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Wyszukujesz frazę ""Zinc Finger Protein GLI1"" wg kryterium: Temat


Tytuł :
RSPO2 silence inhibits tumorigenesis of nasopharyngeal carcinoma by ZNRF3/Hedgehog-Gli1 signal pathway.
Autorzy :
Wang Z; Department of Oncology and Radiotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Wang Y; Department of Oncology and Radiotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Ma X; Department of Oncology and Radiotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Dang C; Tumor Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Oct 01; Vol. 282, pp. 119817. Date of Electronic Publication: 2021 Jul 14.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Silencing*
Signal Transduction*
Carcinogenesis/*metabolism
Hedgehog Proteins/*metabolism
Intercellular Signaling Peptides and Proteins/*biosynthesis
Nasopharyngeal Carcinoma/*metabolism
Nasopharyngeal Neoplasms/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Zinc Finger Protein GLI1/*metabolism
Animals ; Carcinogenesis/genetics ; Cell Line, Tumor ; Hedgehog Proteins/genetics ; Humans ; Intercellular Signaling Peptides and Proteins/genetics ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Nasopharyngeal Carcinoma/genetics ; Nasopharyngeal Neoplasms/genetics ; Ubiquitin-Protein Ligases/genetics ; Zinc Finger Protein GLI1/genetics
Czasopismo naukowe
Tytuł :
RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic Gli via HDAC6.
Autorzy :
Wang H; State Key Laboratory of Genetic and Resources, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, 650223, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, 650223, China.
Yang C; State Key Laboratory of Genetic and Resources, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, 650223, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, 650223, China.
Li Y; State Key Laboratory of Genetic and Resources, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, 650223, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, 650223, China.
Zhao S; Department of Reproduction and Genetics, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.
Ma P; State Key Laboratory of Genetic and Resources, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, 650223, China. Electronic address: .
Mao B; State Key Laboratory of Genetic and Resources, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, 650223, China; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Jun 11; Vol. 557, pp. 323-328. Date of Electronic Publication: 2021 Apr 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytoplasm/*metabolism
Cytoskeleton/*metabolism
Hedgehog Proteins/*metabolism
Histone Deacetylase 6/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Ubiquitination/*genetics
Zinc Finger Protein GLI1/*metabolism
Animals ; Autophagy/genetics ; Cytoskeleton/genetics ; HEK293 Cells ; Histone Deacetylase 6/genetics ; Humans ; Mice ; Mice, Inbred C57BL ; RNA, Small Interfering ; Signal Transduction/genetics ; Ubiquitin-Protein Ligases/genetics ; Zinc Finger Protein GLI1/genetics
Czasopismo naukowe
Tytuł :
Regulation of hepatic stellate cell contraction and cirrhotic portal hypertension by Wnt/β-catenin signalling via interaction with Gli1.
Autorzy :
Zhang F; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Wang F; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
He J; The Third Institute of Oceanography, Ministry of Natural Resources, Xiamen, China.
Lian N; School of Medicine and Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Wang Z; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Shao J; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Ding H; Department of Integrated TCM & Western Medicine in Hepatology, The Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing, China.
Tan S; Department of Integrated TCM & Western Medicine in Hepatology, The Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing, China.
Chen A; Department of Pathology, School of Medicine, Saint Louis University, St. Louis, Missouri, USA.
Zhang Z; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Wang S; Shandong Co-innovation Center of TCM Formula, College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Zheng S; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
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Źródło :
British journal of pharmacology [Br J Pharmacol] 2021 Jun; Vol. 178 (11), pp. 2246-2265. Date of Electronic Publication: 2021 Apr 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hepatic Stellate Cells*
Hypertension, Portal*/pathology
Wnt Signaling Pathway*
Zinc Finger Protein GLI1*
Animals ; Cell Line ; Humans ; Liver Cirrhosis/pathology ; Mice ; Transcription Factor 4
Czasopismo naukowe
Tytuł :
LINC01123 enhances osteosarcoma cell growth by activating the Hedgehog pathway via the miR-516b-5p/Gli1 axis.
Autorzy :
Pan X; Department of Orthopedics, Changzhou No.2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, China.
Tan J; Department of Orthopedics, Changzhou No.2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, China.
Tao T; Department of Orthopedics, Changzhou No.2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, China.
Zhang X; Reproductive Medicine Department, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China.
Weng Y; Department of Orthopedics, Changzhou No.2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, China.
Weng X; Department of Radiotherapy, Changzhou No.2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, China.
Xu J; Department of Nutrition, Changzhou No.2 People's Hospital, Nanjing Medical University, Changzhou, China.
