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    Tytuł:
    Lysyl hydroxylase LH1 promotes confined migration and metastasis of cancer cells by stabilizing Septin2 to enhance actin network.
    Autorzy:
    Yang Z; Department of Biomedical Sciences, and Tung Biomedical Sciences Center, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, People's Republic of China.; Department of Precision Diagnostic and Therapeutic Technology, City University of Hong Kong Futian Research Institute, Shenzhen, Guangdong, China.
    Zhou L; Department of Biomedical Sciences, and Tung Biomedical Sciences Center, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, People's Republic of China.; Department of Gastroenterology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
    Si T; Department of Biomedical Sciences, and Tung Biomedical Sciences Center, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, People's Republic of China.; Department of Precision Diagnostic and Therapeutic Technology, City University of Hong Kong Futian Research Institute, Shenzhen, Guangdong, China.
    Chen S; Department of Gastroenterology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
    Liu C; State Key Laboratory of Chemical Biology and Drug Discovery, Research Institute for Future Food and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China.
    Ng KK; Department of Biomedical Sciences, and Tung Biomedical Sciences Center, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, People's Republic of China.; Department of Precision Diagnostic and Therapeutic Technology, City University of Hong Kong Futian Research Institute, Shenzhen, Guangdong, China.
    Wang Z; Department of Biomedical Sciences, and Tung Biomedical Sciences Center, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, People's Republic of China.; Department of Precision Diagnostic and Therapeutic Technology, City University of Hong Kong Futian Research Institute, Shenzhen, Guangdong, China.
    Chen Z; Department of Gastroenterology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
    Qiu C; Department of Gastroenterology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
    Liu G; Department of Biomedical Sciences, and Tung Biomedical Sciences Center, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, People's Republic of China.; Department of Precision Diagnostic and Therapeutic Technology, City University of Hong Kong Futian Research Institute, Shenzhen, Guangdong, China.
    Wang Q; Department of Pathology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
    Zhou X; Department of Biomedical Sciences, and Tung Biomedical Sciences Center, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, People's Republic of China.; Department of Precision Diagnostic and Therapeutic Technology, City University of Hong Kong Futian Research Institute, Shenzhen, Guangdong, China.
    Zhang L; Department of Biomedical Sciences, and Tung Biomedical Sciences Center, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, People's Republic of China.; Department of Precision Diagnostic and Therapeutic Technology, City University of Hong Kong Futian Research Institute, Shenzhen, Guangdong, China.
    Yao Z; State Key Laboratory of Chemical Biology and Drug Discovery, Research Institute for Future Food and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China.
    He S; Department of Gastroenterology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
    Yang M; Department of Biomedical Sciences, and Tung Biomedical Sciences Center, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, People's Republic of China. .; Department of Precision Diagnostic and Therapeutic Technology, City University of Hong Kong Futian Research Institute, Shenzhen, Guangdong, China. .
    Zhou Z; Department of Biomedical Sciences, and Tung Biomedical Sciences Center, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, People's Republic of China. .; Department of Gastroenterology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. .
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    Źródło:
    Molecular cancer [Mol Cancer] 2023 Jan 31; Vol. 22 (1), pp. 21. Date of Electronic Publication: 2023 Jan 31.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Carcinoma, Hepatocellular*/genetics
    Carcinoma, Pancreatic Ductal*/genetics
    Liver Neoplasms*/genetics
    Pancreatic Neoplasms*/genetics
    Animals ; Mice ; Actins ; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase/genetics ; Septins
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Establishment and Validation of an MTORC1 Signaling-Related Gene Signature to Predict Overall Survival in Patients with Hepatocellular Carcinoma.
    Autorzy:
    Yao Z; Department of Radiology Intervention, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, 310000 Zhejiang, China.
    Wen S; Department of Radiology Intervention, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, 310000 Zhejiang, China.
    Luo J; Department of Radiology Intervention, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, 310000 Zhejiang, China.
    Hao W; Department of Radiology Intervention, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, 310000 Zhejiang, China.
    Liang W; Department of Radiology Intervention, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, 310000 Zhejiang, China.
    Chen Y; Department of Radiology Intervention, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, 310000 Zhejiang, China.
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    Źródło:
    BioMed research international [Biomed Res Int] 2021 Nov 22; Vol. 2021, pp. 6299472. Date of Electronic Publication: 2021 Nov 22 (Print Publication: 2021).
