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Tytuł :
N 1 H- and N 1 -Substituted Phenylguanidines as α7 Nicotinic Acetylcholine (nACh) Receptor Antagonists: Structure-Activity Relationship Studies.
Autorzy :
Alwassil OI; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia 23298, United States.
Khatri S; Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, Pennsylvania 19104, United States.
Schulte MK; Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, Pennsylvania 19104, United States.
Aripaka SS; Neurobiology Research Unit, University Hospital Copenhagen, DK-2100 Copenhagen, Denmark.
Mikkelsen JD; Neurobiology Research Unit, University Hospital Copenhagen, DK-2100 Copenhagen, Denmark.; Institute of Neuroscience, University of Copenhagen, DK-1017 Copenhagen, Denmark.
Dukat M; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia 23298, United States.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Jun 16; Vol. 12 (12), pp. 2194-2201. Date of Electronic Publication: 2021 May 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, Nicotinic*/metabolism
alpha7 Nicotinic Acetylcholine Receptor*
Acetylcholine ; Animals ; Guanidines ; Humans ; Nicotinic Antagonists/pharmacology ; Oocytes/metabolism ; Structure-Activity Relationship ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Stable desensitization of α 7 nicotinic acetylcholine receptors by NS6740 requires interaction with S36 in the orthosteric agonist binding site.
Autorzy :
Pismataro MC; Department of Pharmaceutical Sciences, Medicinal Chemistry Section 'Pietro Pratesi', University of Milan, Via L. Mangiagalli 25, 20133, Milan, Italy; Department of Chemistry, University of Florida, P.O. Box 117200, Gainesville, FL, 32611-7200, USA.
Horenstein NA; Department of Chemistry, University of Florida, P.O. Box 117200, Gainesville, FL, 32611-7200, USA.
Stokes C; Department of Pharmacology and Therapeutics, University of Florida, P.O. Box 100267, Gainesville, FL, 32610-0267, USA.
Dallanoce C; Department of Pharmaceutical Sciences, Medicinal Chemistry Section 'Pietro Pratesi', University of Milan, Via L. Mangiagalli 25, 20133, Milan, Italy. Electronic address: .
Thakur GA; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, MA, 02115, USA.
Papke RL; Department of Pharmacology and Therapeutics, University of Florida, P.O. Box 100267, Gainesville, FL, 32610-0267, USA.
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 Aug 15; Vol. 905, pp. 174179. Date of Electronic Publication: 2021 May 15.
Typ publikacji :
Journal Article
MeSH Terms :
Azabicyclo Compounds/*pharmacology
Furans/*pharmacology
Nicotinic Agonists/*pharmacology
Serine/*chemistry
Serine/*metabolism
alpha7 Nicotinic Acetylcholine Receptor/*metabolism
Acetylcholine/agonists ; Acetylcholine/antagonists & inhibitors ; Allosteric Regulation ; Animals ; Azabicyclo Compounds/agonists ; Binding Sites ; Drug Partial Agonism ; Furans/agonists ; Isoxazoles/pharmacology ; Molecular Docking Simulation ; Phenylurea Compounds/pharmacology ; Protein Domains ; Xenopus laevis/genetics ; alpha7 Nicotinic Acetylcholine Receptor/agonists ; alpha7 Nicotinic Acetylcholine Receptor/genetics
Czasopismo naukowe
Tytuł :
Expression of Cholinergic Markers and Characterization of Splice Variants during Ontogenesis of Rat Dorsal Root Ganglia Neurons.
Autorzy :
Corsetti V; Department of Biology and Biotechnology Charles Darwin, 'Sapienza' University of Rome, 00185 Rome, Italy.
Perrone-Capano C; Department of Pharmacy, University of Naples Federico II, 80138 Naples, Italy.; Institute of Genetics and Biophysics 'Adriano Buzzati Traverso', CNR, 80131 Naples, Italy.
Salazar Intriago MS; Department of Biology and Biotechnology Charles Darwin, 'Sapienza' University of Rome, 00185 Rome, Italy.
