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Tytuł :
A Clinical Metabolite of Azidothymidine Inhibits Experimental Choroidal Neovascularization and Retinal Pigmented Epithelium Degeneration.
Autorzy :
Narendran S; .; .; .
Pereira F; .; .
Yerramothu P; .; .
Apicella I; .; .
Wang SB; .; .
Varshney A; .; .
Baker KL; .
Marion KM; .
Ambati M; .; .; .
Ambati VL; .
Ambati K; .; .
Sadda SR; .; .
Gelfand BD; .; .; .
Ambati J; .; .; .; .; .
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Źródło :
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2020 Aug 03; Vol. 61 (10), pp. 4.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Choroidal Neovascularization/*drug therapy
Geographic Atrophy/*drug therapy
Retinal Pigment Epithelium/*drug effects
Reverse Transcriptase Inhibitors/*therapeutic use
Zidovudine/*analogs & derivatives
Animals ; Blotting, Western ; Caspase 1/metabolism ; Choroidal Neovascularization/metabolism ; Enzyme-Linked Immunosorbent Assay ; Female ; Geographic Atrophy/metabolism ; Interleukin-1beta/metabolism ; Intravitreal Injections ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Microscopy, Confocal ; Reverse Transcriptase Inhibitors/administration & dosage ; Zidovudine/administration & dosage ; Zidovudine/therapeutic use ; Zonula Occludens-1 Protein/metabolism
Czasopismo naukowe
Tytuł :
Antibacterial AZT derivative regulates metastasis of breast cancer cells.
Autorzy :
Chirumarry S; Division of Magnetic Resonance, Korea Basic Science Institute (KBSI), Ochang, Chung Buk, 28119, Republic of Korea.
Soung NK; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongju, 28116, Republic of Korea.
Han J; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongju, 28116, Republic of Korea.
Kim EY; Department of Biomedical Science, Graduate School, Cellular and Molecular Medicine, Chosun University, Gwangju, 61452, Republic of Korea.
Ryu EK; Division of Magnetic Resonance, Korea Basic Science Institute (KBSI), Ochang, Chung Buk, 28119, Republic of Korea; Department of Bio-analytical Science, University of Science & Technology, Daejeon, 34113, Republic of Korea.
Lee YH; Division of Magnetic Resonance, Korea Basic Science Institute (KBSI), Ochang, Chung Buk, 28119, Republic of Korea; Department of Bio-analytical Science, University of Science & Technology, Daejeon, 34113, Republic of Korea.
Shin SY; Department of Biomedical Science, Graduate School, Cellular and Molecular Medicine, Chosun University, Gwangju, 61452, Republic of Korea.
Gunasekaran P; Division of Magnetic Resonance, Korea Basic Science Institute (KBSI), Ochang, Chung Buk, 28119, Republic of Korea. Electronic address: .
Bang JK; Division of Magnetic Resonance, Korea Basic Science Institute (KBSI), Ochang, Chung Buk, 28119, Republic of Korea; Department of Bio-analytical Science, University of Science & Technology, Daejeon, 34113, Republic of Korea. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2020 May 01; Vol. 193, pp. 112233. Date of Electronic Publication: 2020 Mar 19.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Antineoplastic Agents/*pharmacology
Breast Neoplasms/*drug therapy
Gram-Negative Bacteria/*drug effects
Gram-Positive Bacteria/*drug effects
Zidovudine/*pharmacology
Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Breast Neoplasms/pathology ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Design ; Drug Screening Assays, Antitumor ; Female ; Gram-Negative Bacteria/growth & development ; Gram-Positive Bacteria/growth & development ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Structure-Activity Relationship ; Tumor Cells, Cultured ; Wound Healing/drug effects ; Zidovudine/chemical synthesis ; Zidovudine/chemistry
Czasopismo naukowe
Tytuł :
In situ microemulsion-gel obtained from bioadhesive hydroxypropyl methylcellulose films for transdermal administration of zidovudine.
