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Tytuł:
Investigation of Tumor Heterogeneity Using Integrated Single-Cell RNA Sequence Analysis to Focus on Genes Related to Breast Cancer-, EMT-, CSC-, and Metastasis-Related Markers in Patients with HER2-Positive Breast Cancer.
Autorzy:
Shiino S; Department of Breast Surgery, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Tokura M; Laboratory of Integrative Oncology, National Cancer Center Research Institute, Tokyo 104-0045, Japan.
Nakayama J; Laboratory of Integrative Oncology, National Cancer Center Research Institute, Tokyo 104-0045, Japan.
Yoshida M; Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Suto A; Department of Breast Surgery, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Yamamoto Y; Laboratory of Integrative Oncology, National Cancer Center Research Institute, Tokyo 104-0045, Japan.
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Źródło:
Cells [Cells] 2023 Sep 15; Vol. 12 (18). Date of Electronic Publication: 2023 Sep 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Breast Neoplasms*/genetics
Humans ; Female ; Base Sequence ; Sequence Analysis, RNA ; Single-Cell Analysis ; Staining and Labeling
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Fulvestrant with or without anti-HER2 therapy in patients in a postmenopausal hormonal state and with ER-positive HER2-positive advanced or metastatic breast cancer: A subgroup analysis of data from the Safari study (JBCRG-C06).
Autorzy:
Masuyama M; Department of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.; Department of Surgery, Breast Oncology, National Hospital Organization Osaka National Hospital, Osaka, Japan.
Masuda N; Department of Breast and Endocrine Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kawaguchi H; Department of Breast Surgery, Matsuyama Red Cross Hospital, Matsuyama, Japan.
Yamamoto Y; Department of Breast and Endocrine Surgery, Kumamoto University Hospital, Kumamoto, Japan.
Saji S; Department of Medical Oncology, Fukushima Medical University, Fukushima, Japan.
Nakayama T; Department of Breast and Endocrine Surgery, Osaka International Cancer Institute, Osaka, Japan.
Aogi K; Department of Breast Oncology, NHO Shikoku Cancer Center, Matsuyama, Japan.
Anan K; Department of Surgery, Kitakyushu Municipal Medical Center, Kitakyushu, Japan.
Ohtani S; Department of Breast Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
Sato N; Department of Breast Oncology, Niigata Cancer Center Hospital, Niigata, Japan.
Takano T; Department of Medical Oncology, Toranomon Hospital, Tokyo, Japan.
Tokunaga E; Department of Breast Oncology, NHO Kyushu Cancer Center, Fukuoka, Japan.
Nakamura S; Department of Surgery, Division of Breast Surgical Oncology, Showa University School of Medicine, Tokyo, Japan.
Hasegawa Y; Department of Breast Surgery, Hachinohe City Hospital, Hachinohe, Japan.
Hattori M; Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.
Fujisawa T; Department of Breast Oncology, Gunma Prefectural Cancer Center, Ohta, Japan.
Morita S; Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Yamaguchi M; Department of Breast Surgery, JCHO Kurume General Hospital, Kurume, Japan.
Yamashita T; Department of Breast Surgery and Oncology, Kanagawa Cancer Center, Yokohama, Japan.
Yotsumoto D; Department of Breast and Thyroid Surgery, Hakuaikai Social Medical Corporation, Sagara Hospital, Kagoshima, Japan.
Toi M; Department of Breast Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Ohno S; Breast Oncology Center, The Cancer Institute Hospital of JFCR, Tokyo, Japan.
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Źródło:
Cancer medicine [Cancer Med] 2023 Sep; Vol. 12 (17), pp. 17718-17730. Date of Electronic Publication: 2023 Aug 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Breast Neoplasms*/pathology
Humans ; Female ; Fulvestrant/therapeutic use ; Postmenopause ; Retrospective Studies ; Receptor, ErbB-2/metabolism ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
GM-CSF derived from the inflammatory microenvironment potentially enhanced PD-L1 expression on tumor-associated macrophages in human breast cancer.
Autorzy:
Yonemitsu K; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuouku, Kumamoto, 860-8556, Japan.