Li H; Department of Orthopedics, Changzhou No.2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, China.
Jiang Y; Department of Orthopedics, Changzhou No.2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, China.
Zhou D; Department of Orthopedics, Changzhou No.2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, China.; Department of Orthopedics, Wuqia People's Hospital, Xinjiang, China.
Shen Y; Department of Orthopedics, Changzhou No.2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, China.; Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Shanghai Tongji University, Shanghai, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Jun; Vol. 112 (6), pp. 2260-2271. Date of Electronic Publication: 2021 May 07.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Neoplasms/*pathology
Hedgehog Proteins/*metabolism
MicroRNAs/*metabolism
Osteosarcoma/*pathology
RNA, Long Noncoding/*metabolism
Zinc Finger Protein GLI1/*metabolism
Animals ; Bone Neoplasms/genetics ; Bone Neoplasms/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; MicroRNAs/genetics ; Neoplasm Metastasis ; Osteosarcoma/genetics ; Osteosarcoma/metabolism ; RNA, Long Noncoding/genetics ; Signal Transduction ; Zinc Finger Protein GLI1/genetics
Czasopismo naukowe
Tytuł :
GLI1 reduces drug sensitivity by regulating cell cycle through PI3K/AKT/GSK3/CDK pathway in acute myeloid leukemia.
Autorzy :
Zhou C; Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Du J; Department of Hematology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510630, China.
Zhao L; Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Liu W; Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Zhao T; Department of Hematology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510630, China.
Liang H; Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Fang P; Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Zhang K; Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Zeng H; Department of Hematology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510630, China. .
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Źródło :
Cell death & disease [Cell Death Dis] 2021 Mar 03; Vol. 12 (3), pp. 231. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm*
Antimetabolites, Antineoplastic/*pharmacology
Cell Cycle/*drug effects
Cyclin-Dependent Kinases/*metabolism
Cytarabine/*pharmacology
Glycogen Synthase Kinase 3/*metabolism
Leukemia, Myeloid, Acute/*drug therapy
Phosphatidylinositol 3-Kinase/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Zinc Finger Protein GLI1/*metabolism
Animals ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Cell Proliferation/drug effects ; Cyclin-Dependent Kinases/antagonists & inhibitors ; Female ; Gene Expression Regulation, Leukemic ; HEK293 Cells ; Humans ; Leukemia, Myeloid, Acute/enzymology ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/pathology ; Mice, Nude ; Piperazines/pharmacology ; Protein Kinase Inhibitors/pharmacology ; Pyridines/pharmacology ; Pyrimidines/pharmacology ; Signal Transduction ; THP-1 Cells ; Tumor Burden/drug effects ; U937 Cells ; Xenograft Model Antitumor Assays ; Zinc Finger Protein GLI1/antagonists & inhibitors ; Zinc Finger Protein GLI1/genetics
Czasopismo naukowe
Tytuł :
Gli affects the stemness and prognosis of epithelial ovarian cancer via homeobox protein NANOG.
Autorzy :
Zhao H; Department of Obstetrics and Gynecology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China.
Li N; Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei 050000, P.R. China.
Pang Y; Department of Obstetrics and Gynecology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China.
Zhao J; Department of Obstetrics and Gynecology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China.
Wu X; Teaching and Research Section of Obstetrics and Gynecology, Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Feb; Vol. 23 (2). Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Ovarian Epithelial/*metabolism
Nanog Homeobox Protein/*metabolism
Nuclear Proteins/*biosynthesis
Nuclear Proteins/*genetics
Ovarian Neoplasms/*metabolism
Zinc Finger Protein GLI1/*biosynthesis
Zinc Finger Protein GLI1/*genetics
Zinc Finger Protein Gli2/*biosynthesis
Zinc Finger Protein Gli2/*genetics
ATP Binding Cassette Transporter, Subfamily B/metabolism ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Ovarian Epithelial/genetics ; Carcinoma, Ovarian Epithelial/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cisplatin/pharmacology ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Female ; Hedgehog Proteins/metabolism ; Hedgehog Proteins/pharmacology ; Humans ; Kaplan-Meier Estimate ; Middle Aged ; Nanog Homeobox Protein/genetics ; Nuclear Proteins/antagonists & inhibitors ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Prognosis ; Pyridines/pharmacology ; Pyrimidines/pharmacology ; Signal Transduction/drug effects ; Stem Cells/drug effects ; Tumor Stem Cell Assay ; Young Adult ; Zinc Finger Protein GLI1/antagonists & inhibitors ; Zinc Finger Protein Gli2/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Berberine inhibits chemotherapy-exacerbated ovarian cancer stem cell-like characteristics and metastasis through GLI1.