Autorzy :
Souza de Araujo GR; Department of Pharmacy, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
de Oliveira Porfírio L; Department of Pharmacy, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
Santos Silva LA; Department of Pharmacy, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
Gomes Santana D; Department of Pharmacy, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
Ferreira Barbosa P; Laboratory of Flavor and Chromatographic Analysis, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
Pereira Dos Santos C; Department of Physics, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
Narain N; Laboratory of Flavor and Chromatographic Analysis, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
Vitorino Sarmento VH; Department of Chemistry, Federal University of Sergipe, Itabaiana, Sergipe, Brazil.
de Souza Nunes R; Department of Pharmacy, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
Ting E; Department of Morphology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
Moreira Lira AA; Department of Pharmacy, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil. Electronic address: .
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Źródło :
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2020 Apr; Vol. 188, pp. 110739. Date of Electronic Publication: 2019 Dec 17.
Typ publikacji :
Journal Article
MeSH Terms :
Methylcellulose/*chemistry
Prodrugs/*chemistry
Zidovudine/*chemistry
Administration, Cutaneous ; Animals ; Emulsions/administration & dosage ; Emulsions/chemistry ; Emulsions/metabolism ; Eucalyptus Oil/administration & dosage ; Eucalyptus Oil/chemistry ; Eucalyptus Oil/metabolism ; Gels/administration & dosage ; Gels/chemistry ; Gels/metabolism ; Male ; Methylcellulose/administration & dosage ; Methylcellulose/metabolism ; Particle Size ; Prodrugs/administration & dosage ; Prodrugs/metabolism ; Propylene Glycol/administration & dosage ; Propylene Glycol/chemistry ; Propylene Glycol/metabolism ; Rats ; Rats, Wistar ; Skin/chemistry ; Skin/metabolism ; Skin Absorption ; Surface Properties ; Zidovudine/administration & dosage ; Zidovudine/metabolism
Czasopismo naukowe
Tytuł :
Bile duct ligation enhances AZT CNS toxicity partly by impairing the expression and function of BCRP in rat brain.
Autorzy :
Qin YY; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Xu P; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Wu T; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Qian CQ; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Fan YL; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Gen DH; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Zhu L; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Kong WM; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Yang HY; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Xu F; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Yang YT; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Liu L; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. .
Liu XD; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. .
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Źródło :
Acta pharmacologica Sinica [Acta Pharmacol Sin] 2020 Feb; Vol. 41 (2), pp. 181-191. Date of Electronic Publication: 2019 May 29.
Typ publikacji :
Journal Article
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily G, Member 2/*metabolism
Anti-HIV Agents/*toxicity
Brain/*drug effects
Zidovudine/*toxicity
Animals ; Anti-HIV Agents/pharmacokinetics ; Area Under Curve ; Bile Ducts/pathology ; Blood-Brain Barrier/metabolism ; Brain/pathology ; Cell Line ; Cognition/drug effects ; Cognitive Dysfunction/chemically induced ; Dogs ; Humans ; Madin Darby Canine Kidney Cells ; Male ; Rats ; Rats, Sprague-Dawley ; Tissue Distribution ; Zidovudine/pharmacokinetics
Czasopismo naukowe
Tytuł :
Novel delivery based anionic linear globular dendrimerg2-zidovudine nano-conjugate significantly decreased retroviral activity.
Autorzy :
Pargoo EM; Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Aghasadeghi MR; Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran.
Parivar K; Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Bolhassani A; Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran.
Nikbin M; Middle East Liver Diseases (MELD) Center, Tehran, IR Iran.
Rahimi P; Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran.
Ardestani MS; Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
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Źródło :
Pakistan journal of pharmaceutical sciences [Pak J Pharm Sci] 2020 Mar; Vol. 33 (2), pp. 705-714.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Retroviral Agents/*administration & dosage
Cell Survival/*drug effects
Dendrimers/*administration & dosage
Drug Delivery Systems/*methods
Nanoconjugates/*administration & dosage
Zidovudine/*administration & dosage
Anions ; Anti-Retroviral Agents/chemistry ; Cell Survival/physiology ; Dendrimers/chemistry ; Dose-Response Relationship, Drug ; HEK293 Cells ; HIV-1/drug effects ; HIV-1/physiology ; Humans ; Nanoconjugates/chemistry ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/chemistry ; Stearates/administration & dosage ; Stearates/chemistry ; Zidovudine/chemistry
Czasopismo naukowe
Tytuł :
Nucleotide analogues as inhibitors of SARS-CoV Polymerase.
