Temat: "Zinc Finger Protein GLI1" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: GLI1+ perivascular, renal, progenitor cells: The likely source of spontaneous neoplasia that created the AGMK1-9T7 cell line.
Autorzy:: Lewis AM Jr; Laboratory of DNA Viruses, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America.
Foseh G; Laboratory of DNA Viruses, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America.
Tu W; Laboratory of DNA Viruses, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America.
Peden K; Laboratory of DNA Viruses, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America.
Akue A; Flow Cytometry Unit, OMPT, Center for Biologics Evaluation and Research, OVRR, Food and Drug Administration, Silver Spring, Maryland, United States of America.
KuKuruga M; Flow Cytometry Unit, OMPT, Center for Biologics Evaluation and Research, OVRR, Food and Drug Administration, Silver Spring, Maryland, United States of America.
Rotroff D; Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.
Lewis G; TCL and M Associates, Leesburg, Virginia, United States of America.
Mazo I; HIVE Team, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, FDA, Silver Spring, Maryland, United States of America.
Bauer SR; Division of Cellular and Gene Therapies, Office of Therapeutic Products, Center for Biologics Evaluation and Research, Silver Spring, Maryland, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2023 Dec 07; Vol. 18 (12), pp. e0293406. Date of Electronic Publication: 2023 Dec 07 (Print Publication: 2023).
Typ publikacji:: Journal Article
MeSH Terms:: Mesenchymal Stem Cells*
Neoplasms*/metabolism
Animals ; Mice ; Zinc Finger Protein GLI1/metabolism ; Cell Differentiation ; Cell Line ; Stem Cells ; Kidney ; Cells, Cultured

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Skocz do pozycji: 2.

Tytuł:: Differential phosphorylation determines the repressor and activator potencies of GLI1 proteins and their efficiency in modulating the HPV life cycle.
Autorzy:: Piirsoo A; Institute of Technology, University of Tartu, Tartu, Estonia.
Pink A; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.
Kasak L; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.
Kala M; Institute of Technology, University of Tartu, Tartu, Estonia.
Kasvandik S; Institute of Technology, University of Tartu, Tartu, Estonia.
Ustav M; Institute of Technology, University of Tartu, Tartu, Estonia.
Piirsoo M; Institute of Technology, University of Tartu, Tartu, Estonia.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2019 Nov 26; Vol. 14 (11), pp. e0225775. Date of Electronic Publication: 2019 Nov 26 (Print Publication: 2019).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cyclic AMP-Dependent Protein Kinases/*metabolism
Papillomaviridae/*physiology
Repressor Proteins/*metabolism
Zinc Finger Protein GLI1/*metabolism
Amino Acid Sequence ; Binding Sites ; Cell Line ; Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors ; DNA/metabolism ; Humans ; Oncogene Proteins, Viral/genetics ; Papillomaviridae/genetics ; Phosphorylation ; Promoter Regions, Genetic ; Protein Binding ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Repressor Proteins/chemistry ; Sequence Alignment ; Transcriptional Activation ; Virus Replication ; Zinc Finger Protein GLI1/chemistry ; Zinc Finger Protein GLI1/genetics

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Skocz do pozycji: 3.

Tytuł:: Unique and overlapping GLI1 and GLI2 transcriptional targets in neoplastic chondrocytes.
Autorzy:: Ali SA; Genetics and Development, Krembil Research Institute, Toronto, Ontario, Canada.
Niu B; School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China.
Cheah KSE; School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China.
Alman B; Department of Orthopaedic Surgery, Duke University, Durham, North Carolina, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2019 Jan 29; Vol. 14 (1), pp. e0211333. Date of Electronic Publication: 2019 Jan 29 (Print Publication: 2019).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Bone Neoplasms/*genetics
Chondrosarcoma/*genetics
Gene Expression Profiling/*methods
Nuclear Proteins/*metabolism
Zinc Finger Protein GLI1/*metabolism
Zinc Finger Protein Gli2/*metabolism
Animals ; Bone Neoplasms/metabolism ; Chondrosarcoma/metabolism ; Chromatin Immunoprecipitation ; Gene Expression Regulation, Neoplastic ; Hedgehog Proteins/genetics ; Humans ; Mice ; Nuclear Proteins/chemistry ; Oligonucleotide Array Sequence Analysis ; Protein Binding ; Signal Transduction ; Tumor Cells, Cultured ; Zinc Finger Protein GLI1/chemistry ; Zinc Finger Protein Gli2/chemistry

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Skocz do pozycji: 4.