Autorzy :
Zhao Y; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.
Yang X; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.
Zhao J; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.
Gao M; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.
Zhang M; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.
Shi T; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.
Zhang F; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.
Zheng X; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.
Pan Y; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.
Shao D; Institutes of Life Sciences, School of Biomedical Sciences and Engineering and National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou International Campus, Guangzhou, Guangdong 510006, People's Republic of China.
Li J; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China.
He K; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China. Electronic address: .
Chen L; Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, People's Republic of China; School of Nursing, Jilin University, Changchun 130021, People's Republic of China. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 Mar 15; Vol. 895, pp. 173887. Date of Electronic Publication: 2021 Jan 20.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*toxicity
Berberine/*pharmacology
Carboplatin/*toxicity
Cell Movement/*drug effects
Etoposide/*toxicity
Neoplastic Stem Cells/*drug effects
Ovarian Neoplasms/*drug therapy
Zinc Finger Protein GLI1/*metabolism
Cell Line, Tumor ; Coculture Techniques ; Epithelial-Mesenchymal Transition/drug effects ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplasm Metastasis ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Polycomb Repressive Complex 1/genetics ; Polycomb Repressive Complex 1/metabolism ; Signal Transduction ; Snail Family Transcription Factors/genetics ; Snail Family Transcription Factors/metabolism ; Vimentin/genetics ; Vimentin/metabolism ; Zinc Finger Protein GLI1/genetics
Czasopismo naukowe
Tytuł :
AIM2 inhibits colorectal cancer cell proliferation and migration through suppression of Gli1.
Autorzy :
Xu M; Department of Oncology, The First Affiliated Hospital of Wannan Medical College, Wuhu 241000, China.
Wang J; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu 241000, China.
Li H; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu 241000, China.
Zhang Z; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu 241000, China.
Cheng Z; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu 241000, China.
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Źródło :
Aging [Aging (Albany NY)] 2020 Dec 03; Vol. 13 (1), pp. 1017-1031. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenocarcinoma/*genetics
Cell Proliferation/*genetics
Colorectal Neoplasms/*genetics
DNA-Binding Proteins/*genetics
Epithelial-Mesenchymal Transition/*genetics
Zinc Finger Protein GLI1/*genetics
Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Aged ; Animals ; Cell Line, Tumor ; Cell Movement/genetics ; Chromones/pharmacology ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; DNA-Binding Proteins/metabolism ; Enzyme Inhibitors/pharmacology ; Epithelial-Mesenchymal Transition/drug effects ; Female ; Gene Knockdown Techniques ; HCT116 Cells ; Humans ; Lymphatic Metastasis ; Male ; Mice ; Mice, Nude ; Middle Aged ; Morpholines/pharmacology ; Neoplasm Invasiveness ; Neoplasm Staging ; Neoplasm Transplantation ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; Zinc Finger Protein GLI1/drug effects ; Zinc Finger Protein GLI1/metabolism
Czasopismo naukowe
Tytuł :
Garcinone C suppresses colon tumorigenesis through the Gli1-dependent hedgehog signaling pathway.
Autorzy :
Chen J; Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546, South Korea.
Qiu S; Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546, South Korea.
Kim JT; Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546, South Korea.
Cho JS; Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546, South Korea.
Moon JH; Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546, South Korea.
Zhou Y; Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546, South Korea.
Auh JH; Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546, South Korea. Electronic address: .
Lee HJ; Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546, South Korea. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2020 Dec; Vol. 79, pp. 153334. Date of Electronic Publication: 2020 Sep 03.
Typ publikacji :
Journal Article
MeSH Terms :
Colonic Neoplasms/*drug therapy
Hedgehog Proteins/*metabolism
Xanthones/*pharmacology
Zinc Finger Protein GLI1/*metabolism
Animals ; Anticarcinogenic Agents/pharmacology ; Antineoplastic Agents, Phytogenic/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Colonic Neoplasms/metabolism ; Cyclin D1/metabolism ; Cyclin E/metabolism ; Hedgehog Proteins/antagonists & inhibitors ; Humans ; Male ; Mice, Inbred C57BL ; Oncogene Proteins/metabolism ; Phosphorylation/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; Xenograft Model Antitumor Assays ; Zinc Finger Protein GLI1/genetics
Czasopismo naukowe
Tytuł :
Impaired Hedgehog-Gli1 Pathway Activity Underlies the Vascular Phenotype of Polycystic Kidney Disease.
Autorzy :
Franchi F; From the Department of Cardiovascular Medicine (F.F., K.M.P., K.Q., D.D., M.O., M.P., M.G.R.-P.), Mayo Clinic, Rochester, MN.
