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Tytuł :
Induction of ferroptosis-like cell death of eosinophils exerts synergistic effects with glucocorticoids in allergic airway inflammation.
Autorzy :
Wu Y; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Chen H; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Xuan N; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Zhou L; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Wu Y; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Zhu C; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Li M; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Weng Q; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Shen J; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Zhang H; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Zhang B; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Lan F; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Xia L; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Xiong X; Department of Respiratory Medicine, Central Hospital of Lishui City, Lishui, Zhejiang, China.
Li Z; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Zhao Y; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Wu M; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Ying S; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Li W; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China .
Shen H; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China .; State Key Lab for Respiratory Diseases, National Clinical Research Centre for Respiratory Disease, Guangzhou, Guangdong, China.
Chen Z; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China .
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Źródło :
Thorax [Thorax] 2020 Nov; Vol. 75 (11), pp. 918-927. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ferroptosis*
Bronchial Hyperreactivity/*drug therapy
Eosinophils/*cytology
Animals ; Artesunate/pharmacology ; Benzylamines/pharmacology ; Bronchial Hyperreactivity/pathology ; Bronchoalveolar Lavage Fluid/cytology ; Dexamethasone/pharmacology ; Drug Synergism ; Eosinophils/pathology ; Glucocorticoids/pharmacology ; Humans ; Imidazoles/pharmacology ; Indoles/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Piperazines/pharmacology ; Quinazolines/pharmacology
Czasopismo naukowe
Tytuł :
Bronchial Allergen Challenge of Patients with Atopic Asthma Triggers an Alarmin (IL-33, TSLP, and IL-25) Response in the Airways Epithelium and Submucosa.
Autorzy :
Wang W; Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, People's Republic of China.
Li Y; Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, People's Republic of China.
Lv Z; Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, People's Republic of China.
Chen Y; Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, People's Republic of China.
Li Y; Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, People's Republic of China.
Huang K; Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University and Beijing Institute of Respiratory Medicine, Beijing 100020, People's Republic of China; and.
Corrigan CJ; Asthma UK Centre in Allergic Mechanisms of Asthma, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.
Ying S; Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, People's Republic of China; ying..; Asthma UK Centre in Allergic Mechanisms of Asthma, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2018 Oct 15; Vol. 201 (8), pp. 2221-2231. Date of Electronic Publication: 2018 Sep 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alarmins/*metabolism
Asthma/*immunology
Eosinophils/*immunology
Hypersensitivity, Immediate/*immunology
Neutrophils/*immunology
Respiratory Mucosa/*immunology
Administration, Inhalation ; Adult ; Airway Obstruction ; Allergens/immunology ; Asthma/diagnosis ; Bronchial Provocation Tests ; Cytokines/metabolism ; Female ; Humans ; Hypersensitivity, Immediate/diagnosis ; Immunohistochemistry ; Interleukin-17/metabolism ; Interleukin-33/metabolism ; Male ; Middle Aged ; Respiratory Mucosa/pathology ; Young Adult
Czasopismo naukowe
Tytuł :
mTOR complexes differentially orchestrates eosinophil development in allergy.
Autorzy :
Zhu C; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.
Xia L; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.
Li F; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.
Zhou L; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.
Weng Q; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.
Li Z; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.
Wu Y; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.
Mao Y; Department of Respiratory Medicine, Ningbo No. 2 Hospital, Ningbo, Zhejiang, 315010, China.
Zhang C; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.
Wu Y; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.
Li M; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.
Ying S; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.; Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China.
Chen Z; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.
Shen H; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.
Li W; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China. .
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Źródło :
Scientific reports [Sci Rep] 2018 May 02; Vol. 8 (1), pp. 6883. Date of Electronic Publication: 2018 May 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Leukopoiesis*
Eosinophils/*metabolism
Hypersensitivity/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Animals ; Cells, Cultured ; Eosinophils/cytology ; Hypersensitivity/blood ; Interleukin-5/metabolism ; MAP Kinase Signaling System ; Mice ; Mice, Inbred C57BL ; Ras Homolog Enriched in Brain Protein/metabolism
Czasopismo naukowe
Tytuł :
Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis.