Tytuł:: Conservation of A-to-I RNA editing in bowhead whale and pig.
Autorzy:: Larsen K; Department of Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark.
Heide-Jørgensen MP; Greenland Institute of Natural Resources, Copenhagen K, Denmark.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2021 Dec 09; Vol. 16 (12), pp. e0260081. Date of Electronic Publication: 2021 Dec 09 (Print Publication: 2021).
Typ publikacji:: Journal Article
MeSH Terms:: RNA Editing*
Bowhead Whale/*genetics
RNA, Messenger/*metabolism
Swine/*genetics
Adenosine/metabolism ; Animals ; DNA Glycosylases/genetics ; Inosine/metabolism ; Peptide Elongation Factor 1/genetics ; Shab Potassium Channels/genetics ; Zinc Finger Protein GLI1/genetics

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Skocz do pozycji: 5.

Tytuł:: Functional analysis of the zebrafish ortholog of HMGCS1 reveals independent functions for cholesterol and isoprenoids in craniofacial development.
Autorzy:: Quintana AM; Department of Biological Sciences, University of Texas El Paso, El Paso, TX, United States of America.; Border Biomedical Research Center, NeuroModulation Cluster, University of Texas El Paso, El Paso, TX, United States of America.
Hernandez JA; Department of Biological Sciences, University of Texas El Paso, El Paso, TX, United States of America.
Gonzalez CG; Department of Biological Sciences, University of Texas El Paso, El Paso, TX, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2017 Jul 07; Vol. 12 (7), pp. e0180856. Date of Electronic Publication: 2017 Jul 07 (Print Publication: 2017).
Typ publikacji:: Journal Article
MeSH Terms:: Cholesterol/*biosynthesis
Craniofacial Abnormalities/*genetics
Hedgehog Proteins/*genetics
Hydroxymethylglutaryl CoA Reductases/*genetics
Hydroxymethylglutaryl-CoA Synthase/*genetics
Terpenes/*metabolism
Zebrafish Proteins/*genetics
Zinc Finger Protein GLI1/*genetics
Animals ; Anticholesteremic Agents/pharmacology ; Atorvastatin/pharmacology ; Benzophenones/pharmacology ; Body Patterning/drug effects ; Body Patterning/genetics ; Cell Differentiation/drug effects ; Chondrocytes/drug effects ; Chondrocytes/metabolism ; Chondrocytes/pathology ; Craniofacial Abnormalities/metabolism ; Craniofacial Abnormalities/pathology ; Embryo, Nonmammalian ; Enzyme Inhibitors/pharmacology ; Gene Expression Regulation, Developmental ; Hedgehog Proteins/metabolism ; Humans ; Hydroxymethylglutaryl CoA Reductases/metabolism ; Hydroxymethylglutaryl-CoA Synthase/metabolism ; Neural Crest/drug effects ; Neural Crest/metabolism ; Neural Crest/pathology ; Piperidines/pharmacology ; Pyridines/pharmacology ; Signal Transduction ; Terpenes/antagonists & inhibitors ; Zebrafish ; Zebrafish Proteins/metabolism ; Zinc Finger Protein GLI1/metabolism

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Skocz do pozycji: 6.