    Typ publikacji:
    Journal Article; Validation Study; Retracted Publication
    MeSH Terms:
    Carcinoma, Hepatocellular/*genetics
    Liver Neoplasms/*genetics
    Mechanistic Target of Rapamycin Complex 1/*genetics
    Aged ; Biomarkers, Tumor/genetics ; Carcinoma, Hepatocellular/mortality ; Databases, Genetic ; Female ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Humans ; Kaplan-Meier Estimate ; Liver Neoplasms/mortality ; Male ; Middle Aged ; Prognosis ; Proportional Hazards Models ; Signal Transduction/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Genetic expression and mutational profile analysis in different pathologic stages of hepatocellular carcinoma patients.
    Autorzy:
    Gao X; Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China. .; Key Laboratory of Immune Microenvironment and Disease, Ministry of Education, Key Laboratory of Cellular and Molecular Immunology in Tianjin, Excellent Talent Project, Tianjin Medical University, Tianjin, China. .
    Zhao C; Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.; Key Laboratory of Immune Microenvironment and Disease, Ministry of Education, Key Laboratory of Cellular and Molecular Immunology in Tianjin, Excellent Talent Project, Tianjin Medical University, Tianjin, China.
    Zhang N; Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.; Key Laboratory of Immune Microenvironment and Disease, Ministry of Education, Key Laboratory of Cellular and Molecular Immunology in Tianjin, Excellent Talent Project, Tianjin Medical University, Tianjin, China.
    Cui X; Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.; Key Laboratory of Immune Microenvironment and Disease, Ministry of Education, Key Laboratory of Cellular and Molecular Immunology in Tianjin, Excellent Talent Project, Tianjin Medical University, Tianjin, China.; Department of Neurosurgery Ministry of Education and Tianjin Municipal Government Laboratory of Neuro-Oncology Key Laboratory of Neurotrauma, Variation, and Regeneration , Tianjin Neurological Institute Tianjin Medical University General Hospital , Tianjin, China.
    Ren Y; Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.; Key Laboratory of Immune Microenvironment and Disease, Ministry of Education, Key Laboratory of Cellular and Molecular Immunology in Tianjin, Excellent Talent Project, Tianjin Medical University, Tianjin, China.
    Su C; Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.; Key Laboratory of Immune Microenvironment and Disease, Ministry of Education, Key Laboratory of Cellular and Molecular Immunology in Tianjin, Excellent Talent Project, Tianjin Medical University, Tianjin, China.
    Wu S; Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.; Key Laboratory of Immune Microenvironment and Disease, Ministry of Education, Key Laboratory of Cellular and Molecular Immunology in Tianjin, Excellent Talent Project, Tianjin Medical University, Tianjin, China.
    Yao Z; Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.; Key Laboratory of Immune Microenvironment and Disease, Ministry of Education, Key Laboratory of Cellular and Molecular Immunology in Tianjin, Excellent Talent Project, Tianjin Medical University, Tianjin, China.
    Yang J; Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China. .; Key Laboratory of Immune Microenvironment and Disease, Ministry of Education, Key Laboratory of Cellular and Molecular Immunology in Tianjin, Excellent Talent Project, Tianjin Medical University, Tianjin, China. .
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    Źródło:
    BMC cancer [BMC Cancer] 2021 Jul 08; Vol. 21 (1), pp. 786. Date of Electronic Publication: 2021 Jul 08.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Carcinoma, Hepatocellular/*genetics
    DNA Mutational Analysis/*methods
    Gene Expression Regulation, Neoplastic/*genetics
    Liver Neoplasms/*genetics
    Animals ; Carcinoma, Hepatocellular/pathology ; China ; Disease Models, Animal ; Humans ; Liver Neoplasms/pathology ; Mice ; Neoplasm Staging
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Health care costs associated with chronic hepatitis C virus infection in Ontario, Canada: a retrospective cohort study.
    Autorzy:
    Wong WWL; School of Pharmacy (Wong), University of Waterloo, Kitchener, Ont.; Toronto Health Economics and Technology Assessment Collaborative (Wong, Haines, Bremner, Sander, Thein, Krahn), University Health Network; ICES Central (Wong, Yao, Calzavara, Kwong, Sander); Dalla Lana School of Public Health (Mitsakakis, Kwong, Sander, Thein) and Department of Family and Community Medicine (Kwong), University of Toronto; Public Health Ontario (Kwong, Sander), Toronto, Ont. .