Pan C; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuouku, Kumamoto, 860-8556, Japan.
Fujiwara Y; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuouku, Kumamoto, 860-8556, Japan.
Miyasato Y; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuouku, Kumamoto, 860-8556, Japan.
Shiota T; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuouku, Kumamoto, 860-8556, Japan.
Yano H; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuouku, Kumamoto, 860-8556, Japan.
Hosaka S; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuouku, Kumamoto, 860-8556, Japan.
Tamada K; Department of Immunology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
Yamamoto Y; Department of Breast and Endocrine Surgery, Kumamoto University Hospital, Kumamoto, Japan.
Komohara Y; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuouku, Kumamoto, 860-8556, Japan. .; Center for Metabolic Regulation of Healthy Aging, Kumamoto University, Kumamoto, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2022 Jul 14; Vol. 12 (1), pp. 12007. Date of Electronic Publication: 2022 Jul 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Breast Neoplasms*
Granulocyte-Macrophage Colony-Stimulating Factor*
Animals ; B7-H1 Antigen ; Female ; Humans ; Ligands ; Mice ; Mice, Nude ; Tumor Microenvironment ; Tumor-Associated Macrophages
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Uncovering temperature-dependent extracellular vesicle secretion in breast cancer.
Autorzy:
Otsuka K; Division of Molecular and Cellular Medicine National Cancer Center Research Institute 5-1-1, Tsukiji Chuo-ku Tokyo Japan.; R&D Division Kewpie Corporation Sengawa Kewport 2-5-7, Sengawa-cho Chofu-shi Tokyo Japan.; Division of Molecular and Cellular Medicine Institute of Medical Science Tokyo Medical University 6-7-1, Nishishinjyuku Shinjuku-ku Tokyo Japan.
Yamamoto Y; Division of Molecular and Cellular Medicine National Cancer Center Research Institute 5-1-1, Tsukiji Chuo-ku Tokyo Japan.
Ochiya T; Division of Molecular and Cellular Medicine National Cancer Center Research Institute 5-1-1, Tsukiji Chuo-ku Tokyo Japan.; Division of Molecular and Cellular Medicine Institute of Medical Science Tokyo Medical University 6-7-1, Nishishinjyuku Shinjuku-ku Tokyo Japan.
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Źródło:
Journal of extracellular vesicles [J Extracell Vesicles] 2020 Dec; Vol. 10 (2), pp. e12049. Date of Electronic Publication: 2020 Dec 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Temperature*
Biomarkers, Tumor/*metabolism
Breast/*metabolism
Breast Neoplasms/*pathology
Extracellular Vesicles/*metabolism
Apoptosis ; Biomarkers, Tumor/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Movement ; Cell Proliferation ; Cells, Cultured ; Extracellular Vesicles/genetics ; Female ; Gene Expression Profiling ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Quercetin Inhibits Lef1 and Resensitizes Docetaxel-Resistant Breast Cancer Cells.
Autorzy:
Prieto-Vila M; Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo 104-0045, Japan.; Department of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University, Tokyo 160-0023, Japan.
Shimomura I; Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo 104-0045, Japan.
Kogure A; Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo 104-0045, Japan.; Department of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University, Tokyo 160-0023, Japan.
Usuba W; Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo 104-0045, Japan.; Department of Urology, St. Marianna University School of Medicine, Kanagawa 216-8511, Japan.
Takahashi RU; Department of Cellular and Molecular Biology, Hiroshima University, Hiroshima 734-8553, Japan.
Ochiya T; Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo 104-0045, Japan.; Department of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University, Tokyo 160-0023, Japan.
Yamamoto Y; Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo 104-0045, Japan.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2020 Jun 01; Vol. 25 (11). Date of Electronic Publication: 2020 Jun 01.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Resistance, Neoplasm*
Breast Neoplasms/*drug therapy
Docetaxel/*pharmacology
Lymphoid Enhancer-Binding Factor 1/*metabolism
Quercetin/*pharmacology
ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Caveolin 1/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Cell Survival ; Down-Regulation ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Inhibitory Concentration 50 ; MCF-7 Cells ; Neoplasm Metastasis ; Neoplasm Proteins/metabolism ; RNA, Small Interfering/metabolism ; Signal Transduction ; Transforming Growth Factor beta/metabolism ; Vimentin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Brain metastasis-related microRNAs in patients with advanced breast cancer.
