Urine exosomes from healthy and hypertensive pregnancies display elevated level of α-subunit and cleaved α- and γ-subunits of the epithelial sodium channel—ENaC
The acute blood pressure-lowering effect of amiloride is independent of endothelial ENaC and eNOS in humans and mice.
Autorzy:
Ydegaard R; Department of Cardiovascular and Renal Research, Institute for Molecular Medicine, University of Southern Denmark, Odense C, Denmark. Andersen H; Department of Cardiovascular and Renal Research, Institute for Molecular Medicine, University of Southern Denmark, Odense C, Denmark. Oxlund CS; Department of Endocrinology, Odense University Hospital, Odense, Denmark. Jacobsen IA; Department of Endocrinology, Odense University Hospital, Odense, Denmark. Hansen PBL; Department of Cardiovascular and Renal Research, Institute for Molecular Medicine, University of Southern Denmark, Odense C, Denmark.; Cardiovascular and Metabolic Disease, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden. Jürgensen JF; Department of Cardiovascular and Renal Research, Institute for Molecular Medicine, University of Southern Denmark, Odense C, Denmark. Peluso AA; Department of Cardiovascular and Renal Research, Institute for Molecular Medicine, University of Southern Denmark, Odense C, Denmark. Vanhoutte PM; Department of Pharmacology and Pharmacy, Hong Kong University, China. Staehr M; Department of Cardiovascular and Renal Research, Institute for Molecular Medicine, University of Southern Denmark, Odense C, Denmark. Svenningsen P; Department of Cardiovascular and Renal Research, Institute for Molecular Medicine, University of Southern Denmark, Odense C, Denmark. Jensen BL; Department of Cardiovascular and Renal Research, Institute for Molecular Medicine, University of Southern Denmark, Odense C, Denmark.
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