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Tytuł:
Continuous evolution of compact protein degradation tags regulated by selective molecular glues.
Autorzy:
Mercer JAM; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
DeCarlo SJ; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
Roy Burman SS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Sreekanth V; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA.
Nelson AT; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
Hunkeler M; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Chen PJ; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
Donovan KA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Kokkonda P; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Tiwari PK; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA.
Shoba VM; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Deb A; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Choudhary A; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA.
Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2024 Mar 15; Vol. 383 (6688), pp. eadk4422. Date of Electronic Publication: 2024 Mar 15.
Typ publikacji:
Journal Article
MeSH Terms:
Proteolysis*
Ubiquitin-Protein Ligases*/chemistry
Degrons*/genetics
Zinc Fingers*/genetics
Directed Molecular Evolution*/methods
Cryoelectron Microscopy ; Thalidomide/chemistry ; Ubiquitination ; Proteolysis Targeting Chimera ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon.
Autorzy:
Ma X; Global Discovery Chemistry, Novartis Biomedical Research, Emeryville, CA, 94608, USA.
Leon B; Discovery Sciences, Novartis Biomedical Research, Emeryville, CA, 94608, USA.
Ornelas E; Global Discovery Chemistry, Novartis Biomedical Research, Emeryville, CA, 94608, USA.
Dovala D; Discovery Sciences, Novartis Biomedical Research, Emeryville, CA, 94608, USA.
Tandeske L; Discovery Sciences, Novartis Biomedical Research, Emeryville, CA, 94608, USA.
Luu C; Discovery Sciences, Novartis Biomedical Research, Emeryville, CA, 94608, USA.
Pardee G; Discovery Sciences, Novartis Biomedical Research, Emeryville, CA, 94608, USA.
Widger S; Discovery Sciences, Novartis Biomedical Research, Emeryville, CA, 94608, USA.
Solomon JM; Discovery Sciences, Novartis Biomedical Research, Cambridge, MA, 02139, USA.
Beckwith REJ; Discovery Sciences, Novartis Biomedical Research, Cambridge, MA, 02139, USA.
Moser H; Global Discovery Chemistry, Novartis Biomedical Research, Emeryville, CA, 94608, USA.
Clifton MC; Global Discovery Chemistry, Novartis Biomedical Research, Emeryville, CA, 94608, USA.
Wartchow CA; Global Discovery Chemistry, Novartis Biomedical Research, Emeryville, CA, 94608, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Dec 12; Vol. 13 (1), pp. 22088. Date of Electronic Publication: 2023 Dec 12.
Typ publikacji:
Journal Article
MeSH Terms:
Thalidomide*/pharmacology
Thalidomide*/chemistry
Zinc Fingers*
Teratogens ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation.
Autorzy:
Lin L; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands.; Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands.
DeMartino J; Oncode Institute, Utrecht, Netherlands.; Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands.
Wang D; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands.
van Son GJF; Oncode Institute, Utrecht, Netherlands.; Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands.
van der Linden R; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands.
Begthel H; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands.
Korving J; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands.
Andersson-Rolf A; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands.
van den Brink S; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands.
Lopez-Iglesias C; The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, Netherlands.
van de Wetering WJ; The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, Netherlands.
Balwierz A; Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands.
Margaritis T; Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands.
van de Wetering M; Oncode Institute, Utrecht, Netherlands.; Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands.
Peters PJ; The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, Netherlands.
Drost J; Oncode Institute, Utrecht, Netherlands.; Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands.
van Es JH; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands.
Clevers H; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands.; Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Oct 27; Vol. 382 (6669), pp. 451-458. Date of Electronic Publication: 2023 Oct 26.
Typ publikacji:
Journal Article
MeSH Terms:
CRISPR-Cas Systems*
Enteroendocrine Cells*/cytology
Enteroendocrine Cells*/metabolism
Gene Expression Regulation*
Zinc Fingers*
Cell Lineage*/genetics
Repressor Proteins*/genetics
Repressor Proteins*/metabolism
Humans ; Cell Differentiation/genetics ; Organoids ; Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genome-Wide Identification of GATA Family Genes in Phoebe bournei and Their Transcriptional Analysis under Abiotic Stresses.