Autorzy :
Zhang C; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Institute of Respiratory Diseases, Hangzhou, Zhejiang 310009, China.
Yi W; Institute of Aging Research, Leibniz Link Partner Group on Stem Cell Aging, Hangzhou Normal University School of Medicine, Hangzhou, Zhejiang 310036, China.
Li F; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Institute of Respiratory Diseases, Hangzhou, Zhejiang 310009, China.
Du X; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Institute of Respiratory Diseases, Hangzhou, Zhejiang 310009, China.
Wang H; Institute of Aging Research, Leibniz Link Partner Group on Stem Cell Aging, Hangzhou Normal University School of Medicine, Hangzhou, Zhejiang 310036, China.; Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, Guangdong 510632, China.
Wu P; National Center for Protein Science Shanghai, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201210, China.
Peng C; National Center for Protein Science Shanghai, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201210, China.
Luo M; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Institute of Respiratory Diseases, Hangzhou, Zhejiang 310009, China.
Hua W; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Institute of Respiratory Diseases, Hangzhou, Zhejiang 310009, China.
Wong CC; National Center for Protein Science Shanghai, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201210, China.
Lee JJ; Department of Biochemistry and Molecular Biology, Mayo Clinic in Arizona, Scottsdale, Arizona 85259, USA.
Li W; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Institute of Respiratory Diseases, Hangzhou, Zhejiang 310009, China.
Chen Z; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Institute of Respiratory Diseases, Hangzhou, Zhejiang 310009, China.
Ying S; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Institute of Respiratory Diseases, Hangzhou, Zhejiang 310009, China.; Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.; Stem Cell Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Ju Z; Institute of Aging Research, Leibniz Link Partner Group on Stem Cell Aging, Hangzhou Normal University School of Medicine, Hangzhou, Zhejiang 310036, China.; Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, Guangdong 510632, China.
Shen H; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Institute of Respiratory Diseases, Hangzhou, Zhejiang 310009, China.; State Key Lab of Respiratory Disease, Guangzhou, Guangdong 510120, China.
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Źródło :
Cell research [Cell Res] 2018 Mar; Vol. 28 (3), pp. 323-335. Date of Electronic Publication: 2018 Jan 12.
Typ publikacji :
Journal Article
MeSH Terms :
Homeostasis*
Chemokines, CC/*physiology
Eosinophils/*physiology
Hematopoietic Stem Cells/*physiology
Animals ; CD3 Complex/genetics ; Disease Models, Animal ; Eosinophils/metabolism ; Interleukin-5/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2.
Autorzy :
Xia LX; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Hua W; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Jin Y; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Tian BP; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Qiu ZW; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Zhang C; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Che LQ; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Zhou HB; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Wu YF; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Huang HQ; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Lan F; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Ke YH; Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Lee JJ; Division of Pulmonary Medicine and Hematology and Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale 85259, Arizona.
Li W; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Ying SM; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Chen ZH; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Shen HH; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.; The State Key Laboratory of Respiratory Diseases, Guangzhou, Guangdong 510120, China.
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Źródło :
Cell death & disease [Cell Death Dis] 2016 Apr 07; Vol. 7, pp. e2175. Date of Electronic Publication: 2016 Apr 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*/drug effects
Bone Marrow Cells/*metabolism
Eosinophils/*cytology
Protein Tyrosine Phosphatase, Non-Receptor Type 11/*metabolism
Animals ; Asthma/etiology ; Asthma/metabolism ; Asthma/veterinary ; Benzenesulfonates/toxicity ; Bone Marrow Cells/cytology ; Cells, Cultured ; Cytokines/genetics ; Cytokines/metabolism ; Disease Models, Animal ; Eosinophils/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; GATA1 Transcription Factor/genetics ; GATA1 Transcription Factor/metabolism ; Hydrazones/toxicity ; Interleukin-5/metabolism ; Interleukin-5/pharmacology ; Lung/metabolism ; Lung/pathology ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Membrane Proteins/pharmacology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Myelin Basic Protein/genetics ; Myelin Basic Protein/metabolism ; Ovalbumin/immunology ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/antagonists & inhibitors ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/genetics ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/pharmacology ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Potential roles of eosinophils in cancer therapy: epidemiological studies, experimental models, and clinical pathology.
