentanil ; Area Under Curve ; Cytochrome P-450 CYP3A Inducers
Czasopismo naukowe
Tytuł :
Liver metabolomic characterization of Sophora flavescens alcohol extract-induced hepatotoxicity in rats through UPLC/LTQ-Orbitrap mass spectrometry.
Autorzy :
Jiang P; Department of Pharmacy, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China.
Sun Y; Department of Pharmacy, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China.
Cheng N; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Jun; Vol. 50 (6), pp. 670-676. Date of Electronic Publication: 2019 Nov 20.
Typ publikacji :
Journal Article
MeSH Terms :
Sophora*
Liver/*metabolism
Plant Extracts/*metabolism
Animals ; Chemical and Drug Induced Liver Injury ; Chromatography, High Pressure Liquid ; Ethanol ; Male ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
A hybrid model to evaluate the impact of active uptake transport on hepatic distribution of atorvastatin in rats.
Autorzy :
Kulkarni P; Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA, USA.
Korzekwa K; Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA, USA.
Nagar S; Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA, USA.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 May; Vol. 50 (5), pp. 536-544. Date of Electronic Publication: 2019 Oct 01.
Typ publikacji :
Journal Article
MeSH Terms :
Atorvastatin/*metabolism
Liver/*metabolism
Animals ; Biological Transport ; Organic Anion Transporters/metabolism
Czasopismo naukowe
Tytuł :
A mechanistic modelling approach for the determination of the mechanisms of inhibition by cyclosporine on the uptake and metabolism of atorvastatin in rat hepatocytes using a high throughput uptake method.
Autorzy :
Carter SJ; Biomedical and Biological Systems Laboratory, School of Engineering, University of Warwick, Coventry, United Kingdom.
Ferecskó AS; UCB Pharma Ltd, Slough, United Kingdom.
King L; UCB Pharma Ltd, Slough, United Kingdom.
Ménochet K; UCB Pharma Ltd, Slough, United Kingdom.
Parton T; Mekinopsis Ltd, London, United Kingdom.
Chappell MJ; Biomedical and Biological Systems Laboratory, School of Engineering, University of Warwick, Coventry, United Kingdom.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Apr; Vol. 50 (4), pp. 415-426. Date of Electronic Publication: 2019 Aug 19.
Typ publikacji :
Journal Article
MeSH Terms :
Atorvastatin/*metabolism
Cyclosporine/*metabolism
Liver/*metabolism
Animals ; Biological Transport ; Hepatocytes ; Models, Chemical ; Rats
Czasopismo naukowe
Tytuł :
Conflicting alterations in hepatic expression of CYP3A and enzyme kinetics in rats exposed to 5-fluorouracil: relevance to pharmacokinetics of midazolam.
Autorzy :
Fukuno S; Laboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University , Tondabayashi , Japan.
Nagai K; Laboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University , Tondabayashi , Japan.
Fujiike M; Laboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University , Tondabayashi , Japan.
Sasaki Y; Laboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University , Tondabayashi , Japan.
Konishi H; Laboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University , Tondabayashi , Japan.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Dec; Vol. 49 (12), pp. 1470-1477. Date of Electronic Publication: 2019 Mar 05.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
Cytochrome P-450 CYP3A/*metabolism
Fluorouracil/*pharmacokinetics
Liver/*metabolism
Midazolam/*pharmacokinetics
Administration, Intravenous ; Animals ; Body Weight/drug effects ; Cytochrome P-450 CYP3A Inhibitors/pharmacology ; Hydroxylation/drug effects ; Inactivation, Metabolic ; Kinetics ; Liver/drug effects ; Male ; Microsomes, Liver/drug effects ; Microsomes, Liver/metabolism ; Midazolam/administration & dosage ; Midazolam/blood ; Organ Size/drug effects ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver.
Autorzy :
Miyamoto M; Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , Fujisawa , Kanagawa , Japan.
Iwasaki S; Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , Fujisawa , Kanagawa , Japan.
Chisaki I; Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , Fujisawa , Kanagawa , Japan.
Nakagawa S; Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , Fujisawa , Kanagawa , Japan.
Amano N; Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , Fujisawa , Kanagawa , Japan.
