Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Zymosan"" wg kryterium: Temat


Tytuł :
Polysaccaride-rich extract of Caesalpina ferrea stem barks attenuates mice acute inflammation induced by zymosan: Oxidative stress modulation.
Autorzy :
Holanda BF; Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.
Freitas de Araujo D; Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.
da Silva JNR; Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.
Pereira MG; Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil; Faculdade de Educação, Ciências e Letras do Sertão Central, Universidade Estadual do Ceará, Quixadá, Ceará, Brazil.
de Freitas Pires A; Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil; Centro de Ciências da Saúde, Centro Universitário Estácio do Ceará, Fortaleza, Ceará, Brazil.
Assreuy AM; Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil. Electronic address: .
Pokaż więcej
Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 01; Vol. 267, pp. 113501. Date of Electronic Publication: 2020 Oct 27.
Typ publikacji :
Journal Article
MeSH Terms :
Caesalpinia*/chemistry
Plant Bark*/chemistry
Plant Stems*/chemistry
Anti-Inflammatory Agents/*pharmacology
Antioxidants/*pharmacology
Edema/*prevention & control
Inflammation Mediators/*metabolism
Oxidative Stress/*drug effects
Peritonitis/*prevention & control
Polysaccharides/*pharmacology
Analgesics/pharmacology ; Animals ; Anti-Inflammatory Agents/isolation & purification ; Antioxidants/isolation & purification ; Biomarkers/metabolism ; Disease Models, Animal ; Edema/chemically induced ; Edema/metabolism ; Edema/pathology ; Female ; Mice ; Neutrophil Infiltration ; Nociceptive Pain/chemically induced ; Nociceptive Pain/metabolism ; Nociceptive Pain/prevention & control ; Peritonitis/chemically induced ; Peritonitis/metabolism ; Peritonitis/pathology ; Polysaccharides/isolation & purification ; Signal Transduction ; Zymosan
Czasopismo naukowe
Tytuł :
Effect of zymosan on feed passage in the digestive tract in chicks.
Autorzy :
Tachibana T; Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama, Japan.
Takahashi M; Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama, Japan.
Takeda K; Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama, Japan.
Ogino M; Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama, Japan.
Khan MSI; Department of Anatomy and Embryology, Ehime University Graduate School of Medicine, Toon, Japan.
Makino R; Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama, Japan.
Cline MA; Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Pokaż więcej
Źródło :
British poultry science [Br Poult Sci] 2021 Jun; Vol. 62 (3), pp. 414-423. Date of Electronic Publication: 2021 Jan 20.
Typ publikacji :
Journal Article
MeSH Terms :
Chickens*
Lipopolysaccharides*
Animals ; Gastrointestinal Tract ; Gene Expression ; Zymosan
Czasopismo naukowe
Tytuł :
Apoptotic Cells induce Proliferation of Peritoneal Macrophages.
Autorzy :
Knuth AK; Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Komturstraße 3a, 60528 Frankfurt, Germany.
Huard A; Faculty of Medicine, Institute of Biochemistry I, Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Naeem Z; Institute for Vascular Signaling, Department of Molecular Medicine, Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Rappl P; Faculty of Medicine, Institute of Biochemistry I, Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Bauer R; Faculty of Medicine, Institute of Biochemistry I, Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Mota AC; Faculty of Medicine, Institute of Biochemistry I, Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Schmid T; Faculty of Medicine, Institute of Biochemistry I, Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Fleming I; Institute for Vascular Signaling, Department of Molecular Medicine, Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Brüne B; Faculty of Medicine, Institute of Biochemistry I, Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Fulda S; Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Komturstraße 3a, 60528 Frankfurt, Germany.
Weigert A; Faculty of Medicine, Institute of Biochemistry I, Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 24; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Cell Proliferation*
Macrophages, Peritoneal/*cytology
Peritonitis/*pathology
Animals ; Cells, Cultured ; Coculture Techniques ; Macrophages, Peritoneal/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Peritonitis/chemically induced ; Peritonitis/metabolism ; Phagocytosis ; Zymosan/toxicity
Czasopismo naukowe
Tytuł :
Lipidomic analysis of local inflammation models shows a specific systemic acute phase response to lipopolysaccharides.