    Haines A; School of Pharmacy (Wong), University of Waterloo, Kitchener, Ont.; Toronto Health Economics and Technology Assessment Collaborative (Wong, Haines, Bremner, Sander, Thein, Krahn), University Health Network; ICES Central (Wong, Yao, Calzavara, Kwong, Sander); Dalla Lana School of Public Health (Mitsakakis, Kwong, Sander, Thein) and Department of Family and Community Medicine (Kwong), University of Toronto; Public Health Ontario (Kwong, Sander), Toronto, Ont.
    Bremner KE; School of Pharmacy (Wong), University of Waterloo, Kitchener, Ont.; Toronto Health Economics and Technology Assessment Collaborative (Wong, Haines, Bremner, Sander, Thein, Krahn), University Health Network; ICES Central (Wong, Yao, Calzavara, Kwong, Sander); Dalla Lana School of Public Health (Mitsakakis, Kwong, Sander, Thein) and Department of Family and Community Medicine (Kwong), University of Toronto; Public Health Ontario (Kwong, Sander), Toronto, Ont.
    Yao Z; School of Pharmacy (Wong), University of Waterloo, Kitchener, Ont.; Toronto Health Economics and Technology Assessment Collaborative (Wong, Haines, Bremner, Sander, Thein, Krahn), University Health Network; ICES Central (Wong, Yao, Calzavara, Kwong, Sander); Dalla Lana School of Public Health (Mitsakakis, Kwong, Sander, Thein) and Department of Family and Community Medicine (Kwong), University of Toronto; Public Health Ontario (Kwong, Sander), Toronto, Ont.
    Calzavara A; School of Pharmacy (Wong), University of Waterloo, Kitchener, Ont.; Toronto Health Economics and Technology Assessment Collaborative (Wong, Haines, Bremner, Sander, Thein, Krahn), University Health Network; ICES Central (Wong, Yao, Calzavara, Kwong, Sander); Dalla Lana School of Public Health (Mitsakakis, Kwong, Sander, Thein) and Department of Family and Community Medicine (Kwong), University of Toronto; Public Health Ontario (Kwong, Sander), Toronto, Ont.
    Mitsakakis N; School of Pharmacy (Wong), University of Waterloo, Kitchener, Ont.; Toronto Health Economics and Technology Assessment Collaborative (Wong, Haines, Bremner, Sander, Thein, Krahn), University Health Network; ICES Central (Wong, Yao, Calzavara, Kwong, Sander); Dalla Lana School of Public Health (Mitsakakis, Kwong, Sander, Thein) and Department of Family and Community Medicine (Kwong), University of Toronto; Public Health Ontario (Kwong, Sander), Toronto, Ont.
    Kwong JC; School of Pharmacy (Wong), University of Waterloo, Kitchener, Ont.; Toronto Health Economics and Technology Assessment Collaborative (Wong, Haines, Bremner, Sander, Thein, Krahn), University Health Network; ICES Central (Wong, Yao, Calzavara, Kwong, Sander); Dalla Lana School of Public Health (Mitsakakis, Kwong, Sander, Thein) and Department of Family and Community Medicine (Kwong), University of Toronto; Public Health Ontario (Kwong, Sander), Toronto, Ont.
    Sander B; School of Pharmacy (Wong), University of Waterloo, Kitchener, Ont.; Toronto Health Economics and Technology Assessment Collaborative (Wong, Haines, Bremner, Sander, Thein, Krahn), University Health Network; ICES Central (Wong, Yao, Calzavara, Kwong, Sander); Dalla Lana School of Public Health (Mitsakakis, Kwong, Sander, Thein) and Department of Family and Community Medicine (Kwong), University of Toronto; Public Health Ontario (Kwong, Sander), Toronto, Ont.
    Thein HH; School of Pharmacy (Wong), University of Waterloo, Kitchener, Ont.; Toronto Health Economics and Technology Assessment Collaborative (Wong, Haines, Bremner, Sander, Thein, Krahn), University Health Network; ICES Central (Wong, Yao, Calzavara, Kwong, Sander); Dalla Lana School of Public Health (Mitsakakis, Kwong, Sander, Thein) and Department of Family and Community Medicine (Kwong), University of Toronto; Public Health Ontario (Kwong, Sander), Toronto, Ont.
