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Tytuł :
Xuefu Zhuyu Oral Liquid () Prevents Apoptosis of Ischemic Myocardium Cells in Rats by Regulating SIRT1 and Its Pathway-Related Genes.
Autorzy :
Chen MQ; Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
Yao KW; Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China. .
Liu ZJ; Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
Feng XX; Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
Xiao Y; Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
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Źródło :
Chinese journal of integrative medicine [Chin J Integr Med] 2020 Jun; Vol. 26 (6), pp. 442-447. Date of Electronic Publication: 2019 Dec 23.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Drugs, Chinese Herbal/*pharmacology
Myocytes, Cardiac/*drug effects
Sirtuin 1/*genetics
Sirtuin 1/*metabolism
Animals ; Cells, Cultured ; China ; Gene Expression ; Rats
Czasopismo naukowe
Tytuł :
The CtBP1-p300-FOXO3a transcriptional complex represses the expression of the apoptotic regulators Bax and Bim in human osteosarcoma cells.
Autorzy :
Li C; Department of Orthopaedics, People's Hospital of Jiangxi Province, Nanchang, Jiangxi, China.
Xiao XQ; Department of Oncology, People's Hospital of Jiangxi Province, Nanchang, Jiangxi, China.
Qian YH; Department of Orthopaedics, People's Hospital of Jiangxi Province, Nanchang, Jiangxi, China.
Zhou ZY; Department of Oncology, People's Hospital of Jiangxi Province, Nanchang, Jiangxi, China.
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Źródło :
Journal of cellular physiology [J Cell Physiol] 2019 Dec; Vol. 234 (12), pp. 22365-22377. Date of Electronic Publication: 2019 May 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Transcription, Genetic*
Alcohol Oxidoreductases/*metabolism
Bcl-2-Like Protein 11/*metabolism
DNA-Binding Proteins/*metabolism
E1A-Associated p300 Protein/*metabolism
Forkhead Box Protein O3/*metabolism
Osteosarcoma/*genetics
bcl-2-Associated X Protein/*metabolism
Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Humans ; Models, Biological ; Osteosarcoma/pathology ; Peptides/metabolism ; Phenotype ; Promoter Regions, Genetic/genetics ; Protein Binding/genetics
Czasopismo naukowe
Tytuł :
Racemic neolignans from Crataegus pinnatifida: Chiral resolution, configurational assignment, and cytotoxic activities against human hepatoma cells.
Autorzy :
Guo R; School of Traditional Chinese Materia Medica, Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Lv TM; School of Traditional Chinese Materia Medica, Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Shang XY; School of Traditional Chinese Materia Medica, Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Yao GD; School of Traditional Chinese Materia Medica, Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Lin B; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, People's Republic of China.
Wang XB; Chinese People's Liberation Army Logistics support force No.967 Hospital, Dalian 116021, People's Republic of China.
Huang XX; School of Traditional Chinese Materia Medica, Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Chinese People's Liberation Army Logistics support force No.967 Hospital, Dalian 116021, People's Republic of China. Electronic address: .
Song SJ; School of Traditional Chinese Materia Medica, Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address: .
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Źródło :
Fitoterapia [Fitoterapia] 2019 Sep; Vol. 137, pp. 104287. Date of Electronic Publication: 2019 Aug 03.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Apoptosis/*drug effects
Crataegus/*chemistry
Fruit/*chemistry
Lignans/*pharmacology
Antineoplastic Agents, Phytogenic/isolation & purification ; China ; Hep G2 Cells ; Humans ; Lignans/isolation & purification ; Molecular Structure ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Stereoisomerism
Czasopismo naukowe
Tytuł :
Bif-1 Interacts with Prohibitin-2 to Regulate Mitochondrial Inner Membrane during Cell Stress and Apoptosis.
Autorzy :
Cho SG; Department of Cellular Biology and Anatomy.
Xiao X; Department of Cellular Biology and Anatomy.
Wang S; Department of Cellular Biology and Anatomy.
Gao H; Department of Cellular Biology and Anatomy.
Rafikov R; Vascular Biology Center.
Black S; Vascular Biology Center.
Huang S; Department of Biochemistry and Molecular Biology.
Ding HF; Cancer Center, and.
Yoon Y; Department of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia.
Kirken RA; Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas.
Yin XM; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Wang HG; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania; and.
Dong Z; Department of Cellular Biology and Anatomy, .; Medical Research Line, Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia.
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Źródło :
Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2019 Jul; Vol. 30 (7), pp. 1174-1191. Date of Electronic Publication: 2019 May 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Apoptosis*
Adaptor Proteins, Signal Transducing/*physiology
Mitochondrial Membranes/*physiology
Repressor Proteins/*physiology
Animals ; Cytochromes c/physiology ; GTP Phosphohydrolases/metabolism ; HEK293 Cells ; HeLa Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Proteolysis
Czasopismo naukowe
Tytuł :
Celastrol induce apoptosis of human multiple myeloma cells involving inhibition of proteasome activity.
Autorzy :
Zhong YL; School of Pharmacy, Chengdu Medical College, Chengdu, China.
Xu GJ; School of Pharmacy, Chengdu Medical College, Chengdu, China.
Huang S; School of Pharmacy, Chengdu Medical College, Chengdu, China.
Zhao L; School of Pharmacy, Chengdu Medical College, Chengdu, China.
Zeng Y; School of Pharmacy, Chengdu Medical College, Chengdu, China.
Xiao XF; School of Pharmacy, Chengdu Medical College, Chengdu, China.
An JL; School of Pharmacy, Chengdu Medical College, Chengdu, China.
Liu J; School of Pharmacy, Chengdu Medical College, Chengdu, China; Center for Scientific Research, Chengdu Medical College, Chengdu, China. Electronic address: .
Yang T; School of Pharmacy, Chengdu Medical College, Chengdu, China; Center for Scientific Research, Chengdu Medical College, Chengdu, China. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2019 Jun 15; Vol. 853, pp. 184-192. Date of Electronic Publication: 2019 Mar 27.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Multiple Myeloma/*pathology
Proteasome Endopeptidase Complex/*metabolism
Proteasome Inhibitors/*pharmacology
Triterpenes/*pharmacology
Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Female ; G1 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Mice ; Resting Phase, Cell Cycle/drug effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Varacin-1, a novel analog of varacin C, induces p53-independent apoptosis in cancer cells through ROS-mediated reduction of XIAP.
Autorzy :
Zhou J; Department of Physiology, School of Preclinical Medicine, Guangxi Medical University, Nanning, 530021, China.
Li WL; Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, 511430, China.
Wang ZX; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, 530021, China.; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, 530021, China.
Chen NY; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, 530021, China.
Tang Y; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, 530021, China.; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, 530021, China.
Hu XX; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, 530021, China.; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, 530021, China.
Deng JH; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, 530021, China.
Lu Y; Department of Chemistry, National University of Singapore, Singapore, 117543, Singapore.
Lu GD; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, 530021, China. .; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, 530021, China. .; Key Laboratory of High-incidence-Tumor Prevention & Treatment (Guangxi Medical University), Ministry of Education of China, Nanning, 530021, China. .
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Źródło :
Acta pharmacologica Sinica [Acta Pharmacol Sin] 2019 Feb; Vol. 40 (2), pp. 222-230. Date of Electronic Publication: 2018 May 17.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Cyclic S-Oxides/*pharmacology
Ethylamines/*pharmacology
Sulfides/*pharmacology
X-Linked Inhibitor of Apoptosis Protein/*metabolism
Antineoplastic Agents/chemical synthesis ; Cell Line, Tumor ; Cyclic S-Oxides/chemical synthesis ; Ethylamines/chemical synthesis ; Humans ; Reactive Oxygen Species/metabolism ; Sulfides/chemical synthesis
Czasopismo naukowe
Tytuł :
Involvement of oxidative stress in di-2-ethylhexyl phthalate (DEHP)-induced apoptosis of mouse NE-4C neural stem cells.
Autorzy :
Wu M; Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, PR China.
Xu L; Medical Research Center, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China.
Teng C; The Fourth Clinical Medical College of Nanchang University, Nanchang, 330006, PR China.
Xiao X; The Second Clinical Medical College of Nanchang University, Nanchang, 330006, PR China.
Hu W; Periodical Press, Nanchang University, Nanchang, 330006, PR China.
Chen J; Department of Physiology, Medical College of Nanchang University, Nanchang, 330006, PR China.
Tu W; Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, PR China. Electronic address: .
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Źródło :
Neurotoxicology [Neurotoxicology] 2019 Jan; Vol. 70, pp. 41-47. Date of Electronic Publication: 2018 Nov 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Cell Survival/*drug effects
Diethylhexyl Phthalate/*toxicity
Neural Stem Cells/*drug effects
Oxidative Stress/*drug effects
Plasticizers/*toxicity
Animals ; Apoptosis/physiology ; Cell Line ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; Mice ; Neural Stem Cells/metabolism ; Oxidative Stress/physiology
Czasopismo naukowe
Tytuł :
Osteogenic protein-1 attenuates nucleus pulposus cell apoptosis through activating the PI3K/Akt/mTOR pathway in a hyperosmotic culture.
Autorzy :
Yang Y; Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China.; Hunan Engineering Laboratory of Advanced Artificial Osteo-Materials, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China.
Wang X; Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China .; Hunan Engineering Laboratory of Advanced Artificial Osteo-Materials, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China.
Liu Z; Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China.; Hunan Engineering Laboratory of Advanced Artificial Osteo-Materials, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China.
Xiao X; Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China.; Hunan Engineering Laboratory of Advanced Artificial Osteo-Materials, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China.
Hu W; Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China.; Hunan Engineering Laboratory of Advanced Artificial Osteo-Materials, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China.
Sun Z; Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China.; Hunan Engineering Laboratory of Advanced Artificial Osteo-Materials, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China.
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Źródło :
Bioscience reports [Biosci Rep] 2018 Dec 14; Vol. 38 (6). Date of Electronic Publication: 2018 Dec 14 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Signal Transduction*
Bone Morphogenetic Protein 7/*metabolism
Nucleus Pulposus/*cytology
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Animals ; Cells, Cultured ; Nucleus Pulposus/metabolism ; Osmotic Pressure ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Stereoisomeric guaiacylglycerol-β-coniferyl aldehyde ether induces distinctive apoptosis by downregulation of MEK/ERK pathway in hepatocellular carcinoma cells.
Autorzy :
Yao GD; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Wang J; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Song XY; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Zhou L; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Lou LL; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Zhao WY; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Lin B; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Huang XX; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Chinese People's Liberation Army 210 Hospital, Dalian 116021, People's Republic of China. Electronic address: .
Song SJ; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2018 Dec; Vol. 81, pp. 382-388. Date of Electronic Publication: 2018 Sep 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acrolein/*analogs & derivatives
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Carcinoma, Hepatocellular/*drug therapy
Guaifenesin/*pharmacology
Liver Neoplasms/*drug therapy
MAP Kinase Signaling System/*drug effects
Acrolein/chemistry ; Acrolein/pharmacology ; Antineoplastic Agents/chemistry ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Guaifenesin/analogs & derivatives ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Stereoisomerism
Czasopismo naukowe
Tytuł :
Racemic phenylpropanoids from the root barks of Ailanthus altissima (Mill.) Swingle with cytotoxicity against hepatoma cells.
Autorzy :
Yan ZY; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Chen JJ; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Duan ZK; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Yao GD; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Lin B; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Wang XB; Chinese People's Liberation Army 210 Hospital, Dalian 116021, People's Republic of China.
Huang XX; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Chinese People's Liberation Army 210 Hospital, Dalian 116021, People's Republic of China. Electronic address: .
Song SJ; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address: .
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Źródło :
Fitoterapia [Fitoterapia] 2018 Oct; Vol. 130, pp. 234-240. Date of Electronic Publication: 2018 Sep 15.
Typ publikacji :
Journal Article
MeSH Terms :
Ailanthus/*chemistry
Antineoplastic Agents, Phytogenic/*pharmacology
Apoptosis/*drug effects
Phenylpropionates/*pharmacology
Antineoplastic Agents, Phytogenic/isolation & purification ; China ; Hep G2 Cells ; Humans ; Molecular Structure ; Phenylpropionates/isolation & purification ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Plant Roots/chemistry
Czasopismo naukowe
Tytuł :
Phenylpropanoids from the fruit of Crataegus pinnatifida exhibit cytotoxicity on hepatic carcinoma cells through apoptosis induction.
Autorzy :
Guo R; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Lin B; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Shang XY; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Zhou L; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Yao GD; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Huang XX; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Chinese People's Liberation Army 210 Hospital, Dalian 116021, People's Republic of China. Electronic address: .
Song SJ; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address: .
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Źródło :
Fitoterapia [Fitoterapia] 2018 Jun; Vol. 127, pp. 301-307. Date of Electronic Publication: 2018 Mar 11.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Crataegus/*chemistry
Fruit/*chemistry
Propanols/*isolation & purification
Hep G2 Cells ; Humans ; Molecular Structure ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Propanols/pharmacology ; Stereoisomerism
Czasopismo naukowe
Tytuł :
Flavan enantiomers from Daphne giraldii selectively induce apoptotic cell death in p53-null hepatocarcinoma cells in vitro.
Autorzy :
Yao GD; Department of Natural Products Chemistry, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Sun Q; Department of Natural Products Chemistry, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Xiamen Institute for Food and Drug Quality Control, Xiamen 3161012, People's Republic of China.
Song XY; Department of Natural Products Chemistry, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Huang XX; Department of Natural Products Chemistry, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Chinese People's Liberation Army 210 Hospital, Dalian 116021, People's Republic of China. Electronic address: .
Song SJ; Department of Natural Products Chemistry, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2018 Jun 01; Vol. 289, pp. 1-8. Date of Electronic Publication: 2018 Apr 24.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Carcinoma, Hepatocellular/*pathology
Daphne/*chemistry
Flavonoids/*chemistry
Flavonoids/*pharmacology
Liver Neoplasms/*pathology
Tumor Suppressor Protein p53/*deficiency
Benzothiazoles/pharmacology ; Carbon-13 Magnetic Resonance Spectroscopy ; Carcinoma, Hepatocellular/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chromatography, High Pressure Liquid ; Humans ; Inhibitory Concentration 50 ; Liver Neoplasms/metabolism ; Niacinamide/analogs & derivatives ; Niacinamide/pharmacology ; Phenylurea Compounds/pharmacology ; Proton Magnetic Resonance Spectroscopy ; Reactive Oxygen Species/metabolism ; Sorafenib ; Stereoisomerism ; Toluene/analogs & derivatives ; Toluene/pharmacology ; Tumor Suppressor Protein p53/metabolism ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Synthesis, anionophoric activity and apoptosis-inducing bioactivity of benzimidazolyl-based transmembrane anion transporters.
Autorzy :
Yu XH; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, PR China.
Peng CC; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, PR China.
Sun XX; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, PR China.
Chen WH; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, PR China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2018 May 25; Vol. 152, pp. 115-125. Date of Electronic Publication: 2018 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Anion Transport Proteins/*metabolism
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Benzimidazoles/*pharmacology
Anion Transport Proteins/chemistry ; Anions/chemical synthesis ; Anions/chemistry ; Anions/pharmacology ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Benzimidazoles/chemical synthesis ; Benzimidazoles/chemistry ; Cell Line, Tumor ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Enantiomeric neolignans from Picrasma quassioides exhibit distinctive cytotoxicity on hepatic carcinoma cells through ROS generation and apoptosis induction.
Autorzy :
Lou LL; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Yao GD; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Wang J; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Zhao WY; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Wang XB; Chinese People's Liberation Army 210 Hospital, Dalian 116021, People's Republic of China.
Huang XX; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Chinese People's Liberation Army 210 Hospital, Dalian 116021, People's Republic of China. Electronic address: .
Song SJ; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 May 01; Vol. 28 (8), pp. 1263-1268. Date of Electronic Publication: 2018 Mar 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Lignans/*pharmacology
Phenols/*pharmacology
Picrasma/*chemistry
Reactive Oxygen Species/*metabolism
Antineoplastic Agents/chemistry ; Antineoplastic Agents/isolation & purification ; Cell Line, Tumor ; Humans ; Lignans/chemistry ; Lignans/isolation & purification ; Phenols/chemistry ; Phenols/isolation & purification ; Plant Stems/chemistry ; Stereoisomerism
Czasopismo naukowe
Tytuł :
A systems pharmacology-oriented discovery of a new therapeutic use of the TCM formula Liuweiwuling for liver failure.
Autorzy :
Wang JB; China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing, PR China.
Cui HR; China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing, PR China.; Traditional Chinese Medicine College, Beijing University of Traditional Chinese Medicine, Beijing, PR China.
Wang RL; China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing, PR China.; Integrative Medicine Center, 302 Military Hospital, Beijing, PR China.
Zhang CE; China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing, PR China.; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, PR China.
Niu M; China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing, PR China. .
Bai ZF; China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing, PR China. .
Xu GH; China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing, PR China.
Li PY; China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing, PR China.
Jiang WY; China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing, PR China.
Han JJ; China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing, PR China.
Ma X; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, PR China.
Cai GM; China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing, PR China.
Li RS; Research Center for Clinical and Translational Medicine, 302 Hospital of PLA, Beijing, PR China.
Zhang LP; Traditional Chinese Medicine College, Beijing University of Traditional Chinese Medicine, Beijing, PR China.
Xiao XH; China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing, PR China. .; Integrative Medicine Center, 302 Military Hospital, Beijing, PR China. .
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Źródło :
Scientific reports [Sci Rep] 2018 Apr 04; Vol. 8 (1), pp. 5645. Date of Electronic Publication: 2018 Apr 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Databases, Factual*
Gene Regulatory Networks*
Apoptosis/*drug effects
Drugs, Chinese Herbal/*pharmacology
Liver Failure/*classification
Liver Failure/*drug therapy
Systems Biology/*methods
Animals ; Drug Discovery ; Galactosamine/toxicity ; Lipopolysaccharides/toxicity ; Liver Failure/chemically induced ; Liver Failure/genetics ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Signal Transduction
Czasopismo naukowe
Tytuł :
1,3-Diphenylpropanes from Daphne giraldii induced apoptosis in hepatocellular carcinoma cells through nuclear factor kappa-B inhibition.
Autorzy :
Yao GD; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Sun Q; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Xiamen Institute for Food and Drug Quality Control, Xiamen 3161012, People's Republic of China.
Song XY; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Huang XX; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Chinese People's Liberation Army 210 Hospital, Dalian 116021, People's Republic of China.
Zhang Y; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address: .
Song SJ; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2018 Apr; Vol. 77, pp. 619-624. Date of Electronic Publication: 2018 Feb 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Apoptosis/*drug effects
Carcinoma, Hepatocellular/*drug therapy
Daphne/*chemistry
Liver Neoplasms/*drug therapy
NF-kappa B/*antagonists & inhibitors
Propane/*analogs & derivatives
Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Hep G2 Cells ; Humans ; Liver Neoplasms/pathology ; Molecular Structure ; NF-kappa B/metabolism ; Propane/chemistry ; Propane/isolation & purification ; Propane/pharmacology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
[Effect of dexmedetomidine on apoptosis and CHOP in hypoxia/reoxygenation injury A549 cell].
Autorzy :
Luo ZY; Ischemia/Reperfusion Injury Research Institute of Wenzhou Medical University, Wenzhou 325035.; Pathology Department of Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan 430015, China.
Gao H; Ischemia/Reperfusion Injury Research Institute of Wenzhou Medical University, Wenzhou 325035.
Xiang BQ; Ischemia/Reperfusion Injury Research Institute of Wenzhou Medical University, Wenzhou 325035.
Qiu XX; Ischemia/Reperfusion Injury Research Institute of Wenzhou Medical University, Wenzhou 325035.
Dai YY; Ischemia/Reperfusion Injury Research Institute of Wenzhou Medical University, Wenzhou 325035.
Wang WT; Ischemia/Reperfusion Injury Research Institute of Wenzhou Medical University, Wenzhou 325035.
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Źródło :
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology [Zhongguo Ying Yong Sheng Li Xue Za Zhi] 2018 Feb 08; Vol. 34 (2), pp. 137-142.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Dexmedetomidine/*pharmacology
Transcription Factor CHOP/*physiology
A549 Cells ; Cell Hypoxia ; Humans
Czasopismo naukowe
Tytuł :
Coumarins from the bark of Juglans mandshurica exhibited anti-hepatoma activities via inducing apoptosis.
Autorzy :
Yao GD; a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.; b Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
Cheng ZY; a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.; b Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
Shang XY; a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.; b Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
Gao PY; c College of Pharmaceutical and Biological Engineering , Shenyang University of Chemical Technology , Shenyang 110142 , China.
Huang XX; a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.; b Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
Song SJ; a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.; b Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
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Źródło :
Journal of Asian natural products research [J Asian Nat Prod Res] 2017 Nov; Vol. 19 (11), pp. 1134-1142. Date of Electronic Publication: 2017 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*isolation & purification
Antineoplastic Agents, Phytogenic/*pharmacology
Apoptosis/*drug effects
Carcinoma, Hepatocellular/*drug therapy
Coumarins/*isolation & purification
Coumarins/*pharmacology
Drugs, Chinese Herbal/*isolation & purification
Drugs, Chinese Herbal/*pharmacology
Juglans/*chemistry
Antineoplastic Agents, Phytogenic/chemistry ; Carcinoma, Hepatocellular/metabolism ; Cell Proliferation/drug effects ; Coumarins/chemistry ; Drugs, Chinese Herbal/chemistry ; Hep G2 Cells ; Humans ; Liver Neoplasms/metabolism ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Plant Bark/chemistry
Czasopismo naukowe
Tytuł :
[Effects of dexmedetomidine on hypoxia/reoxygenation injury-induced cell apoptosis and caspase-12 expression in A549 cells].
Autorzy :
Luo ZY; Ischemia/Reperfusion Injury Research Institute of Wenzhou Medical University, Wenzhou 325035, China.; Pathology Department of Hubei Provincial Hospital of Integrated Chinese & Western Medicine, Wuhan 430015, China.
Xiang BQ; Ischemia/Reperfusion Injury Research Institute of Wenzhou Medical University, Wenzhou 325035, China.
Gao H; Ischemia/Reperfusion Injury Research Institute of Wenzhou Medical University, Wenzhou 325035, China.
Qiu XX; Ischemia/Reperfusion Injury Research Institute of Wenzhou Medical University, Wenzhou 325035, China.
Hao ML; Ischemia/Reperfusion Injury Research Institute of Wenzhou Medical University, Wenzhou 325035, China. .
Wang WT; Ischemia/Reperfusion Injury Research Institute of Wenzhou Medical University, Wenzhou 325035, China. .
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Źródło :
Sheng li xue bao : [Acta physiologica Sinica] [Sheng Li Xue Bao] 2017 Aug 25; Vol. 69 (4), pp. 437-444.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Caspase 12/*metabolism
Dexmedetomidine/*pharmacology
A549 Cells ; Caspase 3/metabolism ; Cell Hypoxia ; Cell Line ; Cell Survival ; Cytoprotection ; Heat-Shock Proteins/metabolism ; Humans ; In Situ Nick-End Labeling ; Protective Agents/pharmacology
Czasopismo naukowe
Tytuł :
Autophagy antagonizes apoptosis induced by flavan enantiomers from Daphne giraldii in hepatic carcinoma cells in vitro.
Autorzy :
Sun Q; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Yao GD; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Song XY; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Qi XL; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Xi YF; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Li LZ; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Huang XX; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Chinese People's Liberation Army 210 Hospital, Dalian 116021, People's Republic of China. Electronic address: .
Song SJ; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2017 Jun 16; Vol. 133, pp. 1-10. Date of Electronic Publication: 2017 Mar 30.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*chemistry
Antineoplastic Agents, Phytogenic/*pharmacology
Apoptosis/*drug effects
Autophagy/*drug effects
Daphne/*chemistry
Flavonoids/*chemistry
Flavonoids/*pharmacology
Liver Neoplasms/*drug therapy
AMP-Activated Protein Kinases/metabolism ; Cell Line, Tumor ; Humans ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Phosphorylation/drug effects ; Prenylation ; Stereoisomerism
Czasopismo naukowe

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