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Wyświetlanie 1-20 z 43
Tytuł:
Chromatin expansion microscopy reveals nanoscale organization of transcription and chromatin.
Autorzy:
Pownall ME; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Miao L; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Vejnar CE; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
M'Saad O; Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA.; Department of Biomedical Engineering, Yale University, New Haven, CT 06510, USA.
Sherrard A; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Frederick MA; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Benitez MDJ; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Boswell CW; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Zaret KS; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Bewersdorf J; Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA.; Department of Biomedical Engineering, Yale University, New Haven, CT 06510, USA.; Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA.; Department of Physics, Yale University, New Haven, CT 06510, USA.; Nanobiology Institute, Yale University, West Haven, CT 06477, USA.
Giraldez AJ; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06510, USA.; Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06510, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Jul 07; Vol. 381 (6653), pp. 92-100. Date of Electronic Publication: 2023 Jul 06.
Typ publikacji:
Journal Article
MeSH Terms:
Chromatin*/chemistry
Transcription, Genetic*
Microscopy, Fluorescence*/methods
Zygote*/metabolism
Nucleosomes/chemistry ; RNA Polymerase II/chemistry ; RNA Polymerase II/metabolism ; Animals ; Zebrafish ; Embryo, Nonmammalian ; Nanog Homeobox Protein/chemistry ; Nanog Homeobox Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPSC reprogramming.
Autorzy:
Fu K; Department of Molecular, Cellular and Developmental Biology, Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Chronis C; David Geffen School of Medicine, Department of Biological Chemistry, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Soufi A; Institute for Regenerative Medicine and Epigenetics Program, Department of Cell and Developmental Biology, Smilow Center for Translational Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.; Present address: University of Edinburgh, MRC Centre for Regenerative Medicine, SCRM Building, Edinburgh Bioquarter, Edinburgh, EH16 4UU, UK.
Bonora G; Department of Molecular, Cellular and Developmental Biology, Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Edwards M; Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Smale ST; Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Zaret KS; Institute for Regenerative Medicine and Epigenetics Program, Department of Cell and Developmental Biology, Smilow Center for Translational Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Plath K; David Geffen School of Medicine, Department of Biological Chemistry, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Pellegrini M; Department of Molecular, Cellular and Developmental Biology, Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, 90095, USA. .
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Źródło:
BMC genomics [BMC Genomics] 2018 Dec 22; Vol. 19 (1), pp. 956. Date of Electronic Publication: 2018 Dec 22.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Cellular Reprogramming/*genetics
Chromatin/*metabolism
Induced Pluripotent Stem Cells/*cytology
Transcription Factors/*metabolism
Animals ; Cells, Cultured ; Fibroblasts/cytology ; Humans ; Kruppel-Like Factor 4 ; Kruppel-Like Transcription Factors/metabolism ; Mice ; Octamer Transcription Factor-3/metabolism ; Proto-Oncogene Proteins c-myc/metabolism ; SOXB1 Transcription Factors/metabolism ; Species Specificity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chromatin "pre-pattern" and epigenetic modulation in the cell fate choice of liver over pancreas in the endoderm.
Autorzy:
Xu CR; Institute for Regenerative Medicine, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Zaret KS
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Źródło:
Nucleus (Austin, Tex.) [Nucleus] 2012 Mar 01; Vol. 3 (2), pp. 150-4. Date of Electronic Publication: 2012 Mar 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms:
Epigenesis, Genetic*
Cell Differentiation/*genetics
Chromatin/*genetics
Endoderm/*cytology
Endoderm/*metabolism
Liver/*cytology
Pancreas/*cytology
Animals ; Chromatin/metabolism ; Endoderm/embryology ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas.
Autorzy:
Xu CR; Institute for Regenerative Medicine, Epigenetics Program, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Cole PA
Meyers DJ
Kormish J
Dent S
Zaret KS
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Źródło:
Science (New York, N.Y.) [Science] 2011 May 20; Vol. 332 (6032), pp. 963-6.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Developmental*
Chromatin/*metabolism
Endoderm/*cytology
Histones/*metabolism
Liver/*embryology
Multipotent Stem Cells/*cytology
Pancreas/*embryology
Acetylation ; Animals ; Bone Morphogenetic Proteins/metabolism ; Cell Culture Techniques ; Cell Differentiation ; Cell Separation ; Chromatin Immunoprecipitation ; Embryonic Development ; Embryonic Induction ; Enhancer of Zeste Homolog 2 Protein ; Hepatocytes/cytology ; Histone-Lysine N-Methyltransferase/metabolism ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Liver/cytology ; Liver/metabolism ; Mice ; Multipotent Stem Cells/metabolism ; Pancreas/cytology ; Pancreas/metabolism ; Polycomb Repressive Complex 2 ; Protein Processing, Post-Translational ; Regulatory Elements, Transcriptional ; Signal Transduction ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Transcription Factors/metabolism ; p300-CBP Transcription Factors/antagonists & inhibitors ; p300-CBP Transcription Factors/genetics ; p300-CBP Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The Chromatin Modifier MSK1/2 Suppresses Endocrine Cell Fates during Mouse Pancreatic Development.
Autorzy:
Bhat, Neha
Park, Jeehye
Zoghbi, Huda Y.
Arthur, J. Simon C.
Zaret, Kenneth S.
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Temat:
TREATMENT of diabetes
TYPE 1 diabetes
CELLULAR signal transduction
CELL differentiation
PANCREATIC beta cells
CHROMATIN
MAMMALS
Źródło:
PLoS ONE; 12/14/2016, Vol. 11 Issue 12, p1-31, 31p
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Binding of the winged-helix transcription factor HNF3 to a linker histone site on the nucleosome.
Autorzy:
Cirillo, Lisa A.
McPherson, Clifton E.
Bossard, Pascale
Stevens, Kimberly
Cherian, Sindhu
Shim, Eun Yong
Clark, Kirk L.
Burley, Stephen K.
Zaret, Kenneth S.
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Temat:
TRANSCRIPTION factors
DNA-binding proteins
HISTONES
CHROMATIN
GENE expression
BINDING sites
ALBUMINS
Źródło:
EMBO Journal; 1/1/98, Vol. 17 Issue 1, p244-254, 11p
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 43

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