    Krahn MD; School of Pharmacy (Wong), University of Waterloo, Kitchener, Ont.; Toronto Health Economics and Technology Assessment Collaborative (Wong, Haines, Bremner, Sander, Thein, Krahn), University Health Network; ICES Central (Wong, Yao, Calzavara, Kwong, Sander); Dalla Lana School of Public Health (Mitsakakis, Kwong, Sander, Thein) and Department of Family and Community Medicine (Kwong), University of Toronto; Public Health Ontario (Kwong, Sander), Toronto, Ont.
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    Źródło:
    CMAJ open [CMAJ Open] 2021 Mar 08; Vol. 9 (1), pp. E167-E174. Date of Electronic Publication: 2021 Mar 08 (Print Publication: 2021).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Health Care Costs*
    Carcinoma, Hepatocellular/*economics
    Hepatitis C, Chronic/*economics
    Liver Cirrhosis/*economics
    Liver Neoplasms/*economics
    Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antiviral Agents/economics ; Antiviral Agents/therapeutic use ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/therapy ; Cohort Studies ; Female ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/therapy ; Humans ; Liver Cirrhosis/etiology ; Liver Cirrhosis/therapy ; Liver Neoplasms/etiology ; Liver Neoplasms/therapy ; Liver Transplantation/economics ; Male ; Middle Aged ; Ontario ; Retrospective Studies ; Young Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Texture analysis of MR images to identify the differentiated degree in hepatocellular carcinoma: a retrospective study.
    Autorzy:
    Feng M; Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou city, Jiangsu province, 215000, P.R. China.
    Zhang M; Department of Radiology, the China-Japan Union Hospital of Jilin University, Changchun city, Jilin province, 130033, P.R. China.
    Liu Y; Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou city, Jiangsu province, 215000, P.R. China.
    Jiang N; Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou city, Jiangsu province, 215000, P.R. China.
    Meng Q; Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou city, Jiangsu province, 215000, P.R. China.
    Wang J; Department of Hepatobiliary Surgery Department, the First Affiliated Hospital of Soochow University, Suzhou city, Jiangsu province, 215000, P.R. China.
    Yao Z; Department of Pathology Department, the First Affiliated Hospital of Soochow University, Suzhou city, Jiangsu province, 215000, P.R. China.
    Gan W; Department of Pathology Department, the First Affiliated Hospital of Soochow University, Suzhou city, Jiangsu province, 215000, P.R. China.
    Dai H; Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou city, Jiangsu province, 215000, P.R. China. .; Institute of Medical Imaging, Soochow University, Suzhou city, Jiangsu province, 215000, P.R. China. .
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    Źródło:
    BMC cancer [BMC Cancer] 2020 Jun 30; Vol. 20 (1), pp. 611. Date of Electronic Publication: 2020 Jun 30.
    Typ publikacji:
    Evaluation Study; Journal Article
    MeSH Terms:
    Image Processing, Computer-Assisted*
    Carcinoma, Hepatocellular/*diagnosis
    Liver/*diagnostic imaging
    Liver Neoplasms/*diagnosis
    Magnetic Resonance Imaging/*methods
    Aged ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/surgery ; Contrast Media/administration & dosage ; Female ; Gadolinium DTPA/administration & dosage ; Hepatectomy ; Humans ; Liver/pathology ; Liver/surgery ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Male ; Middle Aged ; ROC Curve ; Retrospective Studies ; Software
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Racial disparities in alpha-fetoprotein testing and alpha-fetoprotein status associated with the diagnosis and outcome of hepatocellular carcinoma patients.
    Autorzy:
    Wu G; Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.; Clinical Medical Center for Digestive Disease of Jiangsu Province, Nanjing, Jiangsu, China.
    Wu J; National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
    Pan X; Hangzhou Key Laboratory of Inflammation and Immunoregulation, Department of Basic Medical Science, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
    Liu B; Department of General Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
    Yao Z; Department of General Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
    Guo Y; Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
    Shi X; Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.; Clinical Medical Center for Digestive Disease of Jiangsu Province, Nanjing, Jiangsu, China.
    Ding Y; Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.; Clinical Medical Center for Digestive Disease of Jiangsu Province, Nanjing, Jiangsu, China.
