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    Wyświetlanie 1-18 z 18
    Tytuł:
    Proteasome Inhibitors Interrupt the Activation of Non-Canonical NF-κB Signaling Pathway and Induce Cell Apoptosis in Cytarabine-Resistant HL60 Cells.
    Autorzy:
    Wang SY; Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan.; Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
    Shih YH; Department of Healthcare Administration, Asia University, Taichung 41354, Taiwan.
    Shieh TM; School of Dentistry, China Medical University, Taichung 40402, Taiwan.; Department of Dental Hygiene, China Medical University, Taichung 40402, Taiwan.
    Tseng YH; Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2021 Dec 29; Vol. 23 (1). Date of Electronic Publication: 2021 Dec 29.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Apoptosis*/drug effects
    Drug Resistance, Neoplasm*/drug effects
    Signal Transduction*/drug effects
    Cytarabine/*pharmacology
    NF-kappa B/*metabolism
    Proteasome Inhibitors/*pharmacology
    Gene Expression Profiling ; Gene Expression Regulation, Leukemic/drug effects ; HL-60 Cells ; Humans ; Models, Biological
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    EMP2 induces cytostasis and apoptosis via the TGFβ/SMAD/SP1 axis and recruitment of P2RX7 in urinary bladder urothelial carcinoma.
    Autorzy:
    Li CF; Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan.; National Cancer Research Institute, National Health Research Institutes, Tainan, Taiwan.; Department of Pathology, Chi-Mei Medical Center, Tainan, Taiwan.
    Chan TC; Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan.; National Cancer Research Institute, National Health Research Institutes, Tainan, Taiwan.
    Pan CT; Institute of Precision Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.; Department of Mechanical and Electro-Mechanical Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan.
    Vejvisithsakul PP; Institute of Biomedical Sciences, National Sun Yat-sen University, 70 Lienhai Rd, 80424, Kaohsiung, Taiwan.; Section for Translational Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
    Lai JC; Institute of Biomedical Sciences, National Sun Yat-sen University, 70 Lienhai Rd, 80424, Kaohsiung, Taiwan.
    Chen SY; Institute of Biomedical Sciences, National Sun Yat-sen University, 70 Lienhai Rd, 80424, Kaohsiung, Taiwan.
    Hsu YW; Institute of Biomedical Sciences, National Sun Yat-sen University, 70 Lienhai Rd, 80424, Kaohsiung, Taiwan.
    Shiao MS; Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
    Shiue YL; Institute of Precision Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan. .; Institute of Biomedical Sciences, National Sun Yat-sen University, 70 Lienhai Rd, 80424, Kaohsiung, Taiwan. .
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    Źródło:
    Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2021 Oct; Vol. 44 (5), pp. 1133-1150. Date of Electronic Publication: 2021 Aug 02.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Apoptosis/*genetics
    Carcinoma, Transitional Cell/*genetics
    Cell Proliferation/*genetics
    Membrane Glycoproteins/*genetics
    Proteins/*genetics
    Receptors, Purinergic P2X7/*genetics
    Urinary Bladder Neoplasms/*genetics
    Animals ; Carcinoma, Transitional Cell/metabolism ; Carcinoma, Transitional Cell/pathology ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Humans ; Immunoblotting ; Membrane Glycoproteins/metabolism ; Mice, Inbred NOD ; Mice, SCID ; Proteins/metabolism ; Receptors, Purinergic P2X7/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/genetics ; Smad Proteins/genetics ; Smad Proteins/metabolism ; Sp1 Transcription Factor/genetics ; Sp1 Transcription Factor/metabolism ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism ; Transplantation, Heterologous ; Urinary Bladder Neoplasms/metabolism ; Urinary Bladder Neoplasms/pathology ; Mice
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Knockdown of long non-coding RNA LEF1-AS1 attenuates apoptosis and inflammatory injury of microglia cells following spinal cord injury.
    Autorzy:
    Cui SY; Department of Orthopedic, Nantong First People's Hospital & The Second Affiliated Hospital of Nantong University, No. 6 Haierxiangbei Road, Nantong, 226001, Jiangsu Province, China.
    Zhang W; Department of Orthopedic, Nantong First People's Hospital & The Second Affiliated Hospital of Nantong University, No. 6 Haierxiangbei Road, Nantong, 226001, Jiangsu Province, China.
