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Tytuł:
RTA dh404 Induces Cell Cycle Arrest, Apoptosis, and Autophagy in Glioblastoma Cells.
Autorzy:
Tsai TH; Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807378, Taiwan.; Department of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.; Graduate Institutes of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.; Division of Neurosurgery, Department of Surgery, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 80145, Taiwan.
Su YF; Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807378, Taiwan.; Department of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.; Graduate Institutes of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
Tsai CY; Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807378, Taiwan.; Department of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.; Graduate Institutes of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
Wu CH; Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807378, Taiwan.; Department of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.; Graduate Institutes of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
Lee KT; Division of Neurosurgery, Department of Surgery, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 80145, Taiwan.
Hsu YC; School of Medicine, I-Shou University, Kaohsiung 82445, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 16; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 16.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*/drug effects
Autophagy*/drug effects
Cell Cycle Checkpoints*/drug effects
Glioblastoma*/pathology
Oleanolic Acid*/pharmacology
Humans ; Cell Line, Tumor ; Cell Proliferation/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
BMX, a specific HDAC8 inhibitor, with TMZ for advanced CRC therapy: a novel synergic effect to elicit p53-, β-catenin- and MGMT-dependent apoptotic cell death.
Autorzy:
Ko HJ; Graduate Institutes of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.; Department of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.
Chiou SJ; Department of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.
Tsai CY; Post Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.; Department of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung, 80708, Taiwan.
Loh JK; Department of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung, 80708, Taiwan.
Lin XY; Graduate Institutes of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.; Department of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.
Tran TH; Taiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, 112, Taiwan.; Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 11211, Taiwan.
Hou CC; New Drug Research & Development Center, NatureWise Biotech & Medicals Corporation, Taipei, 112, Taiwan.
Cheng TS; Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 11211, Taiwan.
Lai JM; Department of Life Science, Fu-Jen Catholic University, New Taipei City, 24205, Taiwan.
Chang PM; Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 11211, Taiwan.; Department of Oncology, Taipei Veterans General Hospital, Taipei, 11217, Taiwan.; Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, 11211, Taiwan.
Wang FS; Department of Chemical Engineering, National Chung Cheng University, Chiayi, 62102, Taiwan.
Su CL; Graduate Program of Nutrition Science, School of Life Science, National Taiwan Normal University, Taipei, 11677, Taiwan.
Huang CF; Department of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan. .; Taiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, 112, Taiwan. .; Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 11211, Taiwan. .; Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei, 11211, Taiwan. .
Hong YR; Graduate Institutes of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan. .; Department of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan. .; Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, 804, Taiwan. .; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, 80708, Taiwan. .; Center for Cancer Research, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan. .; Neuroscience Research Center, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2022 Dec 27; Vol. 20 (1), pp. 200. Date of Electronic Publication: 2022 Dec 27.
Typ publikacji:
Video-Audio Media; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*
Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/metabolism
Temozolomide*/pharmacology
Histone Deacetylase Inhibitors*/pharmacology
Humans ; beta Catenin/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Histone Deacetylases/metabolism ; Repressor Proteins/metabolism ; Tumor Suppressor Protein p53/metabolism ; Wnt Signaling Pathway ; HT29 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The p150 Isoform of ADAR1 Blocks Sustained RLR signaling and Apoptosis during Influenza Virus Infection.
Autorzy:
Vogel OA; Department of Microbiology, University of Chicago, Chicago, Illinois, United States of America.
Han J; Department of Microbiology, University of Chicago, Chicago, Illinois, United States of America.
Liang CY; Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, United States of America.
Manicassamy S; Cancer Immunology, Inflammation, and Tolerance Program, GRU Cancer Center, Augusta University, Augusta, Georgia.
Perez JT; Department of Microbiology, University of Chicago, Chicago, Illinois, United States of America.