Peterson KM; From the Department of Cardiovascular Medicine (F.F., K.M.P., K.Q., D.D., M.O., M.P., M.G.R.-P.), Mayo Clinic, Rochester, MN.
Quandt K; From the Department of Cardiovascular Medicine (F.F., K.M.P., K.Q., D.D., M.O., M.P., M.G.R.-P.), Mayo Clinic, Rochester, MN.
Domnick D; From the Department of Cardiovascular Medicine (F.F., K.M.P., K.Q., D.D., M.O., M.P., M.G.R.-P.), Mayo Clinic, Rochester, MN.
Kline TL; Department of Radiology (T.L.K.), Mayo Clinic, Rochester, MN.
Olthoff M; From the Department of Cardiovascular Medicine (F.F., K.M.P., K.Q., D.D., M.O., M.P., M.G.R.-P.), Mayo Clinic, Rochester, MN.
Parvizi M; From the Department of Cardiovascular Medicine (F.F., K.M.P., K.Q., D.D., M.O., M.P., M.G.R.-P.), Mayo Clinic, Rochester, MN.
Tolosa EJ; Schulze Center for Novel Therapeutic, Division of Oncology Research (E.J.T., M.E.F.-Z.), Mayo Clinic, Rochester, MN.
Torres VE; Division of Nephrology and Hypertension (V.E.T., P.C.H.), Mayo Clinic, Rochester, MN.
Harris PC; Division of Nephrology and Hypertension (V.E.T., P.C.H.), Mayo Clinic, Rochester, MN.
Fernandez-Zapico ME; Schulze Center for Novel Therapeutic, Division of Oncology Research (E.J.T., M.E.F.-Z.), Mayo Clinic, Rochester, MN.
Rodriguez-Porcel MG; From the Department of Cardiovascular Medicine (F.F., K.M.P., K.Q., D.D., M.O., M.P., M.G.R.-P.), Mayo Clinic, Rochester, MN.
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Źródło :
Hypertension (Dallas, Tex. : 1979) [Hypertension] 2020 Dec; Vol. 76 (6), pp. 1889-1897. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Signal Transduction*
Blood Vessels/*metabolism
Hedgehog Proteins/*metabolism
Polycystic Kidney Diseases/*metabolism
Zinc Finger Protein GLI1/*metabolism
Animals ; Cells, Cultured ; Cilia/metabolism ; Hedgehog Proteins/genetics ; Humans ; Muscle, Smooth, Vascular/cytology ; Muscle, Smooth, Vascular/metabolism ; Myocytes, Smooth Muscle/metabolism ; Phenotype ; Polycystic Kidney Diseases/diagnostic imaging ; Polycystic Kidney Diseases/genetics ; Rats, Sprague-Dawley ; X-Ray Microtomography ; Zinc Finger Protein GLI1/genetics
Czasopismo naukowe
Tytuł :
ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL.
Autorzy :
Pietrobono S; Core Research Laboratory - Institute for Cancer Research and Prevention (ISPRO), Viale Pieraccini 6, 50139, Florence, Italy.
Anichini G; Core Research Laboratory - Institute for Cancer Research and Prevention (ISPRO), Viale Pieraccini 6, 50139, Florence, Italy.; Department of Medical Biotechnologies, University of Siena, Viale M. Bracci 16, 53100, Siena, Italy.
Sala C; Department of Clinical and Experimental Medicine, University of Florence, Viale Morgagni 50, 50134, Florence, Italy.
Manetti F; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, 53100, Siena, Italy.
Almada LL; Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, 55905, USA.
Pepe S; Core Research Laboratory - Institute for Cancer Research and Prevention (ISPRO), Viale Pieraccini 6, 50139, Florence, Italy.; Department of Medical Biotechnologies, University of Siena, Viale M. Bracci 16, 53100, Siena, Italy.
Carr RM; Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, 55905, USA.
Paradise BD; Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, 55905, USA.
Sarkaria JN; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, 55905, USA.
Davila JI; Department of Health Sciences Research, Mayo Clinic, Rochester, Rochester, MN, 55905, USA.
Tofani L; Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy.
Battisti I; Proteomics Center, University of Padova and Azienda Ospedaliera di Padova, Via G. Oris 2B, 35129, Padova, Italy.
Arrigoni G; Proteomics Center, University of Padova and Azienda Ospedaliera di Padova, Via G. Oris 2B, 35129, Padova, Italy.; Department of Biomedical Sciences, University of Padova, Via U. Bassi 58B, 35131, Padova, Italy.