    Cui ZM; Department of Orthopedic, Nantong First People's Hospital & The Second Affiliated Hospital of Nantong University, No. 6 Haierxiangbei Road, Nantong, 226001, Jiangsu Province, China.
    Yi H; Department of Orthopedic, Nantong First People's Hospital & The Second Affiliated Hospital of Nantong University, No. 6 Haierxiangbei Road, Nantong, 226001, Jiangsu Province, China.
    Xu DW; Department of Orthopedic, Nantong First People's Hospital & The Second Affiliated Hospital of Nantong University, No. 6 Haierxiangbei Road, Nantong, 226001, Jiangsu Province, China.
    Liu W; Department of Orthopedic, Nantong First People's Hospital & The Second Affiliated Hospital of Nantong University, No. 6 Haierxiangbei Road, Nantong, 226001, Jiangsu Province, China.
    Zhu XH; Department of Orthopedic, Nantong First People's Hospital & The Second Affiliated Hospital of Nantong University, No. 6 Haierxiangbei Road, Nantong, 226001, Jiangsu Province, China. .
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    Źródło:
    Journal of orthopaedic surgery and research [J Orthop Surg Res] 2021 Jan 06; Vol. 16 (1), pp. 6. Date of Electronic Publication: 2021 Jan 06.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Gene Knockdown Techniques*
    Apoptosis/*genetics
    Lymphoid Enhancer-Binding Factor 1/*genetics
    Lymphoid Enhancer-Binding Factor 1/*physiology
    Microglia/*pathology
    RNA, Long Noncoding/*genetics
    RNA, Long Noncoding/*physiology
    Spinal Cord Injuries/*genetics
    Spinal Cord Injuries/*pathology
    Animals ; Cell Survival/genetics ; Disease Progression ; Down-Regulation ; Inflammation ; Lymphoid Enhancer-Binding Factor 1/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Rats, Sprague-Dawley ; Rats, Wistar ; Receptor Activity-Modifying Protein 3/genetics ; Receptor Activity-Modifying Protein 3/metabolism ; Up-Regulation ; Rats
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    4-Acetylantroquinonol B Inhibits Osteoclastogenesis by Inhibiting the Autophagy Pathway in a Simulated Microgravity Model.
    Autorzy:
    Wu CH; Graduate Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei 11490, Taiwan.
    Ou CH; Department of Anesthesiology, Cheng-Hsin General Hospital, Taipei 11220, Taiwan.
    Yen IC; School of Pharmacy, National Defense Medical Center, Taipei 11490, Taiwan.
    Lee SY; Graduate Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei 11490, Taiwan.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2020 Sep 22; Vol. 21 (18). Date of Electronic Publication: 2020 Sep 22.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Weightlessness Simulation*
    4-Butyrolactone/*analogs & derivatives
    Apoptosis/*drug effects
    Autophagy/*drug effects
    Cyclohexanones/*pharmacology
    Osteoclasts/*metabolism
    Signal Transduction/*drug effects
    4-Butyrolactone/pharmacology ; Animals ; Cell Cycle Checkpoints/drug effects ; Gene Expression Regulation/drug effects ; Mice ; RAW 264.7 Cells
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    MiR-708 inhibits MC3T3-E1 cells against H 2 O 2 -induced apoptosis through targeting PTEN.
    Autorzy:
    Zhang W; Department of Orthopedics, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, 215004, Jiangsu, China.
    Cui SY; Department of Orthopedics, The First People's Hospital of Nantong, Nantong, 226001, Jiangsu Province, China.
    Yi H; Department of Orthopedics, The First People's Hospital of Nantong, Nantong, 226001, Jiangsu Province, China.
    Zhu XH; Department of Orthopedics, The First People's Hospital of Nantong, Nantong, 226001, Jiangsu Province, China.
    Liu W; Department of Orthopedics, The First People's Hospital of Nantong, Nantong, 226001, Jiangsu Province, China.
    Xu YJ; Department of Orthopedics, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, 215004, Jiangsu, China. .