Manicassamy B; Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2020 Sep 08; Vol. 16 (9), pp. e1008842. Date of Electronic Publication: 2020 Sep 08 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Apoptosis*
Signal Transduction*
Virus Replication*
Adenosine Deaminase/*metabolism
DEAD Box Protein 58/*metabolism
Influenza A virus/*physiology
Influenza, Human/*metabolism
RNA-Binding Proteins/*metabolism
A549 Cells ; Adenosine Deaminase/genetics ; DEAD Box Protein 58/genetics ; HEK293 Cells ; Humans ; Influenza, Human/genetics ; Isoenzymes/genetics ; Isoenzymes/metabolism ; RNA-Binding Proteins/genetics ; Receptors, Immunologic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Huaier Granule Combined with Tegafur Gimeracil Oteracil Potassium Promotes Stage IIb Gastric Cancer Prognosis and Induces Gastric Cancer Cell Apoptosis by Regulating Livin.
Autorzy:
Qi J; Department of Gastrointestinal Surgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Xie FJ; Department of Operating Room, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Liu S; Department of Gastrointestinal Surgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Yao CY; Department of Gastrointestinal Surgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Liu WH; Department of Gastrointestinal Surgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Cai GQ; Department of Gastrointestinal Surgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Liao GQ; Department of Gastrointestinal Surgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
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Źródło:
BioMed research international [Biomed Res Int] 2020 Jul 08; Vol. 2020, pp. 2403595. Date of Electronic Publication: 2020 Jul 08 (Print Publication: 2020).
Typ publikacji:
Journal Article
MeSH Terms:
Adaptor Proteins, Signal Transducing/*metabolism
Antineoplastic Agents/*therapeutic use
Apoptosis/*drug effects
Complex Mixtures/*therapeutic use
Inhibitor of Apoptosis Proteins/*metabolism
Neoplasm Proteins/*metabolism
Pyridines/*therapeutic use
Stomach Neoplasms/*drug therapy
Tegafur/*therapeutic use
Cell Line, Tumor ; Cell Proliferation/drug effects ; Disease-Free Survival ; Female ; Humans ; Male ; Middle Aged ; Potassium/therapeutic use ; Prognosis ; Retrospective Studies ; Stomach/drug effects ; Stomach/pathology ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Survival Rate ; Trametes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Extract of Juniperus indica Bertol Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase Cascade.
Autorzy:
Huang XF; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.; Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, Taiwan.
Chang KF; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.; Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, Taiwan.
Lee SC; Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung 40201, Taiwan.; Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
Li CY; Department of Life and Death, Nanhua University, Chiayi 62249, Taiwan,.
Liao HH; Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, Taiwan.
Hsieh MC; Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, Taiwan.; Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
Tsai NM; Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, Taiwan.; Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2020 Jun 13; Vol. 25 (12). Date of Electronic Publication: 2020 Jun 13.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents, Phytogenic*/agonists
Antineoplastic Agents, Phytogenic*/chemistry
Antineoplastic Agents, Phytogenic*/pharmacology
Cisplatin*/agonists
Cisplatin*/pharmacology
Mouth Neoplasms*/drug therapy
Mouth Neoplasms*/enzymology
Mouth Neoplasms*/pathology
Plant Extracts*/chemistry
Plant Extracts*/pharmacology
Apoptosis/*drug effects
Caspases/*metabolism
Juniperus/*chemistry
Neoplasm Proteins/*metabolism
Animals ; Cell Line, Tumor ; Dogs ; Drug Synergism ; Enzyme Activation/drug effects ; Humans ; Madin Darby Canine Kidney Cells ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Piscidin-1 Induces Apoptosis via Mitochondrial Reactive Oxygen Species-Regulated Mitochondrial Dysfunction in Human Osteosarcoma Cells.
Autorzy:
Cheng MH; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, 80756, Taiwan.; School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.; Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.
Pan CY; Department and Graduate Institute of Aquaculture, National Kaohsiung University of Science and Technology, Kaohsiung, 81101, Taiwan.
Chen NF; Division of Neurosurgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung, 80284, Taiwan.; Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, 11490, Taiwan.
Yang SN; Department of Internal Medicine, E-DA Hospital and College of Medicine, I-SHOU University, Kaohsiung, 84001, Taiwan.
Hsieh S; Department of Chemistry, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan.
Wen ZH; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan.; Doctoral Degree Program in Marine Biotechnology, Academia Sinica, Taipei, 11529, Taiwan.