Autorzy :
Ju J; Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, New York, USA.; Department of Chemical Engineering, Columbia University, New York, NY, USA.; Department of Molecular Pharmacology and Therapeutics, Columbia University, New York, NY, USA.
Li X; Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, New York, USA.; Department of Chemical Engineering, Columbia University, New York, NY, USA.
Kumar S; Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, New York, USA.; Department of Chemical Engineering, Columbia University, New York, NY, USA.
Jockusch S; Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, New York, USA.; Department of Chemistry, Columbia University, New York, NY, USA.
Chien M; Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, New York, USA.; Department of Chemical Engineering, Columbia University, New York, NY, USA.
Tao C; Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, New York, USA.; Department of Chemical Engineering, Columbia University, New York, NY, USA.
Morozova I; Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, New York, USA.; Department of Chemical Engineering, Columbia University, New York, NY, USA.
Kalachikov S; Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, New York, USA.; Department of Chemical Engineering, Columbia University, New York, NY, USA.
Kirchdoerfer RN; Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Institute of Molecular Virology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Russo JJ; Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, New York, USA.; Department of Chemical Engineering, Columbia University, New York, NY, USA.
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Źródło :
Pharmacology research & perspectives [Pharmacol Res Perspect] 2020 Dec; Vol. 8 (6), pp. e00674.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*pharmacology
Betacoronavirus/*drug effects
Coronavirus Infections/*drug therapy
Pneumonia, Viral/*drug therapy
RNA-Dependent RNA Polymerase/*antagonists & inhibitors
Betacoronavirus/enzymology ; COVID-19 ; Carbamates/pharmacology ; Coronavirus Infections/virology ; Dideoxynucleotides/pharmacology ; Drug Combinations ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Humans ; Pandemics ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Sofosbuvir/pharmacology ; Thymine Nucleotides/pharmacology ; Zidovudine/analogs & derivatives ; Zidovudine/pharmacology
Czasopismo naukowe
Tytuł :
Targeting the SARS-CoV2 nucleocapsid protein for potential therapeutics using immuno-informatics and structure-based drug discovery techniques.
Autorzy :
Kwarteng A; Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana; Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana. Electronic address: .
Asiedu E; Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana.
Sakyi SA; Department of Molecular Medicine, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
Asiedu SO; Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana.
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Dec; Vol. 132, pp. 110914. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19*/drug therapy
COVID-19*/virology
SARS-CoV-2*/drug effects
SARS-CoV-2*/physiology
Coronavirus Nucleocapsid Proteins/*physiology
Drug Discovery/*methods
Viral Vaccines/*pharmacology
Antiviral Agents/pharmacology ; Computational Biology/methods ; Epitopes/immunology ; Humans ; Molecular Docking Simulation/methods ; Phosphoproteins/physiology ; Zidovudine/pharmacology
Czasopismo naukowe
Tytuł :
Synthesis and evaluation of the anti-hepatitis B virus activity of 4'-Azido-thymidine analogs and 4'-Azido-2'-deoxy-5-methylcytidine analogs: structural insights for the development of a novel anti-HBV agent.
Autorzy :
Onitsuka K; Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.
Tokuda R; Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.
Kuwata-Higashi N; Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
Kumamoto H; Department of Pharmaceutical Sciences, Nihon Pharmaceutical University, Saitama, Japan.
Aoki M; Experimental Retrovirology Section, HIV & AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Amano M; Departments of Infectious Diseases and Hematology, Kumamoto University School of Medicine, Kumamoto, Japan.
Kohgo S; Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
Das D; Experimental Retrovirology Section, HIV & AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Haraguchi K; Department of Pharmaceutical Sciences, Nihon Pharmaceutical University, Saitama, Japan.
Mitsuya H; Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.; Experimental Retrovirology Section, HIV & AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.; Departments of Infectious Diseases and Hematology, Kumamoto University School of Medicine, Kumamoto, Japan.
Imoto S; Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.
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Źródło :
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2020; Vol. 39 (4), pp. 518-529. Date of Electronic Publication: 2019 Sep 12.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*pharmacology
Cytidine/*analogs & derivatives
Zidovudine/*analogs & derivatives
Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Cytidine/chemical synthesis ; Cytidine/chemistry ; Cytidine/pharmacology ; Hep G2 Cells ; Hepatitis B virus/drug effects ; Humans ; Microbial Sensitivity Tests ; Molecular Conformation ; Stereoisomerism ; Zidovudine/chemical synthesis ; Zidovudine/chemistry ; Zidovudine/pharmacology
Czasopismo naukowe
Tytuł :
Cryptococcal meningitis and immune reconstitution inflammatory syndrome in a pediatric patient with HIV after switching to second line antiretroviral therapy: a case report.
