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Tytuł:
Assessment of drug-drug interactions of CC-90001, a potent and selective inhibitor of c-Jun N-terminal kinase.
Autorzy:
Tong Z; Nonclinical Development, Bristol Myers Squibb, Summit, NJ, USA.
Gaudy A; Clinical Pharmacology, Bristol Myers Squibb, Summit, NJ, USA.
Tatosian D; Clinical Pharmacology, Bristol Myers Squibb, Summit, NJ, USA.
Ramirez-Valle F; Clinical Pharmacology, Bristol Myers Squibb, Summit, NJ, USA.
Liu H; Nonclinical Development, Bristol Myers Squibb, Summit, NJ, USA.
Chen J; Nonclinical Development, Bristol Myers Squibb, Summit, NJ, USA.
Hoffmann M; Nonclinical Development, Bristol Myers Squibb, Summit, NJ, USA.
Surapaneni S; Nonclinical Development, Bristol Myers Squibb, Summit, NJ, USA.
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Dec; Vol. 51 (12), pp. 1416-1426. Date of Electronic Publication: 2022 Jan 13.
Typ publikacji:
Journal Article
MeSH Terms:
JNK Mitogen-Activated Protein Kinases*
Pharmaceutical Preparations*
ATP Binding Cassette Transporter, Subfamily G, Member 2 ; Drug Interactions ; Humans ; Microsomes, Liver ; Neoplasm Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In silico prediction of volume of distribution of drugs in man using conformal prediction performs on par with animal data-based models.
Autorzy:
Fagerholm U; Prosilico AB, Huddinge, Sweden.
Hellberg S; Prosilico AB, Huddinge, Sweden.
Alvarsson J; Department of Pharmaceutical Biosciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Arvidsson McShane S; Department of Pharmaceutical Biosciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Spjuth O; Department of Pharmaceutical Biosciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Dec; Vol. 51 (12), pp. 1366-1371. Date of Electronic Publication: 2021 Dec 08.
Typ publikacji:
Journal Article
MeSH Terms:
Models, Biological*
Pharmaceutical Preparations*
Animals ; Drug Discovery ; Models, Animal ; Pharmacokinetics ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Prospective prediction of plasma pharmacokinetics of a novel immune-modulating agent in cancer patients after intra-tumoral administration: translation from non-clinical species to humans.
Autorzy:
Vuppugalla R; Metabolism and Pharmacokinetics, Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Lawrenceville, NJ, USA.
Sane R; Metabolism and Pharmacokinetics, Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Cambridge, MA, USA.
Wichroski M; Drug Discovery Biology, Bristol-Myers Squibb Co., Cambridge, MA, USA.
Gavai AK; Drug Discovery Chemistry, Bristol-Myers Squibb Co., Lawrenceville, NJ, USA.
Boyanapalli S; Department of Clinical Pharmacology, Bristol-Myers Squibb Co., Princeton, NJ, USA.
Yang Z; Metabolism and Pharmacokinetics, Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Lawrenceville, NJ, USA.
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Nov; Vol. 51 (11), pp. 1255-1263. Date of Electronic Publication: 2021 Oct 28.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*
Neoplasms*/drug therapy
Pharmaceutical Preparations*
Biological Availability ; Humans ; Pharmacokinetics ; Prospective Studies
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comparison between lab variability and in silico prediction errors for the unbound fraction of drugs in human plasma.
Autorzy:
Fagerholm U; Prosilico AB, Huddinge, Sweden.
Spjuth O; Prosilico AB, Huddinge, Sweden.; Department of Pharmaceutical Biosciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Hellberg S; Prosilico AB, Huddinge, Sweden.
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Oct; Vol. 51 (10), pp. 1095-1100. Date of Electronic Publication: 2021 Aug 13.
Typ publikacji:
Journal Article
MeSH Terms:
Pharmaceutical Preparations*
Plasma*
Computer Simulation ; Humans ; Models, Biological ; Protein Binding
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Empirical and theoretical approaches for the prediction of human hepatic clearance using chimeric mice with humanised liver: the use of physiologically based scaling, a novel solution for potential overprediction due to coexisting mouse metabolism.
Autorzy:
Matsumoto S; Meiji Seika Pharma Co., Ltd., Pharmaceutical Research Labs, Yokohama, Japan.
Kamimura H; Laboratory Animal Research Department, Central Institute for Experimental Animals, Kawasaki, Japan.