Autorzy:
Yin Z; College of Forestry, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Liao W; College of Forestry, Fujian Agriculture and Forestry University, Fuzhou 350002, China.; University Key Laboratory of Forest Stress Physiology, Ecology and Molecular Biology of Fujian Province, College of Forestry, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Li J; College of Forestry, Fujian Agriculture and Forestry University, Fuzhou 350002, China.; University Key Laboratory of Forest Stress Physiology, Ecology and Molecular Biology of Fujian Province, College of Forestry, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Pan J; College of Forestry, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Yang S; College of Forestry, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Chen S; College of Forestry, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Cao S; College of Forestry, Fujian Agriculture and Forestry University, Fuzhou 350002, China.; University Key Laboratory of Forest Stress Physiology, Ecology and Molecular Biology of Fujian Province, College of Forestry, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jun 19; Vol. 24 (12). Date of Electronic Publication: 2023 Jun 19.
Typ publikacji:
Journal Article
MeSH Terms:
GATA Transcription Factors*/genetics
GATA Transcription Factors*/metabolism
Zinc Fingers*
Phylogeny ; Promoter Regions, Genetic ; Stress, Physiological/genetics ; Gene Expression Regulation, Plant ; Plant Proteins/metabolism ; Multigene Family ; Genome, Plant
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Zinc binding of a Cys2His2-type zinc finger protein is enhanced by the interaction with DNA.
Autorzy:
Hajdu B; Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm Tér 7, 6720, Szeged, Hungary.
Hunyadi-Gulyás É; Laboratory of Proteomics Research, Biological Research Centre, Eötvös Loránd Research Network (ELKH), Temesvári Krt. 62, 6726, Szeged, Hungary.
Kato K; Department of Infection Biology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan.
Kawaguchi A; Department of Infection Biology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan.
Nagata K; Department of Infection Biology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan.
Gyurcsik B; Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm Tér 7, 6720, Szeged, Hungary. .
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Źródło:
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry [J Biol Inorg Chem] 2023 Apr; Vol. 28 (3), pp. 301-315. Date of Electronic Publication: 2023 Feb 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Peptides*/chemistry
Zinc Fingers*
Binding Sites ; DNA/metabolism ; Zinc/chemistry ; Protein Binding
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The past, present, and future of artificial zinc finger proteins: design strategies and chemical and biological applications.
Autorzy:
Negi S; Faculty of Pharmaceutical Science, Doshisha Women's University Kyotanabe, Kyoto, 610-0395, Japan. .
Imanishi M; Institute for Chemical Research, Kyoto University, Uji, Kyoto, 611-0011, Japan.
Hamori M; Faculty of Pharmaceutical Science, Doshisha Women's University Kyotanabe, Kyoto, 610-0395, Japan.
Kawahara-Nakagawa Y; Graduate School of Life Science, University of Hyogo, 3-2-1 Kouto, Kamigori-Cho, Ako-Gun, Hyogo, 678-1297, Japan.
Nomura W; Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi Minami-Ku, Hiroshima, 734-8553, Japan.
Kishi K; Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi Minami-Ku, Hiroshima, 734-8553, Japan.
Shibata N; Faculty of Pharmaceutical Science, Doshisha Women's University Kyotanabe, Kyoto, 610-0395, Japan.
Sugiura Y; Faculty of Pharmaceutical Science, Doshisha Women's University Kyotanabe, Kyoto, 610-0395, Japan.
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Źródło:
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry [J Biol Inorg Chem] 2023 Apr; Vol. 28 (3), pp. 249-261. Date of Electronic Publication: 2023 Feb 07.
Typ publikacji:
Systematic Review; Journal Article; Review
MeSH Terms:
Zinc Fingers*
DNA*/chemistry
Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Multidimensional control of therapeutic human cell function with synthetic gene circuits.
Autorzy:
Li HS; Biological Design Center, Boston University, Boston, MA, USA.; Department of Biomedical Engineering, Boston University, Boston, MA, USA.
Israni DV; Biological Design Center, Boston University, Boston, MA, USA.; Department of Biomedical Engineering, Boston University, Boston, MA, USA.
Gagnon KA; Biological Design Center, Boston University, Boston, MA, USA.; Department of Biomedical Engineering, Boston University, Boston, MA, USA.
Gan KA; Biological Design Center, Boston University, Boston, MA, USA.; Program in Molecular Biology, Cell Biology, and Biochemistry, Boston University, Boston, MA, USA.
Raymond MH; Biological Design Center, Boston University, Boston, MA, USA.; Department of Biomedical Engineering, Boston University, Boston, MA, USA.
Sander JD; Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Department of Genomics Technologies, Corteva Agriscience, Johnston, IA, USA.
Roybal KT; Cell Design Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA.
