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    Wyświetlanie 1-4 z 4
    Tytuł:
    Design, Synthesis and Biological Evaluation of 1,3,5-Triazine Derivatives Targeting hA 1 and hA 3 Adenosine Receptor.
    Autorzy:
    Park S; College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea.; Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea.
    Ahn Y; Biometrology Group, Korea Research Institute of Standards and Science (KRISS), Daejeon 34113, Korea.; Department of Precision Measurement, University of Science and Technology (UST), Daejeon 34113, Korea.
    Kim Y; Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea.
    Roh EJ; Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea.
    Lee Y; College of Pharmacy, Chung-Ang University, Seoul 06974, Korea.
    Han C; College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea.; Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea.
    Yoo HM; Biometrology Group, Korea Research Institute of Standards and Science (KRISS), Daejeon 34113, Korea.; Department of Precision Measurement, University of Science and Technology (UST), Daejeon 34113, Korea.
    Yu J; College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea.
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2022 Jun 22; Vol. 27 (13). Date of Electronic Publication: 2022 Jun 22.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Pyrimidines*/chemistry
    Receptor, Adenosine A2A*/metabolism
    Humans ; Molecular Docking Simulation ; Receptor, Adenosine A3/chemistry ; Structure-Activity Relationship ; Triazines/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    The Nedd8-activating enzyme inhibitor MLN4924 (TAK-924/Pevonedistat) induces apoptosis via c-Myc-Noxa axis in head and neck squamous cell carcinoma.
    Autorzy:
    Zhang W; Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China.; Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
    Liang Y; Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China.
    Li L; Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China.
    Wang X; Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China.
    Yan Z; Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China.
    Dong C; Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
    Zeng MS; Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
    Zhong Q; Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
    Liu XK; Department of Head & Neck Cancer, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
    Yu J; College of Pharmacy, Seoul National University, Seoul, Korea.
    Sun S; Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Liu X; Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China.
    Kang J; Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
    Zhao H; Department of Clinical Laboratory, Huadong Hospital, Shanghai Key Laboratory of Clinical Geriatric Medicine, Research Center on Aging and Medicine, Fudan University, Shanghai, China.
    Jeong LS; College of Pharmacy, Seoul National University, Seoul, Korea.
    Zhang Y; Department of Clinical Laboratory, Huadong Hospital, Shanghai Key Laboratory of Clinical Geriatric Medicine, Research Center on Aging and Medicine, Fudan University, Shanghai, China.
    Jia L; Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China.; Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
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    Źródło:
    Cell proliferation [Cell Prolif] 2019 Mar; Vol. 52 (2), pp. e12536. Date of Electronic Publication: 2018 Oct 19.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Apoptosis/*drug effects
    Cyclopentanes/*pharmacology
    Enzyme Inhibitors/*pharmacology
    Head and Neck Neoplasms/*drug therapy
    NEDD8 Protein/*metabolism
    Proto-Oncogene Proteins c-bcl-2/*metabolism
    Proto-Oncogene Proteins c-myc/*metabolism
    Pyrimidines/*pharmacology
    Squamous Cell Carcinoma of Head and Neck/*drug therapy
    Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/pathology ; Humans ; NEDD8 Protein/agonists ; Signal Transduction/drug effects ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Squamous Cell Carcinoma of Head and Neck/pathology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
      Wyświetlanie 1-4 z 4

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