Autorzy :
Cao C
Gu Y
Zhu C
Palmai-Pallag T
Lan F
Chen Z
Li W
Shen H
Ying S; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Institute of Respiratory Diseases, Zhejiang University School of Medicine, Hangzhou, P.R. China. .
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Źródło :
Recent patents on anti-cancer drug discovery [Recent Pat Anticancer Drug Discov] 2014 May; Vol. 9 (2), pp. 241-8.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cytokines/*immunology
Eosinophils/*immunology
Hypersensitivity/*immunology
Neoplasms/*immunology
Humans ; Hypersensitivity/epidemiology ; Neoplasms/drug therapy ; Neoplasms/epidemiology ; Patents as Topic
Czasopismo naukowe
Tytuł :
Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics.
Autorzy :
Flood-Page P; Department of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, London, United Kingdom.
Menzies-Gow A
Phipps S
Ying S
Wangoo A
Ludwig MS
Barnes N
Robinson D
Kay AB
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2003 Oct; Vol. 112 (7), pp. 1029-36.
Typ publikacji :
Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*therapeutic use
Asthma/*therapy
Bronchi/*metabolism
Eosinophils/*physiology
Extracellular Matrix Proteins/*metabolism
Interleukin-5/*antagonists & inhibitors
Antibodies, Monoclonal, Humanized ; Asthma/metabolism ; Basement Membrane/metabolism ; Chondroitin Sulfate Proteoglycans/analysis ; Collagen Type III/analysis ; Double-Blind Method ; Humans ; Immunohistochemistry ; Keratan Sulfate/analysis ; Lumican ; RNA, Messenger ; Tenascin/analysis ; Transforming Growth Factor beta ; Transforming Growth Factor beta1
Czasopismo naukowe
Tytuł :
TH1/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: comparison with the allergen-induced late-phase cutaneous reaction.
Autorzy :
Ying S; Department of Allergy and Clinical Immunology, Faculty of Medicine, Imperial College, National Heart and Lung Institute, London, UK.
Kikuchi Y
Meng Q
Kay AB
Kaplan AP
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Źródło :
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2002 Apr; Vol. 109 (4), pp. 694-700.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Allergens/*immunology
Basophils/*physiology
Cytokines/*biosynthesis
Eosinophils/*physiology
Skin/*pathology
Urticaria/*immunology
Adolescent ; Adult ; Biopsy ; Chronic Disease ; Cytokines/genetics ; Female ; Humans ; Immunohistochemistry ; In Situ Hybridization ; Male ; Middle Aged ; RNA, Messenger/analysis ; Skin/immunology ; Th1 Cells/immunology ; Th2 Cells/immunology ; Urticaria/pathology
Czasopismo naukowe
Tytuł :
Attenuation of the allergen-induced late asthmatic reaction by cyclosporin A is associated with inhibition of bronchial eosinophils, interleukin-5, granulocyte macrophage colony-stimulating factor, and eotaxin.
Autorzy :
Khan LN; Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, United Kingdom.
Kon OM
Macfarlane AJ
Meng Q
Ying S
Barnes NC
Kay AB
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2000 Oct; Vol. 162 (4 Pt 1), pp. 1377-82.
