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Tytuł:
Central blockade of NLRP3 reduces blood pressure via regulating inflammation microenvironment and neurohormonal excitation in salt-induced prehypertensive rats.
Autorzy:
Wang ML; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710061, China.; Department of Immunology, School of Basic Medical Sciences, Jiamusi University, Jiamusi, 154007, China.
Kang YM; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710061, China.
Li XG; Department of Rehabilitation Medicine, People's Hospital of Baoan District, Shenzhen, 518100, China.
Su Q; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710061, China.
Li HB; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710061, China.
Liu KL; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710061, China.
Fu LY; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710061, China.
Saahene RO; Department of Immunology, School of Basic Medical Sciences, Jiamusi University, Jiamusi, 154007, China.
Li Y; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710061, China.
Tan H; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710061, China.; Department of Pathology, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.
Yu XJ; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710061, China. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2018 Mar 24; Vol. 15 (1), pp. 95. Date of Electronic Publication: 2018 Mar 24.
Typ publikacji:
Journal Article
MeSH Terms:
Cytokines/*metabolism
Hypertension/*complications
Inflammation/*etiology
NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
Neurotransmitter Agents/*metabolism
Animals ; Antihypertensive Agents/pharmacology ; Antihypertensive Agents/therapeutic use ; Blood Pressure/drug effects ; Blood Pressure/physiology ; CARD Signaling Adaptor Proteins/metabolism ; Calcium-Binding Proteins/metabolism ; Disease Models, Animal ; Glutamate Decarboxylase/metabolism ; Hypertension/chemically induced ; Hypertension/drug therapy ; Inflammation/drug therapy ; Leukocytes, Mononuclear/drug effects ; Male ; Microfilament Proteins/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/antagonists & inhibitors ; Paraventricular Hypothalamic Nucleus/drug effects ; Paraventricular Hypothalamic Nucleus/metabolism ; Rats ; Rats, Sprague-Dawley ; Sodium Chloride, Dietary/toxicity ; Tyrosine 3-Monooxygenase/metabolism ; Vascular Cell Adhesion Molecule-1/metabolism
Czasopismo naukowe
Tytuł:
Prediction of Incident Hypertension Within the Next Year: Prospective Study Using Statewide Electronic Health Records and Machine Learning.
Autorzy:
Ye C; Department of Health Management, Hangzhou Normal University, Hangzhou, China.; Department of Surgery, Stanford University, Stanford, CA, United States.
Fu T; HBI Solutions Inc, Palo Alto, CA, United States.
Hao S; Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States.; Clinical and Translational Research Program, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford, CA, United States.
Zhang Y; Department of Oncology, The First Hospital of Shijiazhuang, Shijiazhuang, China.
Wang O; HBI Solutions Inc, Palo Alto, CA, United States.
Jin B; HBI Solutions Inc, Palo Alto, CA, United States.
Xia M; HBI Solutions Inc, Palo Alto, CA, United States.
Liu M; HBI Solutions Inc, Palo Alto, CA, United States.
Zhou X; Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Pingjin Hospital Heart Center, Tianjin, China.
Wu Q; China Electric Power Research Institute, Beijing, China.
Guo Y; Department of Surgery, Stanford University, Stanford, CA, United States.; School of Management, Zhejiang University, Hangzhou, China.
Zhu C; HBI Solutions Inc, Palo Alto, CA, United States.
Li YM; Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Pingjin Hospital Heart Center, Tianjin, China.
Culver DS; HealthInfoNet, Portland, ME, United States.
Alfreds ST; HealthInfoNet, Portland, ME, United States.
Stearns F; HBI Solutions Inc, Palo Alto, CA, United States.
Sylvester KG; Department of Surgery, Stanford University, Stanford, CA, United States.
Widen E; HBI Solutions Inc, Palo Alto, CA, United States.
McElhinney D; Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States.; Clinical and Translational Research Program, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford, CA, United States.
Ling X; Department of Surgery, Stanford University, Stanford, CA, United States.; Clinical and Translational Research Program, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford, CA, United States.; Health Care Big Data Center, School of Public Health, Zhejiang University, Hangzhou, China.