Autorzy :
Hahnefeld L; Institute of Clinical Pharmacology, University Hospital Goethe University Frankfurt, Germany. Electronic address: .
Kornstädt L; Institute of Clinical Pharmacology, University Hospital Goethe University Frankfurt, Germany. Electronic address: .
Kratz D; Institute of Clinical Pharmacology, University Hospital Goethe University Frankfurt, Germany. Electronic address: .
Ferreirós N; Institute of Clinical Pharmacology, University Hospital Goethe University Frankfurt, Germany. Electronic address: .
Geisslinger G; Institute of Clinical Pharmacology, University Hospital Goethe University Frankfurt, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology, Frankfurt, Germany; Fraunhofer Cluster of Excellence for Immune-Mediated Diseases (CIMD), Frankfurt, Germany. Electronic address: .
Pierre S; Institute of Clinical Pharmacology, University Hospital Goethe University Frankfurt, Germany. Electronic address: .
Scholich K; Institute of Clinical Pharmacology, University Hospital Goethe University Frankfurt, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology, Frankfurt, Germany; Fraunhofer Cluster of Excellence for Immune-Mediated Diseases (CIMD), Frankfurt, Germany. Electronic address: .
Pokaż więcej
Źródło :
Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2021 Jan; Vol. 1866 (1), pp. 158822. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acute-Phase Reaction/*blood
Edema/*blood
Lipopolysaccharides/*administration & dosage
Phosphatidylcholines/*blood
Phosphatidylethanolamines/*blood
Zymosan/*administration & dosage
Acute-Phase Reaction/chemically induced ; Acute-Phase Reaction/genetics ; Acute-Phase Reaction/pathology ; Animals ; Edema/chemically induced ; Edema/genetics ; Edema/pathology ; Fatty Acids/blood ; Fatty Acids/classification ; Gene Expression Regulation ; Hindlimb/blood supply ; Hindlimb/drug effects ; Hindlimb/metabolism ; Interleukin-1beta/blood ; Interleukin-1beta/genetics ; Interleukin-6/blood ; Interleukin-6/genetics ; Lipidomics/methods ; Mice ; Mice, Inbred C57BL ; Phosphatidylcholines/classification ; Phosphatidylethanolamines/classification ; Signal Transduction ; Toll-Like Receptor 2/blood ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 4/blood ; Toll-Like Receptor 4/genetics
Czasopismo naukowe
Tytuł :
Barley beta-Glucan and Zymosan induce Dectin-1 and Toll-like receptor 2 co-localization and anti-leishmanial immune response in Leishmania donovani-infected BALB/c mice.
Autorzy :
Patidar A; National Centre for Cell Science, Pune, India.
Mahanty T; Department of Molecular Biology and Bioinformatics, Tripura University, Agartala, India.
Raybarman C; Department of Molecular Biology and Bioinformatics, Tripura University, Agartala, India.
Sarode AY; National Centre for Cell Science, Pune, India.
Basak S; Division of Bioinformatics, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India.
Saha B; National Centre for Cell Science, Pune, India.
Bhattacharjee S; Department of Molecular Biology and Bioinformatics, Tripura University, Agartala, India.
Pokaż więcej
Źródło :
Scandinavian journal of immunology [Scand J Immunol] 2020 Dec; Vol. 92 (6), pp. e12952. Date of Electronic Publication: 2020 Aug 27.
Typ publikacji :
Journal Article
MeSH Terms :
Lectins, C-Type/*metabolism
Leishmania donovani/*physiology
Leishmaniasis, Visceral/*immunology
Macrophages/*immunology
Toll-Like Receptor 2/*metabolism
Zymosan/*metabolism
beta-Glucans/*metabolism
Animals ; Cells, Cultured ; Hordeum ; Humans ; Immunity, Innate ; Mice ; Mice, Inbred BALB C ; Protein Binding ; Protein Transport ; Signal Transduction
Czasopismo naukowe
Tytuł :
A new neutrophil subset promotes CNS neuron survival and axon regeneration.
Autorzy :
Sas AR; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.; The Neuroscience Research Institute, The Ohio State University, Columbus, OH, USA.; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.
Carbajal KS; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.