Autorzy:
Sato J; Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
Shimomura A; Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
Kawauchi J; Toray Industries, Inc., Kanagawa, Japan.; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.
Matsuzaki J; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.
Yamamoto Y; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.
Takizawa S; Toray Industries, Inc., Kanagawa, Japan.; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.
Sakamoto H; Department of Biobank and Tissue Resources, Fundamental Innovative Oncology Core, National Cancer Center Research Institute, Tokyo, Japan.
Ohno M; Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan.
Narita Y; Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan.
Ochiya T; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.; Department of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.
Tamura K; Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
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Źródło:
PloS one [PLoS One] 2019 Oct 11; Vol. 14 (10), pp. e0221538. Date of Electronic Publication: 2019 Oct 11 (Print Publication: 2019).
Typ publikacji:
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Biomarkers, Tumor/*blood
Brain Neoplasms/*blood
Breast Neoplasms/*blood
MicroRNAs/*blood
RNA, Neoplasm/*blood
Adult ; Aged ; Aged, 80 and over ; Brain Neoplasms/pathology ; Brain Neoplasms/secondary ; Breast Neoplasms/pathology ; Female ; Humans ; Middle Aged ; Neoplasm Metastasis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Serum microRNA-based prediction of responsiveness to eribulin in metastatic breast cancer.
Autorzy:
Satomi-Tsushita N; Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
Shimomura A; Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.; Department of Breast Medical Oncology, National Center for Global Health and Medicine, Tokyo, Japan.
Matsuzaki J; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.
Yamamoto Y; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.
Kawauchi J; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.; Toray Industries, Inc., Kanagawa, Japan.
Takizawa S; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.; Toray Industries, Inc., Kanagawa, Japan.
Aoki Y; Dynacom Co., Ltd., Chiba, Japan.
Sakamoto H; Department of Biobank and Tissue Resources, National Cancer Center Research Institute, Tokyo, Japan.
Kato K; Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
Shimizu C; Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.; Department of Breast Medical Oncology, National Center for Global Health and Medicine, Tokyo, Japan.
Ochiya T; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.
Tamura K; Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
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Źródło:
PloS one [PLoS One] 2019 Sep 04; Vol. 14 (9), pp. e0222024. Date of Electronic Publication: 2019 Sep 04 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Breast Neoplasms/*blood
Breast Neoplasms/*pathology
Furans/*pharmacology
Ketones/*pharmacology
MicroRNAs/*blood
Adult ; Aged ; Breast Neoplasms/diagnosis ; Breast Neoplasms/drug therapy ; Female ; Furans/therapeutic use ; Humans ; Ketones/therapeutic use ; Middle Aged ; Neoplasm Metastasis ; Prognosis ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Alteration of specific cytokine expression patterns in patients with breast cancer.
Autorzy:
Kawaguchi K; Department of Breast Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan. .
Sakurai M; Human Health Sciences, Graduate School of Medicine and Faculty of Medicine, Kyoto University, Kyoto, Japan.
Yamamoto Y; Department of Disease Control and Prevention, Fujita Health University Graduate School of Health Sciences, Toyoake, Aichi, Japan.
Suzuki E; Department of Breast Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Tsuda M; Department of Breast Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kataoka TR; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Hirata M; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Nishie M; Department of Breast Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Nojiri T; Department of General Thoracic Surgery, Higashiosaka City Medical Center, Osaka, Japan.
Kumazoe M; Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
Saito K; Human Health Sciences, Graduate School of Medicine and Faculty of Medicine, Kyoto University, Kyoto, Japan.; Department of Disease Control and Prevention, Fujita Health University Graduate School of Health Sciences, Toyoake, Aichi, Japan.