Tytuł:: Expression profile of sonic hedgehog signaling-related molecules in basal cell carcinoma.
Autorzy:: Kim HS; Department of Pathology, Jeju National University College of medicine, Jeju, South Korea.
Kim YS; Department of Pathology, Jeju National University College of medicine, Jeju, South Korea.
Lee C; Department of Pathology, Seoul National University College of medicine, Seoul, South Korea.
Shin MS; Department of Plastic Surgery, Jeju National University College of medicine, Jeju, South Korea.
Kim JW; Department of Dermatology, Jeju National University College of medicine, Jeju, South Korea.
Jang BG; Department of Pathology, Jeju National University College of medicine, Jeju, South Korea.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2019 Nov 22; Vol. 14 (11), pp. e0225511. Date of Electronic Publication: 2019 Nov 22 (Print Publication: 2019).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Carcinoma, Basal Cell/*pathology
Hedgehog Proteins/*metabolism
Signal Transduction/*genetics
Carcinoma, Basal Cell/metabolism ; Gene Expression Regulation, Neoplastic ; Hedgehog Proteins/genetics ; Humans ; Patched-2 Receptor/genetics ; Patched-2 Receptor/metabolism ; RNA, Messenger/metabolism ; Skin/metabolism ; Skin/pathology ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology ; Smoothened Receptor/genetics ; Smoothened Receptor/metabolism ; Stem Cells/metabolism ; Zinc Finger Protein GLI1/genetics ; Zinc Finger Protein GLI1/metabolism

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Skocz do pozycji: 7.

Tytuł:: Abnormal activity of transcription factors gli in high-grade gliomas.
Autorzy:: Volnitskiy A; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre 'Kurchatov Institute', Gatchina, Russia.
Shtam T; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre 'Kurchatov Institute', Gatchina, Russia.; N.N. Petrov National Medical Research Center of Oncology, St. Petersburg, Pesochnyj, Leningradskaya, Russia.
Burdakov V; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre 'Kurchatov Institute', Gatchina, Russia.
Kovalev R; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre 'Kurchatov Institute', Gatchina, Russia.
Konev A; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre 'Kurchatov Institute', Gatchina, Russia.
Filatov M; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre 'Kurchatov Institute', Gatchina, Russia.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2019 Feb 07; Vol. 14 (2), pp. e0211980. Date of Electronic Publication: 2019 Feb 07 (Print Publication: 2019).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Brain Neoplasms/*genetics
Glioma/*genetics
Neoplastic Stem Cells/*metabolism
Pyridines/*pharmacology
Pyrimidines/*pharmacology
Repressor Proteins/*genetics
Brain Neoplasms/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Forkhead Box Protein M1/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Knockdown Techniques ; Glioma/metabolism ; HeLa Cells ; Humans ; Neoplastic Stem Cells/drug effects ; Nerve Tissue Proteins/antagonists & inhibitors ; Nerve Tissue Proteins/genetics ; Nuclear Proteins/antagonists & inhibitors ; Nuclear Proteins/genetics ; Repressor Proteins/antagonists & inhibitors ; Zinc Finger Protein GLI1/antagonists & inhibitors ; Zinc Finger Protein GLI1/genetics ; Zinc Finger Protein Gli2/antagonists & inhibitors ; Zinc Finger Protein Gli2/genetics ; Zinc Finger Protein Gli3/antagonists & inhibitors ; Zinc Finger Protein Gli3/genetics

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Skocz do pozycji: 8.