Typ publikacji :
Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Allergens*/immunology
Chemokines, CC*
Asthma/*drug therapy
Cyclosporine/*administration & dosage
Cytokines/*metabolism
Eosinophils/*drug effects
Granulocyte-Macrophage Colony-Stimulating Factor/*metabolism
Interleukin-5/*metabolism
Rhinitis, Allergic, Perennial/*drug therapy
Rhinitis, Allergic, Seasonal/*drug therapy
Adolescent ; Adult ; Asthma/immunology ; Bronchi/drug effects ; Bronchi/immunology ; Bronchoalveolar Lavage Fluid/immunology ; Bronchoscopy ; Chemokine CCL11 ; Cyclosporine/adverse effects ; Double-Blind Method ; Eosinophils/immunology ; Female ; Humans ; Male ; Middle Aged ; Rhinitis, Allergic, Perennial/immunology ; Rhinitis, Allergic, Seasonal/immunology
Czasopismo naukowe
Tytuł :
Blood eosinophils from atopic donors express messenger RNA for the alpha, beta, and gamma subunits of the high-affinity IgE receptor (Fc epsilon RI) and intracellular, but not cell surface, alpha subunit protein.
Autorzy :
Smith SJ; Department of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, United Kingdom.
Ying S
Meng Q
Sullivan MH
Barkans J
Kon OM
Sihra B
Larché M
Levi-Schaffer F
Kay AB
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Źródło :
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2000 Feb; Vol. 105 (2 Pt 1), pp. 309-17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Eosinophils/*immunology
Eosinophils/*metabolism
Hypersensitivity, Immediate/*immunology
Hypersensitivity, Immediate/*metabolism
RNA, Messenger/*biosynthesis
Receptors, IgE/*biosynthesis
Cell Membrane/drug effects ; Cell Membrane/immunology ; Cell Membrane/metabolism ; Cell Membrane Permeability/drug effects ; Cell Separation ; Eosinophils/drug effects ; Erythropoietin/metabolism ; Humans ; Hypersensitivity, Immediate/blood ; Immunoglobulin Fab Fragments/metabolism ; RNA, Messenger/blood ; Receptors, IgE/blood ; Saponins/pharmacology
Czasopismo naukowe
Tytuł :
C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES).
Autorzy :
Ying S; Department of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, United Kingdom.
Robinson DS
Meng Q
Barata LT
McEuen AR
Buckley MG
Walls AF
Askenase PW
Kay AB
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 1999 Oct 01; Vol. 163 (7), pp. 3976-84.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Allergens/*immunology
Basophils/*immunology
Chemokines, CC/*metabolism
Dermatitis, Atopic/*immunology
Eosinophilia/*immunology
Eosinophils/*immunology
Adolescent ; Adult ; Basophils/metabolism ; Basophils/pathology ; Cell Movement/immunology ; Chemokine CCL11 ; Chemokine CCL24 ; Chemokine CCL5/genetics ; Chemokine CCL5/metabolism ; Chemokine CCL7 ; Chemokines, CC/biosynthesis ; Chemokines, CC/genetics ; Cytokines/genetics ; Cytokines/metabolism ; Dermatitis, Atopic/pathology ; Eosinophilia/pathology ; Eosinophils/metabolism ; Eosinophils/pathology ; Humans ; Immunophenotyping ; Middle Aged ; Monocyte Chemoattractant Proteins/genetics ; Monocyte Chemoattractant Proteins/metabolism ; RNA, Messenger/biosynthesis ; Receptors, CCR3 ; Receptors, Chemokine/biosynthesis ; Receptors, Chemokine/genetics ; Time Factors
Czasopismo naukowe
Tytuł :
Increases in eotaxin-positive cells in induced sputum from atopic asthmatic subjects after inhalational allergen challenge.
Autorzy :
Zeibecoglou K; Department of Allergy and Clinical Immunology, Imperial College School of Medicine (Royal Brompton Campus), National Heart and Lung Institute, London, UK.
Macfarlane AJ
Ying S
Meng Q
Pavord I
Barnes NC
Robinson DS
Kay AB
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Źródło :
Allergy [Allergy] 1999 Jul; Vol. 54 (7), pp. 730-5.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chemokines, CC*
Asthma/*immunology
Cytokines/*biosynthesis
Eosinophils/*cytology
Hypersensitivity, Immediate/*immunology
Sputum/*cytology
Adult ; Bronchial Provocation Tests ; Chemokine CCL11 ; Female ; Humans ; Immunohistochemistry ; Macrophages/immunology ; Male ; Middle Aged ; Sputum/immunology
Czasopismo naukowe
Tytuł :
Eosinophil development and bone marrow and tissue eosinophils in atopic asthma.