Botticelli E; Department of Biology and Biotechnology Charles Darwin, 'Sapienza' University of Rome, 00185 Rome, Italy.
Poiana G; Department of Biology and Biotechnology Charles Darwin, 'Sapienza' University of Rome, 00185 Rome, Italy.; Research Center of Neuroscience Daniel Bovet, Sapienza University of Rome, 00185 Rome, Italy.
Augusti-Tocco G; Department of Biology and Biotechnology Charles Darwin, 'Sapienza' University of Rome, 00185 Rome, Italy.; Research Center of Neuroscience Daniel Bovet, Sapienza University of Rome, 00185 Rome, Italy.
Biagioni S; Department of Biology and Biotechnology Charles Darwin, 'Sapienza' University of Rome, 00185 Rome, Italy.; Research Center of Neuroscience Daniel Bovet, Sapienza University of Rome, 00185 Rome, Italy.
Tata AM; Department of Biology and Biotechnology Charles Darwin, 'Sapienza' University of Rome, 00185 Rome, Italy.; Research Center of Neuroscience Daniel Bovet, Sapienza University of Rome, 00185 Rome, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 23; Vol. 22 (11). Date of Electronic Publication: 2021 May 23.
Typ publikacji :
Journal Article
MeSH Terms :
Choline O-Acetyltransferase/*biosynthesis
Cholinergic Neurons/*metabolism
Ganglia, Spinal/*cytology
Nerve Tissue Proteins/*biosynthesis
Sensory Receptor Cells/*metabolism
Vesicular Acetylcholine Transport Proteins/*biosynthesis
Acetylcholine/metabolism ; Alternative Splicing ; Animals ; Choline O-Acetyltransferase/genetics ; Cholinergic Neurons/cytology ; Ganglia, Spinal/embryology ; Ganglia, Spinal/growth & development ; Nerve Tissue Proteins/genetics ; Neurogenesis ; Protein Isoforms/biosynthesis ; Protein Isoforms/genetics ; Rats ; Rats, Wistar ; Reverse Transcriptase Polymerase Chain Reaction ; Sensory Receptor Cells/cytology ; Synaptic Vesicles/metabolism ; Vesicular Acetylcholine Transport Proteins/genetics
Czasopismo naukowe
Tytuł :
Acute Lung Injury in Cholinergic-Deficient Mice Supports Anti-Inflammatory Role of α7 Nicotinic Acetylcholine Receptor.
Autorzy :
Pinheiro NM; Department of Bioscience, Federal University of Sao Paulo, Santos 11015-020, SP, Brazil.; College of Pharmacy, University of Texas at Tyler, Tyler, TX 75799, USA.
Banzato R; Department of Medicine, School of Medicine, University of Sao Paulo, Sao Paulo 01246-903, SP, Brazil.
Tibério I; Department of Medicine, School of Medicine, University of Sao Paulo, Sao Paulo 01246-903, SP, Brazil.
Prado MAM; Molecular Medicine Group, Robarts Research Institute, London, ON N6A 5B7, Canada.; Department of Physiology & Pharmacology, University of Western Ontario, London, ON N6A 5B7, Canada.; Department of Anatomy & Cell Biology, University of Western Ontario, London, ON N6A 5B7, Canada.
Prado VF; Department of Medicine, School of Medicine, University of Sao Paulo, Sao Paulo 01246-903, SP, Brazil.; Molecular Medicine Group, Robarts Research Institute, London, ON N6A 5B7, Canada.
Hamouda AK; College of Pharmacy, University of Texas at Tyler, Tyler, TX 75799, USA.