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    Źródło:
    Journal of orthopaedic surgery and research [J Orthop Surg Res] 2020 Jul 10; Vol. 15 (1), pp. 255. Date of Electronic Publication: 2020 Jul 10.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Apoptosis/*drug effects
    Apoptosis/*genetics
    Hydrogen Peroxide/*adverse effects
    MicroRNAs/*pharmacology
    MicroRNAs/*physiology
    Osteoblasts/*metabolism
    Osteoblasts/*physiology
    PTEN Phosphohydrolase/*metabolism
    3T3 Cells ; Animals ; Cells, Cultured ; Glutathione Peroxidase/metabolism ; Malondialdehyde/metabolism ; Mice ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Tetrahydroxystilbene glucoside relieves the chronic inflammatory pain by inhibiting neuronal apoptosis, microglia activation, and GluN2B overexpression in anterior cingulate cortex.
    Autorzy:
    Fan YF; 1 Department of Orthopedics, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
    Guan SY; 2 Department of Pharmacy, Precision Pharmacy and Drug Development Center, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.; 3 Department of Nature Medicine, School of Pharmacy, Air Force Medical University, Xi'an, China.
    Luo L; 2 Department of Pharmacy, Precision Pharmacy and Drug Development Center, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.
    Li YJ; 2 Department of Pharmacy, Precision Pharmacy and Drug Development Center, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.; 3 Department of Nature Medicine, School of Pharmacy, Air Force Medical University, Xi'an, China.
    Yang L; 2 Department of Pharmacy, Precision Pharmacy and Drug Development Center, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.
    Zhou XX; 3 Department of Nature Medicine, School of Pharmacy, Air Force Medical University, Xi'an, China.
    Guo GD; 1 Department of Orthopedics, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
    Zhao MG; 2 Department of Pharmacy, Precision Pharmacy and Drug Development Center, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.
    Yang Q; 2 Department of Pharmacy, Precision Pharmacy and Drug Development Center, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.
    Liu G; 1 Department of Orthopedics, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
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    Źródło:
    Molecular pain [Mol Pain] 2018 Jan-Dec; Vol. 14, pp. 1744806918814367. Date of Electronic Publication: 2018 Nov 01.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Apoptosis*/drug effects
    Chronic Pain/*drug therapy
    Glucosides/*therapeutic use
    Gyrus Cinguli/*metabolism
    Gyrus Cinguli/*pathology
    Inflammation/*drug therapy
    Microglia/*pathology
    Receptors, N-Methyl-D-Aspartate/*metabolism
    Stilbenes/*therapeutic use
    Animals ; Cell Survival/drug effects ; Chronic Pain/complications ; Chronic Pain/pathology ; Cytokines/metabolism ; Edema/drug therapy ; Freund's Adjuvant/administration & dosage ; Glucosides/chemistry ; Glucosides/pharmacology ; Gyrus Cinguli/drug effects ; Hyperalgesia/complications ; Hyperalgesia/drug therapy ; Inflammation/complications ; Inflammation/pathology ; Inflammation Mediators/metabolism ; Male ; Mice, Inbred C57BL ; Microglia/drug effects ; Microglia/metabolism ; NF-kappa B/metabolism ; Signal Transduction ; Stilbenes/chemistry ; Stilbenes/pharmacology ; p38 Mitogen-Activated Protein Kinases/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Cudraflavone C Induces Apoptosis of A375.S2 Melanoma Cells through Mitochondrial ROS Production and MAPK Activation.
    Autorzy:
    Lee CW; Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chia-Yi 61363, Taiwan. .; Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Chia-Yi 61363, Taiwan. .; Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan. .
    Yen FL; Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. .; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan. .
    Ko HH; Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. .
    Li SY; Department of Pharmacy, College of Pharmacy & Health Care, Tajen University, Pingtung 90741, Taiwan. .
    Chiang YC; Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chia-Yi 61363, Taiwan. .; Center for Drug Abuse and Addiction, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan. .
    Lee MH; Division of Neurosurgery, Department of Surgery, Chang Gung Memorial Hospital, Chia-Yi61363, Taiwan. .
    Tsai MH; Department of Pediatrics, Division of Neonatology and Pediatric Hematology/Oncology, Chang Gung Memorial Hospital, Yunlin 63862, Taiwan. .
    Hsu LF; Department of Respiratory Care, Chang Gung University of Science and Technology, Chia-Yi Campus, Chia-Yi 61363, Taiwan. .
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2017 Jul 13; Vol. 18 (7). Date of Electronic Publication: 2017 Jul 13.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Apoptosis/*drug effects
    Flavones/*pharmacology
    Melanoma/*enzymology
    Melanoma/*pathology
    Mitochondria/*metabolism
    Mitogen-Activated Protein Kinases/*metabolism
    Reactive Oxygen Species/*metabolism
    Caspases/metabolism ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Enzyme Activation/drug effects ; Flavones/chemistry ; Humans ; Melanoma/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/drug effects ; Neoplasm Proteins/metabolism ; Phosphorylation/drug effects
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson's disease.