Chen WF; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan.; Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, 83301, Taiwan.; Department of Neurosurgery, Xiamen Chang Gung Hospital, Xiamen, Fujian, China.
Wang JW; Department of Orthopedic, Kaohsiung Armed Forces General Hospital, Kaohsiung, 80284, Taiwan. .
Lu WH; Department of Orthopedic, Feng Yuan Hospital of the Ministry of Health, Taichung, 42055, Taiwan. .
Kuo HM; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan. .; Center for Neuroscience, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan. .
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Źródło:
Scientific reports [Sci Rep] 2020 Mar 19; Vol. 10 (1), pp. 5045. Date of Electronic Publication: 2020 Mar 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*
Antimicrobial Cationic Peptides/*pharmacology
Apoptosis/*drug effects
Bone Neoplasms/*pathology
Fish Proteins/*pharmacology
Mitochondria/*metabolism
Osteosarcoma/*pathology
Reactive Oxygen Species/*metabolism
Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/metabolism ; Amino Acid Sequence ; Animals ; Antimicrobial Cationic Peptides/chemistry ; Bass ; Fish Proteins/chemistry ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/enzymology ; Superoxide Dismutase/metabolism ; Thionucleotides/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Anti-Inflammatory, Anti-Oxidative, and Anti-Apoptotic Benefits of Stem Cells in Acute Ischemic Kidney Injury.
Autorzy:
Lee KH; Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan.; Institute of Clinical Medicine, National Yang-Ming University, Taipei 11217, Taiwan.; Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), Hsinchu 30010, Taiwan.
Tseng WC; Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan.; Institute of Clinical Medicine, National Yang-Ming University, Taipei 11217, Taiwan.; Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), Hsinchu 30010, Taiwan.
Yang CY; Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan.; Institute of Clinical Medicine, National Yang-Ming University, Taipei 11217, Taiwan.; Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), Hsinchu 30010, Taiwan.
Tarng DC; Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan. .; Institute of Clinical Medicine, National Yang-Ming University, Taipei 11217, Taiwan. .; Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), Hsinchu 30010, Taiwan. .; Department and Institute of Physiology, National Yang-Ming University, Taipei 11217, Taiwan. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Jul 19; Vol. 20 (14). Date of Electronic Publication: 2019 Jul 19.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Apoptosis*
Oxidative Stress*
Acute Kidney Injury/*etiology
Acute Kidney Injury/*metabolism
Reperfusion Injury/*etiology
Reperfusion Injury/*metabolism
Stem Cells/*metabolism
Acute Kidney Injury/pathology ; Acute Kidney Injury/therapy ; Animals ; Clinical Studies as Topic ; Culture Media, Conditioned/pharmacology ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Epithelial Cells/drug effects ; Epithelial Cells/immunology ; Epithelial Cells/metabolism ; Humans ; Inflammation ; Leukocytes/drug effects ; Leukocytes/immunology ; Leukocytes/metabolism ; Mesenchymal Stem Cell Transplantation ; Reperfusion Injury/pathology ; Reperfusion Injury/therapy ; Stem Cells/cytology ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
HDAC1 and HDAC2 Double Knockout Triggers Cell Apoptosis in Advanced Thyroid Cancer.
Autorzy:
Lin CL; Department of Endocrinology and Metabolism, Cathay General Hospital, Taipei 10630, Taiwan. .; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. .
Tsai ML; Department of General Surgery, Cathay General Hospital, Taipei 10630, Taiwan. .
Lin CY; Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu 30068, Taiwan. .; Bioinformatics Center, Institute for Chemical Research, Kyoto University, Kyoto 611-0011, Japan. .
Hsu KW; Institute of New Drug Development, China Medical University, Taichung 40402, Taiwan. .; Research Center for Tumor Medical Science, China Medical University, Taichung 40402, Taiwan. .
Hsieh WS; Department of Medical Laboratory, Taipei Medical University-Shuang Ho Hospital, New Taipei City 23561, Taiwan. .
Chi WM; Department of Clinical Pathology, Taipei Medical University-Shuang Ho Hospital, New Taipei City 23561, Taiwan. .
