Temat: "aPC" - OpacWWW - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Lentiviral in situ targeting of stem cells in unperturbed intestinal epithelium.
Autorzy:: Garside GB; Leibniz Institute on Aging, Fritz Lipmann Institute, 07745, Jena, Germany.; National Center for Tumor Diseases, 01307, Dresden, Germany.
Sandoval M; Division of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Beronja S; Division of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA. .
Rudolph KL; Leibniz Institute on Aging, Fritz Lipmann Institute, 07745, Jena, Germany. .; Pokaż więcej
Źródło:: BMC biology [BMC Biol] 2023 Jan 11; Vol. 21 (1), pp. 6. Date of Electronic Publication: 2023 Jan 11.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Tumor Suppressor Protein p53*/metabolism
Genes, APC*
Mice ; Animals ; Mice, Transgenic ; Intestinal Mucosa/metabolism ; Stem Cells/metabolism

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Skocz do pozycji: 2.

Tytuł:: Newly discovered genomic mutation patterns in radiation-induced small intestinal tumors of ApcMin/+ mice.
Autorzy:: Iizuka D; Department of Radiation Effects Research, Institute for Radiological Science, National Institutes for Quantum Science and Technology, Chiba, Japan.; Department of Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Sasatani M; Department of Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Ishikawa A; Department of Radiation Effects Research, Institute for Radiological Science, National Institutes for Quantum Science and Technology, Chiba, Japan.
Daino K; Department of Radiation Effects Research, Institute for Radiological Science, National Institutes for Quantum Science and Technology, Chiba, Japan.
Hirouchi T; Department of Radiobiology, Institute for Environmental Sciences, Rokkasho, Japan.
Kamiya K; Department of Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2023 Oct 12; Vol. 18 (10), pp. e0292643. Date of Electronic Publication: 2023 Oct 12 (Print Publication: 2023).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Adenomatous Polyposis Coli*/genetics
Intestinal Neoplasms*/genetics
Intestinal Neoplasms*/pathology
Neoplasms, Radiation-Induced*/genetics
Mice ; Animals ; Genes, APC ; Comparative Genomic Hybridization ; Mutation ; Genomics

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Skocz do pozycji: 3.

Tytuł:: A pan-cancer analysis on the carcinogenic effect of human adenomatous polyposis coli.
Autorzy:: Zhang Y; Medical School, Anhui University of Science and Technology, Huainan, China.; Institute of Environment-Friendly Materials and Occupational Health of Anhui University of Science and Technology (Wuhu), Wuhu, China.
Liu X; Medical School, Anhui University of Science and Technology, Huainan, China.
Li A; Medical School, Anhui University of Science and Technology, Huainan, China.; Institute of Environment-Friendly Materials and Occupational Health of Anhui University of Science and Technology (Wuhu), Wuhu, China.
Tang X; Medical School, Anhui University of Science and Technology, Huainan, China.; Institute of Environment-Friendly Materials and Occupational Health of Anhui University of Science and Technology (Wuhu), Wuhu, China.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2022 Mar 18; Vol. 17 (3), pp. e0265655. Date of Electronic Publication: 2022 Mar 18 (Print Publication: 2022).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Adenomatous Polyposis Coli*/genetics
Adenomatous Polyposis Coli*/metabolism
Genes, APC*
Adenomatous Polyposis Coli Protein/genetics ; Adenomatous Polyposis Coli Protein/metabolism ; Animals ; DNA Methylation ; Humans ; Mice ; Promoter Regions, Genetic

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Skocz do pozycji: 4.

Tytuł:: The clinical significance of adenomatous polyposis coli (APC) and catenin Beta 1 (CTNNB1) genetic aberrations in patients with melanoma.
Autorzy:: Karachaliou GS; Department of Medicine, The University of North Carolina at Chapel Chapel Hill, Chapel Hill, NC, USA.
Alkallas R; Department of Biochemistry, McGill University, Montreal, QC, Canada.
Carroll SB; Department of Medicine, The University of North Carolina at Chapel Chapel Hill, Chapel Hill, NC, USA.
Caressi C; California Pacific Medical Center Research Institute, San Francisco, CA, USA.
Zakria D; Department of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.
Patel NM; Department of Pathology & Laboratory Medicine, The University of North Carolina at Chapel Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Trembath DG; Department of Pathology & Laboratory Medicine, The University of North Carolina at Chapel Chapel Hill, Chapel Hill, NC, USA.
Ezzell JA; Department of Cell Biology & Physiology, Histology Research Core Facility, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Pegna GJ; Department of Medicine, The University of North Carolina at Chapel Chapel Hill, Chapel Hill, NC, USA.
Googe PB; Department of Dermatology, The University of North Carolina at Chapel Chapel Hill, Chapel Hill, NC, USA.
Galeotti JP; Department of Pathology & Laboratory Medicine, The University of North Carolina at Chapel Chapel Hill, Chapel Hill, NC, USA.
Ayvali F; Department of Medicine, The University of North Carolina at Chapel Chapel Hill, Chapel Hill, NC, USA.
Collichio FA; Department of Medicine, The University of North Carolina at Chapel Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Lee CB; Department of Medicine, The University of North Carolina at Chapel Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ollila DW; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Surgery, The University of North Carolina at Chapel Chapel Hill, Chapel Hill, NC, USA.
Gulley ML; Department of Pathology & Laboratory Medicine, The University of North Carolina at Chapel Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Johnson DB; Department of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.
Kim KB; California Pacific Medical Center Research Institute, San Francisco, CA, USA.
Watson IR; Department of Biochemistry, McGill University, Montreal, QC, Canada.
Moschos SJ; Department of Medicine, The University of North Carolina at Chapel Chapel Hill, Chapel Hill, NC, USA. .; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. .; Pokaż więcej
Źródło:: BMC cancer [BMC Cancer] 2022 Jan 05; Vol. 22 (1), pp. 38. Date of Electronic Publication: 2022 Jan 05.
Typ publikacji:: Journal Article
MeSH Terms:: Genes, APC*
Melanoma/*genetics
Melanoma/*mortality
Skin Neoplasms/*genetics
Skin Neoplasms/*mortality
beta Catenin/*genetics
Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Lymphocytes, Tumor-Infiltrating/pathology ; Male ; Middle Aged ; Mutation ; Neoplasm Staging ; Prognosis ; Proportional Hazards Models ; Melanoma, Cutaneous Malignant

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Skocz do pozycji: 5.

Tytuł:: CircEAF2 counteracts Epstein-Barr virus-positive diffuse large B-cell lymphoma progression via miR-BART19-3p/APC/β-catenin axis.
Autorzy:: Zhao CX; Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, 350001, Fujian, China.
Yan ZX; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai, 200025, China.
Wen JJ; Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, 350001, Fujian, China.
Fu D; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai, 200025, China.
Xu PP; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai, 200025, China.
Wang L; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai, 200025, China.; Pôle de Recherches Sino-Français en Science du Vivant et Génomique, Laboratory of Molecular Pathology, Shanghai, China.
Cheng S; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai, 200025, China.
Hu JD; Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, 350001, Fujian, China. .
Zhao WL; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai, 200025, China. .; Pôle de Recherches Sino-Français en Science du Vivant et Génomique, Laboratory of Molecular Pathology, Shanghai, China. .; Pokaż więcej
Źródło:: Molecular cancer [Mol Cancer] 2021 Dec 01; Vol. 20 (1), pp. 153. Date of Electronic Publication: 2021 Dec 01.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Genes, APC*
Epstein-Barr Virus Infections/*complications
Lymphoma, Large B-Cell, Diffuse/*etiology
Lymphoma, Large B-Cell, Diffuse/*metabolism
MicroRNAs/*genetics
RNA, Circular/*genetics
Transcription Factors/*genetics
beta Catenin/*metabolism
Adult ; Aged ; Animals ; Biomarkers, Tumor ; Cell Line, Tumor ; Disease Models, Animal ; Disease Susceptibility ; Female ; Gene Expression Regulation, Neoplastic ; Herpesvirus 4, Human ; Humans ; Lymphoma, Large B-Cell, Diffuse/pathology ; Lymphoma, Large B-Cell, Diffuse/therapy ; Male ; Mice ; Middle Aged ; Models, Biological ; Wnt Signaling Pathway

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Skocz do pozycji: 6.

Tytuł:: APC gene promoter methylation as a potential biomarker for lung cancer diagnosis: A meta-analysis.
Autorzy:: Liu F; Department of Respiratory, Zhejiang Hospital, Hangzhou, China.
Lu X; Department of Respiratory, Zhejiang Hospital, Hangzhou, China.
Zhou X; Department of Respiratory, Zhejiang Hospital, Hangzhou, China.
Huang H; Department of Respiratory, Zhejiang Hospital, Hangzhou, China.; Pokaż więcej
Źródło:: Thoracic cancer [Thorac Cancer] 2021 Nov; Vol. 12 (21), pp. 2907-2913. Date of Electronic Publication: 2021 Sep 20.
Typ publikacji:: Journal Article; Meta-Analysis
MeSH Terms:: Genes, APC*
Biomarkers, Tumor/*genetics
DNA Methylation/*genetics
Early Detection of Cancer/*methods
Lung Neoplasms/*genetics
Bronchoalveolar Lavage Fluid ; Humans ; Sputum

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Skocz do pozycji: 7.

Tytuł:: A distinct APC pathogenic germline variant identified in a southern Thai family with familial adenomatous polyposis.
Autorzy:: Wanitsuwan W; Department of Surgery, Faculty of Medicine, Prince of Songkla University, Songkhla, 90110, Thailand.
Vijasika S; Department of Surgery, Faculty of Medicine, Prince of Songkla University, Songkhla, 90110, Thailand.
Jirarattanasopa P; Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Songkhla, 90110, Thailand.
Horpaopan S; Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand. .; Pokaż więcej
Źródło:: BMC medical genomics [BMC Med Genomics] 2021 Mar 19; Vol. 14 (1), pp. 87. Date of Electronic Publication: 2021 Mar 19.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Genes, APC*
Adenomatous Polyposis Coli Protein ; Adolescent ; Child ; Humans ; Male ; Young Adult

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Skocz do pozycji: 8.

Tytuł:: Incidental finding of APC deletion in a child: double trouble or double chance? - a case report.
Autorzy:: Rosina E; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pediatric Highly Intensive Care Unit, Via della Commenda, 9, 20122, Milan, Italy.
Rinaldi B; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pediatric Highly Intensive Care Unit, Via della Commenda, 9, 20122, Milan, Italy. .
Silipigni R; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Laboratory of Medical Genetics, Milan, Italy.
Bergamaschi L; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Gattuso G; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Signoroni S; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Guerneri S; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Laboratory of Medical Genetics, Milan, Italy.
Carnevali A; Department of Radiology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Marchisio PG; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pediatric Highly Intensive Care Unit, Via della Commenda, 9, 20122, Milan, Italy.; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Milani D; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pediatric Highly Intensive Care Unit, Via della Commenda, 9, 20122, Milan, Italy.; Pokaż więcej
Źródło:: Italian journal of pediatrics [Ital J Pediatr] 2021 Feb 15; Vol. 47 (1), pp. 31. Date of Electronic Publication: 2021 Feb 15.
Typ publikacji:: Case Reports; Journal Article
MeSH Terms:: Chromosome Deletion*
Genes, APC*
Incidental Findings*
Chromosomes, Human, Pair 22/*genetics
DiGeorge Syndrome/*genetics
Abdomen/diagnostic imaging ; Child, Preschool ; DiGeorge Syndrome/diagnosis ; Humans ; Male ; Ultrasonography/methods

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Skocz do pozycji: 9.

Tytuł:: Molecular Pathways of Carcinogenesis in Familial Adenomatous Polyposis.
Autorzy:: Ditonno I; Section of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, Italy.
Novielli D; Section of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, Italy.
Celiberto F; Section of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, Italy.; Course in Organs and Tissues Transplantation and Cellular Therapies, Department of Precision Medicine Jonic Area, University 'Aldo Moro' of Bari, 70124 Bari, Italy.
Rizzi S; Section of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, Italy.
Rendina M; Section of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, Italy.
Ierardi E; Section of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, Italy.
Di Leo A; Section of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, Italy.
Losurdo G; Section of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Mar 16; Vol. 24 (6). Date of Electronic Publication: 2023 Mar 16.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Adenomatous Polyposis Coli*/genetics
Adenomatous Polyposis Coli*/pathology
Colorectal Neoplasms*/genetics
Adenoma*/genetics
Humans ; Adenomatous Polyposis Coli Protein/genetics ; Quality of Life ; Genes, APC ; Carcinogenesis/genetics ; Tumor Microenvironment

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Skocz do pozycji: 10.

Tytuł:: Transition state analogue of MTAP extends lifespan of APC mice.
Autorzy:: Firestone RS; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Feng M; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Basu I; Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Peregrina K; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Augenlicht LH; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA. .
Schramm VL; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, 10461, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Apr 23; Vol. 11 (1), pp. 8844. Date of Electronic Publication: 2021 Apr 23.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Genes, APC*
Longevity/*genetics
Purine-Nucleoside Phosphorylase/*metabolism
Adenine/analogs & derivatives ; Adenine/pharmacology ; Adenine/therapeutic use ; Adenine/toxicity ; Adenomatous Polyposis Coli/drug therapy ; Adenomatous Polyposis Coli/enzymology ; Adenomatous Polyposis Coli/genetics ; Animals ; Disease Models, Animal ; Metabolomics ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Protein-Arginine N-Methyltransferases/metabolism ; Purine-Nucleoside Phosphorylase/antagonists & inhibitors ; Purine-Nucleoside Phosphorylase/genetics ; Pyrrolidines/pharmacology ; Pyrrolidines/therapeutic use ; Pyrrolidines/toxicity ; Survival Analysis

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Skocz do pozycji: 11.

Tytuł:: Rare Genetic Variants in Human APC Are Implicated in Mesiodens and Isolated Supernumerary Teeth.
Autorzy:: Panyarat C; Center of Excellence in Medical Genetics Research, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.; Division of Pediatric Dentistry, Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.
Nakornchai S; Department of Pediatric Dentistry, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand.
Chintakanon K; Division of Orthodontics, Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.
Leelaadisorn N; Theera-Niramol Dental Clinic, Roi-et 45000, Thailand.
Intachai W; Center of Excellence in Medical Genetics Research, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.
Olsen B; Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA.
Tongsima S; National Biobank of Thailand, National Science and Technology Development Agency (NSTDA), Thailand Science Park, Pathum Thani 12120, Thailand.
Adisornkanj P; Center of Excellence in Medical Genetics Research, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.; Division of Pediatric Dentistry, Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.; Dental Department, Sawang Daen Din Crown Prince Hospital, Sakon Nakhon 47110, Thailand.
Ngamphiw C; National Biobank of Thailand, National Science and Technology Development Agency (NSTDA), Thailand Science Park, Pathum Thani 12120, Thailand.
Cox TC; Departments of Oral & Craniofacial Sciences, School of Dentistry, and Pediatrics, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA.
Kantaputra P; Center of Excellence in Medical Genetics Research, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.; Division of Pediatric Dentistry, Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Feb 21; Vol. 24 (5). Date of Electronic Publication: 2023 Feb 21.
Typ publikacji:: Journal Article
MeSH Terms:: Adenomatous Polyposis Coli*/genetics
Tooth, Supernumerary*/complications
Tooth, Supernumerary*/genetics
Animals ; Humans ; Mice ; Adenomatous Polyposis Coli Protein/genetics ; beta Catenin/genetics ; Genes, APC

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Skocz do pozycji: 12.

Tytuł:: PCR-based genotyping assays to detect germline APC variant associated with hereditary gastrointestinal polyposis in Jack Russell terriers.
Autorzy:: Yoshizaki K; Laboratory of Veterinary Pathology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
Hirata A; Laboratory of Veterinary Pathology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan. .
Matsushita H; Laboratory of Veterinary Pathology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
Nishii N; Laboratory of Veterinary Internal Medicine, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
Kawabe M; Laboratory of Veterinary Clinical Radiology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
Mori T; Laboratory of Veterinary Clinical Oncology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.; Center for Highly Advanced Integration of Nano and Life Sciences, Gifu University (G-CHAIN), 1-1 Yanagido, Gifu, 501-1193, Japan.
Sakai H; Laboratory of Veterinary Pathology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.; Center for Highly Advanced Integration of Nano and Life Sciences, Gifu University (G-CHAIN), 1-1 Yanagido, Gifu, 501-1193, Japan.; Pokaż więcej
Źródło:: BMC veterinary research [BMC Vet Res] 2021 Jan 18; Vol. 17 (1), pp. 32. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji:: Journal Article
MeSH Terms:: Genes, APC*
Adenomatous Polyposis Coli/*veterinary
Dog Diseases/*genetics
Genetic Testing/*veterinary
Adenomatous Polyposis Coli/diagnosis ; Adenomatous Polyposis Coli/genetics ; Animals ; Dogs ; Genetic Predisposition to Disease ; Genotype ; Germ-Line Mutation ; Japan ; Polymerase Chain Reaction/methods ; Polymerase Chain Reaction/veterinary

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Skocz do pozycji: 13.

Tytuł:: Novel Pathogenic Germline Variant of the Adenomatous Polyposis Coli (APC) Gene, p.S2627Gfs*12 Identified in a Mild Phenotype of APC-Associated Polyposis: A Case Report.
Autorzy:: Koeller DR; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Schwartz A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Manning DK; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Dong F; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Lindeman NI; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Garber JE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA.
Ghazani AA; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Pokaż więcej
Źródło:: The American journal of case reports [Am J Case Rep] 2020 Dec 11; Vol. 21, pp. e927293. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji:: Case Reports; Journal Article
MeSH Terms:: Adenomatous Polyposis Coli*/genetics
Genes, APC*
Adenomatous Polyposis Coli Protein/genetics ; Aged, 80 and over ; Germ Cells ; Germ-Line Mutation ; Humans ; Male ; Phenotype

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Skocz do pozycji: 14.

Tytuł:: Tensin4 (TNS4) is upregulated by Wnt signalling in adenomas in multiple intestinal neoplasia (Min) mice.
Autorzy:: Raposo TP; Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, UK.; Nottingham Molecular Pathology Node, University of Nottingham, Nottingham, UK.
Alfahed A; Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, UK.; Nottingham Molecular Pathology Node, University of Nottingham, Nottingham, UK.; Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Nateri AS; Cancer Genetics and Stem Cell Group, Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, UK.
Ilyas M; Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, UK.; Nottingham Molecular Pathology Node, University of Nottingham, Nottingham, UK.; Pokaż więcej
Źródło:: International journal of experimental pathology [Int J Exp Pathol] 2020 Jun; Vol. 101 (3-4), pp. 80-86. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Genes, APC*
Wnt Signaling Pathway*
Adenomatous Polyps/*metabolism
Intestinal Neoplasms/*metabolism
Intestine, Small/*metabolism
Tensins/*metabolism
Adenomatous Polyps/genetics ; Adenomatous Polyps/pathology ; Animals ; Disease Models, Animal ; Female ; Gene Expression Regulation, Neoplastic ; HCT116 Cells ; Humans ; Intestinal Neoplasms/genetics ; Intestinal Neoplasms/pathology ; Intestine, Small/pathology ; Mice, Inbred C57BL ; Mice, Transgenic ; Tensins/genetics ; Up-Regulation ; beta Catenin/metabolism

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Skocz do pozycji: 15.

Tytuł:: APC mutations in human colon lead to decreased neuroendocrine maturation of ALDH+ stem cells that alters GLP-2 and SST feedback signaling: Clue to a link between WNT and retinoic acid signalling in colon cancer development.
Autorzy:: Zhang T; Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Newark, DE, United States of America.; University of Delaware, Newark, DE, United States of America.; Thomas Jefferson University, Philadelphia, PA, United States of America.
Ahn K; Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Newark, DE, United States of America.; University of Delaware, Newark, DE, United States of America.; Thomas Jefferson University, Philadelphia, PA, United States of America.
Emerick B; Center for Applications of Mathematics in Medicine, Department of Mathematical Sciences, University of Delaware, Newark, DE, United States of America.
Modarai SR; Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Newark, DE, United States of America.; University of Delaware, Newark, DE, United States of America.
Opdenaker LM; Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Newark, DE, United States of America.; University of Delaware, Newark, DE, United States of America.
Palazzo J; Thomas Jefferson University, Philadelphia, PA, United States of America.
Schleiniger G; Center for Applications of Mathematics in Medicine, Department of Mathematical Sciences, University of Delaware, Newark, DE, United States of America.
Fields JZ; CATX, Inc., Princeton, NJ, United States of America.
Boman BM; Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, Newark, DE, United States of America.; University of Delaware, Newark, DE, United States of America.; Thomas Jefferson University, Philadelphia, PA, United States of America.; Center for Applications of Mathematics in Medicine, Department of Mathematical Sciences, University of Delaware, Newark, DE, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2020 Oct 28; Vol. 15 (10), pp. e0239601. Date of Electronic Publication: 2020 Oct 28 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Genes, APC*
Mutation*
Cell Transformation, Neoplastic/*genetics
Colon/*cytology
Colon/*metabolism
Colorectal Neoplasms/*genetics
Glucagon-Like Peptide 2/*metabolism
Somatostatin/*metabolism
Adenomatous Polyposis Coli/genetics ; Adenomatous Polyposis Coli/metabolism ; Adenomatous Polyposis Coli/pathology ; Adult Stem Cells/cytology ; Adult Stem Cells/metabolism ; Aldehyde Dehydrogenase 1 Family/metabolism ; Animals ; Biomarkers/metabolism ; Cell Differentiation/genetics ; Cell Line ; Cell Line, Tumor ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; Chromogranin A/metabolism ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Feedback, Physiological ; Glucagon-Like Peptide-2 Receptor/metabolism ; HCT116 Cells ; HT29 Cells ; Humans ; Mice ; Models, Genetic ; Neuroendocrine Cells/cytology ; Neuroendocrine Cells/metabolism ; Receptors, Somatostatin/metabolism ; Signal Transduction ; Stem Cell Niche ; Tretinoin/metabolism ; Wnt Signaling Pathway

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Skocz do pozycji: 16.

Tytuł:: Multivalent tumor suppressor adenomatous polyposis coli promotes Axin biomolecular condensate formation and efficient β-catenin degradation.
Autorzy:: Li TM; Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA. .; Department of Biology, Stanford University, Stanford, CA, 94305, USA. .; Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK. .
Ren J; Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.
Husmann D; Department of Biology, Stanford University, Stanford, CA, 94305, USA.
Coan JP; Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Department of Biology, Stanford University, Stanford, CA, 94305, USA.
Gozani O; Department of Biology, Stanford University, Stanford, CA, 94305, USA. .
Chua KF; Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA. .; Education, and Clinical Center, Geriatric Research, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, 94304, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Oct 15; Vol. 10 (1), pp. 17425. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Genes, APC*
Axin Protein/*metabolism
beta Catenin/*metabolism
Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Humans ; Proteolysis

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Skocz do pozycji: 17.

Tytuł:: A Japanese patient with ductal carcinoma of the prostate carrying an adenomatosis polyposis coli gene mutation: a case report.
Autorzy:: Umeda K; Department of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Kosaka T; Department of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. .
Nakamura K; Genomics Unit, Keio Cancer Center, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Takeda T; Department of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Mikami S; Division of Diagnostic Pathology, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Nishihara H; Genomics Unit, Keio Cancer Center, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Oya M; Department of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.; Pokaż więcej
Źródło:: Diagnostic pathology [Diagn Pathol] 2020 Aug 06; Vol. 15 (1), pp. 102. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji:: Case Reports; Journal Article
MeSH Terms:: Genes, APC*
Carcinoma, Ductal/*genetics
Carcinoma, Ductal/*pathology
Prostatic Neoplasms/*genetics
Prostatic Neoplasms/*pathology
Aged, 80 and over ; Humans ; Japan ; Male ; Mutation ; beta Catenin/metabolism

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Skocz do pozycji: 18.

Tytuł:: Curated multiple sequence alignment for the Adenomatous Polyposis Coli (APC) gene and accuracy of in silico pathogenicity predictions.
Autorzy:: Karabachev AD; Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States of America.
Martini DJ; Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States of America.
Hermel DJ; Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States of America.
Solcz D; Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States of America.
Richardson ME; Ambry Genetics, Aliso Viejo, California, United States of America.
Pesaran T; Ambry Genetics, Aliso Viejo, California, United States of America.
Sarkar IN; Center for Biomedical Informatics, Brown University, Providence, Rhode Island, United States of America.; Rhode Island Quality Institute, Providence, Rhode Island, United States of America.
Greenblatt MS; Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2020 Aug 04; Vol. 15 (8), pp. e0233673. Date of Electronic Publication: 2020 Aug 04 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Genes, APC*
Mutation, Missense*
Adenomatous Polyposis Coli/*genetics
Adenomatous Polyposis Coli Protein/*genetics
Algorithms ; Amino Acid Sequence ; Computational Biology/methods ; Computer Simulation ; Databases, Protein ; Enhancer Elements, Genetic ; Evolution, Molecular ; Exons ; Genetic Variation ; Humans ; Phylogeny ; Protein Isoforms/genetics ; RNA Splice Sites ; Sequence Alignment/statistics & numerical data

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Skocz do pozycji: 19.

Tytuł:: Epigenetic loss of heterozygosity of Apc and an inflammation-associated mutational signature detected in Lrig1 -driven murine colonic adenomas.
Autorzy:: Preston JL; Institute of Molecular Biology, University of Oregon, Eugene, OR, 97403, USA. .
Stiffler N; Institute of Molecular Biology, University of Oregon, Eugene, OR, 97403, USA.; Pokaż więcej
Źródło:: BMC cancer [BMC Cancer] 2020 Feb 14; Vol. 20 (1), pp. 126. Date of Electronic Publication: 2020 Feb 14.
Typ publikacji:: Journal Article
MeSH Terms:: Epigenesis, Genetic*
Genes, APC*
Loss of Heterozygosity*
Mutation*
Colonic Neoplasms/*genetics
Membrane Glycoproteins/*genetics
Nerve Tissue Proteins/*genetics
Animals ; Cell Transformation, Neoplastic/genetics ; Disease Models, Animal ; Exome ; Gene Expression Profiling ; Gene Silencing ; Humans ; Mice ; Transcriptome

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Skocz do pozycji: 20.

Tytuł:: The CHAMP-study: the CHemopreventive effect of lithium in familial AdenoMatous Polyposis; study protocol of a phase II trial.
Autorzy:: Linssen JDG; Department of Gastroenterology and Hepatology, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands.; Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
van Neerven SM; Cancer Center Amsterdam, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands.; Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
Aelvoet AS; Department of Gastroenterology and Hepatology, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands.; Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands.
Elbers CC; Cancer Center Amsterdam, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands.; Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
Vermeulen L; Cancer Center Amsterdam, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands.; Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
Dekker E; Department of Gastroenterology and Hepatology, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands. .; Cancer Center Amsterdam, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands. .; Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands. .; Pokaż więcej
Źródło:: BMC gastroenterology [BMC Gastroenterol] 2022 Aug 12; Vol. 22 (1), pp. 383. Date of Electronic Publication: 2022 Aug 12.
Typ publikacji:: Clinical Trial Protocol; Journal Article
MeSH Terms:: Adenomatous Polyposis Coli*/drug therapy
Adenomatous Polyposis Coli*/genetics
Adenomatous Polyposis Coli*/prevention & control
Lithium*/therapeutic use
Adenomatous Polyposis Coli Protein/genetics ; Adolescent ; Adult ; Clinical Trials, Phase II as Topic ; Genes, APC ; Humans ; Prospective Studies ; Young Adult

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