Ying L; Department of Dermatology, Mayo Clinic, Rochester, MN, 55905, USA.
Zhang C; Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, 55905, USA.
Li H; Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, 55905, USA.
Meves A; Department of Dermatology, Mayo Clinic, Rochester, MN, 55905, USA.
Fernandez-Zapico ME; Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, 55905, USA.
Stecca B; Core Research Laboratory - Institute for Cancer Research and Prevention (ISPRO), Viale Pieraccini 6, 50139, Florence, Italy. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 17; Vol. 11 (1), pp. 5865. Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Melanoma/*pathology
Proto-Oncogene Proteins/*metabolism
Receptor Protein-Tyrosine Kinases/*metabolism
SOXB1 Transcription Factors/*metabolism
Sialyltransferases/*metabolism
Skin Neoplasms/*pathology
Zinc Finger Protein GLI1/*metabolism
Animals ; Gene Expression Regulation, Neoplastic ; Glycosylation ; Humans ; Melanoma/genetics ; Melanoma/metabolism ; Mice, Nude ; Multiprotein Complexes/genetics ; Multiprotein Complexes/metabolism ; Proto-Oncogene Proteins/genetics ; Receptor Protein-Tyrosine Kinases/genetics ; SOXB1 Transcription Factors/genetics ; Sialyltransferases/genetics ; Skin Neoplasms/genetics ; Skin Neoplasms/metabolism ; Transcription, Genetic ; Xenograft Model Antitumor Assays ; Zinc Finger Protein GLI1/genetics
SCR Disease Name :
Melanoma, Cutaneous Malignant
Czasopismo naukowe
Tytuł :
Relative Levels of Gli1 and Gli2 Determine the Response of Ventral Neural Stem Cells to Demyelination.
Autorzy :
Radecki DZ; Stem Cell and Regenerative Medicine Center, Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.
Messling HM; Stem Cell and Regenerative Medicine Center, Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.
Haggerty-Skeans JR; Department of Neuroscience and Physiology, Neuroscience Institute, NYU Langone Medical Center, New York, NY 10016, USA.
Bhamidipati SK; Stem Cell and Regenerative Medicine Center, Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.
Clawson ED; Stem Cell and Regenerative Medicine Center, Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.
Overman CA; Stem Cell and Regenerative Medicine Center, Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.
Thatcher MM; Stem Cell and Regenerative Medicine Center, Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.
Salzer JL; Department of Neuroscience and Physiology, Neuroscience Institute, NYU Langone Medical Center, New York, NY 10016, USA.
Samanta J; Stem Cell and Regenerative Medicine Center, Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address: .
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Źródło :
Stem cell reports [Stem Cell Reports] 2020 Nov 10; Vol. 15 (5), pp. 1047-1055. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Demyelinating Diseases/*metabolism
Neural Stem Cells/*metabolism
Zinc Finger Protein GLI1/*metabolism
Zinc Finger Protein Gli2/*metabolism
Animals ; Cell Differentiation ; Demyelinating Diseases/genetics ; Lateral Ventricles/metabolism ; Mice ; Mice, Inbred C57BL ; Oligodendrocyte Precursor Cells/metabolism ; Oligodendroglia/metabolism ; Remyelination ; Sequence Deletion ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Up-Regulation ; Zinc Finger Protein GLI1/genetics ; Zinc Finger Protein Gli2/genetics
Czasopismo naukowe
Tytuł :
Galectin-1 promotes vasculogenic mimicry in gastric adenocarcinoma via the Hedgehog/GLI signaling pathway.
Autorzy :
You X; Department of Gastrointestinal Surgery, Hospital Affiliated 5 to Nantong University (Taizhou People's Hospital) Taizhou, Jiangsu Province, China.
Wu J; Department of Gastrointestinal Surgery, Hospital Affiliated 5 to Nantong University (Taizhou People's Hospital) Taizhou, Jiangsu Province, China.
Wang Y; Department of Gastrointestinal Surgery, Hospital Affiliated 5 to Nantong University (Taizhou People's Hospital) Taizhou, Jiangsu Province, China.
Liu Q; Department of Gastrointestinal Surgery, Hospital Affiliated 5 to Nantong University (Taizhou People's Hospital) Taizhou, Jiangsu Province, China.
Cheng Z; Department of Gastrointestinal Surgery, Hospital Affiliated 5 to Nantong University (Taizhou People's Hospital) Taizhou, Jiangsu Province, China.
Zhao X; Department of Gastrointestinal Surgery, Hospital Affiliated 5 to Nantong University (Taizhou People's Hospital) Taizhou, Jiangsu Province, China.