Toi M; Department of Breast Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
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Źródło:
Scientific reports [Sci Rep] 2019 Feb 27; Vol. 9 (1), pp. 2924. Date of Electronic Publication: 2019 Feb 27.
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms/*immunology
Cytokines/*metabolism
Cytokines/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Models, Theoretical ; Neoplasm Metastasis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Clinical significance of plasma cell-free DNA mutations in PIK3CA, AKT1, and ESR1 gene according to treatment lines in ER-positive breast cancer.
Autorzy:
Takeshita T; Department of Breast and Endocrine surgery, Graduate School of Medical Science, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Yamamoto Y; Department of Breast and Endocrine surgery, Graduate School of Medical Science, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Yamamoto-Ibusuki M; Department of Molecular-Targeting Therapy for Breast Cancer, Kumamoto University Hospital, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Tomiguchi M; Department of Breast and Endocrine surgery, Graduate School of Medical Science, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Sueta A; Department of Breast and Endocrine surgery, Graduate School of Medical Science, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Murakami K; Department of Breast and Endocrine surgery, Graduate School of Medical Science, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Iwase H; Department of Breast and Endocrine surgery, Graduate School of Medical Science, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan. .
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Źródło:
Molecular cancer [Mol Cancer] 2018 Feb 26; Vol. 17 (1), pp. 67. Date of Electronic Publication: 2018 Feb 26.
Typ publikacji:
Letter; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell-Free Nucleic Acids*
DNA, Neoplasm*
Mutation*
Breast Neoplasms/*genetics
Class I Phosphatidylinositol 3-Kinases/*genetics
Estrogen Receptor alpha/*genetics
Proto-Oncogene Proteins c-akt/*genetics
Biomarkers, Tumor ; Breast Neoplasms/metabolism ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Female ; Humans ; Kaplan-Meier Estimate ; Prognosis
Raport
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
ESR1 and PIK3CA mutational status in serum and plasma from metastatic breast cancer patients: A comparative study.
Autorzy:
Takeshita T; Department of Breast and Endocrine Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, Japan.
Yamamoto Y; Department of Breast and Endocrine Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, Japan.
Yamamoto-Ibusuki M; Department of Molecular-Targeting Therapy for Breast Cancer, Kumamoto University Hospital, Kumamoto 860-8556, Japan.
Tomiguchi M; Department of Breast and Endocrine Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, Japan.
Sueta A; Department of Breast and Endocrine Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, Japan.
Iwase H; Department of Breast and Endocrine Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, Japan.
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Źródło:
Cancer biomarkers : section A of Disease markers [Cancer Biomark] 2018; Vol. 22 (2), pp. 345-350.
Typ publikacji:
Journal Article
MeSH Terms:
Biomarkers, Tumor*
Circulating Tumor DNA*
Mutation*
Breast Neoplasms/*genetics
Class I Phosphatidylinositol 3-Kinases/*genetics
Estrogen Receptor alpha/*genetics
Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms/blood ; Breast Neoplasms/diagnosis ; Breast Neoplasms/therapy ; Class I Phosphatidylinositol 3-Kinases/blood ; Combined Modality Therapy ; Estrogen Receptor alpha/blood ; Female ; Humans ; Middle Aged ; Neoplasm Grading ; Neoplasm Metastasis ; Neoplasm Staging ; Receptors, Estrogen
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Prevalence of ESR1 E380Q mutation in tumor tissue and plasma from Japanese breast cancer patients.
Autorzy:
Takeshita T; Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto City, 860-8556, Japan.
Yamamoto Y; Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto City, 860-8556, Japan.
Yamamoto-Ibusuki M; Department of Molecular-Targeting Therapy for Breast Cancer, Kumamoto University Hospital, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Sueta A; Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto City, 860-8556, Japan.
Tomiguchi M; Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto City, 860-8556, Japan.
Murakami K; Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto City, 860-8556, Japan.
Omoto Y; Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto City, 860-8556, Japan.; Department of Endocrinological and Breast Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji Agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan.
Iwase H; Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto City, 860-8556, Japan. .