Autorzy :
Otto SBJ; Department of Paediatrics and Child Health, Makerere University College of Health Sciences, P.O. Box 7062, Kampala, Uganda. .
George PE; Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
Mercedes R; Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
Nabukeera-Barungi N; Department of Paediatrics and Child Health, Makerere University College of Health Sciences, P.O. Box 7062, Kampala, Uganda.
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Źródło :
BMC infectious diseases [BMC Infect Dis] 2020 Jan 21; Vol. 20 (1), pp. 68. Date of Electronic Publication: 2020 Jan 21.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
AIDS-Related Opportunistic Infections/*drug therapy
Anti-HIV Agents/*therapeutic use
Cryptococcus neoformans/*isolation & purification
HIV/*drug effects
Immune Reconstitution Inflammatory Syndrome/*diagnosis
Lamivudine/*therapeutic use
Lopinavir/*therapeutic use
Meningitis, Cryptococcal/*diagnosis
Ritonavir/*therapeutic use
Zidovudine/*therapeutic use
AIDS-Related Opportunistic Infections/complications ; Alkynes ; Antifungal Agents/therapeutic use ; Antigens, Fungal/blood ; Benzoxazines/therapeutic use ; Child ; Cyclopropanes ; Dideoxynucleosides/therapeutic use ; Drug Combinations ; Female ; Fluconazole/therapeutic use ; HIV/isolation & purification ; Humans ; Immune Reconstitution Inflammatory Syndrome/etiology ; Lamivudine/adverse effects ; Meningitis, Cryptococcal/drug therapy ; Meningitis, Cryptococcal/etiology ; Ritonavir/adverse effects ; Treatment Outcome ; Viral Load ; Zidovudine/adverse effects
Czasopismo naukowe
Tytuł :
Influence of a herbal preparation on the pharmacokinetics of highly active antiretroviral therapy drugs in rats.
Autorzy :
Su Q; Center for AIDS Research, Ruikang Hospital affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
Lu Z; Center for AIDS Research, Ruikang Hospital affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
Tang Y; Department of Pharmacy, Ruikang Hospital affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
Wei S; Editorial Department, The People's Hospital of Gungxi Zhuang Autonomous Region, Nanning, Guangxi, China.
Zhou Z; Department of Pharmacy, Ruikang Hospital affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
Jiang F; Center for AIDS Research, Ruikang Hospital affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
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Źródło :
Pakistan journal of pharmaceutical sciences [Pak J Pharm Sci] 2020 Jan; Vol. 33 (1), pp. 49-52.
Typ publikacji :
Journal Article
MeSH Terms :
Herb-Drug Interactions*
Alkynes/*pharmacokinetics
Benzoxazines/*pharmacokinetics
Cyclopropanes/*pharmacokinetics
Lamivudine/*pharmacokinetics
Zidovudine/*pharmacokinetics
Alkynes/blood ; Animals ; Benzoxazines/blood ; Cyclopropanes/blood ; Lamivudine/blood ; Male ; Rats ; Zidovudine/blood
Czasopismo naukowe
Tytuł :
Arginine-259 of UGT2B7 Confers UDP-Sugar Selectivity.
Autorzy :
Nair PC; Department of Clinical Pharmacology (P.C.N., N.C., J.O.M.) and Flinders Health and Medical Research Institute (FHMRI) Cancer Program (P.C.N., R.A.M., J.O.M.), Flinders Health and Medical Research Institute, Flinders University College of Medicine and Public Health, Flinders Medical Centre, South Australia, Australia .
Chau N; Department of Clinical Pharmacology (P.C.N., N.C., J.O.M.) and Flinders Health and Medical Research Institute (FHMRI) Cancer Program (P.C.N., R.A.M., J.O.M.), Flinders Health and Medical Research Institute, Flinders University College of Medicine and Public Health, Flinders Medical Centre, South Australia, Australia.