Jerome AD; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.; The Neuroscience Research Institute, The Ohio State University, Columbus, OH, USA.
Menon R; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Yoon C; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Kalinski AL; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Giger RJ; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA.
Segal BM; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA. .; The Neuroscience Research Institute, The Ohio State University, Columbus, OH, USA. .; Department of Neurology, University of Michigan, Ann Arbor, MI, USA. .
Pokaż więcej
Źródło :
Nature immunology [Nat Immunol] 2020 Dec; Vol. 21 (12), pp. 1496-1505. Date of Electronic Publication: 2020 Oct 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Communication*
Nerve Regeneration*
Axons/*metabolism
Central Nervous System/*cytology
Central Nervous System/*metabolism
Neurons/*metabolism
Neutrophils/*metabolism
Animals ; Biomarkers ; Cell Plasticity/immunology ; Cell Survival/drug effects ; Cell Survival/immunology ; Central Nervous System/immunology ; Intercellular Signaling Peptides and Proteins/biosynthesis ; Mice ; Neutrophil Infiltration/immunology ; Neutrophils/immunology ; Optic Nerve/immunology ; Optic Nerve/metabolism ; Receptors, Interleukin-8B/metabolism ; Spinal Cord/cytology ; Spinal Cord/metabolism ; Transcriptome ; Zymosan/metabolism ; Zymosan/pharmacology
Czasopismo naukowe
Tytuł :
Curdlan, zymosan and a yeast-derived β-glucan reshape tumor-associated macrophages into producers of inflammatory chemo-attractants.
Autorzy :
de Graaff P; Laboratory of Tumor Immunology, Department of Medical Oncology, Erasmus MC-Cancer Institute, Rotterdam, The Netherlands. .; Wageningen Food and Biobased Research, Wageningen UR, Wageningen, The Netherlands. .
Berrevoets C; Laboratory of Tumor Immunology, Department of Medical Oncology, Erasmus MC-Cancer Institute, Rotterdam, The Netherlands.
Rӧsch C; Laboratory of Food Chemistry, Wageningen University, Wageningen, The Netherlands.
Schols HA; Laboratory of Food Chemistry, Wageningen University, Wageningen, The Netherlands.
Verhoef K; Department of General Surgery, Erasmus MC-Cancer Institute, Rotterdam, The Netherlands.
Wichers HJ; Wageningen Food and Biobased Research, Wageningen UR, Wageningen, The Netherlands.
Debets R; Laboratory of Tumor Immunology, Department of Medical Oncology, Erasmus MC-Cancer Institute, Rotterdam, The Netherlands.
Govers C; Wageningen Food and Biobased Research, Wageningen UR, Wageningen, The Netherlands. .
Pokaż więcej
Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Feb; Vol. 70 (2), pp. 547-561. Date of Electronic Publication: 2020 Aug 29.
Typ publikacji :
Journal Article
MeSH Terms :
Chemotactic Factors/*therapeutic use
Tumor-Associated Macrophages/*metabolism
Zymosan/*metabolism
beta-Glucans/*metabolism
Chemotactic Factors/pharmacology ; Humans
Czasopismo naukowe
Tytuł :
Caspofungin suppresses zymosan-induced cytokine and chemokine release in THP-1 cells: possible involvement of the spleen tyrosine kinase pathway.
Autorzy :
Itoh K; Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan; Division of Infection Control and Prevention, University of Fukui Hospital, Fukui, Japan. Electronic address: .
Shigemi H; Division of Infection Control and Prevention, University of Fukui Hospital, Fukui, Japan.
Chihara K; Department of Genome Science and Microbiology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Sada K; Department of Genome Science and Microbiology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Yamauchi T; Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Iwasaki H; Division of Infection Control and Prevention, University of Fukui Hospital, Fukui, Japan.
Pokaż więcej
Źródło :
Translational research : the journal of laboratory and clinical medicine [Transl Res] 2021 Jan; Vol. 227, pp. 53-63. Date of Electronic Publication: 2020 Jul 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adjuvants, Immunologic/*pharmacology
Antifungal Agents/*pharmacology
Caspofungin/*pharmacology
Chemokines/*metabolism
Cytokines/*metabolism
Protein-Tyrosine Kinases/*metabolism
Spleen/*enzymology
Zymosan/*pharmacology
Humans ; Signal Transduction ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Synthesis and structure-activity relationships of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives as 5-lipoxygenase inhibitors.