Liu G; Department of Gastrointestinal Surgery, Hospital Affiliated 5 to Nantong University (Taizhou People's Hospital) Taizhou, Jiangsu Province, China.
Huang C; Department of Gastrointestinal Surgery, Hospital Affiliated 5 to Nantong University (Taizhou People's Hospital) Taizhou, Jiangsu Province, China.
Dai J; Department of Gastrointestinal Surgery, Hospital Affiliated 5 to Nantong University (Taizhou People's Hospital) Taizhou, Jiangsu Province, China.
Zhou Y; Department of Gastrointestinal Surgery, Hospital Affiliated 5 to Nantong University (Taizhou People's Hospital) Taizhou, Jiangsu Province, China.
Chen D; Department of Gastrointestinal Surgery, Hospital Affiliated 5 to Nantong University (Taizhou People's Hospital) Taizhou, Jiangsu Province, China.
Chong Y; Department of Gastrointestinal Surgery, Hospital Affiliated 5 to Nantong University (Taizhou People's Hospital) Taizhou, Jiangsu Province, China.
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Źródło :
Aging [Aging (Albany NY)] 2020 Nov 10; Vol. 12 (21), pp. 21837-21853. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Mimicry*
Neovascularization, Pathologic*
Adenocarcinoma/*metabolism
Galectin 1/*metabolism
Hedgehog Proteins/*metabolism
Stomach Neoplasms/*metabolism
Zinc Finger Protein GLI1/*metabolism
Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Animals ; Cell Line, Tumor ; Galectin 1/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice, Nude ; Signal Transduction ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology ; Zinc Finger Protein GLI1/genetics
Czasopismo naukowe
Tytuł :
Gli1 mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung.
Autorzy :
Cassandras M; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, San Francisco, CA, USA.
Wang C; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, San Francisco, CA, USA.
Kathiriya J; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, San Francisco, CA, USA.
Tsukui T; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, San Francisco, CA, USA.
Matatia P; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
Matthay M; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, San Francisco, CA, USA.
Wolters P; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, San Francisco, CA, USA.
Molofsky A; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
Sheppard D; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, San Francisco, CA, USA.
Chapman H; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, San Francisco, CA, USA.
Peng T; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, San Francisco, CA, USA. .
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Źródło :
Nature cell biology [Nat Cell Biol] 2020 Nov; Vol. 22 (11), pp. 1295-1306. Date of Electronic Publication: 2020 Oct 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*
Stem Cell Niche*
Alveolar Epithelial Cells/*metabolism
Bone Morphogenetic Proteins/*metabolism
Lung/*metabolism
Mesenchymal Stem Cells/*metabolism
Pulmonary Fibrosis/*metabolism
Zinc Finger Protein GLI1/*metabolism
Alveolar Epithelial Cells/pathology ; Animals ; Bleomycin ; Cells, Cultured ; Coculture Techniques ; Disease Models, Animal ; Hedgehog Proteins/metabolism ; Keratin-5/metabolism ; Lung/pathology ; Mesenchymal Stem Cells/pathology ; Metaplasia ; Mice, Inbred C57BL ; Mice, Knockout ; Pulmonary Fibrosis/chemically induced ; Pulmonary Fibrosis/genetics ; Pulmonary Fibrosis/pathology ; Signal Transduction ; Smoothened Receptor/metabolism ; Zinc Finger Protein GLI1/genetics
Czasopismo naukowe
Tytuł :
Expression of Sonic Hedgehog and pathway components in the embryonic mouse head: anatomical relationships between regulators of positive and negative feedback.
Autorzy :
Sigulinsky CL; Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.
Li X; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, 1161 21st Ave S, B3307 MCN/2569, Nashville, TN, 37232, USA.
Levine EM; Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA. .; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, 1161 21st Ave S, B3307 MCN/2569, Nashville, TN, 37232, USA. .; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA. .
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Źródło :
BMC research notes [BMC Res Notes] 2021 Aug 05; Vol. 14 (1), pp. 300. Date of Electronic Publication: 2021 Aug 05.
Typ publikacji :
Journal Article
MeSH Terms :
Hedgehog Proteins*/genetics
Signal Transduction*
Head/*embryology
Animals ; Feedback, Physiological ; Mice ; Zinc Finger Protein GLI1/genetics
Czasopismo naukowe
Tytuł :
GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression.
Autorzy :
Tolosa EJ; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, U.S.A.
Fernandez-Barrena MG; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, U.S.A.
Iguchi E; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, U.S.A.
McCleary-Wheeler AL; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, U.S.A.
Carr RM; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, U.S.A.