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Źródło:
BMC cancer [BMC Cancer] 2017 Nov 22; Vol. 17 (1), pp. 786. Date of Electronic Publication: 2017 Nov 22.
Typ publikacji:
Journal Article
MeSH Terms:
Mutation*
Breast Neoplasms/*blood
Breast Neoplasms/*genetics
Estrogen Receptor alpha/*genetics
Adult ; Aged ; Aged, 80 and over ; Alleles ; Amino Acid Substitution ; Biomarkers, Tumor ; Breast Neoplasms/diagnosis ; Circulating Tumor DNA ; Female ; Gene Frequency ; Humans ; Japan ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A tissue microRNA signature that predicts the prognosis of breast cancer in young women.
Autorzy:
Hironaka-Mitsuhashi A; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.; Courses of Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Matsuzaki J; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.
Takahashi RU; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.
Yoshida M; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.
Nezu Y; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.
Yamamoto Y; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.
Shiino S; Department of Breast Surgery, National Cancer Center Hospital, Tokyo, Japan.
Kinoshita T; Department of Breast Surgery, National Cancer Center Hospital, Tokyo, Japan.
Ushijima T; Courses of Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Tokyo, Japan.; Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.
Hiraoka N; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.
Shimizu C; Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
Tamura K; Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
Ochiya T; Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.
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Źródło:
PloS one [PLoS One] 2017 Nov 15; Vol. 12 (11), pp. e0187638. Date of Electronic Publication: 2017 Nov 15 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms/*pathology
MicroRNAs/*genetics
Adult ; Breast Neoplasms/genetics ; Female ; Humans ; Prognosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Quantitative diagnosis of breast tumors by morphometric classification of microenvironmental myoepithelial cells using a machine learning approach.
Autorzy:
Yamamoto Y; Department of Pathology, Shinshu University School of Medicine, Nagano, Japan.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department for Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology (IPMB) and Bioquant, University of Heidelberg, Heidelberg, Germany.; RIKEN Center for Advanced Intelligence Project, Pathology Informatics Unit, Tokyo, Japan.
Saito A; RIKEN Center for Advanced Intelligence Project, Pathology Informatics Unit, Tokyo, Japan.; Quantitative Pathology &Immunology, Tokyo Medical University, Shinjuku, Tokyo, Japan.; Department of Molecular Pathology, Tokyo Medical University, Shinjuku, Tokyo, Japan.
Tateishi A; Department of Pathology, Shinshu University School of Medicine, Nagano, Japan.
Shimojo H; Department of Pathology, Shinshu University School of Medicine, Nagano, Japan.
Kanno H; Department of Pathology, Shinshu University School of Medicine, Nagano, Japan.
Tsuchiya S; Diagnostic Pathology, Ritsuzankai Iida Hospital, Nagano, Japan.
Ito KI; Division of Breast and Endocrine Surgery, Shinshu University School of Medicine, Nagano, Japan.
Cosatto E; Department of Machine Learning, NEC Laboratories America, NJ, USA.
Graf HP; Department of Machine Learning, NEC Laboratories America, NJ, USA.
Moraleda RR; Applied Tumor Immunity Clinical Cooperation Unit, National Center for Tumor Diseases, German Cancer Research Center, Heidelberg, Germany.; Department of informatics, Technical University Federico Santa Maria Valparaiso, Chile.
Eils R; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department for Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology (IPMB) and Bioquant, University of Heidelberg, Heidelberg, Germany.
Grabe N; Department of Medical Oncology, National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany.; Hamamatsu Tissue Imaging and Analysis Center, Bioquant, University of Heidelberg, Heidelberg, Germany.
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Źródło:
Scientific reports [Sci Rep] 2017 Apr 25; Vol. 7, pp. 46732. Date of Electronic Publication: 2017 Apr 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Microenvironment*
Machine Learning*
Breast Neoplasms/*diagnosis
Carcinoma, Intraductal, Noninfiltrating/*diagnosis
Epithelial Cells/*pathology
Hyperplasia/*diagnosis
Aged ; Breast Neoplasms/metabolism ; Carcinoma, Intraductal, Noninfiltrating/metabolism ; Epithelial Cells/metabolism ; Female ; Humans ; Hyperplasia/metabolism ; Immunohistochemistry ; Support Vector Machine ; Transcription Factors/metabolism ; Tumor Suppressor Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The Clinical Significance of CD169-Positive Lymph Node Macrophage in Patients with Breast Cancer.