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Źródło:
Journal of medical Internet research [J Med Internet Res] 2018 Jan 30; Vol. 20 (1), pp. e22. Date of Electronic Publication: 2018 Jan 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Electronic Health Records/*standards
Hypertension/*diagnosis
Machine Learning/*standards
Aged ; Cohort Studies ; Female ; Humans ; Hypertension/pathology ; Male ; Middle Aged ; Prospective Studies ; Retrospective Studies ; Risk Factors
Czasopismo naukowe
Tytuł:
Renin-angiotensin system acting on reactive oxygen species in paraventricular nucleus induces sympathetic activation via AT1R/PKCγ/Rac1 pathway in salt-induced hypertension.
Autorzy:
Su Q; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China.
Huo CJ; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China.
Li HB; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China.
Liu KL; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China.
Li X; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China.
Yang Q; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China.
Song XA; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China.
Chen WS; Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Cui W; Department of Endocrinology and Metabolism, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Zhu GQ; Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, Nanjing 210029, China.
Shi XL; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China.; Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Liu JJ; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China.
Kang YM; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China.
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Źródło:
Scientific reports [Sci Rep] 2017 Mar 24; Vol. 7, pp. 43107. Date of Electronic Publication: 2017 Mar 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Renin-Angiotensin System*
Signal Transduction*
Hypertension/*metabolism
Paraventricular Hypothalamic Nucleus/*metabolism
Reactive Oxygen Species/*metabolism
Animals ; Hypertension/chemically induced ; Hypertension/physiopathology ; Male ; Paraventricular Hypothalamic Nucleus/physiopathology ; Protein Kinase C/metabolism ; Rats ; Rats, Sprague-Dawley ; Sodium Chloride, Dietary/adverse effects ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł:
PVN Blockade of p44/42 MAPK Pathway Attenuates Salt-induced Hypertension through Modulating Neurotransmitters and Attenuating Oxidative Stress.
Autorzy:
Gao HL; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China.
Yu XJ; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China.
Liu KL; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China.
Shi XL; Department of Pharmacology, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an 710061, China.
Qi J; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China.
Chen YM; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China.
Zhang Y; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China.
Bai J; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China.
Yi QY; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China.
Feng ZP; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China.
Chen WS; Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Cui W; Department of Endocrinology and Metabolism, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Liu JJ; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China.
Zhu GQ; Department of Physiology, Nanjing Medical University, Nanjing 210029, China.
Kang YM; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an 710061, China.
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Źródło:
Scientific reports [Sci Rep] 2017 Feb 22; Vol. 7, pp. 43038. Date of Electronic Publication: 2017 Feb 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Oxidative Stress*
Hypertension/*chemically induced
Mitogen-Activated Protein Kinase 1/*antagonists & inhibitors
Mitogen-Activated Protein Kinase 3/*antagonists & inhibitors
Neurotransmitter Agents/*metabolism
Paraventricular Hypothalamic Nucleus/*enzymology
Sodium Chloride/*metabolism
Animals ; Disease Models, Animal ; Paraventricular Hypothalamic Nucleus/physiology ; Rats, Inbred Dahl ; Signal Transduction
Czasopismo naukowe
Tytuł:
VEGF-C-mediated cardiac lymphangiogenesis in high salt intake accelerated progression of left ventricular remodeling in spontaneously hypertensive rats.
Autorzy:
Yang GH; a Institute of Cardiovascular Disease and Heart Center, Pingjin Hospital, Logistics University of the Chinese People's Armed Police Forces , Tianjin , China.; b Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury , Tianjin , China.
Zhou X; a Institute of Cardiovascular Disease and Heart Center, Pingjin Hospital, Logistics University of the Chinese People's Armed Police Forces , Tianjin , China.; b Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury , Tianjin , China.
Ji WJ; b Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury , Tianjin , China.; c Departments of Pulmonary and Critical Care Medicine , Logistics University of the Chinese People's Armed Police Forces , Tianjin , China .
Liu JX; a Institute of Cardiovascular Disease and Heart Center, Pingjin Hospital, Logistics University of the Chinese People's Armed Police Forces , Tianjin , China.; b Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury , Tianjin , China.
Sun J; a Institute of Cardiovascular Disease and Heart Center, Pingjin Hospital, Logistics University of the Chinese People's Armed Police Forces , Tianjin , China.; b Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury , Tianjin , China.
Dong Y; a Institute of Cardiovascular Disease and Heart Center, Pingjin Hospital, Logistics University of the Chinese People's Armed Police Forces , Tianjin , China.