Joung JK; Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA.
Wong WW; Biological Design Center, Boston University, Boston, MA, USA.; Department of Biomedical Engineering, Boston University, Boston, MA, USA.
Khalil AS; Biological Design Center, Boston University, Boston, MA, USA.; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; Program in Molecular Biology, Cell Biology, and Biochemistry, Boston University, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Dec 16; Vol. 378 (6625), pp. 1227-1234. Date of Electronic Publication: 2022 Dec 15.
Typ publikacji:
Journal Article
MeSH Terms:
Cell- and Tissue-Based Therapy*/methods
Gene Regulatory Networks*
Genes, Synthetic*
T-Lymphocytes*/metabolism
T-Lymphocytes*/transplantation
Zinc Fingers*
Transcription Factors*
Humans ; Synthetic Biology/methods ; Genetic Engineering
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Ros/MucR Zinc-Finger Protein Family in Bacteria: Structure and Functions.
Autorzy:
Janczarek M; Department of Industrial and Environmental Microbiology, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, 19 Akademicka, 20-033 Lublin, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Dec 08; Vol. 23 (24). Date of Electronic Publication: 2022 Dec 08.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Bacterial Proteins*/metabolism
Zinc Fingers*/genetics
Phylogeny ; Amino Acid Sequence ; Transcription Factors/genetics ; Bacteria/metabolism ; Zinc/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Non-Conserved Amino Acid Residues Modulate the Thermodynamics of Zn(II) Binding to Classical ββα Zinc Finger Domains.
Autorzy:
Kluska K; Department of Chemical Biology, Faculty of Biotechnology, University of Wrocław, Joliot-Curie 14a, 50-383 Wrocław, Poland.
Chorążewska A; Department of Chemical Biology, Faculty of Biotechnology, University of Wrocław, Joliot-Curie 14a, 50-383 Wrocław, Poland.
Peris-Díaz MD; Department of Chemical Biology, Faculty of Biotechnology, University of Wrocław, Joliot-Curie 14a, 50-383 Wrocław, Poland.
Adamczyk J; Department of Chemical Biology, Faculty of Biotechnology, University of Wrocław, Joliot-Curie 14a, 50-383 Wrocław, Poland.
Krężel A; Department of Chemical Biology, Faculty of Biotechnology, University of Wrocław, Joliot-Curie 14a, 50-383 Wrocław, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Nov 23; Vol. 23 (23). Date of Electronic Publication: 2022 Nov 23.
Typ publikacji:
Journal Article
MeSH Terms:
Amino Acids*
Zinc Fingers*
Amino Acid Sequence ; Thermodynamics ; Binding Sites ; Zinc/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Novel GATA1 Variant in the C-Terminal Zinc Finger Compared with the Platelet Phenotype of Patients with A Likely Pathogenic Variant in the N-Terminal Zinc Finger.
Autorzy:
Bastida JM; Departmento de Hematología, Complejo Asistencial Universitario de Salamanca (CAUSA), Instituto de Investigación Biomédica de Salamanca (IBSAL), Universidad de Salamanca (USAL), 37007 Salamanca, Spain.
Malvestiti S; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Faculty of Medicine, Medical Center-University of Freiburg, 79106 Freiburg, Germany.
Boeckelmann D; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Faculty of Medicine, Medical Center-University of Freiburg, 79106 Freiburg, Germany.
Palma-Barqueros V; Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER-U765, 30003 Murcia, Spain.
Wolter M; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Faculty of Medicine, Medical Center-University of Freiburg, 79106 Freiburg, Germany.
Lozano ML; Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER-U765, 30003 Murcia, Spain.
Glonnegger H; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Faculty of Medicine, Medical Center-University of Freiburg, 79106 Freiburg, Germany.
Benito R; Instituto de Investigación Biomédica de Salamanca (IBSAL), Instituto de Biología Molecular y Cellular del Cáncer (IBMCC), Centro de Investigación del Cáncer (CIC), Universidad de Salamanca-Consejo Superior de Investigaciones Cientificas (CSIC), 37007 Salamanca, Spain.
Zaninetti C; Institut für Transfusionsmedizin, Universitätsmedizin Greifswald, 17475 Greisfwald, Germany.
Sobotta F; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Faculty of Medicine, Medical Center-University of Freiburg, 79106 Freiburg, Germany.
Schilling FH; Children's Hospital, Kantonsspital Luzern, 6000 Lucerne, Switzerland.
Morgan NV; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Freson K; Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, KU Leuven, 3000 Leuven, Belgium.