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    Źródło:
    Cancer medicine [Cancer Med] 2019 Nov; Vol. 8 (15), pp. 6614-6623. Date of Electronic Publication: 2019 Sep 13.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Up-Regulation*
    Carcinoma, Hepatocellular/*diagnosis
    Carcinoma, Hepatocellular/*ethnology
    Liver Neoplasms/*diagnosis
    Liver Neoplasms/*ethnology
    alpha-Fetoproteins/*metabolism
    Adult ; Aged ; Carcinoma, Hepatocellular/metabolism ; Early Detection of Cancer ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Liver Neoplasms/metabolism ; Logistic Models ; Male ; Middle Aged ; Prognosis ; SEER Program ; Survival Rate ; United States/ethnology ; Young Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Inhibition of cyclin E1 sensitizes hepatocellular carcinoma cells to regorafenib by mcl-1 suppression.
    Autorzy:
    Xu J; Hepatobilliary Surgery Department, The Third affiliated Hospital of Sun Yat-sen University, No. 600, Tianhe District, Guangzhou, Guangdong, China.
    Huang F; Anesthesiology Department, The third affiliated hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
    Yao Z; General surgery, The Third affiliated hospital of Sun Yat-sen University, No. 600, Tianhe District, Guangzhou, 510630, Guangdong, China. .
    Jia C; Cell & Gene therapy center, The Third affiliated Hospital of Sun Yat-sen Uuniversity, Guangzhou, Guangdong, China.
    Xiong Z; General surgery, The Third affiliated hospital of Sun Yat-sen University, No. 600, Tianhe District, Guangzhou, 510630, Guangdong, China.
    Liang H; General surgery, The Third affiliated hospital of Sun Yat-sen University, No. 600, Tianhe District, Guangzhou, 510630, Guangdong, China.
    Lin N; Hepatobilliary Surgery Department, The Third affiliated Hospital of Sun Yat-sen University, No. 600, Tianhe District, Guangzhou, Guangdong, China.
    Deng M; Hepatobilliary Surgery Department, The Third affiliated Hospital of Sun Yat-sen University, No. 600, Tianhe District, Guangzhou, Guangdong, China. .
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    Źródło:
    Cell communication and signaling : CCS [Cell Commun Signal] 2019 Jul 26; Vol. 17 (1), pp. 85. Date of Electronic Publication: 2019 Jul 26.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Carcinoma, Hepatocellular/*pathology
    Cyclin E/*antagonists & inhibitors
    Liver Neoplasms/*pathology
    Myeloid Cell Leukemia Sequence 1 Protein/*antagonists & inhibitors
    Oncogene Proteins/*antagonists & inhibitors
    Phenylurea Compounds/*pharmacology
    Pyridines/*pharmacology
    Animals ; Apoptosis/drug effects ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Cell Line, Tumor ; Cyclic N-Oxides ; Drug Synergism ; Flavonoids/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Indolizines ; Male ; Mice ; Myeloid Cell Leukemia Sequence 1 Protein/genetics ; Piperidines/pharmacology ; Prognosis ; Pyridinium Compounds/pharmacology ; STAT3 Transcription Factor/metabolism ; Sorafenib/pharmacology ; Xenograft Model Antitumor Assays
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    [YAP regulates the proliferation and modifies the sensitivity to sorafenib in hepatocellular carcinoma cells].
    Autorzy:
    Guo LW; Department of Interventional Therapy, Zhejiang Cancer Hospital, Hangzhou 310022, China.
    Shao GL; Department of Interventional Therapy, Zhejiang Cancer Hospital, Hangzhou 310022, China.
    Luo J; Department of Interventional Therapy, Zhejiang Cancer Hospital, Hangzhou 310022, China.
    Hao WY; Department of Interventional Therapy, Zhejiang Cancer Hospital, Hangzhou 310022, China.
    Yao Z; Department of Interventional Therapy, Zhejiang Cancer Hospital, Hangzhou 310022, China.
    Zheng JP; Department of Interventional Therapy, Zhejiang Cancer Hospital, Hangzhou 310022, China.