Jiang TM; a Institute of Cardiovascular Disease and Heart Center, Pingjin Hospital, Logistics University of the Chinese People's Armed Police Forces , Tianjin , China.; b Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury , Tianjin , China.
Li YM; a Institute of Cardiovascular Disease and Heart Center, Pingjin Hospital, Logistics University of the Chinese People's Armed Police Forces , Tianjin , China.; b Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury , Tianjin , China.
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Źródło:
Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2017; Vol. 39 (8), pp. 740-747. Date of Electronic Publication: 2017 Jun 28.
Typ publikacji:
Journal Article
MeSH Terms:
Lymphangiogenesis*
Ventricular Remodeling*
Hypertension/*physiopathology
Sodium Chloride, Dietary/*administration & dosage
Transcription Factors/*metabolism
Vascular Endothelial Growth Factor C/*metabolism
Ventricular Dysfunction, Left/*physiopathology
Animals ; Blood Pressure ; Echocardiography ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/pathology ; Male ; Myocardium/metabolism ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Signal Transduction ; Up-Regulation
Czasopismo naukowe
Tytuł:
Oral CoQ10 attenuates high salt-induced hypertension by restoring neurotransmitters and cytokines in the hypothalamic paraventricular nucleus.
Autorzy:
Gao HL; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Yu XJ; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Qi J; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Yi QY; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Jing WH; Department of Pharmaceutical Analysis, School of Pharmacy, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Sun WY; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Cui W; Department of Endocrinology and Metabolism, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Mu JJ; Department of Cardiology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710061, China.
Yuan ZY; Department of Cardiology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710061, China.
Zhao XF; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Liu KL; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Zhu GQ; Department of Physiology, Nanjing Medical University, Nanjing 210029, China.
Shi XL; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.; Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Liu JJ; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Kang YM; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
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Źródło:
Scientific reports [Sci Rep] 2016 Jul 25; Vol. 6, pp. 30301. Date of Electronic Publication: 2016 Jul 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antioxidants/*administration & dosage
Free Radical Scavengers/*administration & dosage
Hypertension/*drug therapy
Paraventricular Hypothalamic Nucleus/*metabolism
Ubiquinone/*analogs & derivatives
Animals ; Gene Expression Regulation/drug effects ; Humans ; Hypertension/chemically induced ; Hypertension/metabolism ; Hypertension/pathology ; Interleukin-1beta/metabolism ; NADPH Oxidase 2/metabolism ; Neurotransmitter Agents/metabolism ; Norepinephrine/metabolism ; Paraventricular Hypothalamic Nucleus/drug effects ; Rats ; Salts/toxicity ; Superoxide Dismutase-1/metabolism ; Tyrosine 3-Monooxygenase/metabolism ; Ubiquinone/administration & dosage
Czasopismo naukowe
Tytuł:
Central blockade of salusin β attenuates hypertension and hypothalamic inflammation in spontaneously hypertensive rats.
Autorzy:
Li HB; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Qin DN; Department of Physiology, Shantou University Medical College, Shantou 515041, China.
Cheng K; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Su Q; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Miao YW; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Guo J; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Zhang M; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Zhu GQ; Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, Nanjing 210029, China.
Kang YM; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
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Źródło:
Scientific reports [Sci Rep] 2015 Jul 29; Vol. 5, pp. 11162. Date of Electronic Publication: 2015 Jul 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hypertension/*etiology
Hypertension/*metabolism
Hypothalamus/*metabolism
Inflammation/*metabolism
Intercellular Signaling Peptides and Proteins/*metabolism
Animals ; Antibodies, Monoclonal/pharmacology ; Blood Pressure/drug effects ; Cardiomegaly/diagnosis ; Cardiomegaly/drug therapy ; Cardiomegaly/etiology ; Cytokines/metabolism ; Essential Hypertension ; Heart Rate/drug effects ; Hypertension/physiopathology ; Hypothalamus/drug effects ; Hypothalamus/pathology ; Immunoglobulin G/pharmacology ; Inflammation/drug therapy ; Inflammation Mediators/metabolism ; Male ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; NADPH Oxidase 2 ; NADPH Oxidases/genetics ; NADPH Oxidases/metabolism ; NF-kappa B/metabolism ; Oxidative Stress/drug effects ; Paraventricular Hypothalamic Nucleus/drug effects ; Paraventricular Hypothalamic Nucleus/metabolism ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Rats ; Rats, Inbred SHR ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł:
Exercise training attenuates hypertension and cardiac hypertrophy by modulating neurotransmitters and cytokines in hypothalamic paraventricular nucleus.