Autorzy:
Shiota T; Department of Cell Pathology Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Miyasato Y; Department of Cell Pathology Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Ohnishi K; Department of Cell Pathology Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Yamamoto-Ibusuki M; Department of Molecular-Targeting Therapy for Breast Cancer, Kumamoto University Hospital, Kumamoto, Japan.
Yamamoto Y; Department of Breast and Endocrine Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan.
Iwase H; Department of Breast and Endocrine Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan.
Takeya M; Department of Cell Pathology Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Komohara Y; Department of Cell Pathology Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
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Źródło:
PloS one [PLoS One] 2016 Nov 18; Vol. 11 (11), pp. e0166680. Date of Electronic Publication: 2016 Nov 18 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms/*metabolism
Breast Neoplasms/*pathology
Lymph Nodes/*metabolism
Lymph Nodes/*pathology
Macrophages/*metabolism
Sialic Acid Binding Ig-like Lectin 1/*metabolism
Adult ; Biomarkers ; Breast Neoplasms/mortality ; Breast Neoplasms/surgery ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Lymphatic Metastasis ; Macrophages/immunology ; Middle Aged ; Neoplasm Staging ; Prognosis ; Survival Analysis ; Tumor Burden ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Clinical significance of the expression of autophagy-associated marker, beclin 1, in breast cancer patients who received neoadjuvant endocrine therapy.
Autorzy:
Ueno T; Department of Breast Surgery, Kyoto University Hospital, Kyoto, Japan. .; Department of Breast Surgery, Kyorin University Hospital, 6-20-2 Shinkawa Mitaka, 181-8611, Tokyo, Japan. .
Saji S; Department of Target Therapy Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Sugimoto M; Institute for Advanced Biosciences Keio University, Yamagata, Japan.
Masuda N; National Hospital Organization Osaka National Hospital, Osaka, Japan.
Kuroi K; Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Sato N; Niigata Cancer Center Hospital, Niigata, Japan.
Takei H; Division of Breast Surgery, Saitama Cancer Center, Saitama, Japan.
Yamamoto Y; Department of Breast and Endocrine Surgery, Kumamoto University, Kumamoto, Japan.
Ohno S; National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.
Yamashita H; Breast and Endocrine Surgery, Hokkaido University Hospital, Sapporo, Japan.
Hisamatsu K; Hiroshima City Asa Hospital, Hiroshima, Japan.
Aogi K; National Hospital Organization Shikoku Cancer Center, Ehime, Japan.
Iwata H; Aichi Cancer Center Hospital, Nagoya, Japan.
Imoto S; Department of Breast Surgery, Kyorin University Hospital, 6-20-2 Shinkawa Mitaka, 181-8611, Tokyo, Japan.
Sasano H; Tohoku University School of Medicine, Sendai, Japan.
Toi M; Department of Breast Surgery, Kyoto University Hospital, Kyoto, Japan.
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Źródło:
BMC cancer [BMC Cancer] 2016 Mar 16; Vol. 16, pp. 230. Date of Electronic Publication: 2016 Mar 16.
Typ publikacji:
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neoadjuvant Therapy*
Beclin-1/*biosynthesis
Biomarkers, Tumor/*biosynthesis
Breast Neoplasms/*drug therapy
Microtubule-Associated Proteins/*biosynthesis
Aged ; Androstadienes/administration & dosage ; Apoptosis Regulatory Proteins/biosynthesis ; Apoptosis Regulatory Proteins/genetics ; Autophagy/drug effects ; Autophagy/genetics ; Beclin-1/genetics ; Biomarkers, Tumor/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Proliferation/drug effects ; Estrogen Receptor alpha/biosynthesis ; Estrogen Receptor alpha/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Microtubule-Associated Proteins/genetics ; Middle Aged ; Neoplasm Staging ; Prognosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Syringomatous adenoma of the nipple: a case report.
