Autor: "Xu Qikai" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
Autorzy:: Kang C; Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.
Xu Q; Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.
Martin TD; Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.
Li MZ; Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.
Demaria M; Buck Institute for Research on Aging, Novato, CA 94945, USA.
Aron L; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Lu T; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Yankner BA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Campisi J; Buck Institute for Research on Aging, Novato, CA 94945, USA.
Elledge SJ; Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA. .; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2015 Sep 25; Vol. 349 (6255), pp. aaa5612.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: DNA Damage*
Aging/*genetics
Autophagy/*genetics
Cellular Senescence/*genetics
GATA4 Transcription Factor/*metabolism
Inflammation/*genetics
Adaptor Proteins, Signal Transducing ; Aging/metabolism ; Animals ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Brain/metabolism ; Cell Cycle/genetics ; Cells, Cultured ; Cyclin-Dependent Kinase Inhibitor p16 ; Fibroblasts ; GATA4 Transcription Factor/genetics ; Gene Expression Profiling ; Humans ; Interleukin-1alpha/genetics ; Interleukin-1alpha/metabolism ; Mice ; Mice, Inbred C57BL ; MicroRNAs/genetics ; MicroRNAs/metabolism ; NF-kappa B/metabolism ; Phenotype ; Promoter Regions, Genetic ; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins/genetics ; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins/metabolism ; Tumor Suppressor Protein p53/metabolism

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Skocz do pozycji: 2.

Tytuł:: Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome.
Autorzy:: Xu GJ; Program in Biophysics, Harvard University, Cambridge, MA 02115, USA. Harvard-Massachusetts Institute of Technology (MIT) Division of Health Sciences and Technology, Cambridge, MA 02139, USA. Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA. Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA.
Kula T; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA. Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA. Program in Biological and Biomedical Sciences, Harvard University, Cambridge, MA 02115, USA.
Xu Q; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA. Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA.
Li MZ; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA. Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA.
Vernon SD; Solve ME/CFS Initiative, Los Angeles, CA 90036, USA.
Ndung'u T; KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, Durban, South Africa. Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University, Cambridge, MA 02139, USA. Max Planck Institute for Infection Biology, Chariteplatz, D-10117 Berlin, Germany.
Ruxrungtham K; Vaccine and Cellular Immunology Laboratory, Department of Medicine, Faculty of Medicine; and Chula-Vaccine Research Center, Chulalongkorn University, Bangkok, Thailand.
Sanchez J; Asociación Civil IMPACTA Salud y Educación, Lima, Peru.
Brander C; AIDS Research Institute-IrsiCaixa and AIDS Unit, Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
Chung RT; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.
O'Connor KC; Department of Neurology, Yale School of Medicine, New Haven, CT 06520, USA.
Walker B; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, Durban, South Africa. Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University, Cambridge, MA 02139, USA.
Larman HB; Division of Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.
Elledge SJ; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA. Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA. Solve ME/CFS Initiative, Los Angeles, CA 90036, USA. .; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2015 Jun 05; Vol. 348 (6239), pp. aaa0698.
Typ publikacji:: Evaluation Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Antibodies, Viral/*blood
Epitopes, B-Lymphocyte/*immunology
Host-Pathogen Interactions/*immunology
Immune System/*virology
Virus Diseases/*diagnosis
Viruses/*immunology
Epitopes, B-Lymphocyte/genetics ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Immunoprecipitation/methods ; Peptide Library ; Serologic Tests ; Virus Diseases/blood ; Virus Diseases/immunology