Autorzy:
Jia LL; Department of Physiology and Pathophysiology, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an Jiaotong University School of Medicine, Xi'an, China.
Kang YM; Department of Physiology and Pathophysiology, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an Jiaotong University School of Medicine, Xi'an, China.
Wang FX; Department of Neurology, The First Affiliated Hospital of Jiamusi University, Jiamusi, China.
Li HB; Department of Physiology and Pathophysiology, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an Jiaotong University School of Medicine, Xi'an, China.
Zhang Y; Department of Physiology and Pathophysiology, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an Jiaotong University School of Medicine, Xi'an, China.
Yu XJ; Department of Physiology and Pathophysiology, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an Jiaotong University School of Medicine, Xi'an, China.
Qi J; Department of Physiology and Pathophysiology, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an Jiaotong University School of Medicine, Xi'an, China.
Suo YP; Department of Obstetrics and Gynecology, Shanxi Provincial People's Hospital, Taiyuan, China.
Tian ZJ; Institute of Sports and Exercise Biology, School of Physical Education, Shaanxi Normal University, Xi'an, China.
Zhu Z; Department of Hypertension and Endocrinology, Center for Hypertension and Metabolic Diseases, Daping Hospital, The Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, China.
Zhu GQ; Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, Nanjing, China.
Qin DN; Department of Physiology, Shantou University Medical College, Shantou, China.
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Źródło:
PloS one [PLoS One] 2014 Jan 17; Vol. 9 (1), pp. e85481. Date of Electronic Publication: 2014 Jan 17 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Arterial Pressure/*physiology
Cardiomegaly/*therapy
Cytokines/*metabolism
Hypertension/*therapy
Paraventricular Hypothalamic Nucleus/*metabolism
Physical Conditioning, Animal/*physiology
Animals ; Cardiomegaly/metabolism ; Cardiomegaly/physiopathology ; Glutamic Acid/metabolism ; Hypertension/metabolism ; Hypertension/physiopathology ; Male ; NADPH Oxidases/metabolism ; NF-kappa B/metabolism ; Norepinephrine/metabolism ; Oxidative Stress/physiology ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Sympathetic Nervous System/metabolism ; Sympathetic Nervous System/physiopathology ; gamma-Aminobutyric Acid/metabolism
Czasopismo naukowe
Tytuł:
Effects of poststroke hypertension and hyperglycemia on functional outcomes in stroke patients without history of hypertension or diabetes.
Autorzy:
Wang LY
Xu J
Wang YL
Zhao XQ
Wang CX
Liu LP
Wang AX
Liu GF
Xu YM
Wang YJ
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2012 Nov; Vol. 18 (11), pp. 942-4.
Typ publikacji:
Letter; Research Support, Non-U.S. Gov't
MeSH Terms:
Hyperglycemia/*epidemiology
Hyperglycemia/*therapy
Hypertension/*epidemiology
Hypertension/*therapy
Stroke/*epidemiology
Stroke/*therapy
Aged ; Cohort Studies ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/physiopathology ; Female ; Humans ; Hyperglycemia/physiopathology ; Hypertension/physiopathology ; Male ; Middle Aged ; Prospective Studies ; Recovery of Function/physiology ; Stroke/physiopathology ; Treatment Outcome
Raport
Tytuł:
Efficacy and tolerability of a single-pill combination of amlodipine/valsartan in Asian hypertensive patients not adequately controlled with valsartan monotherapy.
Autorzy:
Huang J; The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Sun NL
Hao YM
Zhu JR
Tu Y
Curt V
Zhang Y
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Corporate Authors:
Trial Investigators
Źródło:
Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2011; Vol. 33 (3), pp. 179-86. Date of Electronic Publication: 2011 Apr 05.
Typ publikacji:
Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Amlodipine/*therapeutic use
Antihypertensive Agents/*therapeutic use
Asian People/*ethnology
Hypertension/*drug therapy
Hypertension/*ethnology
Tetrazoles/*therapeutic use
Valine/*analogs & derivatives
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Amlodipine/adverse effects ; Angiotensin II Type 1 Receptor Blockers/adverse effects ; Angiotensin II Type 1 Receptor Blockers/therapeutic use ; Antihypertensive Agents/adverse effects ; Calcium Channel Blockers/adverse effects ; Calcium Channel Blockers/therapeutic use ; China/epidemiology ; Double-Blind Method ; Drug Combinations ; Drug-Related Side Effects and Adverse Reactions ; Female ; Humans ; Hypertension/epidemiology ; Korea/epidemiology ; Male ; Middle Aged ; Tetrazoles/adverse effects ; Thailand/epidemiology ; Treatment Outcome ; Valine/adverse effects ; Valine/therapeutic use ; Valsartan ; Young Adult
Czasopismo naukowe
Tytuł:
Long-term MMP inhibition by doxycycline exerts divergent effect on ventricular extracellular matrix deposition and systolic performance in stroke-prone spontaneously hypertensive rats.
Autorzy:
Zeng S; Institute of Cardiovascular Diseases and Division of Cardiology, Pingjin Hospital, Medical College of Chinese People's Armed Police Forces, Tianjin, China.
Zhou X
Tu Y
Yao M
Han ZQ
Gao F
Li YM
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Źródło:
Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2011; Vol. 33 (5), pp. 316-24. Date of Electronic Publication: 2011 Jun 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Matrix Metalloproteinase Inhibitors*
Doxycycline/*pharmacology
Hypertension/*drug therapy
Animals ; Base Sequence ; Doxycycline/administration & dosage ; Doxycycline/toxicity ; Extracellular Matrix/drug effects ; Extracellular Matrix/pathology ; Extracellular Matrix/physiology ; Hypertension/genetics ; Hypertension/pathology ; Hypertension/physiopathology ; Male ; Matrix Metalloproteinase 2/genetics ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinases/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Systole/drug effects ; Systole/physiology ; Time Factors ; Tissue Inhibitor of Metalloproteinase-1/genetics ; Tissue Inhibitor of Metalloproteinase-2/genetics ; Ventricular Remodeling/drug effects ; Ventricular Remodeling/physiology
Czasopismo naukowe
Tytuł:
High salt intake accelerated cardiac remodeling in spontaneously hypertensive rats: time window of left ventricular functional transition and its relation to salt-loading doses.
Autorzy:
Gao F; Graduate School of Medicine, Tianjin Medical University, China.
Han ZQ
Zhou X
Shi R
Dong Y
Jiang TM
Li YM
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Źródło:
Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2011; Vol. 33 (7), pp. 492-9. Date of Electronic Publication: 2011 May 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hypertension/*complications
Hypertrophy, Left Ventricular/*etiology
Sodium Chloride, Dietary/*adverse effects
Ventricular Remodeling/*physiology
Animals ; Apoptosis ; Cell Enlargement ; Collagen/metabolism ; DNA Damage ; Hemodynamics ; Hypertension/pathology ; Hypertension/physiopathology ; Hypertrophy, Left Ventricular/pathology ; Hypertrophy, Left Ventricular/physiopathology ; Male ; Myocytes, Cardiac/pathology ; Oxidative Stress ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Sodium Chloride, Dietary/administration & dosage ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/pathology ; Ventricular Dysfunction, Left/physiopathology
Czasopismo naukowe
Tytuł:
Severity of fatty liver is highly correlated with the risk of hypertension and diabetes: a cross-sectional and longitudinal cohort study
Autorzy:
Shih, Chin-I.Aff1, Aff2
Wu, Kuan-Ta
Hsieh, Meng-HsuanAff3, Aff5, Aff6
Yang, Jeng-Fu
Chen, Yi-Yu
Tsai, Wei-LunAff2, Aff4
Chen, Wen-ChiAff2, Aff4
Liang, Po-Cheng
Wei, Yu-Ju
Tsai, Pei-Chien
Hsu, Po-Yao
Hsieh, Ming-Yen
Lin, Yi-Hung
Jang, Tyng-Yuan
Wang, Chih-WenAff5, Aff6
Yeh, Ming-LunAff5, Aff6
Huang, Chung-FengAff5, Aff6
Huang, Jee-FuAff5, Aff6
Dai, Chia-YenAff5, Aff6
Ho, Chi-Kung
Chuang, Wan-LongAff5, Aff6
Yu, Ming-LungAff2, Aff5, Aff6, IDs1207202310576z_cor22
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Źródło:
Hepatology International. 18(1):138-154
Czasopismo naukowe

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