Autorzy:
Ishikawa S; Department of Surgery, Omihachiman Community Medical Center, 1379 Tsuchida-cho, Omihachiman City, Shiga, 523-0082, Japan. .
Sako H; Department of Surgery, Omihachiman Community Medical Center, 1379 Tsuchida-cho, Omihachiman City, Shiga, 523-0082, Japan.
Masuda K; Department of Surgery, Omihachiman Community Medical Center, 1379 Tsuchida-cho, Omihachiman City, Shiga, 523-0082, Japan.
Tanaka T; Department of Surgery, Omihachiman Community Medical Center, 1379 Tsuchida-cho, Omihachiman City, Shiga, 523-0082, Japan.
Akioka K; Department of Surgery, Omihachiman Community Medical Center, 1379 Tsuchida-cho, Omihachiman City, Shiga, 523-0082, Japan.
Yamamoto Y; Department of Pathology and Laboratory Medicine, Omihachiman Community Medical Center, 1379 Tsuchida-cho, Omihachiman City, Shiga, 523-0082, Japan.
Hosokawa Y; Department of Pathology and Laboratory Medicine, Omihachiman Community Medical Center, 1379 Tsuchida-cho, Omihachiman City, Shiga, 523-0082, Japan.
Manabe T; Research Institute, Shiga Medical Center for Adults, 5-4-30, Moriyama, Moriyama City, Shiga, 524-8524, Japan.
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Źródło:
Journal of medical case reports [J Med Case Rep] 2015 Nov 13; Vol. 9, pp. 256. Date of Electronic Publication: 2015 Nov 13.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Adenoma/*diagnosis
Breast Neoplasms/*diagnosis
Nipples/*pathology
Syringoma/*diagnosis
Adenoma/pathology ; Adult ; Breast Neoplasms/pathology ; Female ; Humans ; Neoplasm Recurrence, Local ; Prognosis ; Syringoma/pathology ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
C6ORF97-ESR1 breast cancer susceptibility locus: influence on progression and survival in breast cancer patients.
Autorzy:
Yamamoto-Ibusuki M; Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Yamamoto Y; 1] Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan [2] Department of Molecular Targeting Therapy for Breast Cancer, Graduate School of Medical Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan.
Fujiwara S; Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Sueta A; 1] Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan [2] Department of Molecular Targeting Therapy for Breast Cancer, Graduate School of Medical Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan.
Yamamoto S; Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Hayashi M; Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Tomiguchi M; Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Takeshita T; Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Iwase H; Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
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Źródło:
European journal of human genetics : EJHG [Eur J Hum Genet] 2015 Jul; Vol. 23 (7), pp. 949-56. Date of Electronic Publication: 2014 Nov 05.
Typ publikacji:
Journal Article
MeSH Terms:
Polymorphism, Single Nucleotide*
Breast Neoplasms/*genetics
Carrier Proteins/*genetics
Estrogen Receptor alpha/*genetics
Genetic Predisposition to Disease/*genetics
Adult ; Alleles ; Breast Neoplasms/metabolism ; Carrier Proteins/metabolism ; Disease Progression ; Disease-Free Survival ; Estrogen Receptor alpha/metabolism ; Female ; Gene Frequency ; Genome-Wide Association Study ; Genotype ; Humans ; Immunohistochemistry ; Linkage Disequilibrium ; Middle Aged
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
ANGPTL2 increases bone metastasis of breast cancer cells through enhancing CXCR4 signaling.
Autorzy:
Masuda T; 1] Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan [2] Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
Endo M; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
Yamamoto Y; Department of Molecular-Targeting Therapy for Breast Cancer, Kumamoto University Hospital, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
Odagiri H; 1] Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan [2] Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan [3] Institute of Resource Development and Analysis, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
Kadomatsu T; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
Nakamura T; 1] Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan [2] Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
Tanoue H; 1] Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan [2] Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
Ito H; 1] Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan [2] Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
Yugami M; 1] Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan [2] Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
Miyata K; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
Morinaga J; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
Horiguchi H; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
Motokawa I; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
Terada K; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
Morioka MS; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Manabe I; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Iwase H; Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
Mizuta H; Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
Oike Y; 1] Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan [2] Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan.