Kosugi Y; Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , Fujisawa , Kanagawa , Japan.
Hirabayashi H; Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , Fujisawa , Kanagawa , Japan.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Dec; Vol. 49 (12), pp. 1379-1387. Date of Electronic Publication: 2019 Mar 18.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
Liver*/drug effects
Pharmacokinetics*
Animals ; Chimera ; Half-Life ; Hepatocytes ; Humans ; Male ; Mice, SCID ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Predictability of human pharmacokinetics of diisononyl phthalate (DINP) using chimeric mice with humanized liver.
Autorzy :
Iwata H; a LSI Medience Corporation , Kamisu , Japan.
Goto M; a LSI Medience Corporation , Kamisu , Japan.
Sakai N; a LSI Medience Corporation , Kamisu , Japan.
Suemizu H; b Central Institute for Experimental Animals , Kawasaki , Japan.
Yamazaki H; c Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University , Machida , Japan.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Nov; Vol. 49 (11), pp. 1311-1322. Date of Electronic Publication: 2019 Jun 21.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
Liver/*metabolism
Phthalic Acids/*pharmacokinetics
Administration, Oral ; Adult ; Animals ; Carbon Radioisotopes ; Chimera ; Dose-Response Relationship, Drug ; Feces/chemistry ; Female ; Hepatocytes/transplantation ; Humans ; Liver/drug effects ; Male ; Mice, Inbred NOD ; Mice, SCID ; Oxidation-Reduction ; Phthalic Acids/administration & dosage ; Phthalic Acids/metabolism
Czasopismo naukowe
Tytuł :
Application of unbound liver-to-plasma concentration ratio to quantitative projection of cytochrome P450-mediated drug-drug interactions using physiologically based pharmacokinetic modelling approach.
Autorzy :
Iwasaki S; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.; b Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co. , Cambridge , MA , USA.
Kosugi Y; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Zhu AZX; b Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co. , Cambridge , MA , USA.
Nakagawa S; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Sano N; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Funami M; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Kosaka M; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Furuta A; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Hirabayashi H; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Amano N; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Nov; Vol. 49 (11), pp. 1251-1259. Date of Electronic Publication: 2019 Feb 03.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
Drug Interactions*
Pharmacokinetics*
Cytochrome P-450 Enzyme System/*metabolism
Erythrocytes/*drug effects
Liver/*drug effects
Animals ; Area Under Curve ; Erythrocytes/metabolism ; Humans ; Itraconazole/pharmacokinetics ; Liver/metabolism ; Male ; Models, Biological ; Rats, Sprague-Dawley ; Software ; Triazolam/pharmacokinetics
Czasopismo naukowe
Tytuł :
Comparative study on the metabolism of the ergot alkaloids ergocristine, ergocryptine, ergotamine, and ergovaline in equine and human S9 fractions and equine liver preparations.
Autorzy :
Rudolph W; a Institute of Forensic Medicine , Jena University Hospital , Jena , Germany.
Remane D; a Institute of Forensic Medicine , Jena University Hospital , Jena , Germany.
Wissenbach DK; a Institute of Forensic Medicine , Jena University Hospital , Jena , Germany.
Peters FT; a Institute of Forensic Medicine , Jena University Hospital , Jena , Germany.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Oct; Vol. 49 (10), pp. 1149-1157. Date of Electronic Publication: 2019 Jan 09.
Typ publikacji :
Journal Article
MeSH Terms :
Ergolines*/pharmacokinetics
Ergolines*/pharmacology
Ergotamine*/pharmacokinetics
Ergotamine*/pharmacology
Ergotamines*/pharmacokinetics
Ergotamines*/pharmacology
Liver/*metabolism
Animals ; Chromatography, High Pressure Liquid ; Horses ; Humans ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
In vivo hepatic clearance of lipophilic drugs predicted by in vitro uptake data into cryopreserved hepatocytes suspended in sera of rats, guinea pigs, monkeys and humans.
Autorzy :
Koyanagi T; a Discovery Technology Research Laboratories, Ono Pharmaceutical Co., Ltd , Osaka , Japan.
