Skocz do pozycji: 1.

Tytuł:

Investigation on the in vitro metabolism of bicyclol using liver microsomes, hepatocytes and human recombinant cytochrome P450 enzymes.

Autorzy:

Chen F; Department of Clinical Laboratory Center, the First Affiliated Hospital of Jinan University, Guangzhou, P.R. China.
Zou H; Department of Clinical Laboratory Center, the First Affiliated Hospital of Jinan University, Guangzhou, P.R. China.
Zhang P; Department of Clinical Laboratory Center, the First Affiliated Hospital of Jinan University, Guangzhou, P.R. China.
Yan Y; Department of Clinical Laboratory Center, the First Affiliated Hospital of Jinan University, Guangzhou, P.R. China.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Apr; Vol. 53 (4), pp. 231-240. Date of Electronic Publication: 2023 Jun 19.

Typ publikacji:

Journal Article

MeSH Terms:

Microsomes, Liver*/metabolism
Cytochrome P-450 Enzyme System*/metabolism
Humans ; Biphenyl Compounds/metabolism ; Hepatocytes/metabolism ; Glutathione/metabolism ; Chromatography, High Pressure Liquid

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 2.

Tytuł:

Cell cycle dysregulation on prenatal and postnatal arsenic exposure in skin of Wistar rat neonates.

Autorzy:

Kumar N; Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur, India.
Mathur A; Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur, India.
Bunker SK; Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur, India.
John PJ; Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur, India.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Apr; Vol. 53 (4), pp. 320-331. Date of Electronic Publication: 2023 Jul 20.

Typ publikacji:

Journal Article

MeSH Terms:

Arsenic*/toxicity
Pregnancy ; Rats ; Female ; Animals ; Rats, Wistar ; Skin ; Cell Cycle ; Cell Division

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 3.

Tytuł:

Determination of enzymatic kinetics of metabolism of dimethoate and omethoate in rats and humans.

Autorzy:

Nallani G; FMC Corporation, Philadelphia, PA, USA.
Chandrasekaran A; FMC Corporation, Philadelphia, PA, USA.
Kassahun K; Frontage Laboratories Inc, Exton, PA, USA.
Shen L; Frontage Laboratories Inc, Exton, PA, USA.
Reiss R; Exponent, Alexandria, VA, USA.
Whatling P; FMC Corporation, Philadelphia, PA, USA.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Apr; Vol. 53 (4), pp. 279-287. Date of Electronic Publication: 2023 Jul 03.

Typ publikacji:

Journal Article

MeSH Terms:

Dimethoate*/pharmacokinetics
Insecticides*
Humans ; Rats ; Animals ; Tandem Mass Spectrometry ; Kinetics

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 4.

Tytuł:

Meeting report: DMDG peptide and oligonucleotide ADME workshop 2022.

Autorzy:

Christensen JK; Development ADME, Novo Nordisk A/S, Måløv, Denmark.
Bjørnsdottir I; Development ADME, Novo Nordisk A/S, Måløv, Denmark.
Sonesson A; Global DMPK, Copenhagen, Denmark.
Hood S; In Vitro/In Vivo Translation, Research, Stevenage, GlaxoSmithKline, UK.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Apr; Vol. 53 (4), pp. 332-337. Date of Electronic Publication: 2023 Jun 19.

Typ publikacji:

Journal Article; Review

MeSH Terms:

Peptides*/metabolism
Drug Interactions ; Metabolic Clearance Rate

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 5.

Tytuł:

Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in chimeric mice with humanised liver.

Autorzy:

Hayashi S; Preclinical Research Unit, Drug Research Division, Sumitomo Pharma Co., Ltd, Osaka, Japan.; Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan.
Kawaguchi H; Preclinical Research Unit, Drug Research Division, Sumitomo Pharma Co., Ltd, Osaka, Japan.
Watanabe T; Drug Research Division, Sumitomo Pharma Co., Ltd, Osaka, Japan.
Miyawaki I; Preclinical Research Unit, Drug Research Division, Sumitomo Pharma Co., Ltd, Osaka, Japan.
Fukami T; Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan.; WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kanazawa, Japan.
Nakajima M; Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan.; WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kanazawa, Japan.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Apr; Vol. 53 (4), pp. 241-247. Date of Electronic Publication: 2023 Jun 15.

Typ publikacji:

Journal Article

MeSH Terms:

Cytochrome P-450 CYP2D6*/genetics
Cytochrome P-450 CYP2D6*/metabolism
Cytochrome P-450 CYP2D6 Inhibitors*/metabolism
Cytochrome P-450 CYP2D6 Inhibitors*/pharmacology
Humans ; Mice ; Animals ; Half-Life ; Quality of Life ; Enzyme Inhibitors/pharmacology ; Cytochrome P-450 Enzyme System/metabolism ; Liver/metabolism ; Microsomes, Liver/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 6.

Tytuł:

Power of integrating PBPK with PBBM (PBPK-BM): a single model predicting food effect, gender impact, drug-drug interactions and bioequivalence in fasting & fed conditions.

Autorzy:

Boddu R; Biopharmaceutics Group, Global Clinical Management, Dr. Reddy's Laboratories Ltd., Integrated Product Development Organization (IPDO), Hyderabad, India.
Kollipara S; Biopharmaceutics Group, Global Clinical Management, Dr. Reddy's Laboratories Ltd., Integrated Product Development Organization (IPDO), Hyderabad, India.
Vijaywargi G; Biopharmaceutics Group, Global Clinical Management, Dr. Reddy's Laboratories Ltd., Integrated Product Development Organization (IPDO), Hyderabad, India.
Ahmed T; Biopharmaceutics Group, Global Clinical Management, Dr. Reddy's Laboratories Ltd., Integrated Product Development Organization (IPDO), Hyderabad, India.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Apr; Vol. 53 (4), pp. 260-278. Date of Electronic Publication: 2023 Jul 25.

Typ publikacji:

Case Reports; Journal Article

MeSH Terms:

Models, Biological*
Fasting*
Humans ; Therapeutic Equivalency ; Solubility ; Drug Interactions ; Administration, Oral

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 7.

Tytuł:

ADME properties of CHF6366, a novel bi-functional M3 muscarinic receptor antagonist and ß 2 adrenoceptor agonist (MABA) radiolabelled at both functional moieties.

Autorzy:

Ghiglieri A; Accelera Srl, Nerviano, Milano, Italy.
Messina M; Accelera Srl, Nerviano, Milano, Italy.
Cenacchi V; Chiesi Farmaceutici SpA, Parma, Italy.
Piutti C; Accelera Srl, Nerviano, Milano, Italy.
Cinato F; Accelera Srl, Nerviano, Milano, Italy.
Brogin G; Chiesi Farmaceutici SpA, Parma, Italy.
Puccini P; Chiesi Farmaceutici SpA, Parma, Italy.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Apr; Vol. 53 (4), pp. 288-308. Date of Electronic Publication: 2023 Jul 14.

Typ publikacji:

Journal Article

MeSH Terms:

Body Fluids*
Feces ; Glucuronides ; Carbamates ; Receptors, Adrenergic ; Administration, Oral

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 8.

Tytuł:

Comparisons between human and rodent hepatic glutathione S-Transferase activities reveal sex and species differences.

Autorzy:

Doerksen MJ; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada.
Seo D; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada.
Smith AD; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada.
Jones RS; Genentech Inc, South San Francisco, CA, USA.
Coughtrie MWH; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada.
Collier AC; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Apr; Vol. 53 (4), pp. 223-230. Date of Electronic Publication: 2023 Jul 16.

Typ publikacji:

Journal Article

MeSH Terms:

Rodentia*/metabolism
Glutathione Transferase*/metabolism
Male ; Female ; Humans ; Rats ; Mice ; Animals ; Species Specificity ; Liver/metabolism ; Glutathione

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 9.

Tytuł:

An integrated analytical strategy to decipher the metabolic profile of alkaloids in Compound Kushen injection based on UHPLC-ESI-QTOF/MS .

Autorzy:

Zhang L; Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Li R; Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei, China.
Zheng T; Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei, China.
Wu H; Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei, China.; Anhui Province Key Laboratory of Research and Development of Chinese Medicine & Anhui Province Key Laboratory of Chinese Medicinal Formula, Anhui University of Chinese Medicine, Hefei, China.
Yin Y; Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Apr; Vol. 53 (4), pp. 248-259. Date of Electronic Publication: 2023 Jun 30.

Typ publikacji:

Journal Article

MeSH Terms:

Alkaloids*
Drugs, Chinese Herbal*/metabolism
Antineoplastic Agents*
Liver Neoplasms*
Rats ; Animals ; Chromatography, High Pressure Liquid/methods ; Rats, Sprague-Dawley ; Metabolome

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 10.

Tytuł:

Biochemical responses of the mussel Perna perna after exposure to environmental concentrations of the UV filter Benzophenone-3.

Autorzy:

Cruz GS; Laboratory of Biomarkers of Aquatic Contamination and Immunochemistry (LABCAI), Federal University of Santa Catarina, UFSC, Florianópolis, Santa Catarina, Brazil.
Moser JR; Laboratory of Biomarkers of Aquatic Contamination and Immunochemistry (LABCAI), Federal University of Santa Catarina, UFSC, Florianópolis, Santa Catarina, Brazil.
Saldaña-Serrano M; Laboratory of Biomarkers of Aquatic Contamination and Immunochemistry (LABCAI), Federal University of Santa Catarina, UFSC, Florianópolis, Santa Catarina, Brazil.
Bastolla CLV; Laboratory of Biomarkers of Aquatic Contamination and Immunochemistry (LABCAI), Federal University of Santa Catarina, UFSC, Florianópolis, Santa Catarina, Brazil.
Lima D; Laboratory of Biomarkers of Aquatic Contamination and Immunochemistry (LABCAI), Federal University of Santa Catarina, UFSC, Florianópolis, Santa Catarina, Brazil.
Gomes CHAM; Laboratory of Marine Mollusks (LMM), Department of Aquaculture, Center of Agricultural Science, Federal University of Santa Catarina, UFSC, Florianópolis, Santa Catarina, Brazil.
de Castro MR; Laboratory of Toxicology, Federal University of Rio Grande (FURG), Rio Grande, Brazil.
Dos Santos URA; Laboratory of Biomarkers of Aquatic Contamination and Immunochemistry (LABCAI), Federal University of Santa Catarina, UFSC, Florianópolis, Santa Catarina, Brazil.
Coutinho GS; Laboratory of Biomarkers of Aquatic Contamination and Immunochemistry (LABCAI), Federal University of Santa Catarina, UFSC, Florianópolis, Santa Catarina, Brazil.
Mattos JJ; Aquaculture Pathology Research Center (NEPAq), Federal University of Santa Catarina, UFSC, Florianópolis, Santa Catarina, Brazil.
Marques MRF; Laboratory of Biomarkers of Aquatic Contamination and Immunochemistry (LABCAI), Federal University of Santa Catarina, UFSC, Florianópolis, Santa Catarina, Brazil.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Apr; Vol. 53 (4), pp. 309-319. Date of Electronic Publication: 2023 Jul 21.

Typ publikacji:

Journal Article

MeSH Terms:

Perna*/physiology
Water Pollutants, Chemical*/toxicity
Animals ; Antioxidants ; Ecosystem ; Catalase ; Glutathione Transferase ; Glutathione Reductase/pharmacology ; Glutathione Peroxidase/pharmacology ; Biomarkers

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 11.

Tytuł:

Combination of losartan and puerarin induced pharmacokinetic interaction in hypertension rats enhances the antihypertensive effect of losartan.

Autorzy:

Huang Y; Department of Pharmacy, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China.
Xue M; Department of Pharmacy, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Mar; Vol. 53 (3), pp. 201-206. Date of Electronic Publication: 2023 May 02.

Typ publikacji:

Journal Article

MeSH Terms:

Antihypertensive Agents*/pharmacokinetics
Hypertension*/drug therapy
Rats ; Humans ; Animals ; Losartan/pharmacokinetics ; Cytochrome P-450 CYP2C9/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 12.

Tytuł:

Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs.

Autorzy:

Uno Y; Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima-city, Kagoshima, Japan.
Noda Y; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan.
Morikuni S; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan.
Murayama N; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan.
Yamazaki H; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Mar; Vol. 53 (3), pp. 140-148. Date of Electronic Publication: 2023 May 11.

Typ publikacji:

Journal Article

MeSH Terms:

Cytochrome P-450 CYP3A*/metabolism
Microsomes, Liver*/metabolism
Dogs ; Rats ; Animals ; Nifedipine ; Midazolam/metabolism ; Alprazolam/metabolism ; Liver/metabolism ; Estradiol ; RNA, Messenger/metabolism ; Hydroxylation

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 13.

Tytuł:

Mechanism-based inactivation of cytochrome P450 3A by evodol.

Autorzy:

Zhao J; Pharmaceutical Animal Experimental Center, China Pharmaceutical University, Nanjing, China.
He J; R&D Institute, Chia Tai Tianqing Pharmaceutical Group Co., LTD, Nanjing, China.
Xu J; Department of Phase I Clinical Trial Research, Nanjing Gaoxin Hospital, Nanjing, China.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Mar; Vol. 53 (3), pp. 129-139. Date of Electronic Publication: 2023 May 02.

Typ publikacji:

Journal Article

MeSH Terms:

Cytochrome P-450 CYP3A*
Midazolam*/pharmacology
Humans ; Microsomes, Liver ; Ketoconazole/pharmacology ; Testosterone

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 14.