    Autorzy:
    Liu HF; Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong.
    Ho PW; Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong.
    Leung GC; Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong.
    Lam CS; Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong.
    Pang SY; Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong.
    Li L; Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong.
    Kung MH; Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong.
    Ramsden DB; Institute of Metabolism and Systems Research, University of Birmingham, United Kingdom.
    Ho SL; Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong.
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    Źródło:
    Scientific reports [Sci Rep] 2017 Jan 18; Vol. 7, pp. 40887. Date of Electronic Publication: 2017 Jan 18.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Apoptosis/*drug effects
    Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/*genetics
    Parkinson Disease/*pathology
    Rotenone/*pharmacology
    Administration, Oral ; Aging ; Animals ; Disease Models, Animal ; Dopamine/metabolism ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/metabolism ; Electron Transport Complex I/metabolism ; Gene Knock-In Techniques ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Mutagenesis, Site-Directed ; Neurons/cytology ; Neurons/drug effects ; Neurons/metabolism ; Parkinson Disease/drug therapy ; Parkinson Disease/metabolism ; Rotenone/therapeutic use ; Synaptosomes/metabolism ; Vacuolar Proton-Translocating ATPases/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Dual role of acetaminophen in promoting hepatoma cell apoptosis and kidney fibroblast proliferation.
    Autorzy:
    Yu YL; Graduate Institute of Cancer Biology and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan, R.O.C.
    Yiang GT; Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231, Taiwan, R.O.C.
    Chou PL; Division of Allergy‑Immunology‑Rheumatology, Department of Internal Medicine, Saint Mary's Hospital Luodong, Yilan 265, Taiwan, R.O.C.
    Tseng HH; Division of General Surgery, Taichung Hospital, Ministry of Health and Welfare, Taichung 403, Taiwan, R.O.C.
    Wu TK; 2The Ph.D. Program for Cancer Biology and Drug Discovery, China Medical University, Taichung 404, Taiwan, R.O.C.
    Hung YT; Department of Nutrition, Master Program of Biomedical Nutrition, Hungkuang University, Taichung 433, Taiwan, R.O.C.
    Lin PS; Department of Nutrition, Master Program of Biomedical Nutrition, Hungkuang University, Taichung 433, Taiwan, R.O.C.
    Lin SY; Department of Nutrition, Master Program of Biomedical Nutrition, Hungkuang University, Taichung 433, Taiwan, R.O.C.
    Liu HC; Department of Nursing, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231, Taiwan, R.O.C.
    Chang WJ; Graduate Institute of Cancer Biology and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan, R.O.C.
    Wei CW; Department of Nutrition, Master Program of Biomedical Nutrition, Hungkuang University, Taichung 433, Taiwan, R.O.C.
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    Źródło:
    Molecular medicine reports [Mol Med Rep] 2014 Jun; Vol. 9 (6), pp. 2077-84. Date of Electronic Publication: 2014 Mar 28.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Acetaminophen/*pharmacology
    Apoptosis/*drug effects
    Acetaminophen/toxicity ; Animals ; Carcinoma, Hepatocellular/metabolism ; Caspase 3/metabolism ; Caspase 9/metabolism ; Cell Line ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Enzyme Activation/drug effects ; Epithelial Cells/drug effects ; Fibroblasts/drug effects ; Humans ; Kidney/cytology ; Kidney Tubules/cytology ; Rats
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Tanshinone IIA induces apoptosis in human oral cancer KB cells through a mitochondria-dependent pathway.
    Autorzy:
    Tseng PY; Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, No. 135 Nanxiao Street, Changhua 500, Taiwan.
    Lu WC; Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan.
    Hsieh MJ; Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan ; Institute of Medicine, Chung Shan Medical University, Taichung 500, Taiwan ; School of Optometry, Chung Shan Medical University, Taichung 402, Taiwan.
    Chien SY; Department of Pharmacy, Changhua Christian Hospital, No. 135 Nanxiao Street, Changhua 500, Taiwan ; School of Pharmacy, China Medical University, Taichung 404, Taiwan ; College of Health Sciences, Chang Jung Christian University, Tainan 711, Taiwan.
