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    Tytuł:
    A novel LGI1 mutation causing autosomal dominant lateral temporal lobe epilepsy confirmed by a precise knock-in mouse model.
    Autorzy:
    Hu P; Department of Prenatal Diagnosis, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health care Hospital, Nanjing, China.
    Wu D; Minister of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Neurology, Drum Tower Hospital, Medical School, Nanjing University, Nanjing, China.; State Key Laboratory of Pharmaceutical Biotechnology, National Resource for Mutant Mice, Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, China.
    Zang YY; Minister of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Neurology, Drum Tower Hospital, Medical School, Nanjing University, Nanjing, China.; State Key Laboratory of Pharmaceutical Biotechnology, National Resource for Mutant Mice, Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, China.
    Wang Y; Department of Prenatal Diagnosis, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health care Hospital, Nanjing, China.
    Zhou YP; School of Pharmacy, Nanjing Medical University, Nanjing, China.
    Qiao F; Department of Prenatal Diagnosis, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health care Hospital, Nanjing, China.
    Teng XY; Minister of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Neurology, Drum Tower Hospital, Medical School, Nanjing University, Nanjing, China.; State Key Laboratory of Pharmaceutical Biotechnology, National Resource for Mutant Mice, Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, China.
    Chen J; Minister of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Neurology, Drum Tower Hospital, Medical School, Nanjing University, Nanjing, China.; State Key Laboratory of Pharmaceutical Biotechnology, National Resource for Mutant Mice, Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, China.
    Li QQ; Minister of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Neurology, Drum Tower Hospital, Medical School, Nanjing University, Nanjing, China.; State Key Laboratory of Pharmaceutical Biotechnology, National Resource for Mutant Mice, Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, China.
    Sun JH; Minister of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Neurology, Drum Tower Hospital, Medical School, Nanjing University, Nanjing, China.; State Key Laboratory of Pharmaceutical Biotechnology, National Resource for Mutant Mice, Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, China.
    Liu T; Minister of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Neurology, Drum Tower Hospital, Medical School, Nanjing University, Nanjing, China.; State Key Laboratory of Pharmaceutical Biotechnology, National Resource for Mutant Mice, Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, China.
    Feng HY; Department of Prenatal Diagnosis, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health care Hospital, Nanjing, China.
    Zhou QG; School of Pharmacy, Nanjing Medical University, Nanjing, China.
    Shi YS; Minister of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Neurology, Drum Tower Hospital, Medical School, Nanjing University, Nanjing, China.; State Key Laboratory of Pharmaceutical Biotechnology, National Resource for Mutant Mice, Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, China.; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing, China.; Institute for Brain Sciences, Nanjing University, Nanjing, China.
    Xu Z; Department of Prenatal Diagnosis, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health care Hospital, Nanjing, China.
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    Źródło:
    CNS neuroscience & therapeutics [CNS Neurosci Ther] 2022 Feb; Vol. 28 (2), pp. 237-246. Date of Electronic Publication: 2021 Nov 12.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Disease Models, Animal*
    Epilepsy, Temporal Lobe/*genetics
    Epilepsy, Temporal Lobe/*physiopathology
    Intracellular Signaling Peptides and Proteins/*genetics
    Animals ; Child ; Female ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Pedigree
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    SNP rs10420324 in the AMPA receptor auxiliary subunit TARP γ-8 regulates the susceptibility to antisocial personality disorder.
    Autorzy:
    Peng SX; MOE Key Laboratory of Model Animal for Disease Study, Department of Neurology, Drum Tower Hospital, Medical School, Nanjing University, Nanjing, 210032, China.; State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, National Resource Center for Mutant Mice, Medical School, Nanjing University, Nanjing, 210032, China.
    Wang YY; MOE Key Laboratory of Model Animal for Disease Study, Department of Neurology, Drum Tower Hospital, Medical School, Nanjing University, Nanjing, 210032, China.; State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, National Resource Center for Mutant Mice, Medical School, Nanjing University, Nanjing, 210032, China.
    Zhang M; School of Psychology, Nanjing Normal University, Nanjing, 210029, China.
    Zang YY; MOE Key Laboratory of Model Animal for Disease Study, Department of Neurology, Drum Tower Hospital, Medical School, Nanjing University, Nanjing, 210032, China.; State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, National Resource Center for Mutant Mice, Medical School, Nanjing University, Nanjing, 210032, China.
    Wu D; MOE Key Laboratory of Model Animal for Disease Study, Department of Neurology, Drum Tower Hospital, Medical School, Nanjing University, Nanjing, 210032, China.
    Pei J; MOE Key Laboratory of Model Animal for Disease Study, Department of Neurology, Drum Tower Hospital, Medical School, Nanjing University, Nanjing, 210032, China.; State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, National Resource Center for Mutant Mice, Medical School, Nanjing University, Nanjing, 210032, China.
    Li Y; Reward, Competition and Social Neuroscience Lab, Department of Psychology, School of Social and Behavioral Sciences, Nanjing University, Nanjing, 210023, China.
    Dai J; Chinese Brain Bank Center, Wuhan, 430074, China.
    Guo X; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
    Luo X; Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06510, USA.
    Zhang N; School of Psychology, Nanjing Normal University, Nanjing, 210029, China.; Department of Medical Psychology, Nanjing Medical University Affiliated Nanjing Brain Hospital, Nanjing, 210029, China.
    Yang JJ; Department of Anesthesiology and Perioperative Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China.
    Zhang C; School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, 100069, China.
    Gao X; MOE Key Laboratory of Model Animal for Disease Study, Department of Neurology, Drum Tower Hospital, Medical School, Nanjing University, Nanjing, 210032, China.; State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, National Resource Center for Mutant Mice, Medical School, Nanjing University, Nanjing, 210032, China.
    Liu N; Department of Medical Psychology, Nanjing Medical University Affiliated Nanjing Brain Hospital, Nanjing, 210029, China. naliu_.
    Shi YS; MOE Key Laboratory of Model Animal for Disease Study, Department of Neurology, Drum Tower Hospital, Medical School, Nanjing University, Nanjing, 210032, China. .; State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, National Resource Center for Mutant Mice, Medical School, Nanjing University, Nanjing, 210032, China. .; Institute for Brain Sciences, Nanjing University, Nanjing, 210032, China. .; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing, 210032, China. .
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    Źródło:
    Scientific reports [Sci Rep] 2021 Jun 07; Vol. 11 (1), pp. 11997. Date of Electronic Publication: 2021 Jun 07.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antisocial Personality Disorder/*metabolism
    Calcium Channels/*metabolism
    Cerebral Cortex/*metabolism
    Hippocampus/*metabolism
    Receptors, AMPA/*metabolism
    Animals ; Behavior, Animal ; Clustered Regularly Interspaced Short Palindromic Repeats ; HEK293 Cells ; Humans ; Mice, Knockout ; Pyramidal Cells/metabolism ; Receptors, Glutamate/metabolism ; Synaptic Transmission ; Mice
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Effects of natural deep eutectic solvents on lactic acid bacteria viability during cryopreservation.
    Autorzy:
    Qiao Y; Glycomics and Glycan Bioengineering Research Center, College of Food Science and Technology, Nanjing Agricultural University, 210095, Nanjing, People's Republic of China.
    Cai HL; Glycomics and Glycan Bioengineering Research Center, College of Food Science and Technology, Nanjing Agricultural University, 210095, Nanjing, People's Republic of China.
    Yang X; Glycomics and Glycan Bioengineering Research Center, College of Food Science and Technology, Nanjing Agricultural University, 210095, Nanjing, People's Republic of China.
    Zang YY; Glycomics and Glycan Bioengineering Research Center, College of Food Science and Technology, Nanjing Agricultural University, 210095, Nanjing, People's Republic of China.
    Chen ZG; Glycomics and Glycan Bioengineering Research Center, College of Food Science and Technology, Nanjing Agricultural University, 210095, Nanjing, People's Republic of China. .
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    Źródło:
    Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2018 Jul; Vol. 102 (13), pp. 5695-5705. Date of Electronic Publication: 2018 May 08.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Cryopreservation*
    Lactobacillales/*drug effects
    Microbial Viability/*drug effects
    Solvents/*pharmacology
    Cryoprotective Agents/pharmacology ; Hydrogen Bonding ; Solvents/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Role of CACNA1C gene polymorphisms and protein expressions in the pathogenesis of schizophrenia: a case-control study in a Chinese population.
    Autorzy:
    Zhang SY; Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Institute of Forensic Science, Ministry of Justice, No. 1347, Guangfu West Road, Putuo District, Shanghai, 200063, People's Republic of China.
    Hu Q; Department of Psychology, Qiqihar Mental Health Center, No. 28, Linhua Road, Jianhua District, Qiqihar, 161000, Heilongjiang Province, People's Republic of China. .
    Tang T; Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Institute of Forensic Science, Ministry of Justice, No. 1347, Guangfu West Road, Putuo District, Shanghai, 200063, People's Republic of China.
    Liu C; Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Institute of Forensic Science, Ministry of Justice, No. 1347, Guangfu West Road, Putuo District, Shanghai, 200063, People's Republic of China.
    Li CC; Department of Psychiatry, Qiqihar Medical University, Qiqihar, 161000, People's Republic of China.
    Yang XG; Department of Psychology, Qiqihar Mental Health Center, No. 28, Linhua Road, Jianhua District, Qiqihar, 161000, Heilongjiang Province, People's Republic of China.
    Zang YY; Center for the Treatment and Study of Anxiety, University of Pennsylvania, Philadelphia, PA, 19104, USA.
    Cai WX; Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Institute of Forensic Science, Ministry of Justice, No. 1347, Guangfu West Road, Putuo District, Shanghai, 200063, People's Republic of China. .
    Pokaż więcej
    Źródło:
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2017 Aug; Vol. 38 (8), pp. 1393-1403. Date of Electronic Publication: 2017 Jun 07.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Calcium Channels, L-Type/*genetics
    Calcium Channels, L-Type/*metabolism
    Genetic Predisposition to Disease/*genetics
    Polymorphism, Single Nucleotide/*genetics
    Schizophrenia/*genetics
    Schizophrenia/*metabolism
    Adult ; Animals ; Asian People ; Brain/metabolism ; Brain/pathology ; Case-Control Studies ; DNA Mutational Analysis ; Disease Models, Animal ; Female ; Gene Frequency ; Genetic Association Studies ; Genotype ; Humans ; Male ; Mice ; Phenotype ; Psychiatric Status Rating Scales ; Schizophrenia/ethnology ; Schizophrenia/pathology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-4 z 4

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