Autorzy :
Phillips OA; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Kuwait University, Safat, Kuwait.
Bosso MA; Faculty of Medicine, Department of Pharmacology & Toxicology, Kuwait University, Safat, Kuwait.
Ezeamuzie CI; Faculty of Medicine, Department of Pharmacology & Toxicology, Kuwait University, Safat, Kuwait.
Pokaż więcej
Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 1471-1482.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Arachidonate 5-Lipoxygenase/*metabolism
Hydroxamic Acids/*pharmacology
Inflammation/*drug therapy
Lipoxygenase Inhibitors/*pharmacology
Oxazolidinones/*pharmacology
Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Cell Line ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Female ; Humans ; Hydroxamic Acids/chemical synthesis ; Hydroxamic Acids/chemistry ; Inflammation/chemically induced ; Inflammation/metabolism ; Leukotriene B4/antagonists & inhibitors ; Leukotriene B4/biosynthesis ; Lipoxygenase Inhibitors/chemical synthesis ; Lipoxygenase Inhibitors/chemistry ; Male ; Mice ; Mice, Inbred BALB C ; Molecular Structure ; Oxazolidinones/chemical synthesis ; Oxazolidinones/chemistry ; Structure-Activity Relationship ; Zymosan
Czasopismo naukowe
Tytuł :
Myeloid CFTR loss-of-function causes persistent neutrophilic inflammation in cystic fibrosis.
Autorzy :
Ng HP; Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Jennings S; Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Wellems D; Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Sun F; Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, USA.
Xu J; Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical Center, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Nauseef WM; Department of Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, and Veterans Administration Medical Center, Iowa City, Iowa, USA.
Wang G; Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Pokaż więcej
Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2020 Dec; Vol. 108 (6), pp. 1777-1785. Date of Electronic Publication: 2020 Jun 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cystic Fibrosis/*immunology
Cystic Fibrosis Transmembrane Conductance Regulator/*deficiency
Macrophages, Peritoneal/*immunology
Neutrophils/*immunology
Animals ; Cystic Fibrosis/pathology ; Cystic Fibrosis Transmembrane Conductance Regulator/immunology ; Inflammation/chemically induced ; Inflammation/genetics ; Inflammation/immunology ; Inflammation/pathology ; Loss of Function Mutation ; Macrophages, Peritoneal/pathology ; Mice ; Mice, Mutant Strains ; Neutrophils/pathology ; Zymosan/toxicity
Czasopismo naukowe
Tytuł :
Biochanin A attenuates zymosan-induced arthritis in mice similarly to 17-β estradiol: an alternative to hormone replacement therapy?
Autorzy :
Felix FB; Postgraduate Program in Physiological Sciences, Cellular Migration Laboratory, Federal University of Sergipe, São Cristovão, Brazil.
Araújo JMD; Postgraduate Program in Physiological Sciences, Cellular Migration Laboratory, Federal University of Sergipe, São Cristovão, Brazil.
de Souza EV; Postgraduate Program in Physiological Sciences, Cellular Migration Laboratory, Federal University of Sergipe, São Cristovão, Brazil.
Pinho V; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Camargo EA; Postgraduate Program in Physiological Sciences, Laboratory of Pharmacology of the Inflammatory Process, Federal University of Sergipe, São Cristovão, Brazil.
Corrêa CB; Postgraduate Program in Physiological Sciences, Cell Culture Laboratory, Federal University of Sergipe, São Cristovão, Brazil.
Grespan R; Postgraduate Program in Physiological Sciences, Cellular Migration Laboratory, Federal University of Sergipe, São Cristovão, Brazil. .
