- Tytuł:
-
Discovery of novel inhibitors of
Streptococcus pneumoniae based on the virtual screening with the homology-modeled structure of histidine kinase (VicK). - Autorzy:
- Źródło:
- BMC microbiology [BMC Microbiol] 2009 Jun 27; Vol. 9, pp. 129. Date of Electronic Publication: 2009 Jun 27.
- Typ publikacji:
- Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
Anti-Bacterial Agents/*pharmacology
Bacterial Proteins/*metabolism
Drug Discovery/*methods
Protein Kinase Inhibitors/*pharmacology
Protein Kinases/*metabolismStreptococcus pneumoniae /*drug effects
Amino Acid Sequence ; Animals ; Chlorocebus aethiops ; Computational Biology ; Female ; Histidine Kinase ; Male ; Mice ; Mice, Inbred BALB C ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Structure ; Protein Structure, Secondary ; Sepsis/drug therapy ; Sequence Alignment ; Signal Transduction ;Streptococcus pneumoniae /enzymology ; Vero Cells
Czasopismo naukowe