Rivera J; Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER-U765, 30003 Murcia, Spain.
Zieger B; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Faculty of Medicine, Medical Center-University of Freiburg, 79106 Freiburg, Germany.
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Źródło:
Cells [Cells] 2022 Oct 14; Vol. 11 (20). Date of Electronic Publication: 2022 Oct 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
GATA1 Transcription Factor*/genetics
GATA1 Transcription Factor*/metabolism
Thrombocytopenia*/genetics
Zinc Fingers*/genetics
Genetic Diseases, X-Linked*/genetics
Genetic Variation*
Anemia, Dyserythropoietic, Congenital*/genetics
Humans ; Male ; Integrins/metabolism ; Phenotype ; Blood Platelets/pathology
SCR Disease Name:
Thrombocytopenia 1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Heterozygous loss of Zbtb38 leads to early embryonic lethality via the suppression of Nanog and Sox2 expression.
Autorzy:
Nishio M; Functional Genomics and Medicine, Nara Institute of Science and Technology, Ikoma, Japan.; Cosmo Bio Co., Ltd., Tokyo, Japan.
Matsuura T; Functional Genomics and Medicine, Nara Institute of Science and Technology, Ikoma, Japan.
Hibi S; Functional Genomics and Medicine, Nara Institute of Science and Technology, Ikoma, Japan.
Ohta S; Functional Genomics and Medicine, Nara Institute of Science and Technology, Ikoma, Japan.
Oka C; Functional Genomics and Medicine, Nara Institute of Science and Technology, Ikoma, Japan.
Sasai N; Development Biomedical Science, Nara Institute of Science and Technology, Ikoma, Japan.
Ishida Y; Functional Genomics and Medicine, Nara Institute of Science and Technology, Ikoma, Japan.
Matsuda E; Functional Genomics and Medicine, Nara Institute of Science and Technology, Ikoma, Japan.
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Źródło:
Cell proliferation [Cell Prolif] 2022 Apr; Vol. 55 (4), pp. e13215. Date of Electronic Publication: 2022 Mar 17.
Typ publikacji:
Journal Article
MeSH Terms:
Embryonic Stem Cells*/metabolism
Zinc Fingers*
Animals ; Cell Differentiation/genetics ; DNA Methylation ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Mammals/metabolism ; Mice ; Mouse Embryonic Stem Cells/metabolism ; Nanog Homeobox Protein/genetics ; Nanog Homeobox Protein/metabolism ; Octamer Transcription Factor-3/genetics ; Repressor Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation.
Autorzy:
Zhang X; School of Life science and Technology, Weifang Medical University, Weifang, 261053, Shandong Province, China.; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China.
Zheng Q; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China.
Yue X; Tianjin Baodi Hospital, Baodi Clinical College of Tianjin Medical University, Tianjin, 301800, China.
Yuan Z; Tianjin Baodi Hospital, Baodi Clinical College of Tianjin Medical University, Tianjin, 301800, China.
Ling J; School of Life science and Technology, Weifang Medical University, Weifang, 261053, Shandong Province, China.; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China.
Yuan Y; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China.
Liang Y; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China.; School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271016, Shandong, China.
Sun A; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China.
Liu Y; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China.
Li H; Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.
Xu K; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China.
He F; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China.
Wang J; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China. .
Wu J; Department of Pediatric Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200092, China. .; Department of Gastroenterology and Nutrition, Shanghai Institute for Pediatric Research, School of Medicine, Shanghai Jiaotong University, Shanghai, 200092, China. .
Zhao C; School of Life science and Technology, Weifang Medical University, Weifang, 261053, Shandong Province, China. .
Tian C; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2022 Feb 28; Vol. 41 (1), pp. 79. Date of Electronic Publication: 2022 Feb 28.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/genetics
Carcinoma, Hepatocellular*/metabolism
Carcinoma, Hepatocellular*/pathology
Ferroptosis*
Liver Neoplasms*/metabolism
Liver Neoplasms*/pathology
Tumor Suppressor Protein p53*/genetics
Tumor Suppressor Protein p53*/metabolism
Zinc Fingers*
Animals ; Apoptosis ; Carcinogenesis/genetics ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Mice ; Phosphorylation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Poly(ADP-ribose) potentiates ZAP antiviral activity.
Autorzy:
Xue G; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, United States of America.
Braczyk K; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, United States of America.
Gonçalves-Carneiro D; Laboratory of Retrovirology, Howard Hughes Medical Institute, The Rockefeller University, New York, New York, United States of America.
Dawidziak DM; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, United States of America.
Sanchez K; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, United States of America.
Ong H; Laboratory of Retrovirology, Howard Hughes Medical Institute, The Rockefeller University, New York, New York, United States of America.
Wan Y; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, United States of America.
Zadrozny KK; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, United States of America.
Ganser-Pornillos BK; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, United States of America.
Bieniasz PD; Laboratory of Retrovirology, Howard Hughes Medical Institute, The Rockefeller University, New York, New York, United States of America.
Pornillos O; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2022 Feb 07; Vol. 18 (2), pp. e1009202. Date of Electronic Publication: 2022 Feb 07 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Zinc Fingers*
HIV-1/*metabolism
Leukemia Virus, Murine/*metabolism
Poly Adenosine Diphosphate Ribose/*metabolism
RNA-Binding Proteins/*chemistry
RNA-Binding Proteins/*metabolism
Animals ; Antiviral Agents/pharmacology ; Crystallography, X-Ray ; HEK293 Cells ; HeLa Cells ; Humans ; Mice ; Mutation ; Protein Binding ; Protein Conformation ; Protein Domains ; RNA Stability ; RNA, Viral ; RNA-Binding Proteins/pharmacology
Czasopismo naukowe
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Tytuł:
Zinc finger proteins of Plasmodium falciparum.
Autorzy:
Ngwa CJ; Division of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, Aachen, Germany.
Farrukh A; Division of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, Aachen, Germany.
Pradel G; Division of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, Aachen, Germany.
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Źródło:
Cellular microbiology [Cell Microbiol] 2021 Dec; Vol. 23 (12), pp. e13387. Date of Electronic Publication: 2021 Sep 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Plasmodium falciparum*/genetics
Zinc Fingers*/genetics
DNA ; Gene Expression Regulation ; Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
ZNF224 Protein: Multifaceted Functions Based on Its Molecular Partners.
Autorzy:
Cesaro E; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
Lupo A; Department of Sciences and Technologies, University of Sannio, 82100 Benevento, Italy.
Rapuano R; Department of Sciences and Technologies, University of Sannio, 82100 Benevento, Italy.
Pastore A; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
Grosso M; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
Costanzo P; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Oct 18; Vol. 26 (20). Date of Electronic Publication: 2021 Oct 18.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Zinc Fingers*
Intracellular Signaling Peptides and Proteins/*metabolism
Neoplasms/*metabolism
Neoplasms/*pathology
Protein-Arginine N-Methyltransferases/*metabolism
Repressor Proteins/*metabolism
Tripartite Motif-Containing Protein 28/*metabolism
Animals ; Humans ; Neoplasms/genetics ; Protein Interaction Domains and Motifs
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A CCCH zinc finger gene regulates doublesex alternative splicing and male development in Bombyx mori.
Autorzy:
Yang F; Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China.; CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing, 100049, China.
Zhang Z; Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China.; CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing, 100049, China.
Hu B; Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China.; CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing, 100049, China.
Yu Y; Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China.; CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing, 100049, China.
Tan A; Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China.; CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing, 100049, China.
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Źródło:
Insect science [Insect Sci] 2021 Oct; Vol. 28 (5), pp. 1253-1261. Date of Electronic Publication: 2020 Nov 03.
Typ publikacji:
Journal Article
MeSH Terms:
Alternative Splicing*
Bombyx*/genetics
Bombyx*/growth & development
Zinc Fingers*
Insect Proteins/*physiology
Sex Determination Processes/*genetics
Animals ; Female ; Insect Proteins/genetics ; Male ; RNA, Small Interfering
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Analyzing master regulators and scRNA-seq of COVID-19 patients reveals an underlying anti-SARS-CoV-2 mechanism of ZNF proteins.
Autorzy:
Qin S; Comparative Genomics and Bioinformatics Laboratory of the College of Life Sciences, Nanjing Normal University, China.
Xu W; COVID-19 Research Center, Institute of laboratory medicine, Jinling Hospital, Nanjing University School of medicine, the first school of clinical medicine, Southern Medical University, China.
Wang C; Comparative Genomics and Bioinformatics Laboratory of the College of Life Sciences, Nanjing Normal University, China.
Jiang S; College of Arts and Sciences, Emory University, Atlanta, USA.
Dai W; COVID-19 Research Center, Institute of laboratory medicine, Jinling Hospital, Nanjing University School of medicine, the first school of clinical medicine, Southern Medical University, China.
Yang Y; COVID-19 Research Center, Institute of laboratory medicine, Jinling Hospital, Nanjing University School of medicine, the first school of clinical medicine, Southern Medical University, China.
Shen J; COVID-19 Research Center, Institute of laboratory medicine, Jinling Hospital, Nanjing University School of medicine, the first school of clinical medicine, Southern Medical University, China.
Jin P; Laboratory of Comparative Genomics and Bioinformatics, School of Life Sciences, Nanjing Normal University, China.
Ma F; Laboratory of Comparative Genomics and Bioinformatics at the School of Life Sciences, Nanjing Normal University, China.
Xia X; COVID-19 Research Center, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine; Nanjing Clinical College of Southern Medical University, Nanjing, China.
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Źródło:
Briefings in bioinformatics [Brief Bioinform] 2021 Sep 02; Vol. 22 (5).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Zinc Fingers*
COVID-19/*metabolism
SARS-CoV-2/*pathogenicity
Sequence Analysis, RNA/*methods
Adult ; Aged ; Aged, 80 and over ; COVID-19/genetics ; COVID-19/virology ; Female ; Flow Cytometry ; Humans ; Lymphocyte Subsets ; Male ; Middle Aged ; Prognosis ; SARS-CoV-2/isolation & purification ; Single-Cell Analysis/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effect of the Forth and Fifth Zinc Finger Deletions of MTF-1 on the Expression of Metal Ion Metabolism Related Gene.
Autorzy:
Xu H; Sport and Health College, Shandong Sport University, 250102, Jinan, China.; Key Laboratory of Biomedical Engineering and Technology of Shandong High School, Qilu Medical University, 255300, Zibo, China.
Luo Y; Department of Clinical laboratory, Zibo Central Hospital, 255000, Zibo, China.
Tu X; Sport and Health College, Shandong Sport University, 250102, Jinan, China.
Cui W; Key Laboratory of Biomedical Engineering and Technology of Shandong High School, Qilu Medical University, 255300, Zibo, China.
Dou Y; Key Laboratory of Biomedical Engineering and Technology of Shandong High School, Qilu Medical University, 255300, Zibo, China.
Wang Q; Sport and Health College, Shandong Sport University, 250102, Jinan, China. wql_.; Key Laboratory of Biomedical Engineering and Technology of Shandong High School, Qilu Medical University, 255300, Zibo, China. wql_.
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Źródło:
Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2021 Sep; Vol. 500 (1), pp. 385-392. Date of Electronic Publication: 2021 Oct 25.
Typ publikacji:
Journal Article
MeSH Terms:
Zinc Fingers*
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The Roles of CCCH Zinc-Finger Proteins in Plant Abiotic Stress Tolerance.
Autorzy:
Han G; Shandong Provincial Key Laboratory of Plant Stress, College of Life Science, Shandong Normal University, Ji'nan 250014, China.
Qiao Z; Shandong Provincial Key Laboratory of Plant Stress, College of Life Science, Shandong Normal University, Ji'nan 250014, China.
Li Y; Shandong Provincial Key Laboratory of Plant Stress, College of Life Science, Shandong Normal University, Ji'nan 250014, China.
Wang C; Shandong Provincial Key Laboratory of Plant Stress, College of Life Science, Shandong Normal University, Ji'nan 250014, China.
Wang B; Shandong Provincial Key Laboratory of Plant Stress, College of Life Science, Shandong Normal University, Ji'nan 250014, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 03; Vol. 22 (15). Date of Electronic Publication: 2021 Aug 03.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Adaptation, Physiological*
Gene Expression Regulation, Plant*
Plant Development*
Stress, Physiological*
Zinc Fingers*
Plant Proteins/*metabolism
Plants/*metabolism
Droughts ; Plant Proteins/genetics ; Plants/genetics ; Plants/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Study of the N-Terminal Domain Homodimerization in Human Proteins with Zinc Finger Clusters.
Autorzy:
Fursenko DV; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
Georgiev PG; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
Bonchuk AN; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia. bonchuk_.
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Źródło:
Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2021 Jul; Vol. 499 (1), pp. 257-259. Date of Electronic Publication: 2021 Aug 23.
Typ publikacji:
Journal Article
MeSH Terms:
Zinc Fingers*
CCCTC-Binding Factor/*chemistry
CCCTC-Binding Factor/*metabolism
Humans ; Protein Domains ; Protein Multimerization ; Protein Structure, Quaternary
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 1358

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