Huang LC; Department of Endocrinology and Metabolism, Cathay General Hospital, Taipei 10630, Taiwan. .; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. .
Lee CH; Department of Medical Laboratory, Taipei Medical University-Shuang Ho Hospital, New Taipei City 23561, Taiwan. .; School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan. .; Ph.D. Program in Medicine Biotechnology, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. .; TMU Research Center of Cancer Translational Medicine, Taipei 11031, Taiwan. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Jan 21; Vol. 20 (2). Date of Electronic Publication: 2019 Jan 21.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*genetics
Histone Deacetylase 1/*genetics
Histone Deacetylase 2/*genetics
Thyroid Neoplasms/*genetics
Thyroid Neoplasms/*pathology
Acetylation ; Apoptosis/drug effects ; CRISPR-Cas Systems ; Cell Line, Tumor ; Gene Editing ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Knockout Techniques ; Histone Deacetylase Inhibitors/pharmacology ; Histones/metabolism ; Humans ; Neoplasm Metastasis ; Neoplasm Staging ; Thyroid Neoplasms/drug therapy ; Thyroid Neoplasms/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy.
Autorzy:
Chang TC; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Surgery, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Division of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Wei PL; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Surgery, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Division of Colorectal Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.; Cancer Research Center and Translational Laboratory, Department of Medical Research, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University, Taipei, Taiwan.
Makondi PT; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; International PhD Program in Medicine, Taipei Medical University, Taipei, Taiwan.
Chen WT; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Huang CY; Department of Surgery, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Division of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Chang YJ; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Cancer Research Center and Translational Laboratory, Department of Medical Research, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.; International PhD Program in Medicine, Taipei Medical University, Taipei, Taiwan.
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Źródło:
PloS one [PLoS One] 2019 Jan 18; Vol. 14 (1), pp. e0210274. Date of Electronic Publication: 2019 Jan 18 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy*
Apoptosis/*drug effects
Bromelains/*pharmacology
Cell Proliferation/*drug effects
Colorectal Neoplasms/*pathology
Reactive Oxygen Species/*metabolism
Animals ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/metabolism ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays ; Zebrafish
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MLN4924, a Protein Neddylation Inhibitor, Suppresses the Growth of Human Chondrosarcoma through Inhibiting Cell Proliferation and Inducing Endoplasmic Reticulum Stress-Related Apoptosis.
Autorzy:
Wu MH; Department of Orthopaedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. .; Department of Orthopedics, Taipei Medical University Hospital, Taipei 11031, Taiwan. .; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan. .
Lee CY; Department of Orthopaedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. .; Department of Orthopedics, Taipei Medical University Hospital, Taipei 11031, Taiwan. .; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan. .
Huang TJ; Department of Orthopaedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. .; Department of Orthopedics, Taipei Medical University Hospital, Taipei 11031, Taiwan. .
Huang KY; Department of Orthopedics, National Cheng Kung University Hospital, Tainan 70101, Taiwan. .
Tang CH; Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan. .
Liu SH; Graduate Institute of Toxicology, National Taiwan University College of Medicine, Taipei 10051, Taiwan. .
Kuo KL; Graduate Institute of Toxicology, National Taiwan University College of Medicine, Taipei 10051, Taiwan. .; Department of Urology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 11031, Taiwan. .
Kuan FC; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan. .; Department of Hematology and Oncology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan. .
Lin WC; Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei 10051, Taiwan. .; Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 11031, Taiwan. .
Shi CS; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan. .; Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2018 Dec 24; Vol. 20 (1). Date of Electronic Publication: 2018 Dec 24.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Cell Proliferation/*drug effects
Cyclopentanes/*pharmacology
Enzyme Inhibitors/*pharmacology
Pyrimidines/*pharmacology
Animals ; Bone Neoplasms/drug therapy ; Bone Neoplasms/metabolism ; Bone Neoplasms/pathology ; Caspase 3/metabolism ; Cell Line, Tumor ; Chondrosarcoma/drug therapy ; Chondrosarcoma/metabolism ; Chondrosarcoma/pathology ; Cyclopentanes/therapeutic use ; Endoplasmic Reticulum Chaperone BiP ; Endoplasmic Reticulum Stress/drug effects ; Enzyme Inhibitors/therapeutic use ; G2 Phase Cell Cycle Checkpoints/drug effects ; Heat-Shock Proteins/metabolism ; Histones/metabolism ; Humans ; Mice ; Mice, Nude ; NEDD8 Protein/antagonists & inhibitors ; NEDD8 Protein/metabolism ; Phosphorylation/drug effects ; Pyrimidines/therapeutic use ; Transcription Factor CHOP/metabolism ; Transplantation, Heterologous
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Ergosterol peroxide from marine fungus Phoma sp. induces ROS-dependent apoptosis and autophagy in human lung adenocarcinoma cells.
Autorzy:
Wu HY; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.; Chemical Biology and Molecular Biophysics Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan.; Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan.
Yang FL; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Li LH; Department of Laboratory Medicine, Linsen, Chinese Medicine and Kunming Branch, Taipei City Hospital, Taipei, Taiwan.
Rao YK; Department of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan.
Ju TC; Department of Animal Science and Biotechnology, Tunghai University, Taichung, Taiwan.
Wong WT; Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.
Hsieh CY; Department of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan.
Pivkin MV; G.B. Elyakov Pacific Institute of Bioorganic Chemistry FEB RAS, Vladivostok, Russia.
Hua KF; Department of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan. .; Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. .; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. .
Wu SH; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan. .
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Źródło:
Scientific reports [Sci Rep] 2018 Dec 18; Vol. 8 (1), pp. 17956. Date of Electronic Publication: 2018 Dec 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis/*drug effects
Aquatic Organisms/*chemistry
Autophagy/*drug effects
Ergosterol/*analogs & derivatives
Fungi/*chemistry
A549 Cells ; Adenocarcinoma of Lung/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Synergism ; Ergosterol/chemistry ; Ergosterol/pharmacology ; Ergosterol/toxicity ; Fungi/isolation & purification ; Humans ; Inflammasomes ; Molecular Structure ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Reactive Oxygen Species/metabolism ; Sorafenib/pharmacology ; Tumor Stem Cell Assay
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Metformin induces apoptosis in mesenchymal stromal cells and dampens their therapeutic efficacy in infarcted myocardium.
Autorzy:
He X; Department of Stem Cell and Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China.; First Department, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China.
Yao MW; Department of Stem Cell and Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China.; First Department, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China.; Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Army Medical University, Chongqing, People's Republic of China.
Zhu M; Department of Stem Cell and Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China.; First Department, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China.
Liang DL; Department of Stem Cell and Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China.; First Department, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China.; Department of Histology and Embryology, Qingdao University Medical College, Qingdao, Shandong, People's Republic of China.
Guo W; Department of Stem Cell and Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China.; First Department, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China.
Yang Y; Department of Stem Cell and Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China.; First Department, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China.
Zhao RS; Department of Stem Cell and Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China.; First Department, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China.
Ren TT; Department of Stem Cell and Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China.; First Department, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China.; Department of Histology and Embryology, Qingdao University Medical College, Qingdao, Shandong, People's Republic of China.
Ao X; Department of Stem Cell and Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China.; First Department, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China.
Wang W; Department of Cardiology, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China.
Zeng CY; Department of Cardiology, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China.
Liang HP; First Department, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China.
Jiang DP; Department of Critical Care Medicine, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, 400042, People's Republic of China.
Yu J; Department of Pathology of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
Xu X; Department of Stem Cell and Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China. .; First Department, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital and Research Institute of Surgery, Army Medical University, Chongqing, People's Republic of China. .; Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Army Medical University, Chongqing, People's Republic of China. .
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Źródło:
Stem cell research & therapy [Stem Cell Res Ther] 2018 Nov 08; Vol. 9 (1), pp. 306. Date of Electronic Publication: 2018 Nov 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mesenchymal Stem Cell Transplantation*
Apoptosis/*drug effects
Mesenchymal Stem Cells/*cytology
Metformin/*pharmacology
Myocardial Infarction/*pathology
Myocardial Infarction/*therapy
Adenylate Kinase/metabolism ; Animals ; Cardiotonic Agents/metabolism ; Diabetes Mellitus, Experimental ; Female ; Humans ; Male ; Mice ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Downregulation of miR‑29b targets DNMT3b to suppress cellular apoptosis and enhance proliferation in pancreatic cancer.
Autorzy:
Wang LH; Department of Gastroenterology, Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China.
Huang J; Department of Queen Mary University, Medical College of Nanchang University, Nanchang, Jiangxi 330038, P.R. China.
Wu CR; Department of Gastroenterology, Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China.
Huang LY; Department of Gastroenterology, Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China.
Cui J; Department of Gastroenterology, Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China.
Xing ZZ; Department of Gastroenterology, Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China.
Zhao CY; Department of Gastroenterology, Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2018 Feb; Vol. 17 (2), pp. 2113-2120. Date of Electronic Publication: 2017 Nov 23.
Typ publikacji:
Journal Article; Retracted Publication
MeSH Terms:
Apoptosis/*genetics
DNA (Cytosine-5-)-Methyltransferases/*genetics
MicroRNAs/*genetics
Pancreatic Neoplasms/*genetics
3' Untranslated Regions ; Animals ; Cell Line, Tumor ; Cell Proliferation ; Cell Survival/genetics ; DNA Methyltransferase 3A ; Disease Models, Animal ; Disease Progression ; Gene Expression ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Genes, Reporter ; Humans ; Immunohistochemistry ; Male ; Mice ; Pancreatic Neoplasms/pathology ; RNA Interference ; DNA Methyltransferase 3B
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Epigallocatechin-3-Gallate Suppresses Human Herpesvirus 8 Replication and Induces ROS Leading to Apoptosis and Autophagy in Primary Effusion Lymphoma Cells.
Autorzy:
Tsai CY; Department of Medical Laboratory Science and Biotechnology, Fooyin-University, Kaohsiung 83102, Taiwan. .
Chen CY; Department of Medical Laboratory Science and Biotechnology, Fooyin-University, Kaohsiung 83102, Taiwan. .
Chiou YH; Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung 83102, Taiwan. .
Shyu HW; Department of Medical Laboratory Science and Biotechnology, Fooyin-University, Kaohsiung 83102, Taiwan. .
Lin KH; Department of Medical Laboratory Science and Biotechnology, Fooyin-University, Kaohsiung 83102, Taiwan. .
Chou MC; Department of Medical Laboratory Science and Biotechnology, Fooyin-University, Kaohsiung 83102, Taiwan. .
Huang MH; Department of Medical Laboratory Science and Biotechnology, Fooyin-University, Kaohsiung 83102, Taiwan. .
Wang YF; Department of Medical Laboratory Science and Biotechnology, Fooyin-University, Kaohsiung 83102, Taiwan. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2017 Dec 21; Vol. 19 (1). Date of Electronic Publication: 2017 Dec 21.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Autophagy/*drug effects
Catechin/*analogs & derivatives
Herpesviridae Infections/*drug therapy
Herpesvirus 8, Human/*drug effects
Lymphoma, Primary Effusion/*drug therapy
Reactive Oxygen Species/*metabolism
Virus Replication/*drug effects
Antineoplastic Agents/pharmacology ; Antiviral Agents/pharmacology ; Catechin/pharmacology ; Catechin/therapeutic use ; Cell Line, Tumor ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; HEK293 Cells ; Herpesviridae Infections/complications ; Humans ; Lymphoma, Primary Effusion/virology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
microRNA‑372 inhibits proliferation and induces apoptosis in human breast cancer cells by directly targeting E2F1.
Autorzy:
Zhao YX; Department of General Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China.
Liu HC; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China.
Ying WY; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China.
Wang CY; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China.
Yu YJ; Department of General Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China.
Sun WJ; Department of General Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China.
Liu JF; Department of General Practice, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2017 Dec; Vol. 16 (6), pp. 8069-8075. Date of Electronic Publication: 2017 Sep 22.
Typ publikacji:
Journal Article
MeSH Terms:
RNA Interference*
Apoptosis/*genetics
Breast Neoplasms/*genetics
E2F1 Transcription Factor/*genetics
MicroRNAs/*genetics
Breast Neoplasms/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Reactive oxygen species are required for zoledronic acid-induced apoptosis in osteoclast precursors and mature osteoclast-like cells.
Autorzy:
Tai TW; Department of Orthopedics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.; Department of Biomedical Engineering, College of Engineering, National Cheng Kung University, Tainan 701, Taiwan.
Chen CY; Department of Orthopedics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Su FC; Department of Biomedical Engineering, College of Engineering, National Cheng Kung University, Tainan 701, Taiwan.
Tu YK; Department of Orthopedics, E-Da Hospital, Kaohsiung 824, Taiwan.
Tsai TT; Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Lin CF; Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Jou IM; Department of Biomedical Engineering, College of Engineering, National Cheng Kung University, Tainan 701, Taiwan.; Department of Orthopedics, E-Da Hospital, Kaohsiung 824, Taiwan.
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Źródło:
Scientific reports [Sci Rep] 2017 Mar 10; Vol. 7, pp. 44245. Date of Electronic Publication: 2017 Mar 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis/*drug effects
Diphosphonates/*pharmacology
Imidazoles/*pharmacology
Osteoclasts/*drug effects
Reactive Oxygen Species/*metabolism
Stem Cells/*drug effects
Acetylcysteine/pharmacology ; Animals ; Caspase 3/metabolism ; Cell Differentiation/drug effects ; Cells, Cultured ; Glycogen Synthase Kinase 3 beta/metabolism ; HL-60 Cells ; Humans ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Osteoclasts/metabolism ; RAW 264.7 Cells ; Reactive Oxygen Species/antagonists & inhibitors ; Stem Cells/metabolism ; THP-1 Cells ; Zoledronic Acid
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
BL-038, a Benzofuran Derivative, Induces Cell Apoptosis in Human Chondrosarcoma Cells through Reactive Oxygen Species/Mitochondrial Dysfunction and the Caspases Dependent Pathway.
Autorzy:
Liu JF; Central Laboratory, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan. .
Chen CY; School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan. .
Chen HT; Department of Orthopedic Surgery, China Medical University Hospital, Taichung 404, Taiwan. .; School of Chinese Medicine, China Medical University, Taichung 404, Taiwan. .
Chang CS; School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan. .
Tang CH; Graduate Institute of Basic Medical Science, China Medical University, Taichung 404, Taiwan. .; Department of Pharmacology, School of Medicine, China Medical University, Taichung 404, Taiwan. .; Department of Biotechnology, College of Health Science, Asia University, Taichung 413, Taiwan. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2016 Sep 07; Vol. 17 (9). Date of Electronic Publication: 2016 Sep 07.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Benzofurans/*pharmacology
Caspases/*metabolism
Mitochondria/*drug effects
Reactive Oxygen Species/*metabolism
Signal Transduction/*drug effects
Antineoplastic Agents/chemistry ; Apoptosis Regulatory Proteins/metabolism ; Benzofurans/chemistry ; Blotting, Western ; Caspase 3/metabolism ; Caspase 9/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Chondrosarcoma/metabolism ; Chondrosarcoma/pathology ; Cytochromes c/metabolism ; Dose-Response Relationship, Drug ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/metabolism ; Molecular Structure ; Poly(ADP-ribose) Polymerases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Perfluorooctanesulfonate Mediates Renal Tubular Cell Apoptosis through PPARgamma Inactivation.
Autorzy:
Wen LL; Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan.; Department of Clinical Laboratory, En Chu Kong Hospital, New Taipei City, Taiwan.; Department of Medical Laboratory Science and Biotechnology, Yuanpei University, Hsinchu, Taiwan.