Almada LL; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, U.S.A.
Flores LF; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, U.S.A.
Vera RE; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, U.S.A.
Alfonse GW; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, U.S.A.
Marks DL; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, U.S.A.
Hogenson TL; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, U.S.A.
Vrabel AM; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, U.S.A.
Horn IP; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, U.S.A.
Koenig AN; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, U.S.A.
Safgren SL; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, U.S.A.
Sigafoos AN; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, U.S.A.
Erkan M; Department of Surgery, Koc University School of Medicine, Istanbul, Turkey.
Romecin-Duran PA; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, U.S.A.
Sarabia Gonzalez A; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, U.S.A.
Zhou B; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, U.S.A.
Javelaud D; Institut Curie, PSL Research University, INSERM U1021, CNRS UMR3347, Team 'TGF-ß and Oncogenesis', Equipe Labellisée LIGUE 2016, F-91400, Orsay, France.; Université Paris-Sud, F-91400, Orsay, France.
Marsaud V; Institut Curie, PSL Research University, INSERM U1021, CNRS UMR3347, Team 'TGF-ß and Oncogenesis', Equipe Labellisée LIGUE 2016, F-91400, Orsay, France.; Université Paris-Sud, F-91400, Orsay, France.
Graham RP; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, U.S.A.
Mauviel A; Institut Curie, PSL Research University, INSERM U1021, CNRS UMR3347, Team 'TGF-ß and Oncogenesis', Equipe Labellisée LIGUE 2016, F-91400, Orsay, France.; Université Paris-Sud, F-91400, Orsay, France.
Elsawa SF; Department of Molecular, Cellular and Biomedical Sciences, College of Life Sciences and Agriculture, University of New Hampshire, Durham, NH, U.S.A.
Fernandez-Zapico ME; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, U.S.A.
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Źródło :
The Biochemical journal [Biochem J] 2020 Sep 18; Vol. 477 (17), pp. 3131-3145.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Hedgehog Proteins/*metabolism
Nuclear Proteins/*metabolism
Pancreatic Neoplasms/*metabolism
Rhabdomyosarcoma/*metabolism
Zinc Finger Protein GLI1/*metabolism
Zinc Finger Protein Gli2/*metabolism
Cell Line, Tumor ; Hedgehog Proteins/genetics ; Humans ; Nuclear Proteins/genetics ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Protein Multimerization ; Rhabdomyosarcoma/genetics ; Rhabdomyosarcoma/pathology ; Zinc Finger Protein GLI1/genetics ; Zinc Finger Protein Gli2/genetics
Czasopismo naukowe
Tytuł :
Hedgehog Signaling and Truncated GLI1 in Cancer.
Autorzy :
Doheny D; Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.
Manore SG; Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.
Wong GL; Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.
Lo HW; Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.; Wake Forest Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.
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Źródło :
Cells [Cells] 2020 Sep 17; Vol. 9 (9). Date of Electronic Publication: 2020 Sep 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Hedgehog Proteins/*genetics
Neoplasms/*genetics
Signal Transduction/*genetics
Smoothened Receptor/*genetics
Zinc Finger Protein GLI1/*genetics
Alternative Splicing ; Antineoplastic Agents/therapeutic use ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Cell Differentiation/drug effects ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Hedgehog Proteins/metabolism ; Humans ; Lymphatic Metastasis ; Molecular Targeted Therapy ; Neoplasms/classification ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Patched-1 Receptor/genetics ; Patched-1 Receptor/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Smoothened Receptor/metabolism ; Zinc Finger Protein GLI1/metabolism
Czasopismo naukowe
Tytuł :
GANT61 Reduces Hedgehog Molecule (GLI1) Expression and Promotes Apoptosis in Metastatic Oral Squamous Cell Carcinoma Cells.
Autorzy :
Bacelar Sacramento de Araújo T; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, Bahia, Brazil.; Department of Propedeutics, Faculty of Dentistry, Federal University of Bahia, Salvador 40110-909, Bahia, Brazil.
de Oliveira Siquara da Rocha L; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, Bahia, Brazil.; Department of Propedeutics, Faculty of Dentistry, Federal University of Bahia, Salvador 40110-909, Bahia, Brazil.
Torres Andion Vidal M; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, Bahia, Brazil.; Department of Propedeutics, Faculty of Dentistry, Federal University of Bahia, Salvador 40110-909, Bahia, Brazil.
Cerqueira Coelho PL; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, Bahia, Brazil.
Galvão Dos Reis M; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, Bahia, Brazil.; Department of Pathology, School of Medicine, Federal University of Bahia (UFBA), Salvador 40110-909, Bahia, Brazil.