Tytuł:: Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction.
Autorzy:: Hasegawa D; Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Tokyo, Japan.
Ochiai-Shino H; Department of Biochemistry, Tokyo Dental College, Tokyo, Japan.
Onodera S; Department of Biochemistry, Tokyo Dental College, Tokyo, Japan.
Nakamura T; Department of Biochemistry, Tokyo Dental College, Tokyo, Japan.
Saito A; Department of Biochemistry, Tokyo Dental College, Tokyo, Japan.
Onda T; Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Tokyo, Japan.
Watanabe K; Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Tokyo, Japan.
Nishimura K; Laboratory of Gene Regulation, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Ohtaka M; Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan.
Nakanishi M; Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan.
Kosaki K; Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan.
Yamaguchi A; Oral Health Science Center, Tokyo Dental College, Tokyo, Japan.
Shibahara T; Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Tokyo, Japan.
Azuma T; Department of Biochemistry, Tokyo Dental College, Tokyo, Japan.; Oral Health Science Center, Tokyo Dental College, Tokyo, Japan.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2017 Oct 31; Vol. 12 (10), pp. e0186879. Date of Electronic Publication: 2017 Oct 31 (Print Publication: 2017).
Typ publikacji:: Journal Article
MeSH Terms:: Hedgehog Proteins/*genetics
Induced Pluripotent Stem Cells/*metabolism
Osteogenesis/*genetics
Signal Transduction/*genetics
Acyltransferases/genetics ; Adult ; Basal Cell Nevus Syndrome/genetics ; Basal Cell Nevus Syndrome/pathology ; Bone Morphogenetic Protein 4/genetics ; Bone Morphogenetic Protein 6/genetics ; Cell Differentiation/genetics ; Cells, Cultured ; Gene Expression Profiling/methods ; Humans ; Male ; Middle Aged ; Mutation ; Patched-1 Receptor/genetics ; Wnt Proteins/genetics ; Young Adult ; Zinc Finger Protein GLI1/genetics

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Skocz do pozycji: 9.

Tytuł:: Induction of Connective Tissue Growth Factor Expression by Hypoxia in Human Lung Fibroblasts via the MEKK1/MEK1/ERK1/GLI-1/GLI-2 and AP-1 Pathways.
Autorzy:: Cheng Y; School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Lin CH; Gradual Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Chen JY; Gradual Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Li CH; Gradual Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Liu YT; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Chen BC; School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2016 Aug 03; Vol. 11 (8), pp. e0160593. Date of Electronic Publication: 2016 Aug 03 (Print Publication: 2016).
Typ publikacji:: Journal Article
MeSH Terms:: Connective Tissue Growth Factor/*genetics
Fibroblasts/*metabolism
Hypoxia/*genetics
Lung/*metabolism
MAP Kinase Signaling System/*physiology
Cells, Cultured ; Connective Tissue Growth Factor/metabolism ; Humans ; Hypoxia/metabolism ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/metabolism ; MAP Kinase Kinase 1/metabolism ; MAP Kinase Kinase Kinase 1/metabolism ; MAP Kinase Signaling System/genetics ; Mitogen-Activated Protein Kinase 3/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Primary Cell Culture ; Pulmonary Fibrosis/genetics ; Pulmonary Fibrosis/metabolism ; Pulmonary Fibrosis/pathology ; Transcription Factor AP-1/metabolism ; Zinc Finger Protein GLI1/genetics ; Zinc Finger Protein GLI1/metabolism ; Zinc Finger Protein Gli2

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Skocz do pozycji: 10.

Tytuł:: Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions.
Autorzy:: Urman NM; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America.
Mirza A; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America.
Atwood SX; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America.; Department of Developmental and Cell Biology, Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA, United States of America.
Whitson RJ; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America.
Sarin KY; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America.
Tang JY; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America.
Oro AE; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2016 Dec 28; Vol. 11 (12), pp. e0168031. Date of Electronic Publication: 2016 Dec 28 (Print Publication: 2016).
Typ publikacji:: Journal Article
MeSH Terms:: Mutation*
Signal Transduction*
Carcinoma, Basal Cell/*metabolism
Hedgehog Proteins/*metabolism
Repressor Proteins/*genetics
Repressor Proteins/*metabolism
Skin Neoplasms/*metabolism
Animals ; Carcinogenesis ; Carcinoma, Basal Cell/genetics ; Carcinoma, Basal Cell/pathology ; Cell Proliferation ; Disease Progression ; HEK293 Cells ; Humans ; Mice ; Models, Molecular ; NIH 3T3 Cells ; Protein Conformation ; Repressor Proteins/chemistry ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Young Adult ; Zinc Finger Protein GLI1/metabolism

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Skocz do pozycji: 11.

Tytuł:: Identification and Validation of Novel Hedgehog-Responsive Enhancers Predicted by Computational Analysis of Ci/Gli Binding Site Density.
Autorzy:: Gurdziel K; Department of Cell and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, United States of America.; Department of Computational Medicine and Bioinformatics, The University of Michigan, Ann Arbor, MI 48109, United States of America.
Lorberbaum DS; Department of Cell and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, United States of America.; Cellular and Molecular Biology Program, The University of Michigan, Ann Arbor, MI 48109, United States of America.
Udager AM; Department of Cell and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, United States of America.
Song JY; Department of Cell and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, United States of America.; Cellular and Molecular Biology Program, The University of Michigan, Ann Arbor, MI 48109, United States of America.
Richards N; Department of Cell and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, United States of America.
Parker DS; Department of Cell and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, United States of America.
Johnson LA; Department of Cell and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, United States of America.
Allen BL; Department of Cell and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, United States of America.
Barolo S; Department of Cell and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, United States of America.
Gumucio DL; Department of Cell and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2015 Dec 28; Vol. 10 (12), pp. e0145225. Date of Electronic Publication: 2015 Dec 28 (Print Publication: 2015).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Computational Biology/*methods
DNA-Binding Proteins/*metabolism
Drosophila Proteins/*genetics
Drosophila Proteins/*metabolism
Drosophila melanogaster/*embryology
Hedgehog Proteins/*genetics
Oncogene Proteins/*metabolism
Trans-Activators/*metabolism
Transcription Factors/*metabolism
Animals ; Base Sequence ; Binding Sites/genetics ; Chick Embryo ; Drosophila melanogaster/genetics ; Embryo, Nonmammalian/metabolism ; Gene Expression Regulation, Developmental ; Green Fluorescent Proteins/genetics ; Hedgehog Proteins/metabolism ; Neural Tube/metabolism ; Regulatory Sequences, Nucleic Acid ; Sequence Analysis, DNA ; Signal Transduction/genetics ; Wings, Animal/embryology ; Zinc Finger Protein GLI1

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Skocz do pozycji: 12.

Tytuł:: SOX18 Is a Novel Target Gene of Hedgehog Signaling in Cervical Carcinoma Cell Lines.
Autorzy:: Petrovic I; Laboratory for Human Molecular Genetics, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, P.O.BOX 23, 11000 Belgrade, Serbia.
Milivojevic M; Laboratory for Human Molecular Genetics, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, P.O.BOX 23, 11000 Belgrade, Serbia.
Popovic J; Laboratory for Human Molecular Genetics, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, P.O.BOX 23, 11000 Belgrade, Serbia.
Schwirtlich M; Laboratory for Human Molecular Genetics, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, P.O.BOX 23, 11000 Belgrade, Serbia.
Rankovic B; Laboratory for Human Molecular Genetics, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, P.O.BOX 23, 11000 Belgrade, Serbia.
Stevanovic M; Laboratory for Human Molecular Genetics, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, P.O.BOX 23, 11000 Belgrade, Serbia.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2015 Nov 20; Vol. 10 (11), pp. e0143591. Date of Electronic Publication: 2015 Nov 20 (Print Publication: 2015).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Expression Regulation, Neoplastic*
Signal Transduction*
Hedgehog Proteins/*genetics
Kruppel-Like Transcription Factors/*genetics
Nuclear Proteins/*genetics
SOXF Transcription Factors/*genetics
Transcription Factors/*genetics
Binding Sites ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Diffusion Chambers, Culture ; Female ; HeLa Cells ; Hedgehog Proteins/metabolism ; Humans ; Kruppel-Like Transcription Factors/metabolism ; Nuclear Proteins/metabolism ; Promoter Regions, Genetic ; Protein Binding ; SOXF Transcription Factors/metabolism ; Transcription Factors/metabolism ; Zinc Finger Protein GLI1 ; Zinc Finger Protein Gli2

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Skocz do pozycji: 13.

