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Tytuł :
[Analysis of APC gene variants in a pedigree affected with familial adenomatous polyposis].
Autorzy :
Cong Y; Department of Rehabilitation, Yiwu Maternal and Child Health Care Hospital, Yiwu, Zhejiang 322000, China. .
Hu L
Wu K
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Źródło :
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics [Zhonghua Yi Xue Yi Chuan Xue Za Zhi] 2021 Sep 10; Vol. 38 (9), pp. 884-886.
Typ publikacji :
Journal Article
MeSH Terms :
Adenomatous Polyposis Coli*/genetics
Genes, APC*
Adenomatous Polyposis Coli Protein/genetics ; Female ; Humans ; Male ; Neoplasm Recurrence, Local ; Pedigree
Czasopismo naukowe
Tytuł :
EHF is essential for epidermal and colonic epithelial homeostasis, and suppresses Apc-initiated colonic tumorigenesis.
Autorzy :
Reehorst CM; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, 3084Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, 3084Australia.
Nightingale R; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, 3084Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, 3084Australia.
Luk IY; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, 3084Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, 3084Australia.
Jenkins L; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, 3084Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, 3084Australia.
Koentgen F; Ozgene, Perth, Western Australia, 6983Australia.
Williams DS; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, 3084Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, 3084Australia.
Darido C; Peter MacCallum Cancer Centre, Melbourne, 3000Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, 3010Australia.
Tan F; Peter MacCallum Cancer Centre, Melbourne, 3000Australia.
Anderton H; Walter and Eliza Hall Institute, Melbourne, 3052Australia.
Chopin M; Walter and Eliza Hall Institute, Melbourne, 3052Australia.; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, 3010Australia.
Schoffer K; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, 3084Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, 3084Australia.
Eissmann MF; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, 3084Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, 3084Australia.
Buchert M; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, 3084Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, 3084Australia.
Mouradov D; Walter and Eliza Hall Institute, Melbourne, 3052Australia.
Sieber OM; Walter and Eliza Hall Institute, Melbourne, 3052Australia.; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, 3010Australia.; Department of Surgery, The University of Melbourne, Parkville, Victoria, 3010Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800Australia.
Ernst M; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, 3084Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, 3084Australia.
Dhillon AS; Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, 3216Australia.
Mariadason JM; Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, 3084Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, 3084Australia.; Department of Medicine, University of Melbourne, Parkville, Victoria, 3010Australia.
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Źródło :
Development (Cambridge, England) [Development] 2021 Jun 15; Vol. 148 (12). Date of Electronic Publication: 2021 Jun 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, APC*
Homeostasis*
Cell Transformation, Neoplastic/*genetics
Colonic Neoplasms/*etiology
Epidermis/*metabolism
Intestinal Mucosa/*metabolism
Transcription Factors/*genetics
Animals ; Cellular Reprogramming/genetics ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology ; Female ; Gene Expression Regulation ; Goblet Cells/metabolism ; Goblet Cells/pathology ; Male ; Mice ; Mice, Knockout ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Apc-mutant cells act as supercompetitors in intestinal tumour initiation.
Autorzy :
van Neerven SM; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
de Groot NE; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
Nijman LE; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
Scicluna BP; Center for Experimental Molecular Medicine, Amsterdam Infection & Immunity, Amsterdam UMC, Amsterdam, The Netherlands.; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, Amsterdam, The Netherlands.
van Driel MS; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
Lecca MC; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
Warmerdam DO; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.; CRISPR Platform, University of Amsterdam, Cancer Center Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Kakkar V; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
Moreno LF; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
Vieira Braga FA; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
Sanches DR; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
Ramesh P; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
Ten Hoorn S; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
Aelvoet AS; Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
van Boxel MF; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
Koens L; Department of Pathology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Krawczyk PM; Department of Medical Biology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Koster J; Department of Oncogenomics, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Dekker E; Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Medema JP; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
Winton DJ; Cancer Research UK, Cambridge Institute, University of Cambridge, Cambridge, UK.
Bijlsma MF; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
Morrissey E; MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Léveillé N; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
Vermeulen L; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, The Netherlands. .; Oncode Institute, Amsterdam, The Netherlands. .
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Źródło :
Nature [Nature] 2021 Jun; Vol. 594 (7863), pp. 436-441. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Competition*
Genes, APC*
Mutation*
Adenomatous Polyposis Coli Protein/*genetics
Intestinal Neoplasms/*genetics
Intestinal Neoplasms/*pathology
Adenoma/genetics ; Adenoma/metabolism ; Adenoma/pathology ; Adenomatous Polyposis Coli Protein/deficiency ; Animals ; Cell Differentiation/genetics ; Female ; Glycogen Synthase Kinase 3 beta/antagonists & inhibitors ; Humans ; Intestinal Neoplasms/metabolism ; Lithium Chloride/pharmacology ; Male ; Mice ; Organoids/cytology ; Organoids/metabolism ; Organoids/pathology ; Wnt Proteins/antagonists & inhibitors ; Wnt Proteins/metabolism
Czasopismo naukowe
Tytuł :
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Autorzy :
Flanagan DJ; Cancer Research UK Beatson Institute, Glasgow, UK.
Pentinmikko N; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.; Molecular and Integrative Bioscience Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.
Luopajärvi K; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.; Molecular and Integrative Bioscience Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.
Willis NJ; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, London, UK.
Gilroy K; Cancer Research UK Beatson Institute, Glasgow, UK.; SpecifiCancer CRUK Grand Challenge Team (C7932/A29055), Department of Genetics, Harvard Medical School, Boston, MA, USA.
Raven AP; Cancer Research UK Beatson Institute, Glasgow, UK.; SpecifiCancer CRUK Grand Challenge Team (C7932/A29055), Department of Genetics, Harvard Medical School, Boston, MA, USA.
Mcgarry L; Cancer Research UK Beatson Institute, Glasgow, UK.
Englund JI; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.; Molecular and Integrative Bioscience Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.
Webb AT; Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden.
Scharaw S; Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden.
Nasreddin N; Intestinal Stem Cell Biology Lab, Wellcome Trust Centre Human Genetics, University of Oxford, Oxford, UK.
Hodder MC; Cancer Research UK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
Ridgway RA; Cancer Research UK Beatson Institute, Glasgow, UK.
Minnee E; Cancer Research UK Beatson Institute, Glasgow, UK.; Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Sphyris N; Cancer Research UK Beatson Institute, Glasgow, UK.
Gilchrist E; Cancer Research UK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
Najumudeen AK; Cancer Research UK Beatson Institute, Glasgow, UK.
Romagnolo B; Université de Paris, Institut Cochin, INSERM, CNRS, Paris, France.
Perret C; Université de Paris, Institut Cochin, INSERM, CNRS, Paris, France.
Williams AC; Colorectal Tumour Biology Group, School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK.
Clevers H; SpecifiCancer CRUK Grand Challenge Team (C7932/A29055), Department of Genetics, Harvard Medical School, Boston, MA, USA.; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, Utrecht, The Netherlands.
Nummela P; Department of Pathology, Applied Tumor Genomics, Research Programs Unit and HUSLAB, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Lähde M; Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Wihuri Research Institute, University of Helsinki, Helsinki, Finland.
Alitalo K; Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Wihuri Research Institute, University of Helsinki, Helsinki, Finland.
Hietakangas V; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.; Molecular and Integrative Bioscience Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.
Hedley A; Cancer Research UK Beatson Institute, Glasgow, UK.
Clark W; Cancer Research UK Beatson Institute, Glasgow, UK.
Nixon C; Cancer Research UK Beatson Institute, Glasgow, UK.
Kirschner K; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
Jones EY; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Ristimäki A; Department of Pathology, Applied Tumor Genomics, Research Programs Unit and HUSLAB, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Leedham SJ; Intestinal Stem Cell Biology Lab, Wellcome Trust Centre Human Genetics, University of Oxford, Oxford, UK.