Lin CY; Department of Internal Medicine, En Chu Kong Hospital, New Taipei City, Taiwan.; School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
Chou HC; Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan.; Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Chang CC; Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan.; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Lo HY; Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan.; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Juan SH; Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan.; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
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Źródło:
PloS one [PLoS One] 2016 May 12; Vol. 11 (5), pp. e0155190. Date of Electronic Publication: 2016 May 12 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Alkanesulfonic Acids/*toxicity
Apoptosis/*drug effects
Fluorocarbons/*toxicity
Kidney Tubules/*pathology
PPAR gamma/*metabolism
Acetylation/drug effects ; Animals ; Antioxidants/metabolism ; Carnitine/pharmacology ; Cell Line ; Cell Proliferation/drug effects ; Cytochromes c/metabolism ; Cytosol/metabolism ; Genes, Reporter ; Inflammation/pathology ; Kidney Function Tests ; Kidney Tubules/drug effects ; Kidney Tubules/metabolism ; Kidney Tubules/physiopathology ; Male ; Mice, Inbred BALB C ; Oxidation-Reduction/drug effects ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Protective Agents/pharmacology ; Protein Binding/drug effects ; Rats ; Response Elements/genetics ; Rosiglitazone ; Signal Transduction/drug effects ; Sirtuin 1/metabolism ; Thiazolidinediones/pharmacology ; Tumor Suppressor Protein p53/metabolism ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Role of Signal Regulatory Protein α in Arsenic Trioxide-induced Promyelocytic Leukemia Cell Apoptosis.
Autorzy:
Pan C; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Advanced Institute for Life Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.; Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, 22 Hankou Road, Nanjing, Jiangsu 210093, China.
Zhu D; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Advanced Institute for Life Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.; Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, 22 Hankou Road, Nanjing, Jiangsu 210093, China.
Zhuo J; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Advanced Institute for Life Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.; Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, 22 Hankou Road, Nanjing, Jiangsu 210093, China.
Li L; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Advanced Institute for Life Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.; Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, 22 Hankou Road, Nanjing, Jiangsu 210093, China.
Wang D; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Advanced Institute for Life Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.; Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, 22 Hankou Road, Nanjing, Jiangsu 210093, China.
Zhang CY; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Advanced Institute for Life Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.; Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, 22 Hankou Road, Nanjing, Jiangsu 210093, China.
Liu Y; Department of Biology, Georgia State University, Atlanta, GA 30303.
Zen K; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Advanced Institute for Life Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.; Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, 22 Hankou Road, Nanjing, Jiangsu 210093, China.; Department of Biology, Georgia State University, Atlanta, GA 30303.
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Źródło:
Scientific reports [Sci Rep] 2016 Mar 24; Vol. 6, pp. 23710. Date of Electronic Publication: 2016 Mar 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antigens, Differentiation/*physiology
Apoptosis/*drug effects
Arsenicals/*pharmacology
Leukemia, Promyelocytic, Acute/*pathology
Oxides/*pharmacology
Receptors, Immunologic/*physiology
Arsenic Trioxide ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Humans ; MicroRNAs/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Roe Protein Hydrolysates of Giant Grouper (Epinephelus lanceolatus) Inhibit Cell Proliferation of Oral Cancer Cells Involving Apoptosis and Oxidative Stress.
Autorzy:
Yang JI; Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung 81157, Taiwan.
Tang JY; Department of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan; Department of Radiation Oncology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 80708, Taiwan.
Liu YS; Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung 81157, Taiwan.
Wang HR; Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Lee SY; School of Dentistry, Taipei Medical University, Taipei 11031, Taiwan; Division of Orthodontics, Wan-Fang Medical Center, Taipei Medical University, Taipei 11648, Taiwan.
Yen CY; School of Dentistry, Taipei Medical University, Taipei 11031, Taiwan; Department of Oral and Maxillofacial Surgery, Chi-Mei Medical Center, Tainan 71004, Taiwan.
Chang HW; Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan; Center for Research Resources and Development of Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
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Źródło:
BioMed research international [Biomed Res Int] 2016; Vol. 2016, pp. 8305073. Date of Electronic Publication: 2016 Apr 18.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Oxidative Stress*
Fish Proteins/*pharmacology
Ovum/*chemistry
Protein Hydrolysates/*pharmacology
Reactive Oxygen Species/*metabolism
Animals ; Antioxidants/metabolism ; Cell Cycle ; Cell Line, Tumor/drug effects ; Cell Proliferation ; Cell Survival ; Dose-Response Relationship, Drug ; Humans ; Hydrolysis ; Membrane Potential, Mitochondrial ; Mouth Neoplasms/pathology ; Perciformes ; Superoxides/metabolism ; Ultrafiltration
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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