Pokaż więcej
Źródło :
Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2020 Dec; Vol. 69 (12), pp. 1245-1256. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :
Journal Article
MeSH Terms :
Estrogen Replacement Therapy*
Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
Arthritis/*drug therapy
Estradiol/*therapeutic use
Genistein/*therapeutic use
Animals ; Apoptosis/drug effects ; Arthritis/chemically induced ; Cytokines/metabolism ; DNA/metabolism ; Edema/chemically induced ; Edema/drug therapy ; Female ; Mice ; Neutrophils/drug effects ; Ovariectomy ; Tetradecanoylphorbol Acetate ; Zymosan
Czasopismo naukowe
Tytuł :
Methyl gallate attenuates inflammation induced by Toll-like receptor ligands by inhibiting MAPK and NF-Κb signaling pathways.
Autorzy :
Correa LB; Laboratory of Applied Pharmacology, Farmanguinhos, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.; National Institute for Science and Technology on Innovation on Diseases of Neglected Populations (INCT/IDPN), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Seito LN; Laboratory of Applied Pharmacology, Farmanguinhos, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.; National Institute for Science and Technology on Innovation on Diseases of Neglected Populations (INCT/IDPN), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Manchope MF; Department of Pathology, Center for Biological Sciences, State University of Londrina, Paraná, Brazil.
Verri WA Jr; Department of Pathology, Center for Biological Sciences, State University of Londrina, Paraná, Brazil.
Cunha TM; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Henriques MG; Laboratory of Applied Pharmacology, Farmanguinhos, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil. .; National Institute for Science and Technology on Innovation on Diseases of Neglected Populations (INCT/IDPN), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. .
Rosas EC; Laboratory of Applied Pharmacology, Farmanguinhos, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil. .; National Institute for Science and Technology on Innovation on Diseases of Neglected Populations (INCT/IDPN), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. .
Pokaż więcej
Źródło :
Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2020 Dec; Vol. 69 (12), pp. 1257-1270. Date of Electronic Publication: 2020 Oct 09.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Gallic Acid/*analogs & derivatives
Inflammation/*drug therapy
Mitogen-Activated Protein Kinases/*antagonists & inhibitors
NF-kappa B/*antagonists & inhibitors
Signal Transduction/*drug effects
Toll-Like Receptors/*drug effects
Animals ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Cytokines/metabolism ; Edema/chemically induced ; Edema/drug therapy ; Gallic Acid/pharmacology ; Gallic Acid/therapeutic use ; Hyperalgesia/drug therapy ; Male ; Mice ; RAW 264.7 Cells ; Zymosan
Czasopismo naukowe
Tytuł :
Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid.
Autorzy :
Brouwers H; Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Jónasdóttir HS; Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.; Center for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Kuipers ME; Center for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Kwekkeboom JC; Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Auger JL; Department of Pediatrics and Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55454.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455.
Gonzalez-Torres M; Department of Pediatrics and Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55454.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455.
López-Vicario C; Hospital Clínic-IDIBAPS, University of Barcelona, 08007 Barcelona, Spain.
Clària J; Hospital Clínic-IDIBAPS, University of Barcelona, 08007 Barcelona, Spain.
Freysdottir J; University of Iceland and Landspitali-The National University Hospital of Iceland, 101 Reykjavik, Iceland; and.
Hardardottir I; University of Iceland and Landspitali-The National University Hospital of Iceland, 101 Reykjavik, Iceland; and.
Garrido-Mesa J; William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London E1 4NS, United Kingdom.
Norling LV; William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London E1 4NS, United Kingdom.
Perretti M; William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London E1 4NS, United Kingdom.
Huizinga TWJ; Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Kloppenburg M; Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Toes REM; Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Binstadt B; Department of Pediatrics and Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55454.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455.
Giera M; Center for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands; .
Ioan-Facsinay A; Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Pokaż więcej
Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2020 Nov 15; Vol. 205 (10), pp. 2840-2849. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*metabolism
Arthritis, Experimental/*immunology
Fatty Acids, Omega-6/*metabolism
Fatty Acids, Unsaturated/*metabolism
Peritonitis/*immunology
Animals ; Anti-Inflammatory Agents/analysis ; Arachidonic Acid/metabolism ; Arthritis, Experimental/pathology ; Cells, Cultured ; Fatty Acids, Omega-6/analysis ; Fatty Acids, Unsaturated/analysis ; Humans ; Leukotriene B4/metabolism ; Lipidomics ; Macrophages/immunology ; Macrophages/metabolism ; Male ; Mice ; Mice, Transgenic ; Neutrophils/immunology ; Neutrophils/metabolism ; Peritoneal Lavage ; Peritonitis/pathology ; Primary Cell Culture ; THP-1 Cells ; Zymosan/administration & dosage ; Zymosan/immunology
Czasopismo naukowe
Tytuł :
Transdermal entry of yeast components elicits transient B cell-associated responses in skin-draining lymph nodes.