Solano de Freitas Souza B; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, Bahia, Brazil.; D'Or Institute for Research and Education (IDOR), Sao Rafael Hospital, Salvador 41253-190, BA, Brazil.
Botelho Pereira Soares M; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, Bahia, Brazil.
Almeida Pereira T; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Della Coletta R; Department of Oral Diagnosis, School of Dentistry, University of Campinas, Piracicaba 13414-903, Sao Paulo, Brazil.
Pereira Bezerra D; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, Bahia, Brazil.
Borges Dias R; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, Bahia, Brazil.; Department of Propedeutics, Faculty of Dentistry, Federal University of Bahia, Salvador 40110-909, Bahia, Brazil.
Araújo Gurgel Rocha C; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, Bahia, Brazil.; Department of Propedeutics, Faculty of Dentistry, Federal University of Bahia, Salvador 40110-909, Bahia, Brazil.; Department of Pathology, School of Medicine, Federal University of Bahia (UFBA), Salvador 40110-909, Bahia, Brazil.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Aug 24; Vol. 21 (17). Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Carcinoma, Squamous Cell/*pathology
Mouth Neoplasms/*pathology
Pyridines/*pharmacology
Pyrimidines/*pharmacology
Zinc Finger Protein GLI1/*genetics
Adult ; Apoptosis/genetics ; Carcinoma, Squamous Cell/genetics ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Cell Survival/drug effects ; Cell Survival/genetics ; Cells, Cultured ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Mouth Neoplasms/genetics ; Neoplasm Metastasis ; Zinc Finger Protein GLI1/metabolism
Czasopismo naukowe
Tytuł :
Hedgehog-GLI signalling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells.
Autorzy :
Po A; Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 291, 00161, Rome, Italy.
Citarella A; Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 291, 00161, Rome, Italy.
Catanzaro G; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
Besharat ZM; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
Trocchianesi S; Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 291, 00161, Rome, Italy.
Gianno F; Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 291, 00161, Rome, Italy.
Sabato C; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
Moretti M; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
De Smaele E; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
Vacca A; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
Fiori ME; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161, Rome, Italy.
Ferretti E; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy. .; Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Viale Regina Elena 291, 00161, Rome, Italy. .
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Źródło :
Scientific reports [Sci Rep] 2020 Aug 19; Vol. 10 (1), pp. 13988. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
ATP-Binding Cassette Transporters/*metabolism
Colorectal Neoplasms/*metabolism
Hedgehog Proteins/*metabolism
Zinc Finger Protein GLI1/*metabolism
ATP-Binding Cassette Transporters/genetics ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Apoptosis/genetics ; Cell Line, Tumor ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Fluorouracil/pharmacology ; Gene Expression Regulation, Neoplastic ; Hedgehog Proteins/genetics ; Humans ; Kaplan-Meier Estimate ; Oxaliplatin/pharmacology ; Promoter Regions, Genetic/genetics ; Protein Binding ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Zinc Finger Protein GLI1/genetics
Czasopismo naukowe
Tytuł :
A Gli inhibitor GANT61 suppresses cell proliferation, promotes cell apoptosis and induces G1/G0 cycle retardation with a dose- and time-dependent manner through inhibiting Notch pathway in multiple myeloma.
Autorzy :
Zhang Z; Department of Hematology, The Affiliated Hospital of Chengde Medical College , Chengde, Hebei, China.
Hao C; Department of Hematology, The Affiliated Hospital of Chengde Medical College , Chengde, Hebei, China.
Zhang R; Department of Hematology, The Affiliated Hospital of Chengde Medical College , Chengde, Hebei, China.
Pei X; Department of Hematology, The Affiliated Hospital of Chengde Medical College , Chengde, Hebei, China.
Li J; Department of Hematology, The Affiliated Hospital of Chengde Medical College , Chengde, Hebei, China.
Wang L; Department of Hematology, The Affiliated Hospital of Chengde Medical College , Chengde, Hebei, China.
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Źródło :
Cell cycle (Georgetown, Tex.) [Cell Cycle] 2020 Aug; Vol. 19 (16), pp. 2063-2073. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*/drug effects
G1 Phase Cell Cycle Checkpoints*/drug effects
Multiple Myeloma/*pathology
Pyridines/*pharmacology
Pyrimidines/*pharmacology
Receptors, Notch/*metabolism
Zinc Finger Protein GLI1/*antagonists & inhibitors
Cell Line, Tumor ; Cell Proliferation/drug effects ; Humans ; Time Factors ; Zinc Finger Protein GLI1/metabolism
Czasopismo naukowe

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