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    Źródło:
    Zhonghua zhong liu za zhi [Chinese journal of oncology] [Zhonghua Zhong Liu Za Zhi] 2018 Nov 23; Vol. 40 (11), pp. 818-823.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Carcinoma, Hepatocellular*/drug therapy
    Carcinoma, Hepatocellular*/metabolism
    Liver Neoplasms*/drug therapy
    Liver Neoplasms*/metabolism
    Adaptor Proteins, Signal Transducing/*metabolism
    Antineoplastic Agents/*therapeutic use
    Cell Proliferation/*drug effects
    Neoplasm Proteins/*metabolism
    Phosphoproteins/*metabolism
    Sorafenib/*therapeutic use
    Animals ; Cell Cycle Proteins ; Cell Line, Tumor ; Cell Survival ; Hep G2 Cells ; Humans ; Mice ; Mice, Nude ; Up-Regulation ; YAP-Signaling Proteins
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Preoperative diagnosis and prediction of hepatocellular carcinoma: Radiomics analysis based on multi-modal ultrasound images.
    Autorzy:
    Yao Z; Department of Electronic Engineering, Fudan University, No. 220, Handan Road, Yangpu District, Shanghai, 200433, China.
    Dong Y; Department of Ultrasound, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
    Wu G; Department of Electronic Engineering, Fudan University, No. 220, Handan Road, Yangpu District, Shanghai, 200433, China.
    Zhang Q; Department of Ultrasound, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
    Yang D; Department of Ultrasound, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
    Yu JH; Department of Electronic Engineering, Fudan University, No. 220, Handan Road, Yangpu District, Shanghai, 200433, China. .
    Wang WP; Department of Ultrasound, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. .
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    Źródło:
    BMC cancer [BMC Cancer] 2018 Nov 12; Vol. 18 (1), pp. 1089. Date of Electronic Publication: 2018 Nov 12.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Carcinoma, Hepatocellular/*diagnosis
    Liver Neoplasms/*diagnosis
    Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/surgery ; Elasticity Imaging Techniques ; Female ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/surgery ; Male ; Middle Aged ; Multimodal Imaging ; Preoperative Period ; Prognosis ; ROC Curve ; Reproducibility of Results ; Sensitivity and Specificity ; Ultrasonography/methods ; Young Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    A piperazidine derivative of 23-hydroxy betulinic acid induces a mitochondria-derived ROS burst to trigger apoptotic cell death in hepatocellular carcinoma cells.
    Autorzy:
    Yao N; College of Pharmacy, Jinan University, No.601 West Huangpu Avenue, Guangzhou, 510632, China.
    Li YJ; College of Pharmacy, Jinan University, No.601 West Huangpu Avenue, Guangzhou, 510632, China.
    Lei YH; College of Pharmacy, Jinan University, No.601 West Huangpu Avenue, Guangzhou, 510632, China.
    Hu N; College of Pharmacy, Jinan University, No.601 West Huangpu Avenue, Guangzhou, 510632, China.
    Chen WM; College of Pharmacy, Jinan University, No.601 West Huangpu Avenue, Guangzhou, 510632, China.
    Yao Z; College of Pharmacy, Jinan University, No.601 West Huangpu Avenue, Guangzhou, 510632, China.
    Yu M; College of Pharmacy, Jinan University, No.601 West Huangpu Avenue, Guangzhou, 510632, China.
    Liu JS; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
    Ye WC; College of Pharmacy, Jinan University, No.601 West Huangpu Avenue, Guangzhou, 510632, China. .
    Zhang DM; College of Pharmacy, Jinan University, No.601 West Huangpu Avenue, Guangzhou, 510632, China. .
    Pokaż więcej
    Źródło:
    Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2016 Dec 08; Vol. 35 (1), pp. 192. Date of Electronic Publication: 2016 Dec 08.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Carcinoma, Hepatocellular/*drug therapy
    Liver Neoplasms/*drug therapy
    Mitochondria/*drug effects
    Piperazines/*administration & dosage
    Reactive Oxygen Species/*metabolism
    Animals ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Hep G2 Cells ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Mice ; Mitochondria/metabolism ; Piperazines/chemistry ; Piperazines/pharmacology ; Triterpenes/chemistry ; Xenograft Model Antitumor Assays
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Laparoscopic RFA with splenectomy for hepatocellular carcinoma.
    Autorzy:
    Hu K; Department of General Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510000, China.
    Lei P; Department of Gastrointestinal Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510000, China.
    Yao Z; Department of General Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510000, China.
    Wang C; Department of General Surgery, Affiliated Hospital of Jiangnan University, Wuxi, 214000, China.
    Wang Q; Department of General Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510000, China.
    Xu S; Department of General Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510000, China.
    Xiong Z; Department of Hepatobiliary Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510000, China.
    Huang H; Department of General Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510000, China.
    Xu R; Department of Hepatobiliary Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510000, China.
    Deng M; Department of Hepatobiliary Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510000, China.
    Liu B; Department of General Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510000, China. .
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    Źródło:
    World journal of surgical oncology [World J Surg Oncol] 2016 Jul 27; Vol. 14 (1), pp. 196. Date of Electronic Publication: 2016 Jul 27.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Carcinoma, Hepatocellular/*surgery
    Catheter Ablation/*methods
    Liver Neoplasms/*surgery
    Splenectomy/*methods
    Adult ; Aged ; Blood Loss, Surgical ; Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/pathology ; Catheter Ablation/adverse effects ; Disease-Free Survival ; Esophageal and Gastric Varices/etiology ; Esophageal and Gastric Varices/surgery ; Female ; Follow-Up Studies ; Humans ; Hypersplenism/surgery ; Laparoscopy ; Length of Stay ; Ligation ; Liver Cirrhosis/complications ; Liver Neoplasms/complications ; Liver Neoplasms/pathology ; Male ; Middle Aged ; Neoplasm Invasiveness/prevention & control ; Neoplasm Recurrence, Local/pathology ; Operative Time ; Platelet Count ; Retrospective Studies ; Splenectomy/adverse effects ; Treatment Outcome
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Resistance of SMMC-7721 hepatoma cells to etoposide in hypoxia is reversed by VEGF inhibitor.
    Autorzy:
    Shi S; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China.
    Yuan C; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China.
    Zhuang K; Department of Pharmacy, Fenghua Hospital, Ningbo, Zhejiang 315040, P.R. China.
    Liang G; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China.
    Yao Z; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China.
    Wang D; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China.
    Weng Q; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China.
    Cao J; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China.
    Luo P; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China.
    Zhu H; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China.
    Ding L; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China.
    Ma S; Department of Pharmacy, Hangzhou First People's Hospital, Hangzhou, Zhejiang 310009, P.R. China.
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    Źródło:
    Molecular medicine reports [Mol Med Rep] 2015 May; Vol. 11 (5), pp. 3842-7. Date of Electronic Publication: 2015 Jan 16.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Drug Resistance, Neoplasm*
    Antineoplastic Agents/*pharmacology
    Carcinoma, Hepatocellular/*metabolism
    Etoposide/*pharmacology
    Hypoxia/*metabolism
    Liver Neoplasms/*metabolism
    Vascular Endothelial Growth Factor A/*metabolism
    Cell Cycle Checkpoints/drug effects ; Cell Hypoxia/drug effects ; Cell Line, Tumor ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; NF-kappa B/metabolism ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Vascular Endothelial Growth Factor A/antagonists & inhibitors
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Increased ARPP-19 expression is associated with hepatocellular carcinoma.
    Autorzy:
    Song H; Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. .
    Pan J; Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. .
    Liu Y; Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. .
    Wen H; Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. .
    Wang L; Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. .
    Cui J; Liver Cancer Institute of Zhongshan Hospital, Fudan University, Shanghai 200032, China. .
    Liu Y; Liver Cancer Institute of Zhongshan Hospital, Fudan University, Shanghai 200032, China. .
    Hu B; Department of Oncology and Institute of Traditional Chinese Medicine in Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. .
    Yao Z; Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1H 8M5, Canada. .
    Ji G; Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. .
    Pokaż więcej
    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2014 Dec 24; Vol. 16 (1), pp. 178-92. Date of Electronic Publication: 2014 Dec 24.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Carcinoma, Hepatocellular/*metabolism
    Liver Neoplasms/*metabolism
    Phosphoproteins/*metabolism
    Adult ; Aged ; Aged, 80 and over ; CDC2 Protein Kinase ; Case-Control Studies ; Cell Proliferation ; Cyclin-Dependent Kinases/genetics ; Cyclin-Dependent Kinases/metabolism ; Female ; Hep G2 Cells ; Humans ; Male ; Middle Aged ; Phosphoproteins/genetics ; Up-Regulation
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-14 z 14

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