    Chen MK; Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, No. 135 Nanxiao Street, Changhua 500, Taiwan ; Institute of Medicine, Chung Shan Medical University, Taichung 500, Taiwan.
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    Źródło:
    BioMed research international [Biomed Res Int] 2014; Vol. 2014, pp. 540516. Date of Electronic Publication: 2014 May 13.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication
    MeSH Terms:
    Abietanes/*pharmacology
    Apoptosis/*drug effects
    Mitochondria/*drug effects
    Mouth Neoplasms/*drug therapy
    Caspases/metabolism ; Cell Death/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; G2 Phase Cell Cycle Checkpoints/drug effects ; Humans ; KB Cells ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/metabolism ; Mouth Neoplasms/metabolism ; Poly(ADP-ribose) Polymerases/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Effect of mitochondria-targeted antioxidant SkQ1 on programmed cell death induced by viral proteins in tobacco plants.
    Autorzy:
    Solovieva AD; Faculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia.
    Frolova OY
    Solovyev AG
    Morozov SY
    Zamyatnin AA Jr
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    Źródło:
    Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2013 Sep; Vol. 78 (9), pp. 1006-12.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Antioxidants/*pharmacology
    Apoptosis/*drug effects
    Mitochondria/*drug effects
    Plastoquinone/*analogs & derivatives
    Nicotiana/*drug effects
    Viral Proteins/*metabolism
    Animals ; Apoptosis/physiology ; Endoplasmic Reticulum Stress/drug effects ; Endoplasmic Reticulum Stress/physiology ; Humans ; Mitochondria/metabolism ; Plant Viruses ; Plastoquinone/pharmacology ; Nicotiana/cytology ; Nicotiana/metabolism ; Viral Proteins/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    The role of globular heads of the C1q receptor in HPV 16 E2-induced human cervical squamous carcinoma cell apoptosis is associated with p38 MAPK/JNK activation.
    Autorzy:
    Gao LJ; State Key Laboratory of Reproductive Medicine, Department of Clinical Laboratory, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Tianfei Alley, Nanjing Mochou Road, Nanjing, 210004, PR China. />Gu PQ
    Zhao W
    Ding WY
    Zhao XQ
    Guo SY
    Zhong TY
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    Źródło:
    Journal of translational medicine [J Transl Med] 2013 May 08; Vol. 11, pp. 118. Date of Electronic Publication: 2013 May 08.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Apoptosis*
    Signal Transduction*
    Carcinoma, Squamous Cell/*pathology
    DNA-Binding Proteins/*metabolism
    Membrane Glycoproteins/*metabolism
    Oncogene Proteins, Viral/*metabolism
    Receptors, Complement/*metabolism
    Uterine Cervical Neoplasms/*pathology
    Carcinoma, Squamous Cell/metabolism ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Cell Survival ; Female ; Gene Expression Regulation, Neoplastic ; Human papillomavirus 16 ; Humans ; MAP Kinase Kinase 4/metabolism ; Protein Structure, Tertiary ; Uterine Cervical Neoplasms/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Paeoniflorin protects myocardial cell from doxorubicin-induced apoptosis through inhibition of NADPH oxidase.
    Autorzy:
    Li JZ; Department of Pharmacy, Ruikang Hospital, Guangxi University of Traditional Chinese Medicine, Nanning, China.
    Yu SY
    Wu JH
    Shao QR
    Dong XM
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    Źródło:
    Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2012 Dec; Vol. 90 (12), pp. 1569-75. Date of Electronic Publication: 2012 Nov 19.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antibiotics, Antineoplastic/*toxicity
    Apoptosis/*drug effects
    Benzoates/*pharmacology
    Bridged-Ring Compounds/*pharmacology
    Doxorubicin/*toxicity
    Glucosides/*pharmacology
    Myocytes, Cardiac/*drug effects
    NADPH Oxidases/*antagonists & inhibitors
    Animals ; Apoptosis/genetics ; Caspase 3/genetics ; Caspase 3/metabolism ; Cells, Cultured ; Drug Interactions ; Membrane Glycoproteins/antagonists & inhibitors ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Monoterpenes ; Myocytes, Cardiac/metabolism ; NADPH Oxidase 2 ; NADPH Oxidase 4 ; NADPH Oxidases/genetics ; NADPH Oxidases/metabolism ; RNA, Messenger/genetics ; Rats ; Reactive Oxygen Species/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Induction of apoptosis by ethanolic extract of Corchorus olitorius leaf in human hepatocellular carcinoma (HepG2) cells via a mitochondria-dependent pathway.
    Autorzy:
    Li CJ; Institute of Medical Sciences, Tzu Chi University, No. 701, Sec. 3, Zhongyang Rd., Hualien City, 970, Taiwan.
    Huang SY
    Wu MY
    Chen YC
    Tsang SF
    Chyuan JH
    Hsu HY
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2012 Aug 03; Vol. 17 (8), pp. 9348-60. Date of Electronic Publication: 2012 Aug 03.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antineoplastic Agents/*pharmacology
    Apoptosis/*drug effects
    Corchorus/*chemistry
    Mitochondria/*drug effects
    Plant Extracts/*pharmacology
    Plant Leaves/*chemistry
    Antineoplastic Agents/isolation & purification ; Apoptosis Regulatory Proteins/metabolism ; Carcinoma, Hepatocellular/drug therapy ; Cell Cycle/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; DNA Fragmentation ; Drug Screening Assays, Antitumor ; Ethanol/chemistry ; Hep G2 Cells ; Hepatocytes/drug effects ; Humans ; Liver Neoplasms/drug therapy ; Plant Extracts/isolation & purification ; Solvents/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Stabilization of Nrf2 protein by D3T provides protection against ethanol-induced apoptosis in PC12 cells.
    Autorzy:
    Dong J; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina, USA.
    Yan D
    Chen SY
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    Źródło:
    PloS one [PLoS One] 2011 Feb 03; Vol. 6 (2), pp. e16845. Date of Electronic Publication: 2011 Feb 03.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Apoptosis/*drug effects
    Cytoprotection/*drug effects
    Ethanol/*toxicity
    NF-E2-Related Factor 2/*metabolism
    Thiones/*pharmacology
    Thiophenes/*pharmacology
    Animals ; Antioxidants/pharmacology ; Drug Evaluation, Preclinical ; Mice ; NF-E2-Related Factor 2/drug effects ; NF-E2-Related Factor 2/physiology ; PC12 Cells ; Protein Stability/drug effects ; Rats
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Inducing apoptosis of human colon cancer cells by an IGF-I D domain analogue peptide.
    Autorzy:
    Yang SY; University Department of Surgery, Royal Free & University College Medical School, University College London, Rowland Hill Street, London NW3 2PF, UK. />Sales KM
    Fuller BJ
    Seifalian AM
    Winslet MC
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    Źródło:
    Molecular cancer [Mol Cancer] 2008 Feb 08; Vol. 7, pp. 17. Date of Electronic Publication: 2008 Feb 08.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antineoplastic Agents/*pharmacology
    Apoptosis/*drug effects
    Colonic Neoplasms/*drug therapy
    Peptides/*pharmacology
    Receptor, IGF Type 1/*antagonists & inhibitors
    Amino Acid Motifs ; Amino Acid Sequence ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/therapeutic use ; Caspases ; Cell Line, Tumor ; Cell Proliferation ; Colonic Neoplasms/metabolism ; Humans ; Insulin-Like Growth Factor I/analogs & derivatives ; Insulin-Like Growth Factor I/pharmacology ; Intercellular Signaling Peptides and Proteins ; Molecular Sequence Data ; Peptides/chemical synthesis ; Peptides/therapeutic use ; Protein Structure, Tertiary ; Tumor Cells, Cultured ; bcl-2-Associated X Protein/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Carbazole alkaloids as new cell cycle inhibitor and apoptosis inducers from Clausena dunniana Levl.
    Autorzy:
    Cui CB; Beijing Institute of Biomedicine, Beijing 100091, People's Republic of China. />Yan SY
    Cai B
    Yao XS
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    Źródło:
    Journal of Asian natural products research [J Asian Nat Prod Res] 2002 Dec; Vol. 4 (4), pp. 233-41.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Alkaloids/*pharmacology
    Apoptosis/*drug effects
    Carbazoles/*pharmacology
    Cell Cycle/*drug effects
    Rutaceae/*chemistry
    Alkaloids/isolation & purification ; Biological Assay ; Carbazoles/chemistry ; Carbazoles/isolation & purification ; DNA Damage ; Fibrosarcoma/pathology ; Humans ; Tumor Cells, Cultured
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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