Autorzy :
Robinson DS; Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, UK. d.s. />North J
Zeibecoglou K
Ying S
Meng Q
Rankin S
Hamid Q
Tavernier J
Kay AB
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Źródło :
International archives of allergy and immunology [Int Arch Allergy Immunol] 1999 Feb-Apr; Vol. 118 (2-4), pp. 98-100.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chemokines, CC*
Asthma/*immunology
Bone Marrow Cells/*immunology
Eosinophils/*immunology
Antigens, CD34 ; Asthma/pathology ; Cell Differentiation/immunology ; Cells, Cultured ; Chemokine CCL11 ; Cytokines/immunology ; Eosinophils/pathology ; Humans ; Interleukin-5/immunology ; Receptors, CCR3 ; Receptors, Chemokine/immunology ; Receptors, Interleukin/immunology ; Receptors, Interleukin-5
Czasopismo naukowe
Tytuł :
Increased mature and immature CCR3 messenger RNA+ eosinophils in bone marrow from patients with atopic asthma compared with atopic and nonatopic control subjects.
Autorzy :
Zeibecoglou K; Department of Allergy and Clinical Immunology, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom.
Ying S
Yamada T
North J
Burman J
Bungre J
Meng Q
Kay AB
Robinson DS
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Źródło :
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 1999 Jan; Vol. 103 (1 Pt 1), pp. 99-106.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Asthma/*blood
Bone Marrow/*chemistry
Eosinophils/*metabolism
Hypersensitivity, Immediate/*blood
Receptors, Chemokine/*blood
Receptors, Chemokine/*genetics
Adult ; Antigens, CD34/analysis ; Bone Marrow Cells/cytology ; Bone Marrow Cells/immunology ; Cell Count ; Eosinophils/cytology ; Female ; Humans ; Male ; Middle Aged ; RNA, Messenger/blood ; Receptors, CCR3 ; Receptors, HIV/blood ; Receptors, HIV/genetics ; Stem Cells/immunology
Czasopismo naukowe
Tytuł :
Increased expression of high affinity IgE (FcepsilonRI) receptor-alpha chain mRNA and protein-bearing eosinophils in human allergen-induced atopic asthma.
Autorzy :
Rajakulasingam K; Upper Respiratory Medicine and Allergy and Clinical Immunology, Imperial College School of Medicine at the National Heart and Lung Institute, Dovehouse Street, London, United Kingdom.
Till S
Ying S
Humbert M
Barkans J
Sullivan M
Meng Q
Corrigan CJ
Bungre J
Grant JA
Kay AB
Durham SR
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 1998 Jul; Vol. 158 (1), pp. 233-40.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Asthma/*immunology
Eosinophils/*immunology
RNA, Messenger/*metabolism
Receptors, IgE/*biosynthesis
Adult ; Antibodies, Monoclonal ; Bronchial Provocation Tests ; Bronchoalveolar Lavage Fluid ; Bronchoscopy ; Cell Count ; Female ; Humans ; Immunoglobulin Fc Fragments ; Immunoglobulin alpha-Chains ; Immunohistochemistry ; In Situ Hybridization ; Lymphocytes/immunology ; Macrophages/immunology ; Male ; Neutrophils/immunology
Czasopismo naukowe
Tytuł :
IL-4- and IL-5-positive T lymphocytes, eosinophils, and mast cells in allergen-induced late-phase cutaneous reactions in atopic subjects.
Autorzy :
Barata LT; Allergy and Clinical Immunology, Imperial College School of Medicine-Royal Brompton Campus, National Heart and Lung Institute, London, England.
Ying S
Meng Q
Barkans J
Rajakulasingam K
Durham SR
Kay AB
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Źródło :
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 1998 Feb; Vol. 101 (2 Pt 1), pp. 222-30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Allergens/*immunology
Dermatitis, Atopic/*immunology
Eosinophils/*immunology
Hypersensitivity, Immediate/*immunology
Interleukin-4/*immunology
Interleukin-5/*immunology
Mast Cells/*immunology
T-Lymphocytes/*immunology
Adult ; Allergens/adverse effects ; Dermatitis, Atopic/metabolism ; Dermatitis, Atopic/pathology ; Eosinophils/metabolism ; Female ; Humans ; Hypersensitivity, Immediate/metabolism ; Hypersensitivity, Immediate/pathology ; Interleukin-4/biosynthesis ; Interleukin-5/biosynthesis ; Male ; Mast Cells/metabolism ; Phenotype ; Polymerase Chain Reaction ; RNA, Messenger/metabolism ; T-Lymphocytes/metabolism ; Time Factors ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Effects of rapamycin, cyclosporin A, and dexamethasone on interleukin 5-induced eosinophil degranulation and prolonged survival.
Autorzy :
Meng Q; Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, UK.
Ying S
Corrigan CJ
Wakelin M
Assoufi B
Moqbel R
Kay AB
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Źródło :
Allergy [Allergy] 1997 Nov; Vol. 52 (11), pp. 1095-101.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ribonucleases*
Anti-Inflammatory Agents/*pharmacology
Cyclosporine/*pharmacology
Dexamethasone/*pharmacology
Eosinophils/*cytology
Immunosuppressive Agents/*pharmacology
Interleukin-5/*pharmacology
Polyenes/*pharmacology
Blood Proteins/metabolism ; Cell Degranulation/drug effects ; Cell Survival/drug effects ; Eosinophil Granule Proteins ; Eosinophils/drug effects ; Humans ; Inflammation Mediators/metabolism ; Recombinant Proteins/pharmacology ; Sirolimus ; Time Factors
Czasopismo naukowe
Tytuł :
Associations between IL-13 and IL-4 (mRNA and protein), vascular cell adhesion molecule-1 expression, and the infiltration of eosinophils, macrophages, and T cells in allergen-induced late-phase cutaneous reactions in atopic subjects.
Autorzy :
Ying S; Allergy and Clinical Immunology, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom.
Meng Q
Barata LT
Robinson DS
Durham SR
Kay AB
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 1997 May 15; Vol. 158 (10), pp. 5050-7.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Eosinophils/*metabolism
Hypersensitivity/*immunology
Interleukin-13/*metabolism
Interleukin-4/*metabolism
Macrophages/*metabolism
T-Lymphocytes/*metabolism
Vascular Cell Adhesion Molecule-1/*metabolism
Adult ; Allergens ; Eosinophils/immunology ; Female ; Gene Expression ; Humans ; Immunologic Techniques ; In Situ Hybridization ; Interleukin-13/genetics ; Interleukin-4/genetics ; Macrophages/immunology ; Male ; RNA, Messenger/genetics ; Skin/immunology ; T-Lymphocytes/immunology ; Time Factors
Czasopismo naukowe
Tytuł :
Allergen-induced recruitment of Fc epsilon RI+ eosinophils in human atopic skin.
Autorzy :
Barata LT; Allergy and Clinical Immunology, Imperial College School of Medicine at the National Heart & Lung Institute, London, GB.
Ying S
Grant JA
Humbert M
Barkans J
Meng Q
Durham SR
Kay AB
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Źródło :
European journal of immunology [Eur J Immunol] 1997 May; Vol. 27 (5), pp. 1236-41.
Typ publikacji :
Journal Article
MeSH Terms :
Allergens/*physiology
Cell Movement/*immunology
Dermatitis, Atopic/*immunology
Eosinophils/*immunology
Receptors, IgE/*analysis
Coloring Agents ; Dermatitis, Atopic/metabolism ; Dermatitis, Atopic/pathology ; Eosinophils/chemistry ; Eosinophils/metabolism ; Humans ; Immunohistochemistry ; Naphthalenesulfonates ; Staining and Labeling
Czasopismo naukowe

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