Tytuł:

Regulation of BCRP expression and sulfasalazine pharmacokinetics by the nuclear receptor REV-ERBα.

Autorzy:

Wu C; The Affiliated Shunde Hospital of Jinan University, Foshan, China.
Xiao Y; Institute of Molecular Rhythm and Metabolism, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Wu C; Institute of Molecular Rhythm and Metabolism, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Xie D; Institute of Molecular Rhythm and Metabolism, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Luo M; Institute of Molecular Rhythm and Metabolism, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Yao D; Institute of Molecular Rhythm and Metabolism, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Chen M; Institute of Molecular Rhythm and Metabolism, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.; College of Pharmacy, Jinan University, Guangzhou, China.
Lu D; Institute of Molecular Rhythm and Metabolism, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Mar; Vol. 53 (3), pp. 215-222. Date of Electronic Publication: 2023 Apr 20.

Typ publikacji:

Journal Article

MeSH Terms:

Sulfasalazine*/pharmacology
Neoplasm Proteins*/genetics
Mice ; Animals ; ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; Gene Expression Regulation ; Receptors, Cytoplasmic and Nuclear

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 15.

Tytuł:

Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study.

Autorzy:

Li SC; Sichuan Key Laboratory of Animal Genetics and Breeding, Sichuan Animal Science Academy, Chengdu, P.R. China.; Veterinary Natural Medicine Research and GCP Experimental Animal Centre, Lezhi, P.R. China.
Zhang M; Sichuan Key Laboratory of Animal Genetics and Breeding, Sichuan Animal Science Academy, Chengdu, P.R. China.; Veterinary Natural Medicine Research and GCP Experimental Animal Centre, Lezhi, P.R. China.
Wang B; Sichuan Key Laboratory of Animal Genetics and Breeding, Sichuan Animal Science Academy, Chengdu, P.R. China.; Veterinary Natural Medicine Research and GCP Experimental Animal Centre, Lezhi, P.R. China.
Li XT; Sichuan Key Laboratory of Animal Genetics and Breeding, Sichuan Animal Science Academy, Chengdu, P.R. China.; Veterinary Natural Medicine Research and GCP Experimental Animal Centre, Lezhi, P.R. China.
Liang G; Sichuan Key Laboratory of Animal Genetics and Breeding, Sichuan Animal Science Academy, Chengdu, P.R. China.; Veterinary Natural Medicine Research and GCP Experimental Animal Centre, Lezhi, P.R. China.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Mar; Vol. 53 (3), pp. 207-214. Date of Electronic Publication: 2023 May 15.

Typ publikacji:

Journal Article

MeSH Terms:

Cytochrome P-450 CYP1A2*/metabolism
Aryl Hydrocarbon Hydroxylases*/metabolism
Rats ; Male ; Animals ; Pilot Projects ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Jejunum/metabolism ; Rats, Sprague-Dawley ; Cytochrome P-450 Enzyme System/metabolism ; Liver/metabolism ; Cytochrome P-450 CYP3A/metabolism ; Cytochrome P450 Family 2/metabolism ; Steroid 16-alpha-Hydroxylase/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 16.

Tytuł:

Metabolism, pharmacokinetics and excretion of [ C]dimethyl fumarate in healthy volunteers: an example of xenobiotic biotransformation following endogenous metabolic pathways.

Autorzy:

Xu L; Clinical Pharmacology and Pharmacometrics, Biogen, Cambridge, MA, USA.
Peng CC; Clinical Pharmacology and Pharmacometrics, Biogen, Cambridge, MA, USA.
Dawson K; Clinical Pharmacology and Pharmacometrics, Biogen, Cambridge, MA, USA.
Stecher S; Clinical Pharmacology and Pharmacometrics, Biogen, Cambridge, MA, USA.
Woodworth J; Clinical Pharmacology and Pharmacometrics, Biogen, Cambridge, MA, USA.
Prakash C; Clinical Pharmacology and Pharmacometrics, Biogen, Cambridge, MA, USA.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Mar; Vol. 53 (3), pp. 163-172. Date of Electronic Publication: 2023 Jun 01.

Typ publikacji:

Journal Article

MeSH Terms:

Dimethyl Fumarate*/therapeutic use
Xenobiotics*
Humans ; Biotransformation ; Acetylcysteine ; Metabolic Networks and Pathways ; Immunosuppressive Agents/therapeutic use

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 17.

Tytuł:

Dose-dependent pharmacokinetics of midazolam in rats: influence of hepatic first-pass metabolism.

Autorzy:

Li R; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Wang Q; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Liu Z; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Xie L; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Diao Z; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Peng Y; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Wang G; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Sun J; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.

Pokaż więcej

Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Mar; Vol. 53 (3), pp. 184-192. Date of Electronic Publication: 2023 Apr 27.

Typ publikacji:

Journal Article

MeSH Terms:

Midazolam*/pharmacokinetics
Liver*/metabolism
Rats ; Animals ; Rats, Sprague-Dawley ; Intestines ; Biological Availability ; Administration, Oral ; Area Under Curve

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 18.

Tytuł:

Clinical pharmacokinetics of cefixime: a systematic review.

Autorzy:

Ajmal M; Department of Pharmacy Practice, Bahauddin Zakariya University, Multan, Pakistan.
Zamir A; Department of Pharmacy Practice, Bahauddin Zakariya University, Multan, Pakistan.
Rehman AU; Department of Pharmacy Practice, Bahauddin Zakariya University, Multan, Pakistan.
Imran I; Department of Pharmacology, Bahauddin Zakariya University, Multan, Pakistan.
Saeed H; University College of Pharmacy, Allama Iqbal Campus, University of the Punjab, Lahore, Pakistan.
Majeed A; Department of Pharmaceutics, Bahauddin Zakariya University, Multan, Pakistan.
Aziz M; Department of Pharmacy Practice, Bahauddin Zakariya University, Multan, Pakistan.
Alqahtani F; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Rasool MF; Department of Pharmacy Practice, Bahauddin Zakariya University, Multan, Pakistan.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Mar; Vol. 53 (3), pp. 149-162. Date of Electronic Publication: 2023 Jun 01.

Typ publikacji:

Systematic Review; Journal Article; Review

MeSH Terms:

Cefotaxime*/pharmacokinetics
Anti-Bacterial Agents*
Humans ; Cefixime ; Cephalosporins ; Biological Availability

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 19.

Tytuł:

The metabolism of the dual orexin receptor antagonist daridorexant.