Autorzy :
Rahman MA; Department of Immunology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Kanda Y; Department of Immunology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Ozawa M; Department of Immunology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Kawamura T; Department of Immunology, School of Allied Health Sciences, Kitasato University, Sagamihara 252-0373, Japan.
Takeuchi A; Department of Immunology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Katakai T; Department of Immunology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan. Electronic address: .
Pokaż więcej
Źródło :
Cellular immunology [Cell Immunol] 2020 Sep; Vol. 355, pp. 104159. Date of Electronic Publication: 2020 Jul 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes/*immunology
Lymph Nodes/*immunology
Skin/*immunology
Administration, Cutaneous ; Animals ; B-Lymphocytes/drug effects ; Cytokines/metabolism ; Female ; Interleukin-10/metabolism ; Interleukin-12/metabolism ; Lymph Nodes/drug effects ; Lymph Nodes/physiology ; Lymphocytes/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Skin/drug effects ; Zymosan/pharmacology
Czasopismo naukowe
Tytuł :
Effects of co-exposure of lipopolysaccharide and β-glucan (Zymosan A) in exacerbating murine allergic asthma associated with Asian sand dust.
Autorzy :
Sadakane K; Department of Health Sciences, Oita University of Nursing and Health Sciences, Oita, 870-1201, Japan.
Ichinose T; Department of Health Sciences, Oita University of Nursing and Health Sciences, Oita, 870-1201, Japan.
Nishikawa M; Environmental Chemistry Division, National Institute for Environmental Studies, Ibaraki, 305-8506, Japan.
Pokaż więcej
Źródło :
Journal of applied toxicology : JAT [J Appl Toxicol] 2019 Apr; Vol. 39 (4), pp. 672-684. Date of Electronic Publication: 2018 Dec 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Sand*
Asthma/*chemically induced
Dust/*immunology
Lipopolysaccharides/*toxicity
Lung/*drug effects
Zymosan/*toxicity
Animals ; Asthma/immunology ; Asthma/pathology ; Bronchoalveolar Lavage Fluid/cytology ; Bronchoalveolar Lavage Fluid/immunology ; Cytokines/analysis ; Disease Progression ; Immunoglobulin E/blood ; Immunoglobulin G/blood ; Lipopolysaccharides/immunology ; Lung/immunology ; Lung/pathology ; Male ; Mice, Inbred BALB C ; Zymosan/immunology
Czasopismo naukowe
Tytuł :
Sulfated polysaccharide from Gracilaria caudata reduces hypernociception and inflammatory response during arthritis in rodents.
Autorzy :
Oliveira FFB; Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, 60430-275 Fortaleza, CE, Brazil.
Bingana RD; Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, 60430-275 Fortaleza, CE, Brazil.
Morais PAF; Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, 60430-275 Fortaleza, CE, Brazil.
Oliveira SRBD; Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, 60430-275 Fortaleza, CE, Brazil.
Barbosa ALDR; Núcleo de Pesquisa em Biodiversidade e Biotecnologia, Universidade Federal do Piauí, 64202-020 Parnaíba, PI, Brazil.
Chaves LS; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, 60440-900 Fortaleza, CE, Brazil.
Alencar POC; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, 60440-900 Fortaleza, CE, Brazil.
Soares PMG; Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, 60430-275 Fortaleza, CE, Brazil.
Souza MHLP; Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, 60430-275 Fortaleza, CE, Brazil.
Freitas ALP; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, 60440-900 Fortaleza, CE, Brazil.
Barros FCN; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, 60440-900 Fortaleza, CE, Brazil; Departamento de Pesquisa, Pós-Graduação e Inovação, 63040-540, Instituto Federal de Educação, Ciência e Tecnologia - CE, Brazil.
Medeiros JR; Núcleo de Pesquisa em Biodiversidade e Biotecnologia, Universidade Federal do Piauí, 64202-020 Parnaíba, PI, Brazil.