McKinnon RA; Department of Clinical Pharmacology (P.C.N., N.C., J.O.M.) and Flinders Health and Medical Research Institute (FHMRI) Cancer Program (P.C.N., R.A.M., J.O.M.), Flinders Health and Medical Research Institute, Flinders University College of Medicine and Public Health, Flinders Medical Centre, South Australia, Australia.
Miners JO; Department of Clinical Pharmacology (P.C.N., N.C., J.O.M.) and Flinders Health and Medical Research Institute (FHMRI) Cancer Program (P.C.N., R.A.M., J.O.M.), Flinders Health and Medical Research Institute, Flinders University College of Medicine and Public Health, Flinders Medical Centre, South Australia, Australia.
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2020 Dec; Vol. 98 (6), pp. 710-718. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arginine/*genetics
Glucuronosyltransferase/*metabolism
Uridine Diphosphate Glucuronic Acid/*metabolism
Binding Sites/genetics ; Coenzymes/metabolism ; Crystallography, X-Ray ; Glucosyltransferases/genetics ; Glucosyltransferases/ultrastructure ; Glucuronides/metabolism ; Glucuronosyltransferase/genetics ; Glycosides/metabolism ; HEK293 Cells ; Humans ; Hymecromone/metabolism ; Medicago truncatula ; Molecular Dynamics Simulation ; Morphine/metabolism ; Mutagenesis, Site-Directed ; Mutation ; Plant Proteins/genetics ; Plant Proteins/ultrastructure ; Sequence Homology, Amino Acid ; Substrate Specificity/genetics ; Zidovudine/metabolism
Czasopismo naukowe
Tytuł :
Long term renal function in Asian HIV-1 infected adults receiving tenofovir disoproxil fumarate without protease inhibitors.
Autorzy :
Liegeon G; Institut de Recherche pour le Développement (IRD) Unit 174-PHPT, Kaew Nawarat Rd, Tambon Wat Ket, Amphoe Mueang Chiang Mai, Chiang Mai, Thailand. Electronic address: .
Harrison L; Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Nechba A; Institut de Recherche pour le Développement (IRD) Unit 174-PHPT, Kaew Nawarat Rd, Tambon Wat Ket, Amphoe Mueang Chiang Mai, Chiang Mai, Thailand. Electronic address: .
Halue G; Phayao Provincial Hospital, Phayao, Thailand.
Banchongkit S; Rayong Hospital, Rayong, Thailand.
Nilmanat A; Hat Yai Hospital, Songkla, Thailland. Electronic address: .
Yutthakasemsunt N; Nong Khai Hospital, Nong Khai, Thailand.
Pathipvanich P; Lampang Hospital, Lampang, Thailand.
Thongpaen S; Mahasarakam Hospital, Mahasarakam, Thailand.
Lertkoonalak R; Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima, Thailand.
Althaus T; Institut de Recherche pour le Développement (IRD) Unit 174-PHPT, Kaew Nawarat Rd, Tambon Wat Ket, Amphoe Mueang Chiang Mai, Chiang Mai, Thailand. Electronic address: .
Lallemant M; Institut de Recherche pour le Développement (IRD) Unit 174-PHPT, Kaew Nawarat Rd, Tambon Wat Ket, Amphoe Mueang Chiang Mai, Chiang Mai, Thailand; Harvard T.H. Chan School of Public Health, Boston, MA, USA; Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand. Electronic address: .
Mary JY; INSERM SBIM, Hôpital Saint Louis, 1 avenue Claude Vellefaux, 75011 Paris, France. Electronic address: .
Jourdain G; Institut de Recherche pour le Développement (IRD) Unit 174-PHPT, Kaew Nawarat Rd, Tambon Wat Ket, Amphoe Mueang Chiang Mai, Chiang Mai, Thailand; Harvard T.H. Chan School of Public Health, Boston, MA, USA; Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand. Electronic address: .
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Źródło :
The Journal of infection [J Infect] 2019 Nov; Vol. 79 (5), pp. 454-461. Date of Electronic Publication: 2019 Aug 08.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-HIV Agents/*adverse effects
HIV Infections/*drug therapy
Renal Insufficiency/*chemically induced
Tenofovir/*adverse effects
Zidovudine/*adverse effects
Adult ; Anti-HIV Agents/administration & dosage ; Asian Continental Ancestry Group ; Body Weight ; Female ; Glomerular Filtration Rate ; Humans ; Male ; Middle Aged ; Tenofovir/administration & dosage ; Thailand ; Zidovudine/administration & dosage
Czasopismo naukowe
Tytuł :
Zidovudine and Lamivudine as Potential Agents to Combat HIV-Associated Neurocognitive Disorder.
Autorzy :
Mdanda S; Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Westville Campus, Durban, South Africa.
Ntshangase S; Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Westville Campus, Durban, South Africa.
Singh SD; Biomedical Resource Unit, University of KwaZulu-Natal, Westville Campus, Durban, South Africa.
Naicker T; Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Westville Campus, Durban, South Africa.
Kruger HG; Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Westville Campus, Durban, South Africa.
Baijnath S; Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Westville Campus, Durban, South Africa.
Govender T; Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Westville Campus, Durban, South Africa.; AnSynth Pty Ltd., Durban, South Africa.
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Źródło :
Assay and drug development technologies [Assay Drug Dev Technol] 2019 Oct; Vol. 17 (7), pp. 322-329.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-HIV Agents/*pharmacology
HIV Infections/*drug therapy
Lamivudine/*pharmacology
Neurocognitive Disorders/*drug therapy
Zidovudine/*pharmacology
Animals ; Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/analysis ; Chromatography, Liquid ; Female ; Injections, Intraperitoneal ; Lamivudine/administration & dosage ; Lamivudine/analysis ; Neurocognitive Disorders/virology ; Rats ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry ; Tissue Distribution ; Zidovudine/administration & dosage ; Zidovudine/analysis
Czasopismo naukowe
Tytuł :
Increasing the anticancer activity of azidothymidine toward the breast cancer via rational design of magnetic drug carrier based on molecular imprinting technology.
Autorzy :
Hassanpour A; Department of Chemistry, Razi University, Kermanshah 67149-67346, Iran.
Irandoust M; Department of Chemistry, Razi University, Kermanshah 67149-67346, Iran. Electronic address: .
Soleimani E; Department of Chemistry, Razi University, Kermanshah 67149-67346, Iran. Electronic address: .
Zhaleh H; Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
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Źródło :
Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2019 Oct; Vol. 103, pp. 109771. Date of Electronic Publication: 2019 May 21.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Drug Carriers*/chemistry
Drug Carriers*/pharmacology
Magnetite Nanoparticles*/chemistry
Magnetite Nanoparticles*/therapeutic use
Molecular Imprinting*
Zidovudine*/chemistry
Zidovudine*/pharmacology
Breast Neoplasms/*drug therapy
Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Female ; Humans ; MCF-7 Cells
Czasopismo naukowe
Tytuł :
Could spray-dried microbeads with chitosan glutamate be considered as promising vaginal microbicide carriers? The effect of process variables on the in vitro functional and physicochemical characteristics.
Autorzy :
Szymanska E; Department of Pharmaceutical Technology, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland. Electronic address: .
Czarnomysy R; Department of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland. Electronic address: .
Jacyna J; Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdansk, Hallera 107, 80-416 Gdansk, Poland. Electronic address: .
Basa A; Institute of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15-245 Bialystok, Poland. Electronic address: .
Wilczewska AZ; Institute of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15-245 Bialystok, Poland. Electronic address: .
Markuszewski M; Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdansk, Hallera 107, 80-416 Gdansk, Poland. Electronic address: .
Winnicka K; Department of Pharmaceutical Technology, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland. Electronic address: .
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Źródło :
International journal of pharmaceutics [Int J Pharm] 2019 Sep 10; Vol. 568, pp. 118558. Date of Electronic Publication: 2019 Jul 25.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Infective Agents/*administration & dosage
Chitosan/*administration & dosage
Drug Carriers/*administration & dosage
Glutamates/*administration & dosage
Zidovudine/*administration & dosage
Administration, Intravaginal ; Anti-Infective Agents/chemistry ; Cell Line ; Cell Survival/drug effects ; Chitosan/chemistry ; Desiccation ; Drug Carriers/chemistry ; Drug Liberation ; Female ; Glutamates/chemistry ; Humans ; Microspheres ; Vagina ; Zidovudine/chemistry
Czasopismo naukowe
Tytuł :
Risk Factors for Adverse Birth Outcomes in the PROMISE 1077BF/1077FF Trial.
Autorzy :
Sebikari D; Clinical Department, Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda.
Farhad M; Harvard T.H. Chan School of Public Health, Center for Biostatistics in AIDS Research, Boston, MA.
Fenton T; Harvard T.H. Chan School of Public Health, Center for Biostatistics in AIDS Research, Boston, MA.
Owor M; Clinical Department, Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda.
Stringer JSA; Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC.
Qin M; Harvard T.H. Chan School of Public Health, Center for Biostatistics in AIDS Research, Boston, MA.
Chakhtoura N; National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Maternal and Paediatric Infectious Diseases Branch, Bethesda, MD.
Chi BH; Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC.
Saidi F; Department of Obstetrics and Gynaecology, University of North Carolina (UNC) Project Lilongwe, Lilongwe, Malawi.
Nevrekar N; Clinical Research Department, Byramiee Jeeieebhoy Government Medical College, Pune, India.
Violari A; Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Chipato T; Department of Obstetrics and Gynecology, University of Zimbabwe, Harare, Zimbabwe.
McIntyre JA; Anova Health Institute, Johannesburg, South Africa.; Division of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, South Africa.
Moodley D; Department of Obstetrics and Gynecology, School of Clinical Medicine, Centre for AIDS Research in South Africa, University of KwaZulu Natal, Durban, South Africa.
Taha TE; Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
Theron G; Department of Obstetrics and Gynecology, Stellenbosch University, Cape Town, South Africa.
Fowler MG; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.
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Źródło :
Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2019 Aug 15; Vol. 81 (5), pp. 521-532.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
MeSH Terms :
Pregnancy Outcome*
HIV Protease Inhibitors/*therapeutic use
Pregnancy Complications, Infectious/*drug therapy
Zidovudine/*therapeutic use
Adult ; Drug Combinations ; Drug Therapy, Combination/adverse effects ; Female ; HIV Protease Inhibitors/administration & dosage ; Humans ; Pregnancy ; Pregnancy Complications, Infectious/virology ; Zidovudine/administration & dosage
Czasopismo naukowe
Tytuł :
Urinary bactericidal activity of colistin and azidothymidine combinations against mcr-1-positive colistin-resistant Escherichia coli.
Autorzy :
Loose M; Clinic for Urology, Paediatric Urology and Andrology, Justus-Liebig University of Giessen, Giessen, Germany. Electronic address: .
Naber KG; Technical University of Munich, Munich, Germany.
Hu Y; Institute for Infection and Immunity, St George's University of London, London, UK.
Coates A; Institute for Infection and Immunity, St George's University of London, London, UK; Helperby Therapeutics Ltd., London, UK.
Wagenlehner FME; Clinic for Urology, Paediatric Urology and Andrology, Justus-Liebig University of Giessen, Giessen, Germany.
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Źródło :
International journal of antimicrobial agents [Int J Antimicrob Agents] 2019 Jul; Vol. 54 (1), pp. 55-61. Date of Electronic Publication: 2019 Apr 26.
Typ publikacji :
Clinical Trial, Phase I; Journal Article
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Colistin/*pharmacology
Escherichia coli/*drug effects
Escherichia coli Proteins/*genetics
Microbial Viability/*drug effects
Urine/*microbiology
Zidovudine/*pharmacology
Acinetobacter/drug effects ; Acinetobacter/growth & development ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/pharmacokinetics ; Colistin/administration & dosage ; Colistin/adverse effects ; Colistin/pharmacokinetics ; Drug Synergism ; Drug Therapy, Combination/adverse effects ; Drug Therapy, Combination/methods ; Escherichia coli/genetics ; Escherichia coli/growth & development ; Humans ; Pseudomonas/drug effects ; Zidovudine/administration & dosage ; Zidovudine/adverse effects ; Zidovudine/pharmacokinetics
Czasopismo naukowe
Tytuł :
Risk factors for delayed viral suppression on first-line antiretroviral therapy among persons living with HIV in Haiti, 2013-2017.
Autorzy :
Rich SN; Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, United States of America.; Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL, United States of America.
Cook RL; Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, United States of America.
Yaghjyan L; Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, United States of America.
Francois K; Programme National de Lutte contre le SIDA, Ministère de la Santé Publique et de la Population, Port au Prince, Haïti.
Puttkammer N; Department of Global Health, International Training and Education Center for Health (I-TECH), University of Washington, Seattle, WA, United States of America.
Robin E; Programme National de Lutte contre le SIDA, Ministère de la Santé Publique et de la Population, Port au Prince, Haïti.
Bae J; College of Pharmacy, Institute for Pharmaceutical Outcomes and Policy, University of Kentucky, Lexington, KY, United States of America.
Joseph N; National Alliance of State and Territorial AIDS Directors, Port au Prince, Haiti.
Pessoa-Brandão L; National Alliance of State and Territorial AIDS Directors, Port au Prince, Haiti.
Delcher C; College of Pharmacy, Institute for Pharmaceutical Outcomes and Policy, University of Kentucky, Lexington, KY, United States of America.; National Alliance of State and Territorial AIDS Directors, Port au Prince, Haiti.; Department of Pharmacy Practice and Science, College of Pharmacy, University of Kentucky, Lexington, KY, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Oct 29; Vol. 15 (10), pp. e0240817. Date of Electronic Publication: 2020 Oct 29 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-HIV Agents/*therapeutic use
Antiretroviral Therapy, Highly Active/*methods
HIV Infections/*drug therapy
HIV-1/*drug effects
Adolescent ; Adult ; Anti-HIV Agents/adverse effects ; Antiretroviral Therapy, Highly Active/adverse effects ; Child ; Child, Preschool ; Female ; HIV Infections/epidemiology ; HIV Infections/virology ; HIV-1/pathogenicity ; Haiti/epidemiology ; Humans ; Lamivudine/therapeutic use ; Male ; Middle Aged ; Nevirapine/adverse effects ; Nevirapine/therapeutic use ; Risk Factors ; Viral Load/drug effects ; Young Adult ; Zidovudine
Czasopismo naukowe
Tytuł :
Preventing mother to child transmission of HIV: lessons learned from China.
Autorzy :
Dong Y; Department of Geriatrics, Zhongnan Hospital of Wuhan University, Wuhan, China.
Guo W; Department of Pathology, Wuhan University School of Basic Medical Sciences, Wuhan, China.; Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Gui X; Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, 430071, China.
Liu Y; Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, 430071, China.
Yan Y; Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, 430071, China.
Feng L; Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, 430071, China.
Liang K; Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, 430071, China. .; Center of Preventing Mother-to-child transmission for Infectious Diseases, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, 430071, China. .; Department of Nosocomial Infection Management, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China. .
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Źródło :
BMC infectious diseases [BMC Infect Dis] 2020 Oct 26; Vol. 20 (1), pp. 792. Date of Electronic Publication: 2020 Oct 26.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-HIV Agents/*therapeutic use
HIV Infections/*drug therapy
HIV Infections/*epidemiology
Infectious Disease Transmission, Vertical/*prevention & control
Pre-Exposure Prophylaxis/*methods
Pregnancy Complications, Infectious/*drug therapy
Pregnancy Complications, Infectious/*epidemiology
Zidovudine/*therapeutic use
Adolescent ; Adult ; CD4 Lymphocyte Count ; China/epidemiology ; Female ; Follow-Up Studies ; HIV Infections/virology ; Humans ; Infant ; Infant, Newborn ; Middle Aged ; Pregnancy ; Pregnancy Complications, Infectious/virology ; Risk Factors ; Young Adult
Czasopismo naukowe
Tytuł :
Azidothymidine (AZT) Inhibits Proliferation of Human Ovarian Cancer Cells by Regulating Cell Cycle Progression.
Autorzy :
Hsieh Y; Department of Obstetrics, Gynecology and Women's Health, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
Tseng JJ; Department of Obstetrics, Gynecology and Women's Health, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C. .
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Źródło :
Anticancer research [Anticancer Res] 2020 Oct; Vol. 40 (10), pp. 5517-5527.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Cycle/*drug effects
Cell Proliferation/*drug effects
Ovarian Neoplasms/*drug therapy
Zidovudine/*pharmacology
Apoptosis/drug effects ; Cell Cycle Checkpoints/drug effects ; Cell Division/drug effects ; Cell Line, Tumor ; Female ; Humans ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology
Czasopismo naukowe

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