Autorzy:

Treiber A; Department of Non-clinical Pharmacokinetics and Metabolism, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Delahaye S; Department of Non-clinical Pharmacokinetics and Metabolism, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Weigel A; Department of Non-clinical Pharmacokinetics and Metabolism, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Aeänismaa P; Department of Non-clinical Pharmacokinetics and Metabolism, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Gatfield J; Department of Biology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Seeland S; Department of Non-clinical Pharmacokinetics and Metabolism, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Mar; Vol. 53 (3), pp. 173-183. Date of Electronic Publication: 2023 May 11.

Typ publikacji:

Journal Article

MeSH Terms:

Orexin Receptor Antagonists*
Sleep Initiation and Maintenance Disorders*/drug therapy
Male ; Rats ; Humans ; Mice ; Animals ; Imidazoles ; Pyrrolidines

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 20.

Tytuł:

Effect of formulation and route of administration on the distribution of 17-hydroxyprogesterone caproate in rats.

Autorzy:

Shaik IH; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
Chaphekar N; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
Vasudevan V; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
Alshabi A; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.; Clinical Pharmacy Department, College of Pharmacy, Najran University, Najran, Saudi Arabia.
Bastian JR; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, UPMC Magee-Women's Hospital, Pittsburgh, PA, USA.
Zhao W; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
Caritis S; Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, UPMC Magee-Women's Hospital, Pittsburgh, PA, USA.; Magee-Women's Research Institute, Pittsburgh, PA, USA.
Venkataramanan R; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.; Magee-Women's Research Institute, Pittsburgh, PA, USA.; Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Mar; Vol. 53 (3), pp. 193-200. Date of Electronic Publication: 2023 Apr 20.

Typ publikacji:

Journal Article

MeSH Terms:

Hydroxyprogesterones*
Premature Birth*/prevention & control
Infant, Newborn ; Humans ; Female ; Rats ; Animals ; 17 alpha-Hydroxyprogesterone Caproate ; 17-alpha-Hydroxyprogesterone ; Rats, Sprague-Dawley

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 21.

Tytuł:

Mass balance study of [ C]SHR0302, a selective and potent JAK1 inhibitor in humans.

Autorzy:

Ge X; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Ma S; Department of Pharmacy, the First Affiliated Hospital of Soochow University, Suzhou, China.; Institute for Interdisciplinary Drug Research and Translational Sciences, Soochow University, Suzhou, China.
Yan S; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Wu Y; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Chen C; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Tang C; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Zhan Y; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Bian YC; Department of Pharmacy, the First Affiliated Hospital of Soochow University, Suzhou, China.; Institute for Interdisciplinary Drug Research and Translational Sciences, Soochow University, Suzhou, China.
Shen K; Jiangsu Hengrui Medicine Co., Ltd, Lianyungang, China.
Feng S; Jiangsu Hengrui Medicine Co., Ltd, Lianyungang, China.
Gao X; Jiangsu Hengrui Medicine Co., Ltd, Lianyungang, China.
Zhong D; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Zhang H; Department of Pharmacy, the First Affiliated Hospital of Soochow University, Suzhou, China.; Institute for Interdisciplinary Drug Research and Translational Sciences, Soochow University, Suzhou, China.
Miao LY; Department of Pharmacy, the First Affiliated Hospital of Soochow University, Suzhou, China.; Institute for Interdisciplinary Drug Research and Translational Sciences, Soochow University, Suzhou, China.; College of Pharmaceutical Sciences, Soochow University, Suzhou, China.; National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Jiangsu, China.
Diao XX; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Feb; Vol. 53 (2), pp. 69-83. Date of Electronic Publication: 2023 Feb 12.

Typ publikacji:

Journal Article

MeSH Terms:

Sulfuric Acids*
Body Fluids*
Humans ; Male ; Feces ; Administration, Oral ; Carbon Radioisotopes ; Janus Kinase 1

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 22.

Tytuł:

Development and validation of an LC-MS/MS method for simultaneous determination of SH-1028, an irreversible third-generation EGFR TKI, and two of its metabolites in human plasma: application in clinical pharmacokinetics.

Autorzy:

Zhou S; Phase I Clinical Trial Unit, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Sha B; Phase I Clinical Trial Unit, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.; Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Wang L; Phase I Clinical Trial Unit, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhao Y; Phase I Clinical Trial Unit, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Wang Z; Nanjing Sanhome Pharmaceutical Co., Ltd., Nanjing, China.
Zhang X; Nanjing Sanhome Pharmaceutical Co., Ltd., Nanjing, China.
Han L; Nanjing Sanhome Pharmaceutical Co., Ltd., Nanjing, China.
Shao F; Phase I Clinical Trial Unit, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.; Department of Clinical Pharmacology, Pharmacy College, Nanjing Medical University, Nanjing, China.
Chen X; Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Feb; Vol. 53 (2), pp. 84-92. Date of Electronic Publication: 2023 Mar 08.

Typ publikacji:

Journal Article

MeSH Terms:

Carcinoma, Non-Small-Cell Lung*/drug therapy
Lung Neoplasms*/drug therapy
Humans ; Chromatography, Liquid/methods ; ErbB Receptors/genetics ; Mutation ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Tandem Mass Spectrometry/methods

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 23.

Tytuł:

Renal tubular transporter-mediated interactions between mirogabalin and cimetidine in rats.

Autorzy:

Yamamura N; Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd, Tokyo, Japan.
Imaoka T; Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd, Tokyo, Japan.
Hoshi M; Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd, Tokyo, Japan.
Yamada M; Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd, Tokyo, Japan.
Itokawa KI; Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd, Tokyo, Japan.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Feb; Vol. 53 (2), pp. 114-122. Date of Electronic Publication: 2023 Feb 09.

Typ publikacji:

Journal Article

MeSH Terms:

Cimetidine*/pharmacology
Metformin*/pharmacology
Rats ; Humans ; Animals ; Organic Cation Transport Proteins ; Organic Cation Transporter 2 ; Kidney

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 24.

Tytuł:

In vitro and in vivo metabolic profiling of PD105, a PI3Kδ inhibitor, using UHPLC-Q-Exactive plus-MS.

Autorzy:

Wei P; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Tang M; State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, China.
Ma Z; State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, China.
Zhao J; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Wu R; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Wan L; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Feb; Vol. 53 (2), pp. 106-113. Date of Electronic Publication: 2023 Mar 13.

Typ publikacji:

Journal Article

MeSH Terms:

Metabolomics*
Microsomes, Liver*/metabolism
Mice ; Animals ; Chromatography, High Pressure Liquid ; Oxidation-Reduction ; Feces

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 25.

Tytuł:

Investigation of the pharmacokinetics and metabolic fate of Fasiglifam (TAK-875) in male and female rats following oral and intravenous administration.

Autorzy:

Molloy BJ; Waters Corporation, Wilmslow, UK.
King A; Waters Corporation, Wilmslow, UK.
Gethings LA; Waters Corporation, Wilmslow, UK.
Plumb RS; Waters Corporation, Milford, MA, USA.
Mortishire-Smith RJ; Waters Corporation, Wilmslow, UK.
Wilson ID; Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College, London, UK.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Feb; Vol. 53 (2), pp. 93-105. Date of Electronic Publication: 2023 Feb 21.

Typ publikacji:

Journal Article

MeSH Terms:

Sulfones*
Receptors, G-Protein-Coupled*/agonists
Rats ; Male ; Female ; Animals ; Rats, Sprague-Dawley ; Administration, Intravenous ; Administration, Oral ; Injections, Intravenous

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 26.

Tytuł:

Meeting report of the 3rd European Biotransformation Workshop.

Autorzy:

Walles M; Department of Pharmacokinetic Sciences, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Pähler A; F Hoffmann-La Roche AG Research and Development Division, Pharma Research and Early Development, Basel, Switzerland.
Isin EM; Les Laboratoires Servier SAS Recherche and Developpement, DMPK, Translational Medicine, Servier, France.
Ahlqvist MM; Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Feb; Vol. 53 (2), pp. 123-127. Date of Electronic Publication: 2023 Jan 31.

Typ publikacji:

Case Reports; Journal Article

MeSH Terms:

Drug Discovery*
Humans ; Mass Spectrometry/methods ; Biotransformation

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 27.

Tytuł:

Species differences in plasma protein binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease inhibitor nirmatrelvir.

Autorzy:

Greenfield SR; Pfizer Worldwide Research, Development & Medical, Cambridge, MA, USA.
Eng H; Pfizer Worldwide Research, Development & Medical, Groton, CT, USA.
Yang Q; Pfizer Worldwide Research, Development & Medical, Cambridge, MA, USA.
Guo C; Pfizer Worldwide Research, Development & Medical, Groton, CT, USA.
Byrnes L; Pfizer Worldwide Research, Development & Medical, Groton, CT, USA.
Dantonio A; Pfizer Worldwide Research, Development & Medical, Groton, CT, USA.
West G; Pfizer Worldwide Research, Development & Medical, Groton, CT, USA.
Di L; Pfizer Worldwide Research, Development & Medical, Groton, CT, USA.
Kalgutkar AS; Pfizer Worldwide Research, Development & Medical, Cambridge, MA, USA.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Jan; Vol. 53 (1), pp. 12-24. Date of Electronic Publication: 2023 Feb 27.

Typ publikacji:

Journal Article

MeSH Terms:

COVID-19*
Anti-Infective Agents*
Rats ; Humans ; Animals ; Dogs ; Rabbits ; Protein Binding ; SARS-CoV-2/metabolism ; Protease Inhibitors ; Species Specificity ; Molecular Docking Simulation ; Blood Proteins/metabolism ; Serum Albumin/metabolism ; Orosomucoid/metabolism ; Antiviral Agents ; Enzyme Inhibitors

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 28.

Tytuł:

2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A22.

Autorzy:

Uno Y; Department of Basic Veterinary Science, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima-city, Japan.
Morikuni S; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.
Murayama N; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.
Yamazaki H; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Jan; Vol. 53 (1), pp. 60-65. Date of Electronic Publication: 2023 Apr 05.

Typ publikacji:

Journal Article

MeSH Terms:

Pork Meat*
Red Meat*
Swine ; Male ; Animals ; Female ; Skatole/metabolism ; Microsomes, Liver/metabolism ; Hydroxylation ; Swine, Miniature/metabolism ; Odorants ; Cytochrome P-450 Enzyme System/metabolism ; Cytochrome P-450 CYP2E1/metabolism ; Liver/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 29.

Tytuł:

Comparative metabolism of THCA and THCV using UHPLC-Q-Exactive Orbitrap-MS.

Autorzy:

Rao Q; Laboratory of Metabolomics and Drug-Induced Liver Injury, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.; Academician Workstation, Jiangxi University of Chinese Medicine, Nanchang, China.
Zhang T; Laboratory of Metabolomics and Drug-Induced Liver Injury, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.; States Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
Pu QL; Advanced Mass Spectrometry Center, Research Core Facility, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Li B; Academician Workstation, Jiangxi University of Chinese Medicine, Nanchang, China.
Zhao Q; Laboratory of Metabolomics and Drug-Induced Liver Injury, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Yan DM; Academician Workstation, Jiangxi University of Chinese Medicine, Nanchang, China.
Wu ZE; Laboratory of Metabolomics and Drug-Induced Liver Injury, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Li F; Laboratory of Metabolomics and Drug-Induced Liver Injury, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.; Department of Gastroenterology & Hepatology, Frontiers Science Center for Disease-related Molecular Network, Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre, West China Hospital, Sichuan University, Chengdu, China.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Jan; Vol. 53 (1), pp. 46-59. Date of Electronic Publication: 2023 Apr 10.

Typ publikacji:

Journal Article

MeSH Terms:

Dronabinol*/metabolism
Dronabinol*/pharmacology
Cannabinoids*
Humans ; Mice ; Animals ; Chromatography, High Pressure Liquid

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 30.

Tytuł:

Experimental and computational models to investigate intestinal drug permeability and metabolism.

Autorzy:

Chen J; Institute of Scientific Research, Southern Medical University, Guangzhou, P.R. China.; TCM-Integrated Hospital, Southern Medical University, Guangzhou, P.R. China.
Yuan Z; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, P.R. China.
Tu Y; Boehringer-Ingelheim, Connecticut, P.R. USA.
Hu W; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, P.R. China.
Xie C; Clinical Pharmacy Center, Nanfang Hospital, Southern Medical University, Guangzhou, P.R. China.
Ye L; TCM-Integrated Hospital, Southern Medical University, Guangzhou, P.R. China.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Jan; Vol. 53 (1), pp. 25-45. Date of Electronic Publication: 2023 Feb 21.

Typ publikacji:

Review; Journal Article

MeSH Terms:

Intestinal Mucosa*/metabolism
Intestines*
Pharmaceutical Preparations/metabolism ; Administration, Oral ; Permeability ; Computer Simulation ; Intestinal Absorption ; Models, Biological

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 31.

Tytuł:

In vitro hepatic metabolism of the natural product quebecol.

Autorzy:

Bernardes G; Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Krol ES; Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Jan; Vol. 53 (1), pp. 1-11. Date of Electronic Publication: 2023 Apr 18.

Typ publikacji:

Journal Article

MeSH Terms:

Glucuronosyltransferase*/metabolism
Microsomes, Liver*/metabolism
Rats ; Animals ; Humans ; Liver/metabolism ; Glucuronides/metabolism ; Kinetics

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 32.

Tytuł:

The effect of ARVs on the MEKKK1 gene promoter, inflammatory cytokine expression and signalling in acute treated Jurkat T cells.

Autorzy:

Moses AK; Medical Biochemistry, Faculty of Health Sciences, Howard College, University of KwaZulu-Natal, Durban, South Africa.
Ghazi T; Medical Biochemistry, Faculty of Health Sciences, Howard College, University of KwaZulu-Natal, Durban, South Africa.
Nagiah S; Medical Biochemistry, Nelson Mandela University Medical School, Bethelsdorp, South Africa.
Chuturgoon A; Medical Biochemistry, Faculty of Health Sciences, Howard College, University of KwaZulu-Natal, Durban, South Africa.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Dec; Vol. 52 (12), pp. 1041-1051. Date of Electronic Publication: 2023 Jan 20.

Typ publikacji:

Journal Article

MeSH Terms:

HIV Infections*/drug therapy
Anti-HIV Agents*
Humans ; Cytokines ; Lamivudine/toxicity ; Lamivudine/therapeutic use ; Tenofovir/therapeutic use ; Benzoxazines ; Decitabine/therapeutic use ; Inflammation/drug therapy ; Inflammation/chemically induced ; T-Lymphocytes

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 33.

Tytuł:

Human pharmacokinetics prediction with an in vitro - in vivo correction factor approach and in vitro drug-drug interaction profile of bictegravir, a potent integrase-strand transfer inhibitor component in approved biktarvy for the treatment of HIV-1 infection.

Autorzy:

Subramanian R; Gilead Sciences, Inc, Foster City, CA, USA.
Wang J; Gilead Sciences, Inc, Foster City, CA, USA.
Murray B; Gilead Sciences, Inc, Foster City, CA, USA.
Custodio J; Gilead Sciences, Inc, Foster City, CA, USA.
Hao J; Gilead Sciences, Inc, Foster City, CA, USA.
Lazerwith S; Gilead Sciences, Inc, Foster City, CA, USA.
MacLennan Staiger K; Gilead Sciences, Inc, Foster City, CA, USA.
Mwangi J; Gilead Sciences, Inc, Foster City, CA, USA.
Sun H; Gilead Sciences, Inc, Foster City, CA, USA.
Tang J; Gilead Sciences, Inc, Foster City, CA, USA.
Wang K; Gilead Sciences, Inc, Foster City, CA, USA.
Rhodes G; Gilead Sciences, Inc, Foster City, CA, USA.
Wijaya S; Gilead Sciences, Inc, Foster City, CA, USA.
Zhang H; Gilead Sciences, Inc, Foster City, CA, USA.
Smith BJ; Gilead Sciences, Inc, Foster City, CA, USA.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Dec; Vol. 52 (12), pp. 1020-1030. Date of Electronic Publication: 2023 Jan 26.

Typ publikacji:

Journal Article

MeSH Terms:

HIV Infections*/drug therapy
HIV Integrase Inhibitors*/pharmacokinetics
HIV-1*
Humans ; Amides ; Drug Interactions ; Heterocyclic Compounds, 3-Ring/pharmacokinetics ; Pyridones

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 34.

Tytuł:

Absorption, distribution, metabolism and excretion of C-Emvododstat following a single oral dose in rats and dogs.

Autorzy:

Ma J; PTC Therapeutics, Inc, South Plainfield, New Jersey, USA.
Ye Q; PTC Therapeutics, Inc, South Plainfield, New Jersey, USA.
Northcutt V; PTC Therapeutics, Inc, South Plainfield, New Jersey, USA.
Babiak J; PTC Therapeutics, Inc, South Plainfield, New Jersey, USA.
Kong R; PTC Therapeutics, Inc, South Plainfield, New Jersey, USA.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Dec; Vol. 52 (12), pp. 1031-1040. Date of Electronic Publication: 2023 Feb 03.

Typ publikacji:

Journal Article

MeSH Terms:

COVID-19*
Body Fluids*
Rats ; Dogs ; Animals ; Rats, Long-Evans ; Feces/chemistry ; Administration, Oral

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 35.

Tytuł:

Characterisation of UDP-glucuronosyltransferase activity in sea turtle Chelonia mydas .

Autorzy:

Dias VHV; Laboratory of Biomarkers of Aquatic Contamination and Immunochemistry-LABCAI, Federal University of Santa Catarina, Florianópolis, Brazil.
Mattos JJ; Aquaculture Pathology Research Center-NEPAQ, Federal University of Santa Catarina, Florianópolis, Brazil.
Bastolla CLV; Laboratory of Biomarkers of Aquatic Contamination and Immunochemistry-LABCAI, Federal University of Santa Catarina, Florianópolis, Brazil.
Lüchmann KH; Department of Scientific and Technological Education, Santa Catarina State University, Florianópolis, Brazil.
Bainy ACD; Laboratory of Biomarkers of Aquatic Contamination and Immunochemistry-LABCAI, Federal University of Santa Catarina, Florianópolis, Brazil.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Dec; Vol. 52 (12), pp. 1011-1019. Date of Electronic Publication: 2023 Jan 16.

Typ publikacji:

Journal Article

MeSH Terms:

Uridine Diphosphate Glucuronic Acid*/metabolism
Turtles*/metabolism
Animals ; Magnesium ; Uridine Diphosphate ; Glucuronosyltransferase/metabolism ; Microsomes, Liver/metabolism ; Alamethicin/pharmacology

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 36.

Tytuł:

Correction.

Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Sep-Nov; Vol. 52 (9-11), pp. I. Date of Electronic Publication: 2022 Dec 12.

Typ publikacji:

Published Erratum

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 37.

Tytuł:

A comprehensive analysis of six forms of cytochrome P450 2C (CYP2C) in pigs.

Autorzy:

Uno Y; Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima-city, Japan.
Morikuni S; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.
Shiraishi M; Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima-city, Japan.
Asano A; Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima-city, Japan.
Kawaguchi H; School of Veterinary Medicine, Kitasato University, Towada, Japan.
Murayama N; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.
Yamazaki H; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Sep-Nov; Vol. 52 (9-11), pp. 963-972. Date of Electronic Publication: 2022 Nov 17.

Typ publikacji:

Journal Article

MeSH Terms:

Cytochrome P-450 Enzyme System*/metabolism
Liver*/metabolism
Swine ; Humans ; Animals ; Intestine, Small ; Cytochrome P-450 CYP2C9/metabolism ; Cytochrome P-450 CYP2C8/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 38.

Tytuł:

Mirogabalin, a novel α 2 δ ligand, is not a substrate of LAT1, but of PEPT1, PEPT2, OAT1, OAT3, OCT2, MATE1 and MATE2-K.

Autorzy:

Yamamura N; Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
Mikkaichi T; Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
Itokawa KI; Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
Hoshi M; Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
Damme K; Tissue and Cell Research Center Munich, Daiichi Sankyo Europe GmbH, Martinsried, Germany.
Geigner S; Tissue and Cell Research Center Munich, Daiichi Sankyo Europe GmbH, Martinsried, Germany.
Baumhauer C; Tissue and Cell Research Center Munich, Daiichi Sankyo Europe GmbH, Martinsried, Germany.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Sep-Nov; Vol. 52 (9-11), pp. 997-1009. Date of Electronic Publication: 2022 Oct 06.

Typ publikacji:

Journal Article

MeSH Terms:

Organic Cation Transport Proteins*/metabolism
Humans ; HEK293 Cells ; Ligands ; Pregabalin ; Organic Cation Transporter 2/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 39.

Tytuł:

Human and nonclinical disposition of [ C]bictegravir, a potent integrase strand-transfer inhibitor for the treatment of HIV-1 infection.

Autorzy:

Subramanian R; Gilead Sciences, Inc., Foster City, CA, USA.
Ling J; Gilead Sciences, Inc., Foster City, CA, USA.
Wang J; Gilead Sciences, Inc., Foster City, CA, USA.
Wang K; Gilead Sciences, Inc., Foster City, CA, USA.
Hao J; Gilead Sciences, Inc., Foster City, CA, USA.
Jin H; Gilead Sciences, Inc., Foster City, CA, USA.
Lai Y; Gilead Sciences, Inc., Foster City, CA, USA.
Murray B; Gilead Sciences, Inc., Foster City, CA, USA.
Wijaya S; Gilead Sciences, Inc., Foster City, CA, USA.
Zhang H; Gilead Sciences, Inc., Foster City, CA, USA.
Smith BJ; Gilead Sciences, Inc., Foster City, CA, USA.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Sep-Nov; Vol. 52 (9-11), pp. 973-985. Date of Electronic Publication: 2023 Jan 06.

Typ publikacji:

Journal Article

MeSH Terms:

HIV Integrase Inhibitors*/pharmacology
HIV Integrase Inhibitors*/therapeutic use
HIV-1*
HIV Infections*/drug therapy
Humans ; Animals ; Mice ; Rats ; Pyridones ; Amides ; Heterocyclic Compounds, 3-Ring/pharmacology ; Heterocyclic Compounds, 3-Ring/therapeutic use ; Heterocyclic Compounds, 4 or More Rings ; Integrases/therapeutic use

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 40.

Tytuł:

Untargeted metabolomics-assisted comparative cytochrome P450-dependent metabolism of fenbendazole in human and dog liver microsomes.

Autorzy:

Jung YH; College of Pharmacy, Yeungnam University, Gyeongsan, Korea.
Lee DC; College of Pharmacy, Yeungnam University, Gyeongsan, Korea.
Kim JO; College of Pharmacy, Yeungnam University, Gyeongsan, Korea.
Kim JH; College of Pharmacy, Yeungnam University, Gyeongsan, Korea.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Sep-Nov; Vol. 52 (9-11), pp. 986-996. Date of Electronic Publication: 2022 Dec 28.

Typ publikacji:

Journal Article

MeSH Terms:

Fenbendazole*/chemistry
Fenbendazole*/metabolism
Anthelmintics*/metabolism
Humans ; Dogs ; Animals ; Microsomes, Liver/metabolism ; Tandem Mass Spectrometry ; Cytochrome P-450 Enzyme System/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 41.

Tytuł:

Use of selective substrates and inhibitors to rapidly characterise batches of cryopreserved primary human hepatocytes for assessment of active uptake liability in drug discovery and development.

Autorzy:

Golding M; Development Science, UCB Biopharma, Slough, UK.
Light O; Immunology Therapeutic Area, UCB Biopharma, Slough, UK.
Williamson B; Development Science, UCB Biopharma, Slough, UK.
Ménochet K; Development Science, UCB Biopharma, Slough, UK.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Aug; Vol. 52 (8), pp. 868-877.

Typ publikacji:

Journal Article

MeSH Terms:

Drug Discovery*/methods
Hepatocytes*/metabolism
Organic Anion Transporters*/metabolism
Humans ; Biological Transport ; HEK293 Cells ; Liver/metabolism ; Membrane Transport Proteins/metabolism ; Organic Anion Transporters, Sodium-Independent/metabolism ; Solute Carrier Organic Anion Transporter Family Member 1B3/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 42.

Tytuł:

One small step in time, one giant leap for DMPK kind - a CRO perspective of the evolving core discipline of drug development.

Autorzy:

Kendrick JS; Labcorp Early Development Laboratories Inc, Harrogate, United Kingdom.
Webber C; Labcorp Early Development Laboratories Inc, Huntingdon, United Kingdom.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Aug; Vol. 52 (8), pp. 797-810.

Typ publikacji:

Journal Article

MeSH Terms:

Drug Development*
Animals ; Pharmaceutical Preparations

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 43.

Tytuł:

Meeting report: oligonucleotide ADME workshop.

Autorzy:

Hood S; Department of Research, In Vitro/In Vivo Translation, GlaxoSmithKline, Stevenage, UK.
Kenworthy D; Department of Research, In Vitro/In Vivo Translation, GlaxoSmithKline, Stevenage, UK.
Christensen JK; Development ADME, Novo Nordisk A/S, Måløv, Denmark.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Aug; Vol. 52 (8), pp. 957-961. Date of Electronic Publication: 2022 Sep 12.

Typ publikacji:

Journal Article

MeSH Terms:

Oligonucleotides*/therapeutic use
Pharmaceutical Preparations/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 44.

Tytuł:

Subcutaneous catabolism of peptide therapeutics: bioanalytical approaches and ADME considerations.

Autorzy:

Esposito S; IRBM SpA, Pomezia, Italy.
Orsatti L; IRBM SpA, Pomezia, Italy.
Pucci V; IRBM SpA, Pomezia, Italy.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Aug; Vol. 52 (8), pp. 828-839.

Typ publikacji:

Review; Journal Article

MeSH Terms:

Peptides*/metabolism
Insulin*
Pharmaceutical Preparations ; Biological Availability ; Chromatography, Liquid ; Injections, Subcutaneous

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 45.

Tytuł:

Time matters - in vitro cellular disposition kinetics help rationalizing cellular potency disconnects.

Autorzy:

Poller B; Pharmacokinetic Sciences, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Werner S; Pharmacokinetic Sciences, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Domange N; Pharmacokinetic Sciences, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Mettler L; Pharmacokinetic Sciences, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Stein RR; Pharmacokinetic Sciences, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Loretan J; Oncology, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Wartmann M; Oncology, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Faller B; Pharmacokinetic Sciences, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Huth F; Pharmacokinetic Sciences, Novartis Institutes for Biomedical Research, Basel, Switzerland.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Aug; Vol. 52 (8), pp. 878-889.

Typ publikacji:

Journal Article

MeSH Terms:

Drug Discovery*
Animals ; Dogs ; Kinetics ; Biological Transport ; Madin Darby Canine Kidney Cells

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 46.

Tytuł:

ADME and DMPK considerations for the discovery and development of antibody drug conjugates (ADCs).

Autorzy:

Beaumont K; Drug Metabolism and Pharmacokinetics, Early Oncology Research and Development, Cambridge, UK.
Pike A; Drug Metabolism and Pharmacokinetics, Early Oncology Research and Development, Cambridge, UK.
Davies M; Drug Metabolism and Pharmacokinetics, Early Oncology Research and Development, Cambridge, UK.
Savoca A; Drug Metabolism and Pharmacokinetics, Early Oncology Research and Development, Cambridge, UK.
Vasalou C; Drug Metabolism and Pharmacokinetics, Early Oncology Research and Development, AstraZeneca, Boston, MA, USA.
Harlfinger S; Drug Metabolism and Pharmacokinetics, Early Oncology Research and Development, Cambridge, UK.
Ramsden D; Drug Metabolism and Pharmacokinetics, Early Oncology Research and Development, AstraZeneca, Boston, MA, USA.
Ferguson D; Drug Metabolism and Pharmacokinetics, Early Oncology Research and Development, AstraZeneca, Boston, MA, USA.
Hariparsad N; Drug Metabolism and Pharmacokinetics, Early Oncology Research and Development, AstraZeneca, Boston, MA, USA.
Jones O; Drug Metabolism and Pharmacokinetics, Early Oncology Research and Development, Cambridge, UK.
McGinnity D; Drug Metabolism and Pharmacokinetics, Early Oncology Research and Development, Cambridge, UK.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Aug; Vol. 52 (8), pp. 770-785.

Typ publikacji:

Review; Journal Article

MeSH Terms:

Antineoplastic Agents*/pharmacokinetics
Immunoconjugates*/pharmacokinetics
Neoplasms*/drug therapy
Humans

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 47.

Tytuł:

A discovery biotransformation strategy: combining in silico tools with high-resolution mass spectrometry and software-assisted data analysis for high-throughput metabolism.

Autorzy:

Weston DJ; GSK, DMPK, Disposition and Biotransformation, Stevenage, UK.
Dave M; GSK, DMPK, Disposition and Biotransformation, Stevenage, UK.
Colizza K; GSK, DMPK, Disposition and Biotransformation, Collegeville, PA, USA.
Thomas S; GSK, DMPK, Disposition and Biotransformation, Stevenage, UK.
Tomlinson L; GSK, DMPK, Discovery DMPK, Stevenage, UK.
Gregory R; GSK, DMPK, Discovery DMPK, Stevenage, UK.
Beaumont C; GSK, DMPK, Disposition and Biotransformation, Stevenage, UK.
Pirhalla J; GSK, DMPK, Disposition and Biotransformation, Collegeville, PA, USA.
Dear GJ; GSK, DMPK, Disposition and Biotransformation, Stevenage, UK.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Aug; Vol. 52 (8), pp. 928-942. Date of Electronic Publication: 2022 Nov 01.

Typ publikacji:

Journal Article

MeSH Terms:

Tandem Mass Spectrometry*/methods
Software*
Chromatography, Liquid/methods ; Chromatography, High Pressure Liquid ; Biotransformation

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 48.

Tytuł:

A translational strategy employing physiologically based modelling to predict the pharmacological active dose of RO7119929, an oral prodrug of a targeted cancer immunotherapy TLR7 agonist.

Autorzy:

Rynn C; Roche Pharma Research & Early Development pRED, Roche Innovation Center Basel, Basel, Switzerland.
Umehara K; Roche Pharma Research & Early Development pRED, Roche Innovation Center Basel, Basel, Switzerland.
Jiang T; Roche Innovation Center Shanghai, Roche R&D Center (China) Ltd, Shanghai, China.
Ait-Goughoulte M; Roche Pharma Research & Early Development pRED, Roche Innovation Center Basel, Basel, Switzerland.
Parrott N; Roche Pharma Research & Early Development pRED, Roche Innovation Center Basel, Basel, Switzerland.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Aug; Vol. 52 (8), pp. 855-867.

Typ publikacji:

Journal Article

MeSH Terms:

Prodrugs*/pharmacokinetics
Neoplasms*
Humans ; Toll-Like Receptor 7 ; Leukocytes, Mononuclear ; Models, Biological ; Administration, Oral ; Immunotherapy ; Cytokines

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 49.

Tytuł:

Drug clearance by aldehyde oxidase: can we avoid clinical failure?

Autorzy:

Toselli F; Development Science, UCB Biopharma, Braine-l'Alleud, Belgium.
Golding M; Development Science, UCB Biopharma, Slough, UK.
Nicolaï J; Development Science, UCB Biopharma, Braine-l'Alleud, Belgium.
Gillent E; Development Science, UCB Biopharma, Braine-l'Alleud, Belgium.
Chanteux H; Development Science, UCB Biopharma, Braine-l'Alleud, Belgium.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Aug; Vol. 52 (8), pp. 890-903.

Typ publikacji:

Journal Article

MeSH Terms:

Aldehyde Oxidase*/metabolism
Drug Elimination Routes*/physiology
Humans ; Drug Discovery ; Liver/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 50.

Tytuł:

Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models.

Autorzy:

Gardner I; Certara UK Ltd., Sheffield, United Kingdom.
Xu M; Pharmaron Beijing Co. Ltd., Beijing, China.
Han C; Pharmaron Beijing Co. Ltd., Beijing, China.
Wang Y; Pharmaron Beijing Co. Ltd., Beijing, China.
Jiao X; Pharmaron Beijing Co. Ltd., Beijing, China.
Jamei M; Certara UK Ltd., Sheffield, United Kingdom.
Khalidi H; Certara UK Ltd., Sheffield, United Kingdom.
Kilford P; Certara UK Ltd., Sheffield, United Kingdom.; Labcorp Drug Development, Harrogate, United Kingdom.
Neuhoff S; Certara UK Ltd., Sheffield, United Kingdom.
Southall R; Certara UK Ltd., Sheffield, United Kingdom.
Turner DB; Certara UK Ltd., Sheffield, United Kingdom.
Musther H; Certara UK Ltd., Sheffield, United Kingdom.
Jones B; Pharmaron UK, Hoddesdon, Hertfordshire, United Kingdom.
Taylor S; Pharmaron UK, Hoddesdon, Hertfordshire, United Kingdom.

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Źródło:

Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 Aug; Vol. 52 (8), pp. 943-956.

Typ publikacji:

Journal Article

MeSH Terms:

Hepatocytes*/metabolism
Microsomes, Liver*/metabolism
Animals ; Dogs ; Humans ; Mice ; Rats ; Haplorhini ; Metabolic Clearance Rate ; Models, Biological ; Swine ; Swine, Miniature ; Reproducibility of Results

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły