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Tytuł:
Impact of Bariatric Surgery on Subtilisin/Kexin Type 9 (PCSK9) Gene Expression and Inflammation in the Adipose Tissue of Obese Diabetic Rats.
Autorzy:
Heald AH; Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PT, UK.; Department of Diabetes, Endocrinology and Obesity Medicine, Salford Royal NHS Foundation Trust, Stott Lane, Salford M6 8HD, UK.
Fachim HA; Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PT, UK.; Department of Diabetes, Endocrinology and Obesity Medicine, Salford Royal NHS Foundation Trust, Stott Lane, Salford M6 8HD, UK.
Bashir B; Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PT, UK.; Department of Diabetes, Endocrinology and Obesity Medicine, Salford Royal NHS Foundation Trust, Stott Lane, Salford M6 8HD, UK.
Garside B; Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PT, UK.; Cardiovascular Trials Unit, Manchester University NHS Foundation Trust, Oxford Road, Manchester M13 9WL, UK.
Adam S; Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PT, UK.; The Christie Hospital NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK.
Iqbal Z; Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PT, UK.; Cardiovascular Trials Unit, Manchester University NHS Foundation Trust, Oxford Road, Manchester M13 9WL, UK.
Syed AA; Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PT, UK.; Department of Diabetes, Endocrinology and Obesity Medicine, Salford Royal NHS Foundation Trust, Stott Lane, Salford M6 8HD, UK.
Donn R; Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
Le Roux CW; Diabetes Complications Research Centre, Conway Institute, School of Medicine, University College Dublin, D04 V1W8 Dublin, Ireland.
Abdelaal M; Diabetes Complications Research Centre, Conway Institute, School of Medicine, University College Dublin, D04 V1W8 Dublin, Ireland.
White J; Diabetes Complications Research Centre, Conway Institute, School of Medicine, University College Dublin, D04 V1W8 Dublin, Ireland.
Soran H; Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PT, UK.; Cardiovascular Trials Unit, Manchester University NHS Foundation Trust, Oxford Road, Manchester M13 9WL, UK.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 30; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 30.
Typ publikacji:
Journal Article
MeSH Terms:
Bariatric Surgery*
Diabetes Mellitus, Experimental*/genetics
Diabetes Mellitus, Experimental*/surgery
Animals ; Rats ; Adipose Tissue/metabolism ; Gene Expression ; Inflammation/genetics ; Obesity/genetics ; Obesity/surgery ; Proprotein Convertase 9/genetics ; Proprotein Convertases/genetics ; Rats, Sprague-Dawley ; Rats, Zucker ; Receptors, LDL/genetics ; Receptors, LDL/metabolism ; Serine Endopeptidases/metabolism ; Subtilisin/genetics ; Tumor Necrosis Factor-alpha/genetics
Czasopismo naukowe
Tytuł:
CSF hyperdynamics in rats mimicking the obesity and androgen excess characteristic of patients with idiopathic intracranial hypertension.
Autorzy:
Wardman JH; Department of Neuroscience, University of Copenhagen, Blegdamsvej 3, Copenhagen, DK-2200, Denmark.
Andreassen SN; Department of Neuroscience, University of Copenhagen, Blegdamsvej 3, Copenhagen, DK-2200, Denmark.
Toft-Bertelsen TL; Department of Neuroscience, University of Copenhagen, Blegdamsvej 3, Copenhagen, DK-2200, Denmark.
Jensen MN; Department of Neuroscience, University of Copenhagen, Blegdamsvej 3, Copenhagen, DK-2200, Denmark.
Wilhjelm JE; Department of Neurophysiology, Rigshospitalet, Copenhagen, Denmark.; Department of Health Technology, Technical University of Denmark, Copenhagen, Denmark.
Styrishave B; Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark.
Hamann S; Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Heegaard S; Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Sinclair AJ; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
MacAulay N; Department of Neuroscience, University of Copenhagen, Blegdamsvej 3, Copenhagen, DK-2200, Denmark. .
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Źródło:
Fluids and barriers of the CNS [Fluids Barriers CNS] 2024 Jan 25; Vol. 21 (1), pp. 10. Date of Electronic Publication: 2024 Jan 25.
Typ publikacji:
Journal Article
MeSH Terms:
Pseudotumor Cerebri*
Humans ; Female ; Rats ; Animals ; Androgens ; Rats, Zucker ; Obesity ; Testosterone
Czasopismo naukowe
Tytuł:
Replacement of dietary carbohydrate with protein increases fat mass and reduces hepatic triglyceride synthesis and content in female obese Zucker rats.
Autorzy:
Dawson MA; Department of Nutrition and Integrative Physiology, Florida State University, Tallahassee, Florida, USA.; Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.
Hennigar SR; Department of Nutrition and Integrative Physiology, Florida State University, Tallahassee, Florida, USA.; Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.; Oak Ridge Institute for Science and Education, Belcamp, Maryland, USA.; Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.
Shankaran M; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California, USA.
Kelley AM; Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.; Oak Ridge Institute for Science and Education, Belcamp, Maryland, USA.
Anderson BJ; Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.; Oak Ridge Institute for Science and Education, Belcamp, Maryland, USA.
Nyangau E; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California, USA.
Field TJ; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California, USA.
Evans WJ; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California, USA.
Hellerstein MK; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California, USA.
McClung JP; Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.
Pasiakos SM; Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.; Military Performance Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.
Berryman CE; Department of Nutrition and Integrative Physiology, Florida State University, Tallahassee, Florida, USA.; Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.; Oak Ridge Institute for Science and Education, Belcamp, Maryland, USA.; Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.
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Źródło:
Physiological reports [Physiol Rep] 2023 Dec; Vol. 11 (23), pp. e15885.
Typ publikacji:
Journal Article
MeSH Terms:
Dietary Carbohydrates*/metabolism
Lipogenesis*
Animals ; Female ; Rats ; Cholesterol/metabolism ; Dietary Proteins/pharmacology ; Dietary Proteins/metabolism ; Liver/metabolism ; Obesity/metabolism ; Rats, Zucker ; Triglycerides
Czasopismo naukowe
Tytuł:
Is the β 3 -Adrenoceptor a Valid Target for the Treatment of Obesity and/or Type 2 Diabetes?
Autorzy:
Dwaib HS; Department of Clinical Nutrition and Dietetics, Palestine Ahliya University, Bethlehem P.O. Box 1041, Palestine.
Michel MC; Department of Pharmacology, University Medical Center, Johannes Gutenberg University, Langenbeckstr. 1, 55131 Mainz, Germany.
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Źródło:
Biomolecules [Biomolecules] 2023 Nov 28; Vol. 13 (12). Date of Electronic Publication: 2023 Nov 28.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetes Mellitus, Type 2*/drug therapy
Rats ; Mice ; Humans ; Animals ; Adrenergic beta-Agonists ; Rats, Zucker ; Obesity/drug therapy ; Adipose Tissue, Brown ; Body Weight ; Receptors, Adrenergic, beta-3
Czasopismo naukowe
Tytuł:
Cardiovascular Protective Effects of NP-6A4, a Drug with the FDA Designation for Pediatric Cardiomyopathy, in Female Rats with Obesity and Pre-Diabetes.
Autorzy:
Belenchia AM; Dalton Cardiovascular Research Center and Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 65211, USA.
Boukhalfa A; Molecular Cardiology Research Institute, Tufts Medical Center, and Department of Medicine, Tufts University, Boston, MA 02111, USA.
DeMarco VG; Department of Medicine, University of Missouri, Columbia, MO 65212, USA.
Mehm A; Molecular Cardiology Research Institute, Tufts Medical Center, and Department of Medicine, Tufts University, Boston, MA 02111, USA.
Mahmood A; Department of Neuroscience, Brandeis University, Waltham, MA 02453, USA.
Liu P; Charles W. Gehrke Proteomics Center, University of Missouri, Columbia, MO 65211, USA.
Tang Y; Molecular Cardiology Research Institute, Tufts Medical Center, and Department of Medicine, Tufts University, Boston, MA 02111, USA.
Gavini MP; Novopyxis Inc., Boston, MA 02108, USA.
Mooney B; Charles W. Gehrke Proteomics Center, University of Missouri, Columbia, MO 65211, USA.; Division of Biochemistry, University of Missouri, Columbia, MO 65211, USA.
Chen HH; Molecular Cardiology Research Institute, Tufts Medical Center, and Department of Medicine, Tufts University, Boston, MA 02111, USA.
Pulakat L; Dalton Cardiovascular Research Center and Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 65211, USA.; Molecular Cardiology Research Institute, Tufts Medical Center, and Department of Medicine, Tufts University, Boston, MA 02111, USA.; Department of Medicine, University of Missouri, Columbia, MO 65212, USA.
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Źródło:
Cells [Cells] 2023 May 12; Vol. 12 (10). Date of Electronic Publication: 2023 May 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Prediabetic State*
Cardiomyopathies*/drug therapy
Cardiomyopathies*/etiology
Heart Diseases*
Hyperglycemia*
Female ; Rats ; Animals ; Rats, Zucker ; Obesity/complications ; Obesity/drug therapy ; Obesity/metabolism
Czasopismo naukowe
Tytuł:
Cognitive Performance during the Development of Diabetes in the Zucker Diabetic Fatty Rat.
Autorzy:
Spoelder M; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Bright Y; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Morrison MC; Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), Sylviusweg 71, 2333 CE Leiden, The Netherlands.
van Kempen V; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
de Groodt L; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Begalli M; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Schuijt N; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Kruiger E; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Bulthuis R; Metris B.V., Kruisweg 829c, 2132 NG Hoofddorp, The Netherlands.
Gross G; Medical and Scientific Affairs, Reckitt|Mead Johnson Nutrition Institute, Middenkampweg 2, 6545 CJ Nijmegen, The Netherlands.
Kleemann R; Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), Sylviusweg 71, 2333 CE Leiden, The Netherlands.
van Diepen JA; Medical and Scientific Affairs, Reckitt|Mead Johnson Nutrition Institute, Middenkampweg 2, 6545 CJ Nijmegen, The Netherlands.
Homberg JR; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
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Źródło:
Cells [Cells] 2023 Oct 16; Vol. 12 (20). Date of Electronic Publication: 2023 Oct 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetes Mellitus, Type 2*/complications
Diabetes Mellitus, Type 2*/metabolism
Rats ; Animals ; Rats, Zucker ; Rats, Long-Evans ; Obesity/metabolism ; Insulin/metabolism ; Cognition
Czasopismo naukowe
Tytuł:
Neuroactive Steroid-Gut Microbiota Interaction in T2DM Diabetic Encephalopathy.
Autorzy:
Diviccaro S; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133 Milan, Italy.
Cioffi L; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133 Milan, Italy.
Piazza R; Dipartimento di Medicina e Chirurgia, Università di Milano-Bicocca, 20126 Milan, Italy.
Caruso D; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133 Milan, Italy.
Melcangi RC; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133 Milan, Italy.
Giatti S; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133 Milan, Italy.
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Źródło:
Biomolecules [Biomolecules] 2023 Aug 29; Vol. 13 (9). Date of Electronic Publication: 2023 Aug 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gastrointestinal Microbiome*
Diabetes Mellitus, Type 2*
Neurosteroids*
Humans ; Rats ; Animals ; Male ; Rats, Zucker ; Pregnanolone
SCR Disease Name:
hypoglycemic encephalopathy
Czasopismo naukowe
Tytuł:
Effect of Metformin Treatment on Serum Metabolic Profile Changes in Lean and Obese Zucker Rat Model for Fatty Liver Disease.
Autorzy:
Melnyk S; Arkansas Children's Research Institute, Little Rock, AR 72202, USA.
Hakkak R; Arkansas Children's Research Institute, Little Rock, AR 72202, USA.; Department of Dietetics and Nutrition, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
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Źródło:
Biomolecules [Biomolecules] 2023 Aug 10; Vol. 13 (8). Date of Electronic Publication: 2023 Aug 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Non-alcoholic Fatty Liver Disease*
Metformin*/pharmacology
Metformin*/therapeutic use
Female ; Animals ; Rats ; Rats, Zucker ; Metabolome ; Obesity/drug therapy
Czasopismo naukowe
Tytuł:
Experimental Models to Study Diabetes Mellitus and Its Complications: Limitations and New Opportunities.
Autorzy:
Martín-Carro B; Bone and Mineral Research Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.; Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS), RICORS2040 (Kidney Disease), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Donate-Correa J; Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS), RICORS2040 (Kidney Disease), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Research Unit, Hospital Universitario Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain.
Fernández-Villabrille S; Bone and Mineral Research Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.; Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS), RICORS2040 (Kidney Disease), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Martín-Vírgala J; Bone and Mineral Research Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.; Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS), RICORS2040 (Kidney Disease), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Panizo S; Bone and Mineral Research Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.; Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS), RICORS2040 (Kidney Disease), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Carrillo-López N; Bone and Mineral Research Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.; Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS), RICORS2040 (Kidney Disease), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Martínez-Arias L; Bone and Mineral Research Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.; Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS), RICORS2040 (Kidney Disease), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Navarro-González JF; Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS), RICORS2040 (Kidney Disease), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Research Unit, Hospital Universitario Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain.; Nephrology Service, Hospital Universitario Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain.
Naves-Díaz M; Bone and Mineral Research Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.; Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS), RICORS2040 (Kidney Disease), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Fernández-Martín JL; Bone and Mineral Research Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.; Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS), RICORS2040 (Kidney Disease), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Alonso-Montes C; Bone and Mineral Research Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.; Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS), RICORS2040 (Kidney Disease), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Cannata-Andía JB; Bone and Mineral Research Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.; Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS), RICORS2040 (Kidney Disease), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Department of Medicine, Universidad de Oviedo, 33006 Oviedo, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jun 18; Vol. 24 (12). Date of Electronic Publication: 2023 Jun 18.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Diabetes Mellitus, Type 1*/complications
Diabetes Mellitus, Type 2*/complications
Humans ; Rats ; Animals ; Disease Models, Animal ; Streptozocin ; Rats, Zucker
Czasopismo naukowe
Tytuł:
Angiotensin II type 2 receptor activation preserves megalin in the kidney and prevents proteinuria in high salt diet fed rats.
Autorzy:
Kulkarni K; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Health 2, 4349 Martin Luther King Boulevard, Houston, TX, 77204-5037, USA.
Patel S; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Health 2, 4349 Martin Luther King Boulevard, Houston, TX, 77204-5037, USA.
Ali R; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Health 2, 4349 Martin Luther King Boulevard, Houston, TX, 77204-5037, USA.
Hussain T; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Health 2, 4349 Martin Luther King Boulevard, Houston, TX, 77204-5037, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Mar 15; Vol. 13 (1), pp. 4277. Date of Electronic Publication: 2023 Mar 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Low Density Lipoprotein Receptor-Related Protein-2*/metabolism
Proteinuria*/metabolism
Receptor, Angiotensin, Type 2*/metabolism
Animals ; Rats ; Diet ; Glycogen Synthase Kinase 3 beta/metabolism ; Kidney Glomerulus/pathology ; Obesity/metabolism ; Rats, Zucker ; Receptor, Angiotensin, Type 1/metabolism ; Sodium Chloride, Dietary/pharmacology
Czasopismo naukowe
Tytuł:
Contribution of calcium dysregulation to impaired coronary artery contraction in Zucker diabetic fatty rats.
Autorzy:
Liu L; Guangdong Provincial Key Laboratory of Clinical Pharmacology, Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.; Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.; Zhuhai hospital affiliated with Jinan University (Zhuhai People's Hospital), Zhuhai, China.; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Yang H; Guangdong Provincial Key Laboratory of Clinical Pharmacology, Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.; Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Kuang SJ; Guangdong Provincial Key Laboratory of Clinical Pharmacology, Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.; Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Zhang L; Guangdong Provincial Key Laboratory of Clinical Pharmacology, Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.; School of biological science and engineering, South China University of Technology, Guangzhou, China.
Zhou MY; Guangdong Provincial Key Laboratory of Clinical Pharmacology, Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.; School of biological science and engineering, South China University of Technology, Guangzhou, China.
Zeng P; Guangdong Provincial Key Laboratory of Clinical Pharmacology, Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.; Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Zhang MZ; Guangdong Provincial Key Laboratory of Clinical Pharmacology, Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.; Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Rao F; Guangdong Provincial Key Laboratory of Clinical Pharmacology, Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.; Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Zhou ZL; Zhuhai hospital affiliated with Jinan University (Zhuhai People's Hospital), Zhuhai, China.
Deng CY; Guangdong Provincial Key Laboratory of Clinical Pharmacology, Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.; Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.; School of biological science and engineering, South China University of Technology, Guangzhou, China.
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Źródło:
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2023 Feb; Vol. 50 (2), pp. 158-168. Date of Electronic Publication: 2022 Nov 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetes Mellitus, Type 2*/metabolism
Diabetes Mellitus, Experimental*/metabolism
Rats ; Animals ; Coronary Vessels/metabolism ; Calcium/metabolism ; Rats, Zucker ; Nifedipine ; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid/pharmacology ; Serotonin/metabolism ; Calcium Channels, L-Type/metabolism
Czasopismo naukowe
Tytuł:
Quercetin Ameliorates Testicular Damage in Zucker Diabetic Fatty Rats through Its Antioxidant, Anti-Inflammatory and Anti-Apoptotic Properties.
Autorzy:
Tvrdá E; Institute of Biotechnology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, 949 76 Nitra, Slovakia.
Kováč J; Institute of Applied Biology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, 949 76 Nitra, Slovakia.
Ferenczyová K; Institute for Heart Research, Centre of Experimental Medicine, Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava, Slovakia.
Kaločayová B; Institute for Heart Research, Centre of Experimental Medicine, Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava, Slovakia.
Ďuračka M; AgroBioTech Research Centre, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, 949 76 Nitra, Slovakia.
Benko F; Institute of Applied Biology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, 949 76 Nitra, Slovakia.
Almášiová V; Department of Morphological Disciplines, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81 Košice, Slovakia.
Barteková M; Institute for Heart Research, Centre of Experimental Medicine, Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava, Slovakia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Dec 16; Vol. 23 (24). Date of Electronic Publication: 2022 Dec 16.
Typ publikacji:
Journal Article
MeSH Terms:
Antioxidants*/pharmacology
Diabetes Mellitus, Type 2*/complications
Diabetes Mellitus, Type 2*/drug therapy
Animals ; Rats ; Male ; Quercetin/pharmacology ; Quercetin/therapeutic use ; Rats, Zucker ; Obesity/complications ; Obesity/drug therapy ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use
Czasopismo naukowe
Tytuł:
Pyruvate Kinase M2: A New Biomarker for the Early Detection of Diabetes-Induced Nephropathy.
Autorzy:
Park YS; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Han JH; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Park JH; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Choi JS; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Kim SH; St. Mark's School, 25 Marlboro Rd, Southborough, MA 01772, USA.
Kim HS; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 31; Vol. 24 (3). Date of Electronic Publication: 2023 Jan 31.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetic Nephropathies*/etiology
Diabetes Mellitus*
Rats ; Animals ; Pyruvate Kinase/metabolism ; Rats, Zucker ; Lipocalin-2 ; Early Diagnosis ; Biomarkers
Czasopismo naukowe
Tytuł:
Supplementation with okra combined or not with exercise training is able to protect the heart of animals with metabolic syndrome.
Autorzy:
Gomes MFP; Department of Bioscience, Universidade Federal de São Paulo (UNIFESP), R. Silva Jardim, 136 - Vila Matias, Santos, SP, 11015-020, Brazil. .; Center for Applied Social Sciences and Health, Universidade Católica de Santos (Unisantos), Av. Conselheiro Nébias, 300, Vila Matias, Santos, SP, 11015-002, Brazil. .
de Moura EOC; Department of Bioscience, Universidade Federal de São Paulo (UNIFESP), R. Silva Jardim, 136 - Vila Matias, Santos, SP, 11015-020, Brazil.
Cardoso NM; Department of Bioscience, Universidade Federal de São Paulo (UNIFESP), R. Silva Jardim, 136 - Vila Matias, Santos, SP, 11015-020, Brazil.
da Silva GA; Department of Bioscience, Universidade Federal de São Paulo (UNIFESP), R. Silva Jardim, 136 - Vila Matias, Santos, SP, 11015-020, Brazil.
Dos Santos ACC; Department of Bioscience, Universidade Federal de São Paulo (UNIFESP), R. Silva Jardim, 136 - Vila Matias, Santos, SP, 11015-020, Brazil.
de Souza FS; Institute of Environmental, Chemical and Pharmaceutical Sciences, Universidade Federal de São Paulo (UNIFESP), Rua Prof. Artur Riedel, n° 275, Eldorado, Diadema, SP, 09972-270, Brazil.
Estadella D; Department of Bioscience, Universidade Federal de São Paulo (UNIFESP), R. Silva Jardim, 136 - Vila Matias, Santos, SP, 11015-020, Brazil.
Lambertucci RH; Department of Bioscience, Universidade Federal de São Paulo (UNIFESP), R. Silva Jardim, 136 - Vila Matias, Santos, SP, 11015-020, Brazil.
Lago JHG; Center of Natural and Human Sciences, Universidade Federal Do ABC, Av. Dos Estados, 500, Bangú, Santo André, SP, 09210-580, Brazil.
Medeiros A; Department of Bioscience, Universidade Federal de São Paulo (UNIFESP), R. Silva Jardim, 136 - Vila Matias, Santos, SP, 11015-020, Brazil.
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Źródło:
Scientific reports [Sci Rep] 2023 Jan 26; Vol. 13 (1), pp. 1468. Date of Electronic Publication: 2023 Jan 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Abelmoschus*
Insulin Resistance*
Metabolic Syndrome*/therapy
Animals ; Male ; Rats ; Dietary Supplements ; Rats, Zucker
Czasopismo naukowe
Tytuł:
Unveiling IL-33/ST2 Pathway Unbalance in Cardiac Remodeling Due to Obesity in Zucker Fatty Rats.
Autorzy:
Sitzia C; Department of Biomedical Science for Health, Medical Faculty, University of Milan, 20122 Milan, Italy.
Vianello E; Department of Biomedical Science for Health, Medical Faculty, University of Milan, 20122 Milan, Italy.
Dozio E; Department of Biomedical Science for Health, Medical Faculty, University of Milan, 20122 Milan, Italy.
Kalousová M; Institute of Medical Biochemistry and Laboratory Diagnostic, First Faculty of Medicine, Charles University and General University Hospital in Prague, 12108 Prague, Czech Republic.
Zima T; Institute of Medical Biochemistry and Laboratory Diagnostic, First Faculty of Medicine, Charles University and General University Hospital in Prague, 12108 Prague, Czech Republic.
Brizzola S; Department of Veterinary Medicine and Animal Science, University of Milan, 26900 Lodi, Italy.
Roccabianca P; Department of Veterinary Medicine and Animal Science, University of Milan, 26900 Lodi, Italy.
Tedeschi G; CRC 'Innovation for Well-Being and Environment' (I-WE), University of Milan, 20122 Milan, Italy.
Lamont J; R&D, RANDOX Laboratories Ltd., County Antrim BT29 4QY, UK.
Tacchini L; Department of Biomedical Science for Health, Medical Faculty, University of Milan, 20122 Milan, Italy.
Corsi-Romanelli MM; Department of Biomedical Science for Health, Medical Faculty, University of Milan, 20122 Milan, Italy.; U.O.C. SMEL-1 of Clinical Pathology, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 19; Vol. 24 (3). Date of Electronic Publication: 2023 Jan 19.
Typ publikacji:
Journal Article
MeSH Terms:
Interleukin-33*/genetics
Interleukin-33*/metabolism
Obesity*/complications
Obesity*/genetics
Obesity*/metabolism
Receptors, Interleukin-1*/genetics
Receptors, Interleukin-1*/metabolism
Ventricular Remodeling*/genetics
Ventricular Remodeling*/physiology
Animals ; Rats ; Cardiomegaly/genetics ; Cardiomegaly/metabolism ; Disease Models, Animal ; Fibrosis/genetics ; Fibrosis/metabolism ; Ghrelin/genetics ; Ghrelin/metabolism ; Guanine Nucleotide Exchange Factors/genetics ; Guanine Nucleotide Exchange Factors/metabolism ; Interleukin-1 Receptor-Like 1 Protein/genetics ; Interleukin-1 Receptor-Like 1 Protein/metabolism ; Myocardium/metabolism ; Rats, Zucker
Czasopismo naukowe
Tytuł:
Combined Therapy with Simvastatin- and Coenzyme-Q10-Loaded Nanoparticles Upregulates the Akt-eNOS Pathway in Experimental Metabolic Syndrome.
Autorzy:
Şaman E; Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 813 71 Bratislava, Slovakia.
Cebova M; Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 813 71 Bratislava, Slovakia.
Barta A; Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 813 71 Bratislava, Slovakia.
Koneracka M; Institute of Experimental Physics, Slovak Academy of Sciences, 040 01 Kosice, Slovakia.
Zavisova V; Institute of Experimental Physics, Slovak Academy of Sciences, 040 01 Kosice, Slovakia.
Eckstein-Andicsova A; Polymer Institute, Slovak Academy of Sciences, 845 41 Bratislava, Slovakia.
Danko M; Polymer Institute, Slovak Academy of Sciences, 845 41 Bratislava, Slovakia.
Mosnacek J; Polymer Institute, Slovak Academy of Sciences, 845 41 Bratislava, Slovakia.; Centre for Advanced Materials Application, 845 11 Bratislava, Slovakia.
Pechanova O; Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 813 71 Bratislava, Slovakia.; Institute of Pathophysiology, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Dec 23; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 23.
Typ publikacji:
Journal Article
MeSH Terms:
Hydroxymethylglutaryl-CoA Reductase Inhibitors*/pharmacology
Metabolic Syndrome*/drug therapy
Male ; Rats ; Animals ; Simvastatin/pharmacology ; Simvastatin/therapeutic use ; Proto-Oncogene Proteins c-akt ; NF-kappa B ; Rats, Zucker ; Nitric Oxide Synthase Type III/metabolism ; Obesity/drug therapy ; Lipids
Czasopismo naukowe
Tytuł:
Transcriptomic and proteomic pathways of diabetic and non-diabetic mitochondrial transplantation.
Autorzy:
Doulamis IP; Department of Cardiac Surgery, Boston Children's Hospital, 300 Longwood Avenue Enders-361.2, Boston, MA, 02115, USA.; Harvard Medical School, Boston, MA, USA.
Nomoto RS; Department of Cardiac Surgery, Boston Children's Hospital, 300 Longwood Avenue Enders-361.2, Boston, MA, 02115, USA.; Harvard Medical School, Boston, MA, USA.
Tzani A; Brigham and Women's Hospital Heart and Vascular Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Hong X; Department of Cardiac Surgery, Boston Children's Hospital, 300 Longwood Avenue Enders-361.2, Boston, MA, 02115, USA.; Harvard Medical School, Boston, MA, USA.
Duignan T; Department of Cardiac Surgery, Boston Children's Hospital, 300 Longwood Avenue Enders-361.2, Boston, MA, 02115, USA.; Harvard Medical School, Boston, MA, USA.
Celik A; Department of Cardiac Surgery, Boston Children's Hospital, 300 Longwood Avenue Enders-361.2, Boston, MA, 02115, USA.; Harvard Medical School, Boston, MA, USA.
Del Nido PJ; Department of Cardiac Surgery, Boston Children's Hospital, 300 Longwood Avenue Enders-361.2, Boston, MA, 02115, USA.; Harvard Medical School, Boston, MA, USA.
McCully JD; Department of Cardiac Surgery, Boston Children's Hospital, 300 Longwood Avenue Enders-361.2, Boston, MA, 02115, USA. .; Harvard Medical School, Boston, MA, USA. .
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Źródło:
Scientific reports [Sci Rep] 2022 Dec 21; Vol. 12 (1), pp. 22101. Date of Electronic Publication: 2022 Dec 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetes Mellitus*/metabolism
Myocardial Reperfusion Injury*/metabolism
Diabetes Mellitus, Type 2*/metabolism
Rats ; Animals ; Transcriptome ; Proteomics ; Rats, Zucker ; Mitochondria/metabolism ; Infarction
Czasopismo naukowe
Tytuł:
Yunpi Heluo decoction reduces ectopic deposition of lipids by regulating the SIRT1-FoxO1 autophagy pathway in diabetic rats.
Autorzy:
Mao Z; College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Liu S; College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Yu T; College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Su J; College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Chai K; College of Basic Medicine, Zhejiang Chinese Medical University, Ningbo, China.
Weng S; Department of Endocrinology, Ningbo Municipal Hospital of TCM, Affliated Hospital of Zhejiang Chinese Medical University, Ningbo, China.
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Źródło:
Pharmaceutical biology [Pharm Biol] 2022 Dec; Vol. 60 (1), pp. 579-588.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Experimental/*drug therapy
Diabetes Mellitus, Type 2/*drug therapy
Drugs, Chinese Herbal/*pharmacology
Lipid Metabolism/*drug effects
Animals ; Apoptosis/drug effects ; Autophagy/drug effects ; Blood Glucose/drug effects ; Hypoglycemic Agents/pharmacology ; Male ; Nerve Tissue Proteins/metabolism ; Random Allocation ; Rats ; Rats, Zucker ; Signal Transduction/drug effects ; Sirtuin 1/metabolism
Czasopismo naukowe

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