Nishiwaki M; CLEA Japan Inc, Meguro-ku, Japan.
Cho N; Meiji Seika Pharma Co., Ltd., Pharmaceutical Research Labs, Yokohama, Japan.
Kato K; Meiji Seika Pharma Co., Ltd., Pharmaceutical Research Labs, Yokohama, Japan.
Yamamoto T; In Vivo Science Inc, Kawasaki, Japan.
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Sep; Vol. 51 (9), pp. 983-994. Date of Electronic Publication: 2021 Jul 15.
Typ publikacji:
Journal Article
MeSH Terms:
Pharmaceutical Preparations*/metabolism
Animals ; Chimera ; Hepatocytes ; Humans ; Liver/metabolism ; Metabolic Clearance Rate ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Drug-drug interaction comparison between tacrolimus and phenobarbital in different formulations for paediatrics and adults.
Autorzy:
Zhao X; Pharmaceutical College, Tianjin Medical University, Tianjin, China.
Lu X; Pharmaceutical College, Tianjin Medical University, Tianjin, China.
Zuo M; Pharmaceutical College, Tianjin Medical University, Tianjin, China.
Wang N; Department of Pharmacy, Tianjin Third Central Hospital, Tianjin, China.
Zhang Y; Department of Pharmacy, Tianjin First Central Hospital, Tianjin, China.
Chen J; Nankai University, Tianjin, China.
Zhu L; Pharmaceutical College, Tianjin Medical University, Tianjin, China.; Department of Pharmacy, Tianjin First Central Hospital, Tianjin, China.
Liu W; Tianjin Children's Hospital, Tianjin, China.
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Aug; Vol. 51 (8), pp. 877-884. Date of Electronic Publication: 2021 Jul 02.
Typ publikacji:
Journal Article
MeSH Terms:
Pediatrics*
Pharmaceutical Preparations*
Adult ; Area Under Curve ; Child ; Drug Interactions ; Humans ; Immunosuppressive Agents ; Models, Biological ; Phenobarbital ; Tacrolimus
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Drug-drug interaction potential and clinical pharmacokinetics of enerisant, a novel potent and selective histamine H 3 receptor antagonist.
Autorzy:
Terasaka S; Drug Metabolism and Pharmacokinetics, Drug Safety and Pharmacokinetics Laboratories, Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Hachiuma K; Drug Metabolism and Pharmacokinetics, Drug Safety and Pharmacokinetics Laboratories, Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Mano Y; Development Headquarters, Taisho Pharmaceutical Co., Ltd., Tokyo, Japan.
Onishi K; Development Headquarters, Taisho Pharmaceutical Co., Ltd., Tokyo, Japan.
Kitajima I; Development Headquarters, Taisho Pharmaceutical Co., Ltd., Tokyo, Japan.
Nishino I; Development Headquarters, Taisho Pharmaceutical Co., Ltd., Tokyo, Japan.
Endo H; Drug Metabolism and Pharmacokinetics, Drug Safety and Pharmacokinetics Laboratories, Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Jul; Vol. 51 (7), pp. 786-795. Date of Electronic Publication: 2021 Apr 28.
Typ publikacji:
Journal Article
MeSH Terms:
Histamine*
Pharmaceutical Preparations*
ATP Binding Cassette Transporter, Subfamily G, Member 2 ; Drug Interactions ; Humans ; Male ; Neoplasm Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In vitro inhibition and induction of human liver cytochrome P450 enzymes by a novel anti-fibrotic drug fluorofenidone.
Autorzy:
Li L; School of Xiangya Pharmaceutical Sciences, Central South University, Changsha, China.
Luo X; The First Affiliated Hospital, School of Medicine, Xiamen University, Xiamen, China.
Cheng Z; School of Xiangya Pharmaceutical Sciences, Central South University, Changsha, China.
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Jul; Vol. 51 (7), pp. 745-751. Date of Electronic Publication: 2021 May 18.
Typ publikacji:
Journal Article
MeSH Terms:
Cytochrome P-450 Enzyme System*
Pharmaceutical Preparations*
Humans ; Liver ; Microsomes, Liver ; Pyridones
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hypothesis of using albumin to improve drug efficacy in cancers accompanied by hypoalbuminemia.
Autorzy:
Bagheri S; Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Saboury AA; Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Jul; Vol. 51 (7), pp. 778-785. Date of Electronic Publication: 2021 May 25.
Typ publikacji:
Journal Article
MeSH Terms:
Hypoalbuminemia*/drug therapy
Neoplasms*/complications
Neoplasms*/drug therapy
Pharmaceutical Preparations*
Albumins ; Drug Delivery Systems ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Evaluation of the drug-drug interaction potential for trazpiroben (TAK-906), a D 2 /D 3 receptor antagonist for gastroparesis, towards cytochrome P450s and transporters.
Autorzy:
Nishihara M; Drug Metabolism and Pharmacokinetics, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
Ramsden D; Global Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co, Cambridge, MA, USA.
Balani SK; Global Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co, Cambridge, MA, USA.
Pokaż więcej
Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Jun; Vol. 51 (6), pp. 668-679. Date of Electronic Publication: 2021 Apr 21.
Typ publikacji:
Journal Article
MeSH Terms:
Gastroparesis*
Organic Anion Transporters*
Pharmaceutical Preparations*
Cytochrome P-450 Enzyme System/metabolism ; Drug Interactions ; Humans ; Membrane Transport Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Influence of vitamin D treatment on functional expression of drug disposition pathways in human kidney proximal tubule cells during simulated uremia.
Autorzy:
Tuey SM; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA.
Atilano-Roque A; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA.
Charkoftaki G; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA.; School of Public Health, Yale University, New Haven, CT, USA.
Thurman JM; Division of Nephrology and Hypertension, School of Medicine, University of Colorado, Aurora, CO, USA.
Nolin TD; Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
Joy MS; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA.; Division of Nephrology and Hypertension, School of Medicine, University of Colorado, Aurora, CO, USA.
Pokaż więcej
Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Jun; Vol. 51 (6), pp. 657-667. Date of Electronic Publication: 2021 Apr 18.
Typ publikacji:
Journal Article
MeSH Terms:
Organic Anion Transporters*
Pharmaceutical Preparations*
Uremia*
Cholecalciferol ; Humans ; Kidney ; Vitamin D
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Preliminary in vitro approach to evaluate the drug-drug interaction potential of EST73502, a dual µ-opioid receptor partial agonist and σ1 receptor antagonist.
Autorzy:
Ayet E; WELAB, Parc Científic Barcelona, Baldiri Reixac 4-8, Barcelona 08028, Spain.
Yeste S; WELAB, Parc Científic Barcelona, Baldiri Reixac 4-8, Barcelona 08028, Spain.
Reinoso RF; WELAB, Parc Científic Barcelona, Baldiri Reixac 4-8, Barcelona 08028, Spain.
Pretel MJ; Early ADME, Drug Discovery and Preclinical Development, ESTEVE Pharmaceuticals S.A, Barcelona, Spain.
Balada A; Early ADME, Drug Discovery and Preclinical Development, ESTEVE Pharmaceuticals S.A, Barcelona, Spain.
Serafini MT; WELAB, Parc Científic Barcelona, Baldiri Reixac 4-8, Barcelona 08028, Spain.
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 May; Vol. 51 (5), pp. 501-512. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji:
Journal Article
MeSH Terms:
Pharmaceutical Preparations*
Receptors, sigma*
Caco-2 Cells ; Drug Interactions ; Humans ; Receptors, Opioid, mu/agonists ; Sigma-1 Receptor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In vitro evaluations for pharmacokinetic drug-drug interactions of a novel serotonin-dopamine activity modulator, brexpiprazole.
Autorzy:
Sasabe H; Drug metabolism and Pharmacokinetics, Tokushima Research Institute, Otsuka Pharmaceutical Co Ltd., Tokushima, Japan.
Koga T; Drug metabolism and Pharmacokinetics, Tokushima Research Institute, Otsuka Pharmaceutical Co Ltd., Tokushima, Japan.
Furukawa M; Drug metabolism and Pharmacokinetics, Tokushima Research Institute, Otsuka Pharmaceutical Co Ltd., Tokushima, Japan.
Matsunaga M; Drug metabolism and Pharmacokinetics, Tokushima Research Institute, Otsuka Pharmaceutical Co Ltd., Tokushima, Japan.
Sasahara K; Drug metabolism and Pharmacokinetics, Tokushima Research Institute, Otsuka Pharmaceutical Co Ltd., Tokushima, Japan.
Hashizume K; ADME & Tox. Research Institute, Sekisui Medical Co., Ltd., Naka-gun, Japan.
Oozone Y; ADME & Tox. Research Institute, Sekisui Medical Co., Ltd., Naka-gun, Japan.
Amunom I; Sekisui XenoTech LLC, Kansas City, KS, USA.
Torii M; Kashima Laboratory, LSIM Safety Institute Corporation, Kamisu-shi, Japan.
Umehara K; Drug metabolism and Pharmacokinetics, Tokushima Research Institute, Otsuka Pharmaceutical Co Ltd., Tokushima, Japan.
Kashiyama E; Drug metabolism and Pharmacokinetics, Tokushima Research Institute, Otsuka Pharmaceutical Co Ltd., Tokushima, Japan.
Takeuchi K; Drug metabolism and Pharmacokinetics, Tokushima Research Institute, Otsuka Pharmaceutical Co Ltd., Tokushima, Japan.
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 May; Vol. 51 (5), pp. 522-535. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji:
Journal Article
MeSH Terms:
Depressive Disorder, Major*
Pharmaceutical Preparations*
ATP Binding Cassette Transporter, Subfamily G, Member 2 ; Dopamine ; Drug Interactions ; Humans ; Neoplasm Proteins ; Quinolones ; Serotonin ; Thiophenes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Verification of a cocktail approach for quantitative drug-drug interaction assessment: a comparative analysis between the results of a single drug and a cocktail drug.
Autorzy:
Miura M; Departments of Pharmacy Practice and Science, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.; Hospital Pharmacy, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Uchida S; Departments of Pharmacy Practice and Science, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Tanaka S; Departments of Pharmacy Practice and Science, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Kamiya C; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Katayama N; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Hakamata A; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Odagiri K; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Inui N; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Kawakami J; Hospital Pharmacy, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Watanabe H; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Namiki N; Departments of Pharmacy Practice and Science, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Apr; Vol. 51 (4), pp. 404-412. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji:
Journal Article
MeSH Terms:
Pharmaceutical Preparations*
Cytochrome P-450 Enzyme System ; Drug Interactions ; Midazolam ; Omeprazole
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Preliminary in vitro assessment of pharmacokinetic drug-drug interactions of EST64401 and EST64514, two sigma-1 receptor antagonists.
Autorzy:
Reinoso RF; Early ADME, Drug Discovery and Preclinical Development, ESTEVE Pharmaceuticals, Barcelona, Spain.
Yeste S; Early ADME, Drug Discovery and Preclinical Development, ESTEVE Pharmaceuticals, Barcelona, Spain.
Ayet E; Early ADME, Drug Discovery and Preclinical Development, ESTEVE Pharmaceuticals, Barcelona, Spain.
Pretel MJ; Early ADME, Drug Discovery and Preclinical Development, ESTEVE Pharmaceuticals, Barcelona, Spain.
Balada A; Early ADME, Drug Discovery and Preclinical Development, ESTEVE Pharmaceuticals, Barcelona, Spain.
Serafini MT; Early ADME, Drug Discovery and Preclinical Development, ESTEVE Pharmaceuticals, Barcelona, Spain.
Pokaż więcej
Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Apr; Vol. 51 (4), pp. 373-386. Date of Electronic Publication: 2021 Jan 20.
Typ publikacji:
Journal Article
MeSH Terms:
Cytochrome P-450 Enzyme Inhibitors*
Pharmaceutical Preparations*
ATP Binding Cassette Transporter, Subfamily G, Member 2 ; Caco-2 Cells ; Drug Interactions ; Humans ; Microsomes, Liver ; Neoplasm Proteins ; Receptors, sigma ; Sigma-1 Receptor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Differential in vitro interactions of the Janus kinase inhibitor ruxolitinib with human SLC drug transporters.
Autorzy:
Bruyère A; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.
Le Vée M; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.
Jouan E; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.
Molez S; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.
Nies AT; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Stuttgart, Germany.; iFIT Cluster of Excellence (EXC2180) 'Image Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.
Fardel O; Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Apr; Vol. 51 (4), pp. 467-478. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji:
Journal Article
MeSH Terms:
Janus Kinase Inhibitors*
Pharmaceutical Preparations*
Drug Interactions ; HEK293 Cells ; Humans ; Nitriles ; Organic Cation Transport Proteins ; Pyrazoles ; Pyrimidines
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comparative assessment for rat strain differences in metabolic profiles of 14 drugs in Wistar Han and Sprague Dawley hepatocytes.
Autorzy:
Wang W; Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.
Teresa M; Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.
Cai J; Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.
Zhang C; Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.
Wong S; Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.
Yan Z; Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.
Khojasteh SC; Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.
Zhang D; Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Jan; Vol. 51 (1), pp. 15-23. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji:
Journal Article
MeSH Terms:
Hepatocytes/*metabolism
Metabolic Clearance Rate/*physiology
Pharmaceutical Preparations/*metabolism
Animals ; Metabolome ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized TK-NOG mouse.
Autorzy:
Miyamoto M; Drug Metabolism and Pharmacokinetics Research Laboratories, Research, Takeda Pharmaceutical Company Limited, Fujisawa city, Japan.
Kosugi Y; Drug Metabolism and Pharmacokinetics Research Laboratories, Research, Takeda Pharmaceutical Company Limited, Fujisawa city, Japan.
Iwasaki S; Drug Metabolism and Pharmacokinetics Research Laboratories, Research, Takeda Pharmaceutical Company Limited, Fujisawa city, Japan.
Chisaki I; Drug Metabolism and Pharmacokinetics Research Laboratories, Research, Takeda Pharmaceutical Company Limited, Fujisawa city, Japan.
Nakagawa S; Drug Metabolism and Pharmacokinetics Research Laboratories, Research, Takeda Pharmaceutical Company Limited, Fujisawa city, Japan.
Amano N; Drug Metabolism and Pharmacokinetics Research Laboratories, Research, Takeda Pharmaceutical Company Limited, Fujisawa city, Japan.
Hirabayashi H; Drug Metabolism and Pharmacokinetics Research Laboratories, Research, Takeda Pharmaceutical Company Limited, Fujisawa city, Japan.
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Jan; Vol. 51 (1), pp. 51-60. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji:
Journal Article
MeSH Terms:
Pharmaceutical Preparations/*metabolism
Animals ; Chimera ; Disease Models, Animal ; Hepatocytes/metabolism ; Humans ; Liver/metabolism ; Mice ; Mice, SCID ; Protein Binding/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Modelled plasma concentrations of pemafibrate with co-administered typical cytochrome P450 inhibitors clopidogrel, fluconazole or clarithromycin predicted by physiologically based pharmacokinetic modelling in virtual populations.
Autorzy:
Ogawa SI; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.
Shimizu M; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.
Yamazaki H; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Dec; Vol. 50 (12), pp. 1413-1422. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji:
Journal Article
MeSH Terms:
Benzoxazoles/*pharmacokinetics
Butyrates/*pharmacokinetics
Cytochrome P-450 Enzyme Inhibitors/*metabolism
Pharmaceutical Preparations/*metabolism
Clarithromycin/pharmacokinetics ; Clopidogrel/pharmacokinetics ; Cytochrome P-450 Enzyme System/metabolism ; Fluconazole/pharmacokinetics ; Humans ; Liver/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: integration with hepatic drug metabolism.
Autorzy:
Sanoh S; Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.; School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan.
Naritomi Y; Analysis and Pharmacokinetics Research Laboratories, Astellas Pharma Inc, Tsukuba, Japan.
Kitamura S; Analysis and Pharmacokinetics Research Laboratories, Astellas Pharma Inc, Tsukuba, Japan.
Shinagawa A; School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan.
Kakuni M; Study Service Dept, PhoenixBio, Co., Ltd, Tsukuba, Japan.
Tateno C; R&D Dept, PhoenixBio, Co., Ltd, Higashi-Hiroshima, Japan.; Research Center for Hepatology and Gastroenterology, Hiroshima University, Higashi-Hiroshima, Japan.
Ohta S; Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.; School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan.; Wakayama Medical University, Wakayama, Japan.
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Nov; Vol. 50 (11), pp. 1370-1379. Date of Electronic Publication: 2020 Jun 05.
Typ publikacji:
Journal Article
MeSH Terms:
Liver/*metabolism
Organic Anion Transporters/*metabolism
Pharmaceutical Preparations/*metabolism
Animals ; Humans ; Inactivation, Metabolic ; Metabolic Clearance Rate ; Mice ; Pharmacokinetics
Czasopismo naukowe
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