Damasceno ROS; Departamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco, 50670-600 Recife, PE, Brazil. Electronic address: .
Pokaż więcej
Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 Oct 15; Vol. 161, pp. 1061-1069. Date of Electronic Publication: 2020 Jun 10.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*chemistry
Anti-Inflammatory Agents/*pharmacology
Gracilaria/*chemistry
Polysaccharides/*chemistry
Polysaccharides/*pharmacology
Sulfates/*chemistry
Animals ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/etiology ; Arthritis, Experimental/pathology ; Biomarkers ; Capillary Permeability/drug effects ; Disease Models, Animal ; Edema/drug therapy ; Edema/etiology ; Freund's Adjuvant ; Immunohistochemistry ; Male ; Mice ; Rodentia ; Zymosan/adverse effects
Czasopismo naukowe
Tytuł :
Zymosan by-passes the requirement for pulmonary antigen encounter in lung tissue-resident memory CD8 T cell development.
Autorzy :
Caminschi I; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia.
Lahoud MH; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia.
Pizzolla A; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia.
Wakim LM; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia. .
Pokaż więcej
Źródło :
Mucosal immunology [Mucosal Immunol] 2019 Mar; Vol. 12 (2), pp. 403-412. Date of Electronic Publication: 2019 Jan 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Influenza A virus/*immunology
Influenza Vaccines/*immunology
Influenza, Human/*immunology
Lung/*immunology
Orthomyxoviridae Infections/*immunology
T-Lymphocytes, Regulatory/*immunology
Zymosan/*immunology
Adjuvants, Immunologic ; Animals ; Antigens/immunology ; Cell Differentiation ; Cells, Cultured ; Cellular Microenvironment ; Humans ; Immunologic Memory ; Inflammation ; Lectins, C-Type/metabolism ; Lymphocyte Activation ; Mice ; Mice, Transgenic ; Signal Transduction ; Vaccination ; Zymosan/administration & dosage
Czasopismo naukowe
Tytuł :
The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide-dependent neutrophil recruitment.
Autorzy :
Takahashi M; Division of Cellular Therapy/Division of Stem Cell Signaling, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Izawa K; Division of Cellular Therapy/Division of Stem Cell Signaling, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Urai M; Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
Yamanishi Y; Division of Cellular Therapy/Division of Stem Cell Signaling, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.; Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Maehara A; Division of Cellular Therapy/Division of Stem Cell Signaling, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Isobe M; Division of Cellular Therapy/Division of Stem Cell Signaling, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Matsukawa T; Division of Cellular Therapy/Division of Stem Cell Signaling, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.; Department of Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-0808, Japan.
Kaitani A; Division of Cellular Therapy/Division of Stem Cell Signaling, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Takamori A; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Uchida S; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.; Departments of Gastroenterology Immunology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Yamada H; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.; Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Nagamine M; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Ando T; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Shimizu T; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.; Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Ogawa H; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Okumura K; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Kinjo Y; Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
Kitamura T; Division of Cellular Therapy/Division of Stem Cell Signaling, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. .
Kitaura J; Division of Cellular Therapy/Division of Stem Cell Signaling, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. .; Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Pokaż więcej
Źródło :
Science signaling [Sci Signal] 2019 Jan 15; Vol. 12 (564). Date of Electronic Publication: 2019 Jan 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neutrophils/*metabolism
Nitric Oxide/*metabolism
Receptors, Immunologic/*metabolism
Sphingosine/*analogs & derivatives
Zymosan/*pharmacology
Animals ; Arthritis/genetics ; Arthritis/metabolism ; Dendritic Cells/metabolism ; Inflammation/genetics ; Inflammation/metabolism ; Lipopolysaccharides/metabolism ; Lipopolysaccharides/pharmacology ; Mice, Inbred C57BL ; Mice, Knockout ; Protein Binding ; Receptors, Immunologic/genetics ; Signal Transduction/drug effects ; Sphingosine/metabolism ; Sphingosine/pharmacology ; Toll-Like Receptor 4/metabolism ; Zymosan/metabolism
Czasopismo naukowe
Tytuł :
The pterocarpanquinone LQB 118 inhibits inflammation triggered by zymosan in vivo and in vitro.
Autorzy :
Lima ÉA; Biotechnology Center, Federal University of Paraíba, João Pessoa 58051‑900, Brazil.
Cavalcante-Silva LHA; Health Science Center, Federal University of Paraíba, João Pessoa 58051‑900, Brazil.
Carvalho DCM; Biotechnology Center, Federal University of Paraíba, João Pessoa 58051‑900, Brazil.
Netto CD; Laboratory of Chemistry, Federal University of Rio de Janeiro, 27930-560, Brazil.
Costa PRR; Laboratory of Bioorganic Chemistry, Natural Products Research Institute, Federal University of Rio de Janeiro, 21941-590, Brazil.
Rodrigues-Mascarenhas S; Biotechnology Center, Federal University of Paraíba, João Pessoa 58051‑900, Brazil. Electronic address: .
Pokaż więcej
Źródło :
International immunopharmacology [Int Immunopharmacol] 2020 Jun; Vol. 83, pp. 106399. Date of Electronic Publication: 2020 Mar 16.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*therapeutic use
Antineoplastic Agents/*therapeutic use
Inflammation/*drug therapy
Macrophages/*immunology
Naphthoquinones/*therapeutic use
Peritoneum/*immunology
Peritonitis/*drug therapy
Pterocarpans/*therapeutic use
Animals ; Cells, Cultured ; Cytokines/metabolism ; Disease Models, Animal ; Female ; Humans ; Inflammation Mediators/metabolism ; Mice ; Zymosan/immunology
Czasopismo naukowe
Tytuł :
Anti-C5a complementary peptide mitigates zymosan-induced severe peritonitis with fibrotic encapsulation in rats pretreated with methylglyoxal.
Autorzy :
Iguchi D; Nephrology, Nagoya University Graduate School of Medicine , Nagoya , Japan.
Mizuno M; Nephrology, Nagoya University Graduate School of Medicine , Nagoya , Japan.; Renal Replacement Therapy, Nagoya University Graduate School of Medicine , Nagoya , Japan.
Suzuki Y; Nephrology, Nagoya University Graduate School of Medicine , Nagoya , Japan.; Renal Replacement Therapy, Nagoya University Graduate School of Medicine , Nagoya , Japan.
Sakata F; Nephrology, Nagoya University Graduate School of Medicine , Nagoya , Japan.; Renal Replacement Therapy, Nagoya University Graduate School of Medicine , Nagoya , Japan.
Maruyama S; Nephrology, Nagoya University Graduate School of Medicine , Nagoya , Japan.
Okada A; Research Institute for Protein Science , Nagoya , Japan.; Department of Neuroscience, Nagoya City University Graduate School of Medical Science , Nagoya , Japan.
Okada H; Research Institute for Protein Science , Nagoya , Japan.; Department of Neuroscience, Nagoya City University Graduate School of Medical Science , Nagoya , Japan.
Ito Y; Nephrology, Nagoya University Graduate School of Medicine , Nagoya , Japan.; Renal Replacement Therapy, Nagoya University Graduate School of Medicine , Nagoya , Japan.; Department of Nephrology and Rheumatology, Aichi Medical University, Nagakute, Japan.
Pokaż więcej
Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2018 Dec 01; Vol. 315 (6), pp. F1732-F1746. Date of Electronic Publication: 2018 Oct 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Pyruvaldehyde*
Zymosan*
Complement Activation/*drug effects
Complement C5a/*antagonists & inhibitors
Complement Inactivating Agents/*pharmacology
Peritoneal Fibrosis/*prevention & control
Peritoneum/*drug effects
Animals ; Complement C5a/immunology ; Disease Models, Animal ; Disease Progression ; Male ; Peritoneal Fibrosis/chemically induced ; Peritoneal Fibrosis/immunology ; Peritoneal Fibrosis/pathology ; Peritoneum/immunology ; Peritoneum/pathology ; Peritonitis/chemically induced ; Peritonitis/immunology ; Peritonitis/metabolism ; Peritonitis/pathology ; Rats, Sprague-Dawley ; Severity of Illness Index ; Signal Transduction/drug effects ; Time Factors
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies