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Wyświetlanie 1-12 z 12
Tytuł :
Mitotic slippage is determined by p31 and the weakening of the spindle-assembly checkpoint.
Autorzy :
Lok TM; Division of Life Science, Center for Cancer Research, and State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong.
Wang Y; Division of Life Science, Center for Cancer Research, and State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong.
Xu WK; Division of Life Science, Center for Cancer Research, and State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong.; Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, USA.
Xie S; Division of Life Science, Center for Cancer Research, and State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong.
Ma HT; Division of Life Science, Center for Cancer Research, and State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong.
Poon RYC; Division of Life Science, Center for Cancer Research, and State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong. .
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Źródło :
Oncogene [Oncogene] 2020 Mar; Vol. 39 (13), pp. 2819-2834. Date of Electronic Publication: 2020 Feb 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Imbalance of the spindle-assembly checkpoint promotes spindle poison-mediated cytotoxicity with distinct kinetics.
Autorzy :
Zeng X; Division of Life Science, Center for Cancer Research, and State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong.; Department of Oncology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xu WK; Division of Life Science, Center for Cancer Research, and State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong.; Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, USA.
Lok TM; Division of Life Science, Center for Cancer Research, and State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong.
Ma HT; Division of Life Science, Center for Cancer Research, and State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong.
Poon RYC; Division of Life Science, Center for Cancer Research, and State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong. .
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Źródło :
Cell death & disease [Cell Death Dis] 2019 Apr 05; Vol. 10 (4), pp. 314. Date of Electronic Publication: 2019 Apr 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Death*/genetics
Chromosome Segregation*/drug effects
M Phase Cell Cycle Checkpoints*/drug effects
M Phase Cell Cycle Checkpoints*/genetics
M Phase Cell Cycle Checkpoints*/physiology
Mitosis*/drug effects
Mitosis*/genetics
Mitosis*/physiology
ATPases Associated with Diverse Cellular Activities/*metabolism
Cell Cycle Proteins/*metabolism
Spindle Apparatus/*metabolism
ATPases Associated with Diverse Cellular Activities/genetics ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/genetics ; HCT116 Cells ; HeLa Cells ; Humans ; Kinetics ; Micronuclei, Chromosome-Defective/drug effects ; Poisons/metabolism ; Protein-Serine-Threonine Kinases/antagonists & inhibitors ; Protein-Serine-Threonine Kinases/metabolism ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/metabolism ; Spindle Apparatus/genetics
Czasopismo naukowe
Tytuł :
Astragaloside IV downregulates the expression of MDR1 in Bel‑7402/FU human hepatic cancer cells by inhibiting the JNK/c‑Jun/AP‑1 signaling pathway.
Autorzy :
Wang PP; Department of Pharmacy, Yijishan Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
Luan JJ; Department of Pharmacy, Yijishan Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
Xu WK; Department of Pharmacy, Yijishan Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
Wang L; Department of Pharmacy, Yijishan Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
Xu DJ; Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
Yang CY; Department of Pharmacy, Yijishan Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
Zhu YH; Department of Pharmacy, Yijishan Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
Wang YQ; School of Pharmacy, Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2017 Sep; Vol. 16 (3), pp. 2761-2766. Date of Electronic Publication: 2017 Jul 05.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Down-Regulation/*drug effects
Drug Resistance, Neoplasm/*drug effects
Fluorouracil/*pharmacology
Liver Neoplasms/*drug therapy
Saponins/*pharmacology
Triterpenes/*pharmacology
ATP Binding Cassette Transporter, Subfamily B/genetics ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; Cell Line, Tumor ; Humans ; JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors ; JNK Mitogen-Activated Protein Kinases/metabolism ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Signal Transduction/drug effects ; Transcription Factor AP-1/antagonists & inhibitors ; Transcription Factor AP-1/metabolism
Czasopismo naukowe
Tytuł :
Minimally Invasive Transforaminal Lumbar Interbody Fusion and Unilateral Fixation for Degenerative Lumbar Disease.
Autorzy :
Wang HW; Department of Orthopaedics, Orthopaedic Hospital of Xingtai, Xingtai, China.
Hu YC; Department of Spinal Surgery, Tianjin Hospital, Tianjin, China.
Wu ZY; Department of Orthopaedics, Orthopaedic Hospital of Xingtai, Xingtai, China.
Wu HR; Department of Orthopaedics, Orthopaedic Hospital of Xingtai, Xingtai, China.
Wu CF; Department of Orthopaedics, Orthopaedic Hospital of Xingtai, Xingtai, China.
Zhang LS; Department of Orthopaedics, Orthopaedic Hospital of Xingtai, Xingtai, China.
Xu WK; Department of Orthopaedics, Orthopaedic Hospital of Xingtai, Xingtai, China.
Fan HL; Department of Orthopaedics, Orthopaedic Hospital of Xingtai, Xingtai, China.
Cai JS; Department of Orthopaedics, Orthopaedic Hospital of Xingtai, Xingtai, China.
Ma JQ; Department of Orthopedic Laboratory, Xingtai Institute of Orthopaedics, Xingtai, China.
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Źródło :
Orthopaedic surgery [Orthop Surg] 2017 Aug; Vol. 9 (3), pp. 277-283.
Typ publikacji :
Evaluation Study; Journal Article
MeSH Terms :
Intervertebral Disc Degeneration/*surgery
Lumbar Vertebrae/*surgery
Spinal Fusion/*methods
Aged ; Blood Loss, Surgical ; Bone Screws ; Bone Transplantation/methods ; Female ; Follow-Up Studies ; Humans ; Intervertebral Disc Degeneration/diagnostic imaging ; Low Back Pain/surgery ; Lumbar Vertebrae/diagnostic imaging ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Minimally Invasive Surgical Procedures/adverse effects ; Minimally Invasive Surgical Procedures/methods ; Pain Measurement/methods ; Radiography ; Retrospective Studies ; Spinal Fusion/adverse effects
Czasopismo naukowe
Tytuł :
Development and in vivo evaluation of self-microemulsion as delivery system for α-mangostin.
Autorzy :
Xu WK; Department of Pharmacy, Yijishan Hospital, Wannan Medical College, Wuhu, China.
Jiang H; Department of Pharmacy, Yijishan Hospital, Wannan Medical College, Wuhu, China.
Yang K; Department of Pharmacy, Yijishan Hospital, Wannan Medical College, Wuhu, China.
Wang YQ; Department of Pharmacy, Yijishan Hospital, Wannan Medical College, Wuhu, China.
Zhang Q; Department of Pharmacy, Yijishan Hospital, Wannan Medical College, Wuhu, China.
Zuo J; Department of Pharmacy, Yijishan Hospital, Wannan Medical College, Wuhu, China; Anhui Provincial Engineering Technology Research Center of Polysaccharides Drug, Wuhu, China. Electronic address: .
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Źródło :
The Kaohsiung journal of medical sciences [Kaohsiung J Med Sci] 2017 Mar; Vol. 33 (3), pp. 116-123. Date of Electronic Publication: 2017 Jan 12.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Compounding/*methods
Drug Delivery Systems/*methods
Garcinia mangostana/*chemistry
Gastrointestinal Absorption/*physiology
Xanthones/*pharmacokinetics
Administration, Oral ; Animals ; Area Under Curve ; Biological Availability ; Chromatography, High Pressure Liquid ; Emulsions ; Factor Analysis, Statistical ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Organ Specificity ; Particle Size ; Plant Extracts/chemistry ; Rats ; Rats, Sprague-Dawley ; Solubility ; Tissue Distribution ; Xanthones/isolation & purification
Czasopismo naukowe
Tytuł :
TRIM16 suppresses the progression of prostate tumors by inhibiting the Snail signaling pathway.
Autorzy :
Qi L; Clinical College of Weifang Medical University, Weifang, Shandong 261031, P.R. China.
Lu Z; Clinical College of Weifang Medical University, Weifang, Shandong 261031, P.R. China.
Sun YH; Clinical College of Weifang Medical University, Weifang, Shandong 261031, P.R. China.
Song HT; Clinical College of Weifang Medical University, Weifang, Shandong 261031, P.R. China.
Xu WK; Clinical College of Weifang Medical University, Weifang, Shandong 261031, P.R. China.
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Źródło :
International journal of molecular medicine [Int J Mol Med] 2016 Dec; Vol. 38 (6), pp. 1734-1742. Date of Electronic Publication: 2016 Oct 17.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
DNA-Binding Proteins/*metabolism
Prostatic Neoplasms/*metabolism
Prostatic Neoplasms/*pathology
Snail Family Transcription Factors/*metabolism
Transcription Factors/*metabolism
Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; DNA-Binding Proteins/genetics ; Disease Progression ; Down-Regulation ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Prognosis ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/mortality ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Fondaparinux vs. enoxaparin in patients with non-ST elevation acute coronary syndromes (NSTE-ACS) treated with percutaneous coronary intervention and tirofiban: an exploratory study in China.
Autorzy :
Zhao XM; Department of Emergency, Henan Provincial People's Hospital and the People's Hospital of Zhengzhou University, Zhengzhou, China.
Gao CY; Department of Cardiology, Henan Provincial People's Hospital and the People's Hospital of Zhengzhou University, Zhengzhou, China.
Chu YJ; Department of Emergency, Henan Provincial People's Hospital and the People's Hospital of Zhengzhou University, Zhengzhou, China.
Yang L; Department of Emergency, Henan Provincial People's Hospital and the People's Hospital of Zhengzhou University, Zhengzhou, China.
Yang XZ; Department of Emergency, Henan Provincial People's Hospital and the People's Hospital of Zhengzhou University, Zhengzhou, China.
Xu WK; Department of Emergency, Henan Provincial People's Hospital and the People's Hospital of Zhengzhou University, Zhengzhou, China.
He WQ; Department of Emergency, Henan Provincial People's Hospital and the People's Hospital of Zhengzhou University, Zhengzhou, China.
Zhang PR; Department of Emergency, Henan Provincial People's Hospital and the People's Hospital of Zhengzhou University, Zhengzhou, China.
Liu XY; Department of Emergency, Henan Provincial People's Hospital and the People's Hospital of Zhengzhou University, Zhengzhou, China.
Tian LX; Department of Emergency, Henan Provincial People's Hospital and the People's Hospital of Zhengzhou University, Zhengzhou, China.
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Źródło :
Journal of clinical pharmacy and therapeutics [J Clin Pharm Ther] 2015 Oct; Vol. 40 (5), pp. 584-589. Date of Electronic Publication: 2015 Aug 06.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Astragaloside Ⅳ reduces the expression level of P-glycoprotein in multidrug-resistant human hepatic cancer cell lines.
Autorzy :
Wang PP; Department of Pharmacy, Yijishan Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
Xu DJ; Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
Huang C; Department of Pharmacy, Anqing Shili Hospital, Anqing, Anhui 246003, P.R. China.
Wang WP; Department of Pharmacy, Yijishan Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
Xu WK; Department of Pharmacy, Yijishan Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2014 Jun; Vol. 9 (6), pp. 2131-7. Date of Electronic Publication: 2014 Mar 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily B, Member 1/*genetics
Antineoplastic Agents, Phytogenic/*pharmacology
Drug Resistance, Neoplasm/*genetics
Drugs, Chinese Herbal/*pharmacology
Gene Expression Regulation, Neoplastic/*drug effects
Saponins/*pharmacology
Triterpenes/*pharmacology
ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Antineoplastic Agents, Phytogenic/toxicity ; Biological Transport ; Carcinoma, Hepatocellular/genetics ; Cell Line, Tumor ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/toxicity ; Fluorouracil/metabolism ; Fluorouracil/pharmacology ; Humans ; Liver Neoplasms/genetics ; Rhodamine 123/metabolism ; Saponins/toxicity ; Triterpenes/toxicity
Czasopismo naukowe
Tytuł :
[Involvement of nucleus amygdaloideus centralis, lateral hypothalamus/perifornical region and nucleus paraventricularis in insular cortex-pressor response].
Autorzy :
Gu YH; Department of Physiology, Beijing Medical University.
Xu WK
Lu YC
Wang YG
Tan L
Pokaż więcej
Źródło :
Sheng li xue bao : [Acta physiologica Sinica] [Sheng Li Xue Bao] 1997 Apr; Vol. 49 (2), pp. 221-6.
Typ publikacji :
English Abstract; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amygdala/*physiology
Cerebral Cortex/*physiology
Hypothalamus/*physiology
Paraventricular Hypothalamic Nucleus/*physiology
Substance P/*pharmacology
Animals ; Blood Pressure ; Glutamic Acid/pharmacology ; Male ; Pressoreceptors/physiology ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
[Rostral ventrolateral medulla-sympathetic vasoconstrictor nerve system mediated insular cortex-pressor response].
Autorzy :
Xu WK; Department of Physiology, Beijing Medical University.
Gu YH
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Źródło :
Sheng li xue bao : [Acta physiologica Sinica] [Sheng Li Xue Bao] 1994 Dec; Vol. 46 (6), pp. 591-6.
Typ publikacji :
English Abstract; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cerebral Cortex/*physiology
Glutamates/*pharmacology
Medulla Oblongata/*physiology
Pressoreceptors/*physiology
Sympathetic Nervous System/*physiology
Animals ; Blood Pressure ; Male ; Microinjections ; Phentolamine/pharmacology ; Propranolol/pharmacology ; Rats ; Rats, Wistar ; Vasoconstriction
Czasopismo naukowe
    Wyświetlanie 1-12 z 12

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