Yano K; a Discovery Technology Research Laboratories, Ono Pharmaceutical Co., Ltd , Osaka , Japan.
Kim S; a Discovery Technology Research Laboratories, Ono Pharmaceutical Co., Ltd , Osaka , Japan.
Murayama N; b Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida , Tokyo , Japan.
Yamazaki H; b Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida , Tokyo , Japan.
Tamai I; c Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University , Kanazawa , Japan.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Aug; Vol. 49 (8), pp. 887-894. Date of Electronic Publication: 2018 Sep 21.
Typ publikacji :
Journal Article
MeSH Terms :
Cryopreservation*
Hepatocytes/*metabolism
Lipids/*chemistry
Liver/*metabolism
Pharmaceutical Preparations/*metabolism
Serum/*metabolism
Animals ; Guinea Pigs ; Haplorhini ; Humans ; Male ; Rats
Czasopismo naukowe
Tytuł :
Liver-specific knockout of histone methyltransferase G9a impairs liver maturation and dysregulates inflammatory, cytoprotective, and drug-processing genes.
Autorzy :
Lu H; a Department of Pharmacology , SUNY Upstate Medical University , Syracuse , USA.
Lei X; a Department of Pharmacology , SUNY Upstate Medical University , Syracuse , USA.
Zhang Q; a Department of Pharmacology , SUNY Upstate Medical University , Syracuse , USA.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Jun; Vol. 49 (6), pp. 740-752. Date of Electronic Publication: 2018 Jul 23.
Typ publikacji :
Journal Article
MeSH Terms :
Histone-Lysine N-Methyltransferase/*physiology
Liver/*metabolism
Animals ; Cytoprotection/genetics ; Gene Expression Regulation ; Gene Knockout Techniques ; Gene Silencing ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Lipid Peroxidation/genetics ; Mice ; Mice, Knockout ; Xenobiotics/metabolism
Czasopismo naukowe
Tytuł :
Limited expression of functional cytochrome p450 2c subtypes in the liver and small intestine of domestic cats.
Autorzy :
Ono Y; a School of Veterinary Medicine , Rakuno Gakuen University , Ebetsu , Hokkaido , Japan.
Sugiyama S; a School of Veterinary Medicine , Rakuno Gakuen University , Ebetsu , Hokkaido , Japan.
Matsushita M; a School of Veterinary Medicine , Rakuno Gakuen University , Ebetsu , Hokkaido , Japan.
Kitazawa T; a School of Veterinary Medicine , Rakuno Gakuen University , Ebetsu , Hokkaido , Japan.
Amano T; b College of Agriculture Food and Environment Sciences , Rakuno Gakuen University , Ebetsu , Hokkaido , Japan.
Uno Y; c Pharmacokinetics and Bioanalysis Center , Shin Nippon Biomedical Laboratories Ltd , Kainan , Wakayama , Japan.
Ikushiro S; d Department of Biotechnology Faculty of Engineering , Toyama Prefectural University , Imizu , Toyama , Japan.
Teraoka H; a School of Veterinary Medicine , Rakuno Gakuen University , Ebetsu , Hokkaido , Japan.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Jun; Vol. 49 (6), pp. 627-635. Date of Electronic Publication: 2018 Jul 13.
Typ publikacji :
Journal Article
MeSH Terms :
Cats/*metabolism
Cytochrome P450 Family 2/*metabolism
Intestine, Small/*metabolism
Liver/*metabolism
Xenobiotics/*metabolism
Alternative Splicing ; Animals ; Cytochrome P450 Family 2/chemistry ; Immunoblotting ; Protein Isoforms/metabolism ; Protein Isoforms/physiology ; Reverse Transcriptase Polymerase Chain Reaction ; Sequence Alignment ; Sequence Analysis, Protein
Czasopismo naukowe
Tytuł :
A metabolomic perspective of pazopanib-induced acute hepatotoxicity in mice.
Autorzy :
Wang YK; a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , China.; b University of Chinese Academy of Sciences , Beijing , China.
Yang XN; a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , China.
Liang WQ; c Center for Medicinal Resources Research, Zhejiang Academy of Traditional Chinese Medicine , Hangzhou , China.
Xiao Y; a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , China.; b University of Chinese Academy of Sciences , Beijing , China.
Zhao Q; a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , China.; b University of Chinese Academy of Sciences , Beijing , China.
Xiao XR; a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , China.
Gonzalez FJ; d Laboratory of Metabolism , Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.
Li F; a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , China.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Jun; Vol. 49 (6), pp. 655-670. Date of Electronic Publication: 2018 Jul 23.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*toxicity
Liver/*drug effects
Pyrimidines/*toxicity
Sulfonamides/*toxicity
Alanine Transaminase/blood ; Animals ; Antineoplastic Agents/metabolism ; Aspartate Aminotransferases/blood ; Biomarkers/blood ; Chromatography, High Pressure Liquid ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Cytochrome P-450 Enzyme System/physiology ; Liver/metabolism ; Liver/pathology ; Male ; Metabolomics ; Mice ; Mice, Inbred C57BL ; Multivariate Analysis ; Oxidative Stress/drug effects ; Pyrimidines/metabolism ; Spectrometry, Mass, Electrospray Ionization ; Sulfonamides/metabolism
Czasopismo naukowe
Tytuł :
Development of simultaneous quantification method of loteprednol etabonate (LE) and its acidic metabolites, and analysis of LE metabolism in rat.
Autorzy :
Samir A; a Graduate School of Pharmaceutical Sciences , Kumamoto University , Kumamoto , Japan.
Kage A; a Graduate School of Pharmaceutical Sciences , Kumamoto University , Kumamoto , Japan.
Ohura K; a Graduate School of Pharmaceutical Sciences , Kumamoto University , Kumamoto , Japan.
Imai T; a Graduate School of Pharmaceutical Sciences , Kumamoto University , Kumamoto , Japan.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 May; Vol. 49 (5), pp. 569-576. Date of Electronic Publication: 2018 Jul 05.
Typ publikacji :
Journal Article
MeSH Terms :
Loteprednol Etabonate*/pharmacokinetics
Loteprednol Etabonate*/pharmacology
Intestinal Mucosa/*metabolism
Liver/*metabolism
Plasma/*metabolism
Animals ; Chromatography, High Pressure Liquid ; Male ; Paraoxon/pharmacology ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Pharmacokinetic alterations in poloxamer 407-induced hyperlipidemic rats.
Autorzy :
Lee U; a Department of Pharmacy , Ewha Womans University Medical Center , Seoul , South Korea.
Kwon MH; b College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences , The Catholic University of Korea , Bucheon , South Korea.
Kang HE; b College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences , The Catholic University of Korea , Bucheon , South Korea.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 May; Vol. 49 (5), pp. 611-625. Date of Electronic Publication: 2018 May 08.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Poloxamer*/pharmacokinetics
Poloxamer*/pharmacology
Cytochrome P-450 CYP3A/*metabolism
Cytochrome P-450 Enzyme System/*metabolism
Hyperlipidemias/*metabolism
Lipoproteins/*metabolism
Liver/*metabolism
Animals ; Hyperlipidemias/pathology ; Liver/pathology ; Rats
Czasopismo naukowe
Tytuł :
Human urinary concentrations of monoisononyl phthalate estimated using physiologically based pharmacokinetic modeling and experimental pharmacokinetics in humanized-liver mice orally administered with diisononyl phthalate.
Autorzy :
Miura T; a Showa Pharmaceutical University , Machida , Japan.
Suemizu H; b Central Institute for Experimental Animals , Kawasaki-ku , Japan.
Goto M; c LSI Medicine Corporation , Kamisu , Japan.
Sakai N; c LSI Medicine Corporation , Kamisu , Japan.
Iwata H; c LSI Medicine Corporation , Kamisu , Japan.
Shimizu M; a Showa Pharmaceutical University , Machida , Japan.
Yamazaki H; a Showa Pharmaceutical University , Machida , Japan.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 May; Vol. 49 (5), pp. 513-520. Date of Electronic Publication: 2018 May 18.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Biological*
Liver/*metabolism
Phthalic Acids/*urine
Animals ; Humans ; Mice ; Phthalic Acids/pharmacokinetics ; Phthalic Acids/toxicity
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies