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Wyświetlanie 1-20 z 250
Tytuł:
Tacrolimus Protects Podocytes from Apoptosis via Downregulation of TRPC6 in Diabetic Nephropathy.
Autorzy:
Ma R; Department of Nephrology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Wang Y; Department of Nephrology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Xu Y; Department of Nephrology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Wang R; Department of Intensive Care Unit, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Wang X; Department of Nephrology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Yu N; Department of Ultrasound, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Li M; Department of Emergency, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Zhou Y; Department of Nephrology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
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Źródło:
Journal of diabetes research [J Diabetes Res] 2021 May 20; Vol. 2021, pp. 8832114. Date of Electronic Publication: 2021 May 20 (Print Publication: 2021).
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Diabetic Nephropathies/*drug therapy
Podocytes/*drug effects
TRPC Cation Channels/*metabolism
TRPC6 Cation Channel/*metabolism
Tacrolimus/*pharmacology
Animals ; Apoptosis Regulatory Proteins/metabolism ; Cell Line ; Diabetic Nephropathies/genetics ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/pathology ; Disease Models, Animal ; Down-Regulation ; Male ; Mice ; Podocytes/metabolism ; Podocytes/ultrastructure ; Rats, Wistar ; Signal Transduction ; TRPC Cation Channels/genetics ; TRPC6 Cation Channel/genetics ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Nicotiflorin attenuates cell apoptosis in renal ischemia-reperfusion injury through activating transcription factor 3.
Autorzy:
Wang L; Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Li C; Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.; Division of Nephrology, Department of Medicine IV, Hospital of the Ludwig Maximilian University of Munich, Munich, Germany.
Guan C; Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Zhang Y; Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Yang C; Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Zhao L; Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Luan H; Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Zhou B; Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Che L; Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Wang Y; Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Zhang W; Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Zhang H; Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Man X; Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Jiang W; Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Xu Y; Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
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Źródło:
Nephrology (Carlton, Vic.) [Nephrology (Carlton)] 2021 Apr; Vol. 26 (4), pp. 358-368. Date of Electronic Publication: 2021 Feb 25.
Typ publikacji:
Journal Article
MeSH Terms:
Activating Transcription Factor 3/*drug effects
Activating Transcription Factor 3/*physiology
Apoptosis/*drug effects
Flavonoids/*pharmacology
Flavonoids/*therapeutic use
Kidney/*blood supply
Phenols/*pharmacology
Phenols/*therapeutic use
Reperfusion Injury/*drug therapy
Animals ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Inhibition of deubiquitination by PR-619 induces apoptosis and autophagy via ubi-protein aggregation-activated ER stress in oesophageal squamous cell carcinoma.
Autorzy:
Wang L; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Li M; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Sha B; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Hu X; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Sun Y; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Zhu M; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Xu Y; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Li P; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Wang Y; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Guo Y; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Li J; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Shi J; Precision Medicine Center, Henan Institute of Medical and Pharmaceutical Sciences & BGI College, Zhengzhou University, Zhengzhou, China.
Li P; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Hu T; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Chen P; Academy of Medical Sciences, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.; Henan Key Laboratory of Precision Clinical Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
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Źródło:
Cell proliferation [Cell Prolif] 2021 Jan; Vol. 54 (1), pp. e12919. Date of Electronic Publication: 2020 Oct 31.
Typ publikacji:
Journal Article
MeSH Terms:
Aminopyridines/*pharmacology
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Autophagy/*drug effects
Endoplasmic Reticulum Stress/*drug effects
Esophageal Neoplasms/*drug therapy
Esophageal Squamous Cell Carcinoma/*drug therapy
Thiocyanates/*pharmacology
Ubiquitination/*drug effects
Cell Cycle/drug effects ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Esophageal Neoplasms/metabolism ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma/metabolism ; Esophageal Squamous Cell Carcinoma/pathology ; Humans ; Protein Aggregates/drug effects ; Tumor Cells, Cultured ; Ubiquitin/antagonists & inhibitors ; Ubiquitin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tamoxifen promotes apoptosis and inhibits invasion in estrogen‑positive breast cancer MCF‑7 cells.
Autorzy:
Li W; Department of General Surgery, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215123, P.R. China.
Shi X; Department of General Surgery, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215123, P.R. China.
Xu Y; Department of General Surgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215123, P.R. China.
Wan J; Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiation Medicine, Jiangsu Higher Education Institutions, Suzhou, Jiangsu 215123, P.R. China.
Wei S; Department of General Surgery, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215123, P.R. China.
Zhu R; Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiation Medicine, Jiangsu Higher Education Institutions, Suzhou, Jiangsu 215123, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2017 Jul; Vol. 16 (1), pp. 478-484. Date of Electronic Publication: 2017 May 18.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents, Hormonal/*pharmacology
Apoptosis/*drug effects
Tamoxifen/*pharmacology
Adenosine Triphosphate/metabolism ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Survival/drug effects ; Humans ; MCF-7 Cells ; Reactive Oxygen Species/metabolism ; Receptors, Estrogen/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
ABCG1 rs57137919G>a polymorphism is functionally associated with varying gene expression and apoptosis of macrophages.
Autorzy:
Liu F; Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wang W; Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xu Y; Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wang Y; Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chen LF; Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Fang Q; Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yan XW; Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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Źródło:
PloS one [PLoS One] 2014 Jun 27; Vol. 9 (6), pp. e97044. Date of Electronic Publication: 2014 Jun 27 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*
Polymorphism, Single Nucleotide*
ATP-Binding Cassette Transporters/*genetics
Atherosclerosis/*genetics
Macrophages/*metabolism
ATP Binding Cassette Transporter, Subfamily G, Member 1 ; ATP-Binding Cassette Transporters/metabolism ; Adolescent ; Adult ; Animals ; BH3 Interacting Domain Death Agonist Protein/genetics ; BH3 Interacting Domain Death Agonist Protein/metabolism ; CHO Cells ; Cell Line, Tumor ; Cholesterol/pharmacology ; Cricetinae ; Cricetulus ; Female ; HEK293 Cells ; Hep G2 Cells ; Humans ; Macrophages/drug effects ; Male ; Middle Aged ; Promoter Regions, Genetic ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Klotho suppresses cardiomyocyte apoptosis in mice with stress-induced cardiac injury via downregulation of endoplasmic reticulum stress.
Autorzy:
Song S; Department of Geriatrics, Southwest Hospital, Third Military Medical University, Chongqing, China.
Gao P
Xiao H
Xu Y
Si LY
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Źródło:
PloS one [PLoS One] 2013 Dec 10; Vol. 8 (12), pp. e82968. Date of Electronic Publication: 2013 Dec 10 (Print Publication: 2013).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*
Endoplasmic Reticulum Stress*
Gene Expression Regulation*
Glucuronidase/*metabolism
Myocardium/*pathology
Myocytes, Cardiac/*cytology
Animals ; Anthracenes/chemistry ; Cells, Cultured ; Imidazoles/chemistry ; Isoproterenol/chemistry ; Klotho Proteins ; Male ; Mice ; Mice, Inbred BALB C ; Myocardium/metabolism ; Myocytes, Cardiac/pathology ; Protein Kinase Inhibitors/chemistry ; Pyridines/chemistry ; Reactive Oxygen Species ; Recombinant Proteins/metabolism ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Effect of carvedilol on cardiomyocyte apoptosis in a rat model of myocardial infarction: a role for toll-like receptor 4.
Autorzy:
Liu Q; Department of Cardiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China.
Zhang J
Xu Y
Huang Y
Wu C
Pokaż więcej
Źródło:
Indian journal of pharmacology [Indian J Pharmacol] 2013 Sep-Oct; Vol. 45 (5), pp. 458-63.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Disease Models, Animal*
Adrenergic beta-Antagonists/*pharmacology
Apoptosis/*drug effects
Carbazoles/*pharmacology
Myocardial Infarction/*pathology
Myocytes, Cardiac/*drug effects
Propanolamines/*pharmacology
Toll-Like Receptor 4/*physiology
Animals ; Carvedilol ; In Situ Nick-End Labeling ; Myocardial Infarction/physiopathology ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Gastric cancer cell supernatant causes apoptosis and fibrosis in the peritoneal tissues and results in an environment favorable to peritoneal metastases, in vitro and in vivo.
Autorzy:
Na D; Department of Oncology, The First Affiliated Hospital, China Medical University, Shenyang, 110001, Liaoning Province, China.
Lv ZD
Liu FN
Xu Y
Jiang CG
Sun Z
Miao ZF
Li F
Xu HM
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Źródło:
BMC gastroenterology [BMC Gastroenterol] 2012 Apr 20; Vol. 12, pp. 34. Date of Electronic Publication: 2012 Apr 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis/*drug effects
Culture Media, Conditioned/*pharmacology
Peritoneal Neoplasms/*secondary
Peritoneum/*drug effects
Peritoneum/*pathology
Stomach Neoplasms/*metabolism
Animals ; Caspase 3/metabolism ; Caspase 8/metabolism ; Cell Line ; Cell Line, Tumor ; Culture Media, Conditioned/metabolism ; Fibrosis ; Humans ; In Vitro Techniques ; Male ; Mice ; Mice, Inbred C57BL ; Models, Animal ; Peritoneum/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Time Factors ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Ectopically expressed perforin-1 is proapoptotic in tumor cell lines by increasing caspase-3 activity and the nuclear translocation of cytochrome C.
Autorzy:
Wang LF; State Key Laboratory of Cancer Biology, Departments of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fourth Military Medical University, Xi'an, China.
Wang F
Li JT
Wen WH
Zhao J
Jia LT
Meng YL
Cao YX
Yao LB
Chen SY
Xu YM
Yang AG
Pokaż więcej
Źródło:
PloS one [PLoS One] 2012; Vol. 7 (7), pp. e40639. Date of Electronic Publication: 2012 Jul 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis/*physiology
Caspase 3/*metabolism
Cytochromes c/*metabolism
Perforin/*metabolism
Apoptosis/genetics ; Apoptosis Inducing Factor/metabolism ; Cell Cycle/drug effects ; Cell Cycle/genetics ; Cell Line, Tumor ; Fluorescent Antibody Technique ; HeLa Cells ; Hep G2 Cells ; Humans ; In Situ Nick-End Labeling ; Perforin/genetics ; Phosphatidylserines/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Bone marrow stromal cells protect myeloma cells from bortezomib induced apoptosis by suppressing microRNA-15a expression.
Autorzy:
Hao M; State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Zhang L
An G
Meng H
Han Y
Xie Z
Xu Y
Li C
Yu Z
Chang H
Qiu L
Pokaż więcej
Źródło:
Leukemia & lymphoma [Leuk Lymphoma] 2011 Sep; Vol. 52 (9), pp. 1787-94. Date of Electronic Publication: 2011 May 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis/*drug effects
Bone Marrow Cells/*metabolism
Boronic Acids/*pharmacology
MicroRNAs/*genetics
Multiple Myeloma/*genetics
Multiple Myeloma/*metabolism
Pyrazines/*pharmacology
Bortezomib ; Cell Cycle/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Gene Expression Regulation, Leukemic ; Humans ; Stromal Cells/metabolism ; Tumor Microenvironment ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis.
Autorzy:
Li S; The Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, China.
Wang B
Xu Y
Zhang J
Pokaż więcej
Źródło:
Molecular cancer [Mol Cancer] 2011 Feb 12; Vol. 10, pp. 18. Date of Electronic Publication: 2011 Feb 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis/*drug effects
Histone Deacetylase Inhibitors/*pharmacology
Histone Deacetylases/*metabolism
Hydroxamic Acids/*pharmacology
Multienzyme Complexes/*metabolism
Phosphodiesterase I/*metabolism
Pyrophosphatases/*metabolism
Acetylation/drug effects ; Anilides/pharmacology ; Cell Line, Tumor ; Cytoprotection/drug effects ; Down-Regulation ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Knockdown Techniques ; Humans ; Lysophospholipids/metabolism ; Lysophospholipids/pharmacology ; Multienzyme Complexes/genetics ; Organophosphonates/pharmacology ; Phosphodiesterase I/genetics ; Phosphoric Diester Hydrolases/metabolism ; Promoter Regions, Genetic/genetics ; Pyrophosphatases/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Lysophosphatidic Acid/metabolism ; Signal Transduction/drug effects ; Up-Regulation/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Identification of PANoptosis-related signature reveals immune infiltration characteristics and immunotherapy responses for renal cell carcinoma.
Autorzy:
Xu, Yan (AUTHOR)
Hua, Jingqi (AUTHOR)
Que, Hongliang (AUTHOR)
Zeng, Tengyue (AUTHOR)
Li, Quan (AUTHOR)
Deng, Junpeng (AUTHOR)
Xie, Jianjun (AUTHOR)
Pokaż więcej
Źródło:
BMC Cancer. 3/4/2024, Vol. 24 Issue 1, p1-13. 13p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 250

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