Fish PV; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, London, UK.; The Francis Crick Institute, London, UK.
Vincent JP; The Francis Crick Institute, London, UK.
Katajisto P; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland. .; Molecular and Integrative Bioscience Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland. .; Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden. .
Sansom OJ; Cancer Research UK Beatson Institute, Glasgow, UK. .; SpecifiCancer CRUK Grand Challenge Team (C7932/A29055), Department of Genetics, Harvard Medical School, Boston, MA, USA. .; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK. .
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Źródło :
Nature [Nature] 2021 Jun; Vol. 594 (7863), pp. 430-435. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Competition*/genetics
Cell Transformation, Neoplastic*/genetics
Genes, APC*
Mutation*
Colorectal Neoplasms/*genetics
Colorectal Neoplasms/*pathology
Esterases/*metabolism
Adenoma/genetics ; Adenoma/pathology ; Adenomatous Polyposis Coli Protein/genetics ; Animals ; Cell Differentiation ; Cell Proliferation ; Culture Media, Conditioned ; Disease Progression ; Esterases/antagonists & inhibitors ; Esterases/genetics ; Female ; Humans ; Ligands ; Male ; Mice ; Mice, Inbred C57BL ; Organoids/cytology ; Organoids/metabolism ; Organoids/pathology ; Stem Cells/cytology ; Stem Cells/metabolism ; Wnt Proteins/metabolism ; Wnt Signaling Pathway
Czasopismo naukowe
Tytuł :
A distinct APC pathogenic germline variant identified in a southern Thai family with familial adenomatous polyposis.
Autorzy :
Wanitsuwan W; Department of Surgery, Faculty of Medicine, Prince of Songkla University, Songkhla, 90110, Thailand.
Vijasika S; Department of Surgery, Faculty of Medicine, Prince of Songkla University, Songkhla, 90110, Thailand.
Jirarattanasopa P; Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Songkhla, 90110, Thailand.
Horpaopan S; Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand. .
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Źródło :
BMC medical genomics [BMC Med Genomics] 2021 Mar 19; Vol. 14 (1), pp. 87. Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, APC*
Adenomatous Polyposis Coli Protein ; Adolescent ; Child ; Humans ; Male ; Young Adult
Czasopismo naukowe
Tytuł :
Transition state analogue of MTAP extends lifespan of APC mice.
Autorzy :
Firestone RS; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Feng M; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Basu I; Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Peregrina K; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Augenlicht LH; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA. .
Schramm VL; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, 10461, USA. .
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Źródło :
Scientific reports [Sci Rep] 2021 Apr 23; Vol. 11 (1), pp. 8844. Date of Electronic Publication: 2021 Apr 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Genes, APC*
Longevity/*genetics
Purine-Nucleoside Phosphorylase/*metabolism
Adenine/analogs & derivatives ; Adenine/pharmacology ; Adenine/therapeutic use ; Adenine/toxicity ; Adenomatous Polyposis Coli/drug therapy ; Adenomatous Polyposis Coli/enzymology ; Adenomatous Polyposis Coli/genetics ; Animals ; Disease Models, Animal ; Metabolomics ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Protein-Arginine N-Methyltransferases/metabolism ; Purine-Nucleoside Phosphorylase/antagonists & inhibitors ; Purine-Nucleoside Phosphorylase/genetics ; Pyrrolidines/pharmacology ; Pyrrolidines/therapeutic use ; Pyrrolidines/toxicity ; Survival Analysis
Czasopismo naukowe
Tytuł :
Incidental finding of APC deletion in a child: double trouble or double chance? - a case report.
Autorzy :
Rosina E; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pediatric Highly Intensive Care Unit, Via della Commenda, 9, 20122, Milan, Italy.
Rinaldi B; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pediatric Highly Intensive Care Unit, Via della Commenda, 9, 20122, Milan, Italy. .
Silipigni R; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Laboratory of Medical Genetics, Milan, Italy.
Bergamaschi L; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Gattuso G; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Signoroni S; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Guerneri S; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Laboratory of Medical Genetics, Milan, Italy.
Carnevali A; Department of Radiology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Marchisio PG; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pediatric Highly Intensive Care Unit, Via della Commenda, 9, 20122, Milan, Italy.; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Milani D; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pediatric Highly Intensive Care Unit, Via della Commenda, 9, 20122, Milan, Italy.
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Źródło :
Italian journal of pediatrics [Ital J Pediatr] 2021 Feb 15; Vol. 47 (1), pp. 31. Date of Electronic Publication: 2021 Feb 15.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Chromosome Deletion*
Genes, APC*
Incidental Findings*
Chromosomes, Human, Pair 22/*genetics
DiGeorge Syndrome/*genetics
Abdomen/diagnostic imaging ; Child, Preschool ; DiGeorge Syndrome/diagnosis ; Humans ; Male ; Ultrasonography/methods
Czasopismo naukowe
Tytuł :
Role of a Rare Variant in APC Gene Promoter 1B Region in Classic Familial Adenomatous Polyposis.
Autorzy :
Yang M; Department of Medical Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhu L; Department of Medical Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhu L; Department of Medical Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xu D; Department of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Yuan Y; Department of Medical Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, .; Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, .
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Źródło :
Digestion [Digestion] 2021; Vol. 102 (4), pp. 527-533. Date of Electronic Publication: 2020 Jul 23.
Typ publikacji :
Journal Article
MeSH Terms :
Adenomatous Polyposis Coli*/genetics
Genes, APC*
Adenomatous Polyposis Coli Protein/genetics ; Genetic Testing ; Humans ; Pedigree
Czasopismo naukowe
Tytuł :
APC loss induces Warburg effect via increased PKM2 transcription in colorectal cancer.
Autorzy :
Cha PH; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
Hwang JH; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
Kwak DK; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
Koh E; Department of Biochemistry and Molecular Biology, Integrated Genomic Research Center for Metabolic Regulation, Institute of Genetic Science, College of Medicine, Yonsei University, Seoul, Korea.
Kim KS; Department of Biochemistry and Molecular Biology, Integrated Genomic Research Center for Metabolic Regulation, Institute of Genetic Science, College of Medicine, Yonsei University, Seoul, Korea.
Choi KY; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea. .; CK Biotechnology Inc., Building 117, 50 Yonsei Ro, Seodaemun-Gu, Seoul, Korea. .
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Źródło :
British journal of cancer [Br J Cancer] 2021 Feb; Vol. 124 (3), pp. 634-644. Date of Electronic Publication: 2020 Oct 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, APC*
Warburg Effect, Oncologic*
Wnt Signaling Pathway*/drug effects
Wnt Signaling Pathway*/genetics
Carrier Proteins/*metabolism
Colorectal Neoplasms/*metabolism
L-Lactate Dehydrogenase/*metabolism
Membrane Proteins/*metabolism
Neoplasm Proteins/*metabolism
Thyroid Hormones/*metabolism
Animals ; Carrier Proteins/genetics ; Colorectal Neoplasms/genetics ; Heterografts ; Humans ; L-Lactate Dehydrogenase/genetics ; Male ; Membrane Proteins/genetics ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Mitochondrial Proton-Translocating ATPases/metabolism ; Neoplasm Proteins/genetics ; Proteomics ; Thiazolidines/pharmacology ; Thyroid Hormones/genetics ; Tissue Array Analysis ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
PCR-based genotyping assays to detect germline APC variant associated with hereditary gastrointestinal polyposis in Jack Russell terriers.
Autorzy :
Yoshizaki K; Laboratory of Veterinary Pathology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
Hirata A; Laboratory of Veterinary Pathology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan. .
Matsushita H; Laboratory of Veterinary Pathology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
Nishii N; Laboratory of Veterinary Internal Medicine, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
Kawabe M; Laboratory of Veterinary Clinical Radiology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
Mori T; Laboratory of Veterinary Clinical Oncology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.; Center for Highly Advanced Integration of Nano and Life Sciences, Gifu University (G-CHAIN), 1-1 Yanagido, Gifu, 501-1193, Japan.
Sakai H; Laboratory of Veterinary Pathology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.; Center for Highly Advanced Integration of Nano and Life Sciences, Gifu University (G-CHAIN), 1-1 Yanagido, Gifu, 501-1193, Japan.
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Źródło :
BMC veterinary research [BMC Vet Res] 2021 Jan 18; Vol. 17 (1), pp. 32. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, APC*
Adenomatous Polyposis Coli/*veterinary
Dog Diseases/*genetics
Genetic Testing/*veterinary
Adenomatous Polyposis Coli/diagnosis ; Adenomatous Polyposis Coli/genetics ; Animals ; Dogs ; Genetic Predisposition to Disease ; Genotype ; Germ-Line Mutation ; Japan ; Polymerase Chain Reaction/methods ; Polymerase Chain Reaction/veterinary
Czasopismo naukowe
Tytuł :
PWD/Ph-Encoded Genetic Variants Modulate the Cellular Wnt/β-Catenin Response to Suppress Apc -Triggered Intestinal Tumor Formation.
Autorzy :
Farrall AL; Max Planck Institute for Molecular Genetics, Berlin, Germany.; College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Lienhard M; Max Planck Institute for Molecular Genetics, Berlin, Germany.
Grimm C; Max Planck Institute for Molecular Genetics, Berlin, Germany.; Department of Translational Epigenetics and Tumor Genetics, University Hospital Cologne, Cologne, Germany.
Kuhl H; Max Planck Institute for Molecular Genetics, Berlin, Germany.; Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Department of Ecophysiology and Aquaculture, Berlin, Germany.
Sluka SHM; Max Planck Institute for Molecular Genetics, Berlin, Germany.
Caparros M; Max Planck Institute for Molecular Genetics, Berlin, Germany.
Forejt J; Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Vestec, Prague, Czech Republic.
Timmermann B; Max Planck Institute for Molecular Genetics, Berlin, Germany.
Herwig R; Max Planck Institute for Molecular Genetics, Berlin, Germany.
Herrmann BG; Max Planck Institute for Molecular Genetics, Berlin, Germany. .; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute for Medical Genetics, Berlin, Germany.
Morkel M; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pathology, Berlin, Germany. .
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Źródło :
Cancer research [Cancer Res] 2021 Jan 01; Vol. 81 (1), pp. 38-49. Date of Electronic Publication: 2020 Nov 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, APC*
Mutation*
Cell Transformation, Neoplastic/*pathology
Colorectal Neoplasms/*prevention & control
Intestines/*pathology
Wnt Proteins/*metabolism
beta Catenin/*metabolism
Animals ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Genetic Predisposition to Disease ; Male ; Mice ; Mice, Inbred C57BL ; Wnt Proteins/genetics ; beta Catenin/genetics
Czasopismo naukowe
Tytuł :
Novel Pathogenic Germline Variant of the Adenomatous Polyposis Coli (APC) Gene, p.S2627Gfs*12 Identified in a Mild Phenotype of APC-Associated Polyposis: A Case Report.
Autorzy :
Koeller DR; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Schwartz A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Manning DK; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Dong F; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Lindeman NI; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Garber JE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA.
Ghazani AA; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
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Źródło :
The American journal of case reports [Am J Case Rep] 2020 Dec 11; Vol. 21, pp. e927293. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Adenomatous Polyposis Coli*/genetics
Genes, APC*
Adenomatous Polyposis Coli Protein/genetics ; Aged, 80 and over ; Germ Cells ; Germ-Line Mutation ; Humans ; Male ; Phenotype
Czasopismo naukowe
Tytuł :
Recurrent APC Splice Variant c.835-8A>G in Patients With Unexplained Colorectal Polyposis Fulfilling the Colibactin Mutational Signature.
Autorzy :
Terlouw D; Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands.
Suerink M; Department of Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Boot A; Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands; Department of Cancer and Stem Cell Biology, Duke-National University of Singapore Medical School, Singapore.
van Wezel T; Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands.
Nielsen M; Department of Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Morreau H; Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands. Electronic address: .
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Źródło :
Gastroenterology [Gastroenterology] 2020 Oct; Vol. 159 (4), pp. 1612-1614.e5. Date of Electronic Publication: 2020 Jun 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, APC*
Adenoma/*genetics
Adenomatous Polyposis Coli/*genetics
Carcinoma/*genetics
Colorectal Neoplasms/*genetics
Mutation/*genetics
Adenoma/pathology ; Adenomatous Polyposis Coli/pathology ; Carcinoma/pathology ; Cohort Studies ; Colorectal Neoplasms/pathology ; Humans ; Mosaicism ; Peptides ; Polyketides
Czasopismo naukowe
Tytuł :
Identification of large deletions in the APC gene in Russian patients with familial adenomatous polyposis.
Autorzy :
Tsukanov AS; National Medical Research Center for Coloproctology, Moscow, Russia.
Zabnenkova VV; Research Center for Medical Genetics, Moscow, Russia.
Shubin VP; National Medical Research Center for Coloproctology, Moscow, Russia.
Pikunov DY; National Medical Research Center for Coloproctology, Moscow, Russia.
Savelyeva TA; National Medical Research Center for Coloproctology, Moscow, Russia.
Kuzminov AM; National Medical Research Center for Coloproctology, Moscow, Russia.
Frolov SA; National Medical Research Center for Coloproctology, Moscow, Russia.
Polyakov AV; Research Center for Medical Genetics, Moscow, Russia.
Shelygin YA; National Medical Research Center for Coloproctology, Moscow, Russia.
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Źródło :
Neoplasma [Neoplasma] 2020 Nov; Vol. 67 (6), pp. 1343-1348. Date of Electronic Publication: 2020 Jul 23.
Typ publikacji :
Journal Article
MeSH Terms :
Adenomatous Polyposis Coli*/genetics
Genes, APC*
Sequence Deletion*
Adenomatous Polyposis Coli Protein/genetics ; Germ-Line Mutation ; Humans ; Promoter Regions, Genetic ; Russia
Czasopismo naukowe
Tytuł :
APC mutations in human colon lead to decreased neuroendocrine maturation of ALDH+ stem cells that alters GLP-2 and SST feedback signaling: Clue to a link between WNT and retinoic acid signalling in colon cancer development.
Autorzy :
Zhang T; Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Newark, DE, United States of America.; University of Delaware, Newark, DE, United States of America.; Thomas Jefferson University, Philadelphia, PA, United States of America.
Ahn K; Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Newark, DE, United States of America.; University of Delaware, Newark, DE, United States of America.; Thomas Jefferson University, Philadelphia, PA, United States of America.
Emerick B; Center for Applications of Mathematics in Medicine, Department of Mathematical Sciences, University of Delaware, Newark, DE, United States of America.
Modarai SR; Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Newark, DE, United States of America.; University of Delaware, Newark, DE, United States of America.
Opdenaker LM; Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Newark, DE, United States of America.; University of Delaware, Newark, DE, United States of America.
Palazzo J; Thomas Jefferson University, Philadelphia, PA, United States of America.
Schleiniger G; Center for Applications of Mathematics in Medicine, Department of Mathematical Sciences, University of Delaware, Newark, DE, United States of America.
Fields JZ; CATX, Inc., Princeton, NJ, United States of America.
Boman BM; Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Newark, DE, United States of America.; University of Delaware, Newark, DE, United States of America.; Thomas Jefferson University, Philadelphia, PA, United States of America.; Center for Applications of Mathematics in Medicine, Department of Mathematical Sciences, University of Delaware, Newark, DE, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Oct 28; Vol. 15 (10), pp. e0239601. Date of Electronic Publication: 2020 Oct 28 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, APC*
Mutation*
Cell Transformation, Neoplastic/*genetics
Colon/*cytology
Colon/*metabolism
Colorectal Neoplasms/*genetics
Glucagon-Like Peptide 2/*metabolism
Somatostatin/*metabolism
Adenomatous Polyposis Coli/genetics ; Adenomatous Polyposis Coli/metabolism ; Adenomatous Polyposis Coli/pathology ; Adult Stem Cells/cytology ; Adult Stem Cells/metabolism ; Aldehyde Dehydrogenase 1 Family/metabolism ; Animals ; Biomarkers/metabolism ; Cell Differentiation/genetics ; Cell Line ; Cell Line, Tumor ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; Chromogranin A/metabolism ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Feedback, Physiological ; Glucagon-Like Peptide-2 Receptor/metabolism ; HCT116 Cells ; HT29 Cells ; Humans ; Mice ; Models, Genetic ; Neuroendocrine Cells/cytology ; Neuroendocrine Cells/metabolism ; Receptors, Somatostatin/metabolism ; Signal Transduction ; Stem Cell Niche ; Tretinoin/metabolism ; Wnt Signaling Pathway
Czasopismo naukowe
Tytuł :
Multivalent tumor suppressor adenomatous polyposis coli promotes Axin biomolecular condensate formation and efficient β-catenin degradation.
Autorzy :
Li TM; Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA. .; Department of Biology, Stanford University, Stanford, CA, 94305, USA. .; Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK. .
Ren J; Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.
Husmann D; Department of Biology, Stanford University, Stanford, CA, 94305, USA.
Coan JP; Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Department of Biology, Stanford University, Stanford, CA, 94305, USA.
Gozani O; Department of Biology, Stanford University, Stanford, CA, 94305, USA. .
Chua KF; Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA. .; Education, and Clinical Center, Geriatric Research, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, 94304, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Oct 15; Vol. 10 (1), pp. 17425. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, APC*
Axin Protein/*metabolism
beta Catenin/*metabolism
Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Humans ; Proteolysis
Czasopismo naukowe
Tytuł :
Highly aggressive thoracic desmoid tumors in adolescent siblings with fatal outcomes in an FAP kindred: a need for increased vigilance and intervention in at-risk AYAs.
Autorzy :
Gad MM; Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA.
Langevin AM; Division of Hematology-Oncology, Department of Pediatrics, UT Health San Antonio, San Antonio, TX, USA.
Sugalski AJ; Division of Hematology-Oncology, Department of Pediatrics, UT Health San Antonio, San Antonio, TX, USA.
Tomlinson GE; Division of Hematology-Oncology, Department of Pediatrics, UT Health San Antonio, San Antonio, TX, USA. .; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX, USA. .
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Źródło :
Familial cancer [Fam Cancer] 2020 Oct; Vol. 19 (4), pp. 311-314.
Typ publikacji :
Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, APC*
Siblings*
Adenomatous Polyposis Coli/*genetics
Fibromatosis, Aggressive/*genetics
Thoracic Neoplasms/*genetics
Adenomatous Polyposis Coli/complications ; Adolescent ; Child, Preschool ; Combined Modality Therapy/methods ; Fatal Outcome ; Female ; Fibromatosis, Aggressive/pathology ; Fibromatosis, Aggressive/therapy ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/therapy ; Humans ; Mutation ; Neoplasms, Multiple Primary/genetics ; Neoplasms, Multiple Primary/pathology ; Pedigree ; Pregnancy ; Pregnancy Complications, Neoplastic/genetics ; Pregnancy Complications, Neoplastic/pathology ; Risk Factors ; Thoracic Neoplasms/pathology ; Thoracic Neoplasms/therapy ; Young Adult
Czasopismo naukowe
Tytuł :
BRAF drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation.
Autorzy :
Reischmann N; Institute of Molecular Medicine and Cell Research (IMMZ), University of Freiburg, Freiburg, Germany.; Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.
Andrieux G; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), partner site Freiburg; and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Griffin R; Institute of Molecular Medicine and Cell Research (IMMZ), University of Freiburg, Freiburg, Germany.
Reinheckel T; Institute of Molecular Medicine and Cell Research (IMMZ), University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), partner site Freiburg; and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Comprehensive Cancer Centre Freiburg (CCCF), University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.; Centre for Biological Signalling Studies BIOSS, University of Freiburg, Freiburg, Germany.
Boerries M; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), partner site Freiburg; and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Comprehensive Cancer Centre Freiburg (CCCF), University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.
Brummer T; Institute of Molecular Medicine and Cell Research (IMMZ), University of Freiburg, Freiburg, Germany. .; German Cancer Consortium (DKTK), partner site Freiburg; and German Cancer Research Center (DKFZ), Heidelberg, Germany. .; Comprehensive Cancer Centre Freiburg (CCCF), University Medical Center Freiburg, University of Freiburg, Freiburg, Germany. .; Centre for Biological Signalling Studies BIOSS, University of Freiburg, Freiburg, Germany. .
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Źródło :
Oncogene [Oncogene] 2020 Sep; Vol. 39 (38), pp. 6053-6070. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, APC*
Genetic Predisposition to Disease*
Mutation*
Cell Dedifferentiation/*genetics
Cell Transformation, Neoplastic/*genetics
Proto-Oncogene Proteins B-raf/*genetics
Tumor Suppressor Protein p53/*genetics
Animals ; Colon/metabolism ; Colon/pathology ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Computational Biology/methods ; Disease Models, Animal ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Genetic Association Studies ; Humans ; Intestine, Small/metabolism ; Intestine, Small/pathology ; MAP Kinase Signaling System ; Mice ; Models, Biological ; Neoplasm Invasiveness ; Oncogenes ; Organoids ; Tissue Culture Techniques
Czasopismo naukowe
Tytuł :
Tensin4 (TNS4) is upregulated by Wnt signalling in adenomas in multiple intestinal neoplasia (Min) mice.
Autorzy :
Raposo TP; Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, UK.; Nottingham Molecular Pathology Node, University of Nottingham, Nottingham, UK.
Alfahed A; Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, UK.; Nottingham Molecular Pathology Node, University of Nottingham, Nottingham, UK.; Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Nateri AS; Cancer Genetics and Stem Cell Group, Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, UK.
Ilyas M; Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, UK.; Nottingham Molecular Pathology Node, University of Nottingham, Nottingham, UK.
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Źródło :
International journal of experimental pathology [Int J Exp Pathol] 2020 Jun; Vol. 101 (3-4), pp. 80-86. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, APC*
Wnt Signaling Pathway*
Adenomatous Polyps/*metabolism
Intestinal Neoplasms/*metabolism
Intestine, Small/*metabolism
Tensins/*metabolism
Adenomatous Polyps/genetics ; Adenomatous Polyps/pathology ; Animals ; Disease Models, Animal ; Female ; Gene Expression Regulation, Neoplastic ; HCT116 Cells ; Humans ; Intestinal Neoplasms/genetics ; Intestinal Neoplasms/pathology ; Intestine, Small/pathology ; Mice, Inbred C57BL ; Mice, Transgenic ; Tensins/genetics ; Up-Regulation ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
A Japanese patient with ductal carcinoma of the prostate carrying an adenomatosis polyposis coli gene mutation: a case report.
Autorzy :
Umeda K; Department of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Kosaka T; Department of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. .
Nakamura K; Genomics Unit, Keio Cancer Center, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Takeda T; Department of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Mikami S; Division of Diagnostic Pathology, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Nishihara H; Genomics Unit, Keio Cancer Center, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Oya M; Department of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
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Źródło :
Diagnostic pathology [Diagn Pathol] 2020 Aug 06; Vol. 15 (1), pp. 102. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Genes, APC*
Carcinoma, Ductal/*genetics
Carcinoma, Ductal/*pathology
Prostatic Neoplasms/*genetics
Prostatic Neoplasms/*pathology
Aged, 80 and over ; Humans ; Japan ; Male ; Mutation ; beta Catenin/metabolism
Czasopismo naukowe

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