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    Tytuł:
    Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease
    Autorzy:
    Olah, MartaAff1, Aff2, Aff3, Aff4
    Menon, VilasAff1, Aff2, Aff3, Aff4
    Habib, NaomiAff4, Aff5
    Taga, Mariko F.Aff1, Aff2, Aff3, Aff4
    Ma, YiyiAff1, Aff2, Aff3, Aff4
    Yung, Christina J.
    Cimpean, Maria
    Khairallah, Anthony
    Coronas-Samano, GuillermoAff2, Aff6
    Sankowski, RomanAff7, Aff8
    Grün, Dominic
    Kroshilina, Alexandra A.
    Dionne, Danielle
    Sarkis, Rani A.
    Cosgrove, Garth R.
    Helgager, Jeffrey
    Golden, Jeffrey A.
    Pennell, Page B.
    Prinz, MarcoAff7, Aff13, Aff14
    Vonsattel, Jean Paul G.Aff2, Aff6
    Teich, Andrew F.Aff2, Aff3, Aff6
    Schneider, Julie A.
    Bennett, David A.
    Regev, AvivAff4, Aff16, Aff17, Aff18
    Elyaman, WassimAff2, Aff3, Aff4
    Bradshaw, Elizabeth M.Aff2, Aff3, Aff4
    De Jager, Philip L.Aff1, Aff2, Aff3, Aff4
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    Źródło:
    Nature Communications. 11(1)
    Czasopismo naukowe
    Szczegóły
    Tytuł:
    BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology.
    Autorzy:
    Taga M; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th st, PH19-311, New York, NY, 10032, USA.; Cell Circuits Program, Broad Institute, Cambridge, MA, USA.
    Petyuk VA; Pacific Northwest National Laboratory, Richland, WA, USA.
    White C; Cell Circuits Program, Broad Institute, Cambridge, MA, USA.
    Marsh G; Biogen, 225 Binney St, Cambridge, MA, 02142, USA.
    Ma Y; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th st, PH19-311, New York, NY, 10032, USA.
    Klein HU; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th st, PH19-311, New York, NY, 10032, USA.; Cell Circuits Program, Broad Institute, Cambridge, MA, USA.
    Connor SM; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th st, PH19-311, New York, NY, 10032, USA.; Cell Circuits Program, Broad Institute, Cambridge, MA, USA.
    Kroshilina A; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th st, PH19-311, New York, NY, 10032, USA.
    Yung CJ; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th st, PH19-311, New York, NY, 10032, USA.
    Khairallah A; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th st, PH19-311, New York, NY, 10032, USA.
    Olah M; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th st, PH19-311, New York, NY, 10032, USA.; Cell Circuits Program, Broad Institute, Cambridge, MA, USA.
    Schneider J; Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
    Karhohs K; Imaging Platform, Broad Institute, Cambridge, MA, USA.
    Carpenter AE; Imaging Platform, Broad Institute, Cambridge, MA, USA.
    Ransohoff R; Third Rock Ventures, 29 Newbury Street, Suite 301, Boston, MA, 02116, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
    Bennett DA; Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
    Crotti A; Biogen, 225 Binney St, Cambridge, MA, 02142, USA.
    Bradshaw EM; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th st, PH19-311, New York, NY, 10032, USA.; Cell Circuits Program, Broad Institute, Cambridge, MA, USA.
    De Jager PL; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th st, PH19-311, New York, NY, 10032, USA. .; Cell Circuits Program, Broad Institute, Cambridge, MA, USA. .
    Pokaż więcej
    Źródło:
    Molecular neurodegeneration [Mol Neurodegener] 2020 Jul 29; Vol. 15 (1), pp. 44. Date of Electronic Publication: 2020 Jul 29.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Adaptor Proteins, Signal Transducing/*metabolism
    Astrocytes/*metabolism
    Microglia/*metabolism
    Nuclear Proteins/*metabolism
    Tumor Suppressor Proteins/*metabolism
    tau Proteins/*metabolism
    Alzheimer Disease/metabolism ; Brain/metabolism ; Humans ; Neurons/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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