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You search for a phrase ""Xenobiotica"" according to the criterion: JN


Title:
Dose-dependent pharmacokinetics of midazolam in rats: influence of hepatic first-pass metabolism.
Authors:
Li R; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Wang Q; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Liu Z; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Xie L; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Diao Z; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Peng Y; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Wang G; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Sun J; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
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Source:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Mar; Vol. 53 (3), pp. 184-192. Date of Electronic Publication: 2023 Apr 27.
Publication Type:
Journal Article
MeSH Terms:
Midazolam*/pharmacokinetics
Liver*/metabolism
Rats ; Animals ; Rats, Sprague-Dawley ; Intestines ; Biological Availability ; Administration, Oral ; Area Under Curve
Academic Journal
Title:
A comprehensive analysis of six forms of cytochrome P450 2C (CYP2C) in pigs.
Authors:
Uno Y; Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima-city, Japan.
Morikuni S; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.
Shiraishi M; Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima-city, Japan.
Asano A; Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima-city, Japan.
Kawaguchi H; School of Veterinary Medicine, Kitasato University, Towada, Japan.
Murayama N; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.
Yamazaki H; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.
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Source:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Sep-Nov; Vol. 52 (9-11), pp. 963-972. Date of Electronic Publication: 2022 Nov 17.
Publication Type:
Journal Article
MeSH Terms:
Cytochrome P-450 Enzyme System*/metabolism
Liver*/metabolism
Swine ; Humans ; Animals ; Intestine, Small ; Cytochrome P-450 CYP2C9/metabolism ; Cytochrome P-450 CYP2C8/metabolism
Academic Journal
Title:
Pharmacokinetics, mass balance, metabolism, and excretion of the liver-targeted acetyl-CoA carboxylase inhibitor PF-05221304 (clesacostat) in humans.
Authors:
Ryder TF; Pfizer Worldwide Research, Development, and Medical, Groton, CT, USA.
Bergman A; Pfizer Worldwide Research, Development, and Medical, Cambridge, MA, USA.
King-Ahmad A; Pfizer Worldwide Research, Development, and Medical, Groton, CT, USA.
Amin NB; Pfizer Worldwide Research, Development, and Medical, Cambridge, MA, USA.
Lall MS; Pfizer Worldwide Research, Development, and Medical, Groton, CT, USA.
Ballard TE; Pfizer Worldwide Research, Development, and Medical, Groton, CT, USA.
Kalgutkar AS; Pfizer Worldwide Research, Development, and Medical, Cambridge, MA, USA.
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Source:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Mar; Vol. 52 (3), pp. 240-253. Date of Electronic Publication: 2022 Apr 13.
Publication Type:
Journal Article
MeSH Terms:
Acetyl-CoA Carboxylase*
Liver*
Administration, Oral ; Enzyme Inhibitors ; Feces ; Humans ; Hydroxylation
Academic Journal
Title:
Species-dependent hepatic and intestinal metabolism of selective oestrogen receptor degrader LSZ102 by sulphation and glucuronidation.
Authors:
Pearson D; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Jin Y; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Romeo A; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Birlinger BL; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Schiller H; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Ji Y; Novartis Institutes for Biomedical Research, East Hanover, NJ, USA.
Gunduz M; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
Baldoni D; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Walles M; Novartis Institutes for Biomedical Research, Basel, Switzerland.
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Source:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Jan; Vol. 52 (1), pp. 26-37. Date of Electronic Publication: 2022 Feb 10.
Publication Type:
Journal Article
MeSH Terms:
Liver*/metabolism
Receptors, Estrogen*/metabolism
Animals ; Hepatocytes/metabolism ; Humans ; Rats ; Thiophenes/metabolism
Academic Journal
Title:
Hepatotoxicological potential of P -toluic acid in humanised-liver mice investigated using simplified physiologically based pharmacokinetic models.
Authors:
Miura T; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.
Kamiya Y; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.
Uehara S; Laboratory Animal Research Department, Central Institute for Experimental Animals, Kawasaki, Japan.
Murayama N; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.
Shimizu M; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.
Suemizu H; Laboratory Animal Research Department, Central Institute for Experimental Animals, Kawasaki, Japan.
Yamazaki H; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.
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Source:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Jun; Vol. 51 (6), pp. 636-642. Date of Electronic Publication: 2021 Apr 07.
Publication Type:
Journal Article
MeSH Terms:
Liver*
Models, Biological*
Animals ; Benzoates ; Mice ; Microsomes, Liver ; Rats
Academic Journal
Title:
Expression of cytochrome P450 isozyme transcripts and activities in human livers.
Authors:
Liu J; Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.; Center for Computational Toxicology and Exposure, US EPA, Durham, NC, USA.
Lu YF; Key Lab of Pharmacology of Ministry of Education, Zunyi Medical University, Zunyi, PR China.
Corton JC; Center for Computational Toxicology and Exposure, US EPA, Durham, NC, USA.
Klaassen CD; Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.
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Source:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Mar; Vol. 51 (3), pp. 279-286. Date of Electronic Publication: 2020 Dec 28.
Publication Type:
Journal Article
MeSH Terms:
Cytochrome P-450 Enzyme System*/genetics
Liver/*enzymology
Black or African American ; Aged ; Child ; Female ; Hispanic or Latino ; Humans ; Isoenzymes/genetics ; Male ; White People
Academic Journal
Title:
Plasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling.
Authors:
Toda A; Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd., Wakayama , Japan.
Shimizu M; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University , Tokyo , Japan.
Uehara S; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University , Tokyo , Japan.; Laboratory Animal Research Department, Central Institute for Experimental Animals , Kawasaki , Japan.
Sasaki T; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University , Tokyo , Japan.
Miura T; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University , Tokyo , Japan.
Mogi M; Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd., Wakayama , Japan.; Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., Kagoshima , Japan.
Utoh M; Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd., Wakayama , Japan.; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University , Tokyo , Japan.; Scientific Affairs Division, Shin Nippon Biomedical Laboratories, Ltd., Tokyo , Japan.
Suemizu H; Laboratory Animal Research Department, Central Institute for Experimental Animals , Kawasaki , Japan.
Yamazaki H; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University , Tokyo , Japan.
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Source:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Mar; Vol. 51 (3), pp. 316-323. Date of Electronic Publication: 2020 Nov 19.
Publication Type:
Journal Article
MeSH Terms:
Acetaminophen/*pharmacokinetics
Liver/*chemistry
Plasma/*chemistry
Administration, Oral ; Animals ; Callithrix ; Humans ; Macaca fascicularis ; Mice ; Rats ; Swine ; Swine, Miniature
Academic Journal
Title:
Kinetics of metabolism of deltamethrin and cis - and trans -permethrin in vitro . Studies using rat and human liver microsomes, isolated rat hepatocytes and rat liver cytosol.
Authors:
Price RJ; Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK.
Scott MP; Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK.
Cantrill C; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK.
Higgins LG; Concept Life Sciences (formerly CXR Biosciences Ltd.), Dundee, UK.
Moreau M; ScitoVation, LLC, Research Triangle Park, NC, USA.
Yoon M; ScitoVation, LLC, Research Triangle Park, NC, USA.
Clewell HJ; Ramboll, Research Triangle Park, NC, USA.
Creek MR; Moire Creek Toxicology Consulting Services, Lincoln, CA, USA.
Osimitz TG; Science Strategies, LLC, Charlottesville, VA, USA.
Houston JB; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK.
Lake BG; Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK.
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Source:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Jan; Vol. 51 (1), pp. 40-50. Date of Electronic Publication: 2020 Aug 26.
Publication Type:
Journal Article
MeSH Terms:
Cytosol/*metabolism
Liver/*metabolism
Permethrin/*metabolism
Animals ; Carboxylesterase/metabolism ; Cytochrome P-450 Enzyme System/metabolism ; Hepatocytes/metabolism ; Humans ; Kinetics ; Male ; Microsomes, Liver/metabolism ; Nitriles/metabolism ; Pyrethrins/metabolism ; Rats ; Rats, Sprague-Dawley
Academic Journal
Title:
Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: integration with hepatic drug metabolism.
Authors:
Sanoh S; Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.; School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan.
Naritomi Y; Analysis and Pharmacokinetics Research Laboratories, Astellas Pharma Inc, Tsukuba, Japan.
Kitamura S; Analysis and Pharmacokinetics Research Laboratories, Astellas Pharma Inc, Tsukuba, Japan.
Shinagawa A; School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan.
Kakuni M; Study Service Dept, PhoenixBio, Co., Ltd, Tsukuba, Japan.