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Źródło:
Scientific reports [Sci Rep] 2015 Mar 16; Vol. 5, pp. 9170. Date of Electronic Publication: 2015 Mar 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Angiopoietins/*metabolism
Bone Neoplasms/*pathology
Breast Neoplasms/*pathology
Receptors, CXCR4/*metabolism
Angiopoietin-Like Protein 2 ; Angiopoietin-like Proteins ; Angiopoietins/antagonists & inhibitors ; Angiopoietins/genetics ; Animals ; Bone Neoplasms/genetics ; Bone Neoplasms/metabolism ; Bone Neoplasms/secondary ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Culture Techniques ; Cell Line, Tumor ; Cell Movement ; Chemokine CXCL12/metabolism ; Female ; Humans ; Matrix Metalloproteinase 13/metabolism ; Mice ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; MicroRNAs/metabolism ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Proto-Oncogene Protein c-ets-1/antagonists & inhibitors ; Proto-Oncogene Protein c-ets-1/genetics ; Proto-Oncogene Protein c-ets-1/metabolism ; Signal Transduction/genetics ; Transplantation, Heterologous
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
An integrative analysis of PIK3CA mutation, PTEN, and INPP4B expression in terms of trastuzumab efficacy in HER2-positive breast cancer.
Autorzy:
Sueta A; Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Science, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan; Department of Molecular-Targeting Therapy for Breast Cancer, Kumamoto University Hospital, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Yamamoto Y; Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Science, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan; Department of Molecular-Targeting Therapy for Breast Cancer, Kumamoto University Hospital, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Yamamoto-Ibusuki M; Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Science, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Hayashi M; Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Science, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Takeshita T; Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Science, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Yamamoto S; Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Science, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Iwase H; Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Science, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
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Źródło:
PloS one [PLoS One] 2014 Dec 26; Vol. 9 (12), pp. e116054. Date of Electronic Publication: 2014 Dec 26 (Print Publication: 2014).
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*therapeutic use
Breast/*drug effects
Breast Neoplasms/*drug therapy
PTEN Phosphohydrolase/*analysis
Phosphatidylinositol 3-Kinases/*genetics
Phosphoric Monoester Hydrolases/*analysis
Receptor, ErbB-2/*analysis
Trastuzumab/*therapeutic use
Adult ; Aged ; Breast/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Class I Phosphatidylinositol 3-Kinases ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Middle Aged ; Mutation ; PTEN Phosphohydrolase/genetics ; Phosphoric Monoester Hydrolases/genetics ; Receptor, ErbB-2/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Breast cancers with high DSS1 expression that potentially maintains BRCA2 stability have poor prognosis in the relapse-free survival.
Autorzy:
Rezano A; Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto 860-8556, Japan. .
Kuwahara K
Yamamoto-Ibusuki M
Kitabatake M
Moolthiya P
Phimsen S
Suda T
Tone S
Yamamoto Y
Iwase H
Sakaguchi N
Pokaż więcej
Źródło:
BMC cancer [BMC Cancer] 2013 Dec 01; Vol. 13, pp. 562. Date of Electronic Publication: 2013 Dec 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
BRCA2 Protein/*metabolism
Breast Neoplasms/*metabolism
Carcinoma, Ductal, Breast/*metabolism
Proteasome Endopeptidase Complex/*metabolism
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/pharmacology ; Apoptosis ; Breast Neoplasms/mortality ; Camptothecin/pharmacology ; Carcinoma, Ductal, Breast/mortality ; Cell Cycle Checkpoints ; Cell Proliferation ; Disease-Free Survival ; Drug Resistance, Neoplasm ; Female ; Gene Expression ; Gene Knockdown Techniques ; Humans ; Kaplan-Meier Estimate ; MCF-7 Cells ; Middle Aged ; Prognosis ; Proteasome Endopeptidase Complex/genetics ; Protein Stability ; RNA, Small Interfering/genetics ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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