Tytuł:: Targeting the Sonic Hedgehog-Gli1 Pathway as a Potential New Therapeutic Strategy for Myelodysplastic Syndromes.
Autorzy:: Zou J; Department of Hematology, Shanghai Jiaotong University Affiliated First People's Hospital, Shanghai, People's Republic of China.
Zhou Z; Department of Intensive Care Unit, Shanghai Jiaotong University Affiliated First People's Hospital, Shanghai, People's Republic of China.
Wan L; Department of Hematology, Shanghai Jiaotong University Affiliated First People's Hospital, Shanghai, People's Republic of China.
Tong Y; Department of Hematology, Shanghai Jiaotong University Affiliated First People's Hospital, Shanghai, People's Republic of China.
Qin Y; Department of Hematology, Shanghai Jiaotong University Affiliated First People's Hospital, Shanghai, People's Republic of China.
Wang C; Department of Hematology, Shanghai Jiaotong University Affiliated First People's Hospital, Shanghai, People's Republic of China.
Zhou K; Department of Hematology, Shanghai Jiaotong University Affiliated First People's Hospital, Shanghai, People's Republic of China.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2015 Aug 28; Vol. 10 (8), pp. e0136843. Date of Electronic Publication: 2015 Aug 28 (Print Publication: 2015).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Hedgehog Proteins/*antagonists & inhibitors
Hedgehog Proteins/*genetics
Myelodysplastic Syndromes/*drug therapy
Myelodysplastic Syndromes/*pathology
Transcription Factors/*genetics
Adolescent ; Adult ; Aged ; Animals ; Azacitidine/analogs & derivatives ; Azacitidine/pharmacology ; Cell Line, Tumor ; Cell Survival/drug effects ; Cyclin-Dependent Kinase Inhibitor p15/genetics ; Cyclin-Dependent Kinase Inhibitor p15/metabolism ; DNA Methylation/drug effects ; DNA Modification Methylases/pharmacology ; Decitabine ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Male ; Mice ; Middle Aged ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/metabolism ; Neoplasm Transplantation ; Prognosis ; Promoter Regions, Genetic/drug effects ; Signal Transduction/drug effects ; Transcription Factors/metabolism ; Young Adult ; Zinc Finger Protein GLI1

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Skocz do pozycji: 14.

Tytuł:: A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response.
Autorzy:: Oh S; Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America; Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Kato M; Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America; Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Zhang C; Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Guo Y; Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Beachy PA; Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America; Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Department of Biochemistry, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2015 Aug 13; Vol. 10 (8), pp. e0135804. Date of Electronic Publication: 2015 Aug 13 (Print Publication: 2015).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: DNA-Binding Proteins/*metabolism
Drosophila Proteins/*metabolism
Hedgehog Proteins/*metabolism
Oncogene Proteins/*metabolism
Repressor Proteins/*metabolism
Trans-Activators/*metabolism
Transcription Factors/*metabolism
Animals ; DNA-Binding Proteins/genetics ; Drosophila ; Drosophila Proteins/genetics ; Hedgehog Proteins/genetics ; Kinesins/genetics ; Kinesins/metabolism ; Mice ; Mice, Mutant Strains ; Oncogene Proteins/genetics ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Repressor Proteins/genetics ; Signal Transduction/genetics ; Signal Transduction/physiology ; Trans-Activators/genetics ; Transcription Factors/genetics ; Zinc Finger Protein GLI1

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Skocz do pozycji: 15.

Tytuł:: HIF-1α contributes to proliferation and invasiveness of neuroblastoma cells via SHH signaling.
Autorzy:: Chen S; Department of Pediatric Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Zhang M; Department of Pediatric Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Xing L; Department of Pediatric Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Wang Y; Department of Pediatric Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Xiao Y; Shanghai Institute for Pediatric Research, Shanghai, China.
Wu Y; Department of Pediatric Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2015 Mar 26; Vol. 10 (3), pp. e0121115. Date of Electronic Publication: 2015 Mar 26 (Print Publication: 2015).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Signal Transduction*
Hedgehog Proteins/*metabolism
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Neuroblastoma/*metabolism
Animals ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Disease Models, Animal ; Gene Expression ; Gene Knockdown Techniques ; Heterografts ; Humans ; Lymphatic Metastasis ; Mice ; Neoplasm Grading ; Neoplasm Staging ; Neuroblastoma/genetics ; Neuroblastoma/pathology ; Oncogene Proteins/genetics ; Trans-Activators/genetics ; Tumor Burden ; Zinc Finger Protein GLI1

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Skocz do pozycji: 16.

Tytuł:: Hedgehog signaling pathway is active in GBM with GLI1 mRNA expression showing a single continuous distribution rather than discrete high/low clusters.
Autorzy:: Chandra V; National Institute of Biomedical Genomics, P.O. N.S.S. Kalyani, West Bengal 741251, India.
Das T; National Institute of Biomedical Genomics, P.O. N.S.S. Kalyani, West Bengal 741251, India.
Gulati P; Bangur Institute of Neurology, 52/1A, S.N. Pandit Street, Bhawanipore, Kolkata 700098, India.
Biswas NK; National Institute of Biomedical Genomics, P.O. N.S.S. Kalyani, West Bengal 741251, India.
Rote S; Bangur Institute of Neurology, 52/1A, S.N. Pandit Street, Bhawanipore, Kolkata 700098, India.
Chatterjee U; Institute of Post Graduate Medical Education and Research, 244 AJC Bose Road, Kolkata-700020, India.
Ghosh SN; Bangur Institute of Neurology, 52/1A, S.N. Pandit Street, Bhawanipore, Kolkata 700098, India.
Deb S; Bangur Institute of Neurology, 52/1A, S.N. Pandit Street, Bhawanipore, Kolkata 700098, India.
Saha SK; Nil Ratan Sarkar Medical College and Hospital, 138, AJC Bose Road, Kolkata-700014, India.
Chowdhury AK; Bangur Institute of Neurology, 52/1A, S.N. Pandit Street, Bhawanipore, Kolkata 700098, India.
Ghosh S; Bangur Institute of Neurology, 52/1A, S.N. Pandit Street, Bhawanipore, Kolkata 700098, India.
Rudin CM; Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States of America.
Mukherjee A; National Institute of Biomedical Genomics, P.O. N.S.S. Kalyani, West Bengal 741251, India.
Basu A; National Institute of Biomedical Genomics, P.O. N.S.S. Kalyani, West Bengal 741251, India.
Dhara S; National Institute of Biomedical Genomics, P.O. N.S.S. Kalyani, West Bengal 741251, India.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2015 Mar 16; Vol. 10 (3), pp. e0116390. Date of Electronic Publication: 2015 Mar 16 (Print Publication: 2015).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Expression Regulation, Neoplastic*/drug effects
Signal Transduction*/drug effects
Glioblastoma/*genetics
Glioblastoma/*pathology
Hedgehog Proteins/*metabolism
Oncogene Proteins/*genetics
Trans-Activators/*genetics
Anilides/pharmacology ; Apoptosis/drug effects ; Cell Cycle Checkpoints/drug effects ; Dose-Response Relationship, Drug ; Down-Regulation/drug effects ; Humans ; Medulloblastoma/genetics ; Medulloblastoma/pathology ; Pyridines/pharmacology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Up-Regulation/drug effects ; Zinc Finger Protein GLI1

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Skocz do pozycji: 17.

Tytuł:: Rapid screening of gene function by systemic delivery of morpholino oligonucleotides to live mouse embryos.
Autorzy:: McClelland KS; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Wainwright EN; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Bowles J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Koopman P; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2015 Jan 28; Vol. 10 (1), pp. e0114932. Date of Electronic Publication: 2015 Jan 28 (Print Publication: 2015).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Embryonic Development/*genetics
Gene Targeting/*methods
Morpholinos/*administration & dosage
ADAM Proteins/genetics ; ADAM Proteins/metabolism ; Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Chymotrypsin/genetics ; Chymotrypsin/metabolism ; Embryo, Mammalian ; Female ; Gene Knockout Techniques ; Gonads/embryology ; Gonads/metabolism ; Injections ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/metabolism ; Male ; Mice ; Organogenesis/genetics ; Pancreas/embryology ; Pancreas/metabolism ; SOX9 Transcription Factor/genetics ; SOX9 Transcription Factor/metabolism ; Testis/embryology ; Testis/metabolism ; Zinc Finger Protein GLI1

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Skocz do pozycji: 18.

Tytuł:: Combination of cyclopamine and tamoxifen promotes survival and migration of mcf-7 breast cancer cells--interaction of hedgehog-gli and estrogen receptor signaling pathways.
Autorzy:: Sabol M; Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia.
Trnski D; Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia.
Uzarevic Z; Faculty of Education, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Ozretic P; Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia.
Musani V; Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia.
Rafaj M; Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia.
Cindric M; Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia.
Levanat S; Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2014 Dec 12; Vol. 9 (12), pp. e114510. Date of Electronic Publication: 2014 Dec 12 (Print Publication: 2014).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cell Movement/*drug effects
Estrogen Receptor alpha/*metabolism
Hedgehog Proteins/*metabolism
Signal Transduction/*drug effects
Tamoxifen/*pharmacology
Transcription Factors/*metabolism
Veratrum Alkaloids/*pharmacology
Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drug Interactions ; Estrogen Receptor alpha/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; MCF-7 Cells ; Proteomics ; Tamoxifen/adverse effects ; Veratrum Alkaloids/adverse effects ; Zinc Finger Protein GLI1

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Skocz do pozycji: 19.

Tytuł:: p, p'-Dichlorodiphenyldichloroethylene induces colorectal adenocarcinoma cell proliferation through oxidative stress.
Autorzy:: Song L; Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan, China; MOE Key Lab of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China.
Liu J; Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan, China.
Jin X; Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan, China.
Li Z; Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan, China; College of Life Science, Zhejiang Chinese Medical University, Hangzhou, China.
Zhao M; Research Center of Environmental Science, Zhejiang University of Technology, Hangzhou, China.
Liu W; MOE Key Lab of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2014 Nov 11; Vol. 9 (11), pp. e112700. Date of Electronic Publication: 2014 Nov 11 (Print Publication: 2014).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Adenocarcinoma/*pathology
Colorectal Neoplasms/*pathology
Dichlorodiphenyl Dichloroethylene/*toxicity
Oxidative Stress/*drug effects
Adenocarcinoma/chemically induced ; Adenocarcinoma/metabolism ; Catalase/metabolism ; Cell Line, Tumor/drug effects ; Cell Proliferation/drug effects ; Colorectal Neoplasms/chemically induced ; Colorectal Neoplasms/metabolism ; Dose-Response Relationship, Drug ; Humans ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Wnt Signaling Pathway/drug effects ; Zinc Finger Protein GLI1 ; beta Catenin/genetics ; beta Catenin/metabolism

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Skocz do pozycji: 20.

Tytuł:: CDO, an Hh-coreceptor, mediates lung cancer cell proliferation and tumorigenicity through Hedgehog signaling.
Autorzy:: Leem YE; Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Suwon, 440-746, Republic of Korea.
Ha HL; Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Suwon, 440-746, Republic of Korea.
Bae JH; Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Suwon, 440-746, Republic of Korea.
Baek KH; Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Suwon, 440-746, Republic of Korea.
Kang JS; Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Suwon, 440-746, Republic of Korea.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2014 Nov 04; Vol. 9 (11), pp. e111701. Date of Electronic Publication: 2014 Nov 04 (Print Publication: 2014).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cell Proliferation*
Carcinogenesis/*metabolism
Cell Adhesion Molecules/*physiology
Hedgehog Proteins/*physiology
Lung Neoplasms/*metabolism
Tumor Suppressor Proteins/*physiology
Animals ; Apoptosis ; Cell Line, Tumor ; Cell Survival ; Female ; Humans ; Lung Neoplasms/pathology ; Mice, Nude ; Neoplasm Staging ; Neoplasm Transplantation ; Signal Transduction ; Transcription Factors/metabolism ; Zinc Finger Protein GLI1

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