Tateno C; R&D Dept, PhoenixBio, Co., Ltd, Higashi-Hiroshima, Japan.; Research Center for Hepatology and Gastroenterology, Hiroshima University, Higashi-Hiroshima, Japan.
Ohta S; Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.; School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan.; Wakayama Medical University, Wakayama, Japan.
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Source:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Nov; Vol. 50 (11), pp. 1370-1379. Date of Electronic Publication: 2020 Jun 05.
Publication Type:
Journal Article
MeSH Terms:
Liver/*metabolism
Organic Anion Transporters/*metabolism
Pharmaceutical Preparations/*metabolism
Animals ; Humans ; Inactivation, Metabolic ; Metabolic Clearance Rate ; Mice ; Pharmacokinetics
Academic Journal
Title:
Quantitative evaluation of hepatic and intestinal induction of CYP3A in clinical practice.
Authors:
Tsutsui H; Research division, Chugai Pharmaceutical Co., Ltd, Gotemba, Shizuoka, Japan.
Kato M; Research division, Chugai Pharmaceutical Co., Ltd, Gotemba, Shizuoka, Japan.
Kuramoto S; Research division, Chugai Pharmaceutical Co., Ltd, Gotemba, Shizuoka, Japan.
Sekiguchi N; Research division, Chugai Pharmaceutical Co., Ltd, Gotemba, Shizuoka, Japan.
Shindoh H; Research division, Chugai Pharmaceutical Co., Ltd, Gotemba, Shizuoka, Japan.
Ozeki K; Research division, Chugai Pharmaceutical Co., Ltd, Gotemba, Shizuoka, Japan.
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Source:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Aug; Vol. 50 (8), pp. 875-884. Date of Electronic Publication: 2020 Jan 07.
Publication Type:
Journal Article
MeSH Terms:
Cytochrome P-450 CYP3A/*metabolism
Intestines/*physiology
Liver/*metabolism
Alfentanil ; Area Under Curve ; Cytochrome P-450 CYP3A Inducers
Academic Journal
Title:
Liver metabolomic characterization of Sophora flavescens alcohol extract-induced hepatotoxicity in rats through UPLC/LTQ-Orbitrap mass spectrometry.
Authors:
Jiang P; Department of Pharmacy, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China.
Sun Y; Department of Pharmacy, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China.
Cheng N; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.
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Source:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Jun; Vol. 50 (6), pp. 670-676. Date of Electronic Publication: 2019 Nov 20.
Publication Type:
Journal Article
MeSH Terms:
Sophora*
Liver/*metabolism
Plant Extracts/*metabolism
Animals ; Chemical and Drug Induced Liver Injury ; Chromatography, High Pressure Liquid ; Ethanol ; Male ; Rats ; Rats, Sprague-Dawley
Academic Journal
Title:
A hybrid model to evaluate the impact of active uptake transport on hepatic distribution of atorvastatin in rats.
Authors:
Kulkarni P; Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA, USA.
Korzekwa K; Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA, USA.
Nagar S; Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA, USA.
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Source:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 May; Vol. 50 (5), pp. 536-544. Date of Electronic Publication: 2019 Oct 01.
Publication Type:
Journal Article
MeSH Terms:
Atorvastatin/*metabolism
Liver/*metabolism
Animals ; Biological Transport ; Organic Anion Transporters/metabolism
Academic Journal
Title:
A mechanistic modelling approach for the determination of the mechanisms of inhibition by cyclosporine on the uptake and metabolism of atorvastatin in rat hepatocytes using a high throughput uptake method.
Authors:
Carter SJ; Biomedical and Biological Systems Laboratory, School of Engineering, University of Warwick, Coventry, United Kingdom.
Ferecskó AS; UCB Pharma Ltd, Slough, United Kingdom.
King L; UCB Pharma Ltd, Slough, United Kingdom.
Ménochet K; UCB Pharma Ltd, Slough, United Kingdom.
Parton T; Mekinopsis Ltd, London, United Kingdom.
Chappell MJ; Biomedical and Biological Systems Laboratory, School of Engineering, University of Warwick, Coventry, United Kingdom.
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Source:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Apr; Vol. 50 (4), pp. 415-426. Date of Electronic Publication: 2019 Aug 19.
Publication Type:
Journal Article
MeSH Terms:
Atorvastatin/*metabolism
Cyclosporine/*metabolism
Liver/*metabolism
Animals ; Biological Transport ; Hepatocytes ; Models, Chemical ; Rats
Academic Journal
Title:
Conflicting alterations in hepatic expression of CYP3A and enzyme kinetics in rats exposed to 5-fluorouracil: relevance to pharmacokinetics of midazolam.
Authors:
Fukuno S; Laboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University , Tondabayashi , Japan.
Nagai K; Laboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University , Tondabayashi , Japan.
Fujiike M; Laboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University , Tondabayashi , Japan.
Sasaki Y; Laboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University , Tondabayashi , Japan.
Konishi H; Laboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University , Tondabayashi , Japan.
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Source:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Dec; Vol. 49 (12), pp. 1470-1477. Date of Electronic Publication: 2019 Mar 05.
Publication Type:
Journal Article; Video-Audio Media
MeSH Terms:
Cytochrome P-450 CYP3A/*metabolism
Fluorouracil/*pharmacokinetics
Liver/*metabolism
Midazolam/*pharmacokinetics
Administration, Intravenous ; Animals ; Body Weight/drug effects ; Cytochrome P-450 CYP3A Inhibitors/pharmacology ; Hydroxylation/drug effects ; Inactivation, Metabolic ; Kinetics ; Liver/drug effects ; Male ; Microsomes, Liver/drug effects ; Microsomes, Liver/metabolism ; Midazolam/administration & dosage ; Midazolam/blood ; Organ Size/drug effects ; Rats, Sprague-Dawley
Academic Journal
Title:
Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver.
Authors:
Miyamoto M; Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , Fujisawa , Kanagawa , Japan.
Iwasaki S; Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , Fujisawa , Kanagawa , Japan.
Chisaki I; Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , Fujisawa , Kanagawa , Japan.
Nakagawa S; Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , Fujisawa , Kanagawa , Japan.
Amano N; Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , Fujisawa , Kanagawa , Japan.
Kosugi Y; Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , Fujisawa , Kanagawa , Japan.
Hirabayashi H; Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , Fujisawa , Kanagawa , Japan.
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Source:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Dec; Vol. 49 (12), pp. 1379-1387. Date of Electronic Publication: 2019 Mar 18.
Publication Type:
Journal Article; Video-Audio Media
MeSH Terms:
Liver*/drug effects
Pharmacokinetics*
Animals ; Chimera ; Half-Life ; Hepatocytes ; Humans ; Male ; Mice, SCID ; Mice, Transgenic
Academic Journal
Title:
Application of unbound liver-to-plasma concentration ratio to quantitative projection of cytochrome P450-mediated drug-drug interactions using physiologically based pharmacokinetic modelling approach.
Authors:
Iwasaki S; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.; b Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co. , Cambridge , MA , USA.
Kosugi Y; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Zhu AZX; b Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co. , Cambridge , MA , USA.
Nakagawa S; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Sano N; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Funami M; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Kosaka M; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Furuta A; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Hirabayashi H; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
Amano N; a Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd. , Fujisawa , Kanagawa , Japan.
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Source:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Nov; Vol. 49 (11), pp. 1251-1259. Date of Electronic Publication: 2019 Feb 03.
Publication Type:
Journal Article; Video-Audio Media
MeSH Terms:
Drug Interactions*
Pharmacokinetics*
Cytochrome P-450 Enzyme System/*metabolism
Erythrocytes/*drug effects
Liver/*drug effects
Animals ; Area Under Curve ; Erythrocytes/metabolism ; Humans ; Itraconazole/pharmacokinetics ; Liver/metabolism ; Male ; Models, Biological ; Rats, Sprague-Dawley ; Software ; Triazolam/pharmacokinetics
Academic Journal
Title:
Predictability of human pharmacokinetics of diisononyl phthalate (DINP) using chimeric mice with humanized liver.
Authors:
Iwata H; a LSI Medience Corporation , Kamisu , Japan.
Goto M; a LSI Medience Corporation , Kamisu , Japan.
Sakai N; a LSI Medience Corporation , Kamisu , Japan.
Suemizu H; b Central Institute for Experimental Animals , Kawasaki , Japan.
Yamazaki H; c Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University , Machida , Japan.
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Source:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Nov; Vol. 49 (11), pp. 1311-1322. Date of Electronic Publication: 2019 Jun 21.
Publication Type:
Journal Article; Video-Audio Media
MeSH Terms:
Liver/*metabolism
Phthalic Acids/*pharmacokinetics
Administration, Oral ; Adult ; Animals ; Carbon Radioisotopes ; Chimera ; Dose-Response Relationship, Drug ; Feces/chemistry ; Female ; Hepatocytes/transplantation ; Humans ; Liver/drug effects ; Male ; Mice, Inbred NOD ; Mice, SCID ; Oxidation-Reduction ; Phthalic Acids/administration & dosage ; Phthalic Acids/metabolism
Academic Journal
Title:
Comparative study on the metabolism of the ergot alkaloids ergocristine, ergocryptine, ergotamine, and ergovaline in equine and human S9 fractions and equine liver preparations.
Authors:
Rudolph W; a Institute of Forensic Medicine , Jena University Hospital , Jena , Germany.
Remane D; a Institute of Forensic Medicine , Jena University Hospital , Jena , Germany.
Wissenbach DK; a Institute of Forensic Medicine , Jena University Hospital , Jena , Germany.
Peters FT; a Institute of Forensic Medicine , Jena University Hospital , Jena , Germany.
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Source:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Oct; Vol. 49 (10), pp. 1149-1157. Date of Electronic Publication: 2019 Jan 09.
Publication Type:
Journal Article
MeSH Terms:
Ergolines*/pharmacokinetics
Ergolines*/pharmacology
Ergotamine*/pharmacokinetics
Ergotamine*/pharmacology
Ergotamines*/pharmacokinetics
Ergotamines*/pharmacology
Liver/*metabolism
Animals ; Chromatography, High Pressure Liquid ; Horses ; Humans ; Tandem Mass Spectrometry
Academic Journal
Title:
In vivo hepatic clearance of lipophilic drugs predicted by in vitro uptake data into cryopreserved hepatocytes suspended in sera of rats, guinea pigs, monkeys and humans.
Authors:
Koyanagi T; a Discovery Technology Research Laboratories, Ono Pharmaceutical Co., Ltd , Osaka , Japan.
Yano K; a Discovery Technology Research Laboratories, Ono Pharmaceutical Co., Ltd , Osaka , Japan.
Kim S; a Discovery Technology Research Laboratories, Ono Pharmaceutical Co., Ltd , Osaka , Japan.
Murayama N; b Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida , Tokyo , Japan.
Yamazaki H; b Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida , Tokyo , Japan.
Tamai I; c Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University , Kanazawa , Japan.
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Source:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Aug; Vol. 49 (8), pp. 887-894. Date of Electronic Publication: 2018 Sep 21.
Publication Type:
Journal Article
MeSH Terms:
Cryopreservation*
Hepatocytes/*metabolism
Lipids/*chemistry
Liver/*metabolism
Pharmaceutical Preparations/*metabolism
Serum/*metabolism
Animals ; Guinea Pigs ; Haplorhini ; Humans ; Male ; Rats
Academic Journal
Title:
A metabolomic perspective of pazopanib-induced acute hepatotoxicity in mice.
Authors:
Wang YK; a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , China.; b University of Chinese Academy of Sciences , Beijing , China.
Yang XN; a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , China.
Liang WQ; c Center for Medicinal Resources Research, Zhejiang Academy of Traditional Chinese Medicine , Hangzhou , China.
Xiao Y; a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , China.; b University of Chinese Academy of Sciences , Beijing , China.
Zhao Q; a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , China.; b University of Chinese Academy of Sciences , Beijing , China.
Xiao XR; a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , China.
Gonzalez FJ; d Laboratory of Metabolism , Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.
Li F; a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , China.
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Source:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Jun; Vol. 49 (6), pp. 655-670. Date of Electronic Publication: 2018 Jul 23.
Publication Type:
Journal Article
MeSH Terms:
Antineoplastic Agents/*toxicity
Liver/*drug effects
Pyrimidines/*toxicity
Sulfonamides/*toxicity
Alanine Transaminase/blood ; Animals ; Antineoplastic Agents/metabolism ; Aspartate Aminotransferases/blood ; Biomarkers/blood ; Chromatography, High Pressure Liquid ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Cytochrome P-450 Enzyme System/physiology ; Indazoles ; Liver/metabolism ; Liver/pathology ; Male ; Metabolomics ; Mice ; Mice, Inbred C57BL ; Multivariate Analysis ; Oxidative Stress/drug effects ; Pyrimidines/metabolism ; Spectrometry, Mass, Electrospray Ionization ; Sulfonamides/metabolism
Academic Journal

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