- Tytuł:
- Identification and analysis of the reactive metabolites related to the hepatotoxicity of safrole.
- Autorzy:
- Źródło:
- Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2018 Nov; Vol. 48 (11), pp. 1164-1172. Date of Electronic Publication: 2017 Nov 22.
- Typ publikacji:
- Journal Article
- MeSH Terms:
-
Chemical and Drug Induced Liver Injury/*metabolism
Microsomes, Liver/*drug effects
Safrole/*pharmacokinetics
Safrole/*toxicity
Chromatography, High Pressure Liquid/methods ; Cytochrome P-450 Enzyme Inhibitors ; Cytochrome P-450 Enzyme System/metabolism ; Cytochrome P-450 Enzyme System/pharmacology ; Glutathione/metabolism ; Humans ; Inactivation, Metabolic ; Inhibitory Concentration 50 ; Microsomes, Liver/metabolism ; Molecular Structure ; Safrole/metabolism ; Tandem Mass Spectrometry
Czasopismo naukowe