Prado CM; Department of Bioscience, Federal University of Sao Paulo, Santos 11015-020, SP, Brazil.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 14; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 14.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Lung Injury/*drug therapy
Anti-Inflammatory Agents/*pharmacology
Benzamides/*pharmacology
Bridged Bicyclo Compounds/*pharmacology
Cholinergic Agents/*metabolism
Pneumonia/*prevention & control
Vesicular Acetylcholine Transport Proteins/*metabolism
alpha7 Nicotinic Acetylcholine Receptor/*metabolism
Acute Lung Injury/chemically induced ; Acute Lung Injury/metabolism ; Acute Lung Injury/pathology ; Animals ; Cytokines/metabolism ; Male ; Mice ; Nicotinic Agonists/pharmacology ; Pneumonia/etiology ; Pneumonia/metabolism ; Pneumonia/pathology ; Vesicular Acetylcholine Transport Proteins/genetics ; alpha7 Nicotinic Acetylcholine Receptor/genetics
Czasopismo naukowe
Tytuł :
Mesencephalic Electrical Stimulation Reduces Neuroinflammation after Photothrombotic Stroke in Rats by Targeting the Cholinergic Anti-Inflammatory Pathway.
Autorzy :
Schuhmann MK; Department of Neurology, University Hospital of Würzburg, 97080 Würzburg, Germany.
Papp L; Department of Neurology, University Hospital of Würzburg, 97080 Würzburg, Germany.
Stoll G; Department of Neurology, University Hospital of Würzburg, 97080 Würzburg, Germany.
Blum R; Institute of Neurobiology, University Hospital of Würzburg, 97078 Würzburg, Germany.
Volkmann J; Department of Neurology, University Hospital of Würzburg, 97080 Würzburg, Germany.
Fluri F; Department of Neurology, University Hospital of Würzburg, 97080 Würzburg, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 27; Vol. 22 (3). Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Journal Article
MeSH Terms :
Inflammation/*therapy
Neuroimmunomodulation/*genetics
Stroke/*therapy
alpha7 Nicotinic Acetylcholine Receptor/*genetics
Acetylcholine/metabolism ; Animals ; Choline O-Acetyltransferase/genetics ; Disease Models, Animal ; Electric Stimulation ; Humans ; Inflammation/genetics ; Inflammation/pathology ; Mesencephalon/pathology ; Mesencephalon/radiation effects ; Neuroimmunomodulation/radiation effects ; Rats ; Stroke/genetics ; Stroke/pathology ; Tumor Necrosis Factor-alpha/genetics ; alpha7 Nicotinic Acetylcholine Receptor/metabolism
Czasopismo naukowe
Tytuł :
The Role of α7nAChR-Mediated Cholinergic Anti-Inflammatory Pathway in Vagal Nerve Regulated Atrial Fibrillation.
Autorzy :
Zhang SJ; Department of Cardiology, Renmin Hospital of Wuhan University.; Cardiovascular Research Insititute, Wuhan University.; Hubei Key Laboratory of Cardiology.
Huang CX; Department of Cardiology, Renmin Hospital of Wuhan University.; Cardiovascular Research Insititute, Wuhan University.; Hubei Key Laboratory of Cardiology.
Zhao QY; Department of Cardiology, Renmin Hospital of Wuhan University.; Cardiovascular Research Insititute, Wuhan University.; Hubei Key Laboratory of Cardiology.
Zhang SD; Department of Neurosurgery, Renmin Hospital of Wuhan University.
Dai ZX; Department of Cardiology, Renmin Hospital of Wuhan University.; Cardiovascular Research Insititute, Wuhan University.; Hubei Key Laboratory of Cardiology.
Zhao HY; Department of Cardiology, Renmin Hospital of Wuhan University.; Cardiovascular Research Insititute, Wuhan University.; Hubei Key Laboratory of Cardiology.
Qian YS; Department of Cardiology, Renmin Hospital of Wuhan University.; Cardiovascular Research Insititute, Wuhan University.; Hubei Key Laboratory of Cardiology.
Zhang YJ; Department of Cardiology, Renmin Hospital of Wuhan University.; Cardiovascular Research Insititute, Wuhan University.; Hubei Key Laboratory of Cardiology.
Wang YC; Department of Cardiology, Renmin Hospital of Wuhan University.; Cardiovascular Research Insititute, Wuhan University.; Hubei Key Laboratory of Cardiology.
He B; Department of Cardiology, Renmin Hospital of Wuhan University.; Cardiovascular Research Insititute, Wuhan University.; Hubei Key Laboratory of Cardiology.
Tang YH; Department of Cardiology, Renmin Hospital of Wuhan University.; Cardiovascular Research Insititute, Wuhan University.; Hubei Key Laboratory of Cardiology.
Wang T; Department of Cardiology, Renmin Hospital of Wuhan University.; Cardiovascular Research Insititute, Wuhan University.; Hubei Key Laboratory of Cardiology.
Wang X; Department of Cardiology, Renmin Hospital of Wuhan University.; Cardiovascular Research Insititute, Wuhan University.; Hubei Key Laboratory of Cardiology.
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Źródło :
International heart journal [Int Heart J] 2021; Vol. 62 (3), pp. 607-615.
Typ publikacji :
Journal Article
MeSH Terms :
Aconitine/*analogs & derivatives
Atrial Fibrillation/*physiopathology
Neuroimmunomodulation/*drug effects
Vagus Nerve/*drug effects
alpha7 Nicotinic Acetylcholine Receptor/*antagonists & inhibitors
Acetylcholine/blood ; Aconitine/administration & dosage ; Aconitine/pharmacology ; Animals ; Cardiac Pacing, Artificial/adverse effects ; Cardiac Pacing, Artificial/methods ; Case-Control Studies ; Disease Models, Animal ; Dogs ; Heart Atria/innervation ; Heart Atria/physiopathology ; Interleukin-6/blood ; NF-kappa B/blood ; Nicotinic Antagonists/administration & dosage ; Nicotinic Antagonists/pharmacology ; Pulmonary Veins/innervation ; Pulmonary Veins/physiopathology ; Refractory Period, Electrophysiological/drug effects ; STAT3 Transcription Factor/blood ; Tumor Necrosis Factor-alpha/blood ; Vagus Nerve Stimulation/adverse effects ; Vagus Nerve Stimulation/methods
Czasopismo naukowe
Tytuł :
Tyrosine phosphorylation differentially fine-tunes ionotropic and metabotropic responses of human α7 nicotinic acetylcholine receptor.
Autorzy :
Chrestia JF; Instituto de Investigaciones Bioquímicas de Bahía Blanca, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 8000, Bahía Blanca, Argentina.
Bruzzone A; Instituto de Investigaciones Bioquímicas de Bahía Blanca, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 8000, Bahía Blanca, Argentina.
Esandi MDC; Instituto de Investigaciones Bioquímicas de Bahía Blanca, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 8000, Bahía Blanca, Argentina.
Bouzat C; Instituto de Investigaciones Bioquímicas de Bahía Blanca, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 8000, Bahía Blanca, Argentina. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Jul; Vol. 78 (13), pp. 5381-5395. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article
MeSH Terms :
Acetylcholine/*metabolism
Neurons/*metabolism
Tyrosine/*metabolism
alpha7 Nicotinic Acetylcholine Receptor/*metabolism
src-Family Kinases/*metabolism
HEK293 Cells ; Humans ; Neurons/cytology ; Phosphorylation ; Signal Transduction ; alpha7 Nicotinic Acetylcholine Receptor/genetics ; src-Family Kinases/genetics
Czasopismo naukowe
Tytuł :
Computational analysis of non-competitive antagonist arylguanidine-α7 nAChR complexes.
Autorzy :
Alwassil OI; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, P.O. Box 980540, Richmond, VA, 23298-540, USA.
Abdrakhmanova GR; Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, P.O. Box 980524, Richmond, VA, 23298, USA.
Dukat M; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, P.O. Box 980540, Richmond, VA, 23298-540, USA. Electronic address: .
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Źródło :
Journal of molecular graphics & modelling [J Mol Graph Model] 2021 Sep; Vol. 107, pp. 107943. Date of Electronic Publication: 2021 May 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, Nicotinic*
alpha7 Nicotinic Acetylcholine Receptor*
Carrier Proteins ; Hydrogen Bonding ; Ligands
Czasopismo naukowe
Tytuł :
Sex-related Differences in Patients with Positive Coronary Spasm as Identified by Acetylcholine Testing.
Autorzy :
Sueda S; Department of Cardiology, Ehime Prefectural Niihama Hospital, Japan.
Sakaue T; Department of Cardiology, Yawatahama City General Hospital, Japan.
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Źródło :
Internal medicine (Tokyo, Japan) [Intern Med] 2021 Aug 01; Vol. 60 (15), pp. 2357-2365. Date of Electronic Publication: 2021 Feb 15.
Typ publikacji :
Journal Article
MeSH Terms :
Acetylcholine*
Coronary Vasospasm*/chemically induced
Coronary Vasospasm*/diagnosis
Coronary Vasospasm*/epidemiology
Coronary Angiography ; Coronary Vessels/diagnostic imaging ; Female ; Humans ; Male ; Retrospective Studies ; Spasm
Czasopismo naukowe
Tytuł :
Nicotinic α7 acetylcholine receptor (α7nAChR) in human airway smooth muscle.
Autorzy :
Borkar NA; Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND, USA.
Roos B; Department of Anesthesiology and Perioperative Medicine, USA.
Prakash YS; Department of Anesthesiology and Perioperative Medicine, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Sathish V; Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND, USA.
Pabelick CM; Department of Anesthesiology and Perioperative Medicine, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2021 Jul 30; Vol. 706, pp. 108897. Date of Electronic Publication: 2021 May 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Asthma/*genetics
Bronchoconstriction/*drug effects
Complex Mixtures/*pharmacology
Myocytes, Smooth Muscle/*drug effects
Nicotine/*pharmacology
alpha7 Nicotinic Acetylcholine Receptor/*genetics
Adult ; Aged ; Aged, 80 and over ; Asthma/metabolism ; Asthma/pathology ; Bronchi/drug effects ; Bronchi/metabolism ; Bronchi/pathology ; Cigarette Smoking/adverse effects ; Cyclic AMP Response Element-Binding Protein/genetics ; Cyclic AMP Response Element-Binding Protein/metabolism ; Female ; Gene Expression Regulation ; Humans ; Interleukin-13/pharmacology ; Male ; Middle Aged ; Muscle, Smooth/drug effects ; Muscle, Smooth/metabolism ; Muscle, Smooth/pathology ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/pathology ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Primary Cell Culture ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Severity of Illness Index ; Transcription Factor AP-1/genetics ; Transcription Factor AP-1/metabolism ; Tumor Necrosis Factor-alpha/pharmacology ; alpha7 Nicotinic Acetylcholine Receptor/metabolism
Czasopismo naukowe
Tytuł :
Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating.
Autorzy :
Favier M; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.; Robarts Research Institute, Department of Physiology and Pharmacology and Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, Ontario, Canada.
Janickova H; Robarts Research Institute, Department of Physiology and Pharmacology and Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, Ontario, Canada.
Justo D; GHU Paris Psychiatrie et Neurosciences (CMME, Hospital Sainte-Anne), Institute of Psychiatry and Neuroscience of Paris (INSERM UMR1266), Paris, France.
Kljakic O; Robarts Research Institute, Department of Physiology and Pharmacology and Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, Ontario, Canada.
Runtz L; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Natsheh JY; Palestinian Neuroscience Initiative, Al-Quds University, Abu Dis, Jerusalem, Palestine.; Kessler Foundation, East Hanover, New Jersey, USA.
Pascoal TA; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Germann J; Cerebral Imaging Centre, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.
Gallino D; Cerebral Imaging Centre, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.
Kang JI; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Meng XQ; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Antinora C; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Raulic S; Robarts Research Institute, Department of Physiology and Pharmacology and Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, Ontario, Canada.
Jacobsen JP; Department of Cell Biology and.
Moquin L; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Vigneault E; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Gratton A; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Caron MG; Department of Cell Biology and.; Department of Medicine, Duke University, Durham, North Carolina, USA.; Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, USA.
Duriez P; GHU Paris Psychiatrie et Neurosciences (CMME, Hospital Sainte-Anne), Institute of Psychiatry and Neuroscience of Paris (INSERM UMR1266), Paris, France.
Brandon MP; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Neto PR; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Chakravarty MM; Cerebral Imaging Centre, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.; Department of Biological and Biomedical Engineering and.; Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Herzallah MM; Palestinian Neuroscience Initiative, Al-Quds University, Abu Dis, Jerusalem, Palestine.; Center for Molecular and Behavioral Neuroscience, School of Arts & Sciences-Newark Rutgers University, Newark, New Jersey, USA.
Gorwood P; GHU Paris Psychiatrie et Neurosciences (CMME, Hospital Sainte-Anne), Institute of Psychiatry and Neuroscience of Paris (INSERM UMR1266), Paris, France.
Prado MA; Robarts Research Institute, Department of Physiology and Pharmacology and Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, Ontario, Canada.
Prado VF; Robarts Research Institute, Department of Physiology and Pharmacology and Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, Ontario, Canada.
El Mestikawy S; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.; Sorbonne Universités, Université Pierre et Marie Curie UM 119 - CNRS UMR 8246 - INSERM U1130, Neurosciences Paris Seine - Institut de Biologie Paris Seine, Paris, France.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2020 Dec 01; Vol. 130 (12), pp. 6616-6630.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Corpus Striatum*/metabolism
Corpus Striatum*/physiopathology
Acetylcholine/*metabolism
Feeding and Eating Disorders/*metabolism
Glutamic Acid/*metabolism
Interneurons/*metabolism
Adult ; Animals ; Donepezil/pharmacology ; Feeding Behavior/drug effects ; Feeding and Eating Disorders/drug therapy ; Feeding and Eating Disorders/genetics ; Feeding and Eating Disorders/physiopathology ; Female ; Humans ; Levodopa/pharmacology ; Male ; Mice ; Mice, Knockout ; Middle Aged ; Vesicular Acetylcholine Transport Proteins/genetics ; Vesicular Acetylcholine Transport Proteins/metabolism
Czasopismo naukowe
Tytuł :
Allosterically Potentiated α 7 Nicotinic Acetylcholine Receptors: Reduced Calcium Permeability and Current-Independent Control of Intracellular Calcium.
Autorzy :
Miller DR; Departments of Neuroscience (D.R.M., H.K.) and Pharmacology and Therapeutics (C.S., R.L.P.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., L.N.C., G.T.).
Khoshbouei H; Departments of Neuroscience (D.R.M., H.K.) and Pharmacology and Therapeutics (C.S., R.L.P.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., L.N.C., G.T.).
Garai S; Departments of Neuroscience (D.R.M., H.K.) and Pharmacology and Therapeutics (C.S., R.L.P.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., L.N.C., G.T.).
Cantwell LN; Departments of Neuroscience (D.R.M., H.K.) and Pharmacology and Therapeutics (C.S., R.L.P.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., L.N.C., G.T.).
Stokes C; Departments of Neuroscience (D.R.M., H.K.) and Pharmacology and Therapeutics (C.S., R.L.P.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., L.N.C., G.T.).
Thakur G; Departments of Neuroscience (D.R.M., H.K.) and Pharmacology and Therapeutics (C.S., R.L.P.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., L.N.C., G.T.).
Papke RL; Departments of Neuroscience (D.R.M., H.K.) and Pharmacology and Therapeutics (C.S., R.L.P.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., L.N.C., G.T.) .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2020 Dec; Vol. 98 (6), pp. 695-709. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Calcium/*metabolism
alpha7 Nicotinic Acetylcholine Receptor/*metabolism
Acetylcholine/metabolism ; Allosteric Regulation/drug effects ; Allosteric Site ; Animals ; Cell Membrane Permeability/drug effects ; HEK293 Cells ; Humans ; Oocytes ; Patch-Clamp Techniques ; Phenylpropionates/pharmacology ; Piperazines/pharmacology ; Quinolines/pharmacology ; Sulfonamides/pharmacology ; Xenopus laevis ; alpha7 Nicotinic Acetylcholine Receptor/agonists
Czasopismo naukowe
Tytuł :
Water-soluble variant of human Lynx1 positively modulates synaptic plasticity and ameliorates cognitive impairment associated with α7-nAChR dysfunction.
Autorzy :
Shenkarev ZO; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.; Moscow Institute of Physics and Technology, Moscow region, Russia.
Shulepko MA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Bychkov ML; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Kulbatskii DS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Shlepova OV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.; Moscow Institute of Physics and Technology, Moscow region, Russia.
Vasilyeva NA; Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia.
Andreev-Andrievskiy AA; Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.; Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
Popova AS; Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.; Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
Lagereva EA; Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
Loktyushov EV; Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.
Koshelev SG; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Thomsen MS; Department of Circuit Biology, H. Lundbeck, Copenhagen, Denmark.
Dolgikh DA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Kozlov SA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Balaban PM; Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia.
Kirpichnikov MP; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.; Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.
Lyukmanova EN; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.; Moscow Institute of Physics and Technology, Moscow region, Russia.
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Źródło :
Journal of neurochemistry [J Neurochem] 2020 Oct; Vol. 155 (1), pp. 45-61. Date of Electronic Publication: 2020 May 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*pharmacology
Cholinesterase Inhibitors/*toxicity
Cognitive Dysfunction/*prevention & control
Cognitive Dysfunction/*psychology
Neuronal Plasticity/*drug effects
alpha7 Nicotinic Acetylcholine Receptor/*antagonists & inhibitors
Acetylcholine/pharmacology ; Adaptor Proteins, Signal Transducing/pharmacokinetics ; Alkaloids/pharmacology ; Animals ; Blood-Brain Barrier/drug effects ; Brain/metabolism ; Cognitive Dysfunction/chemically induced ; Interneurons/drug effects ; Learning/drug effects ; Long-Term Potentiation/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Rats ; Rats, Wistar ; Smell/drug effects ; Visual Cortex/drug effects ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Regulation of the acetylcholine/α7nAChR anti-inflammatory pathway in COVID-19 patients.
Autorzy :
Courties A; Sorbonne Université, INSERM UMR 938, Centre de Recherche Saint-Antoine, Hôpital Saint-Antoine, AP-HP, Paris, France.; Rheumatology Department, AP-HP Saint-Antoine Hospital, 184, rue du Faubourg Saint-Antoine, 75012, Paris, France.
Boussier J; Sorbonne Université, Paris, France.
Hadjadj J; Université de Paris, Imagine Institute Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, INSERM UMR 1163, 75015, Paris, France.; Department of Internal Medicine, National Reference Center for Rare Systemic Autoimmune Diseases, AP-HP, APHP-CUP, Hôpital Cochin, 75014, Paris, France.
Yatim N; Translational Immunology Lab, Department of Immunology, Institut Pasteur, 75015, Paris, France.; Department of Internal Medicine, National Reference Center for Rare Systemic Autoimmune Diseases, AP-HP, APHP-CUP, Hôpital Cochin, 75014, Paris, France.
Barnabei L; Université de Paris, Imagine Institute Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, INSERM UMR 1163, 75015, Paris, France.
Péré H; Université de Paris, INSERM, U970, PARCC, 75015, Paris, France.; Laboratoire de Virologie, Service de Microbiologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, 75015, Paris, France.
Veyer D; Laboratoire de Virologie, Service de Microbiologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, 75015, Paris, France.; Unité de Génomique Fonctionnelle des Tumeurs Solides, Centre de Recherche des Cordeliers, INSERM, Université Paris, 75005, Paris, France.
Kernéis S; Equipe Mobile d'Infectiologie, Hôpital Cochin, AP-HP, APHP-CUP, 75014, Paris, France.; Université de Paris, INSERM, IAME, 75006, Paris, France.; Institut Pasteur, Epidemiology and Modelling of Antibiotic Evasion (EMAE), 75015, Paris, France.
Carlier N; Department of Pulmonology, Hôpital Cochin, AP-HP, APHP-CUP, 75014, Paris, France.
Pène F; Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR 8104, Service de Médecine Intensive-Réanimation, Hôpital Cochin, AP-HP-CUP, 75014, Paris, France.
Rieux-Laucat F; Université de Paris, Imagine Institute Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, INSERM UMR 1163, 75015, Paris, France.
Charbit B; Institut Pasteur, Cytometry and Biomarkers UTechS, CRT, 75015, Paris, France.
Bondet V; Translational Immunology Lab, Department of Immunology, Institut Pasteur, 75015, Paris, France.
Duffy D; Translational Immunology Lab, Department of Immunology, Institut Pasteur, 75015, Paris, France.; Institut Pasteur, Cytometry and Biomarkers UTechS, CRT, 75015, Paris, France.
Berenbaum F; Sorbonne Université, INSERM UMR 938, Centre de Recherche Saint-Antoine, Hôpital Saint-Antoine, AP-HP, Paris, France.; Rheumatology Department, AP-HP Saint-Antoine Hospital, 184, rue du Faubourg Saint-Antoine, 75012, Paris, France.
Terrier B; Department of Internal Medicine, National Reference Center for Rare Systemic Autoimmune Diseases, AP-HP, APHP-CUP, Hôpital Cochin, 75014, Paris, France.; Université de Paris, INSERM, U970, PARCC, 75015, Paris, France.
Sellam J; Sorbonne Université, INSERM UMR 938, Centre de Recherche Saint-Antoine, Hôpital Saint-Antoine, AP-HP, Paris, France. .; Rheumatology Department, AP-HP Saint-Antoine Hospital, 184, rue du Faubourg Saint-Antoine, 75012, Paris, France. .
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Źródło :
Scientific reports [Sci Rep] 2021 Jun 04; Vol. 11 (1), pp. 11886. Date of Electronic Publication: 2021 Jun 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetylcholine/*immunology
COVID-19/*immunology
Inflammation/*immunology
SARS-CoV-2/*immunology
alpha7 Nicotinic Acetylcholine Receptor/*immunology
Adult ; Aged ; COVID-19/genetics ; Down-Regulation ; Female ; Humans ; Inflammation/genetics ; Male ; Middle Aged ; alpha7 Nicotinic Acetylcholine Receptor/genetics
Czasopismo naukowe
Tytuł :
Aβ1-16 controls synaptic vesicle pools at excitatory synapses via cholinergic modulation of synapsin phosphorylation.
Autorzy :
Anni D; Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Weiss EM; Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Guhathakurta D; Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Akdas YE; Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Klueva J; RG Presynaptic Plasticity, Leibniz Institute for Neurobiology, Magdeburg, Germany.
Zeitler S; Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Andres-Alonso M; RG Presynaptic Plasticity, Leibniz Institute for Neurobiology, Magdeburg, Germany.
Huth T; Institute of Physiology and Pathophysiology, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Fejtova A; Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany. .; RG Presynaptic Plasticity, Leibniz Institute for Neurobiology, Magdeburg, Germany. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Jun; Vol. 78 (11), pp. 4973-4992. Date of Electronic Publication: 2021 Apr 17.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid beta-Peptides/*pharmacology
Peptide Fragments/*pharmacology
Synapses/*metabolism
Synapsins/*metabolism
Synaptic Vesicles/*drug effects
alpha7 Nicotinic Acetylcholine Receptor/*metabolism
Animals ; Calcium/metabolism ; Excitatory Postsynaptic Potentials/drug effects ; Female ; Humans ; Mice ; Mice, Knockout ; Neurons/cytology ; Neurons/drug effects ; Neurons/metabolism ; Neurotransmitter Agents/metabolism ; Nicotine/pharmacology ; Phosphorylation/drug effects ; Rats ; Rats, Sprague-Dawley ; Synaptic Vesicles/physiology ; alpha7 Nicotinic Acetylcholine Receptor/deficiency ; alpha7 Nicotinic Acetylcholine Receptor/genetics
Czasopismo naukowe
Tytuł :
Increased cholinergic activity under conditions of low estrogen leads to adverse cardiac remodeling.
Autorzy :
Teixeira VP; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Miranda K; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Scalzo S; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Rocha-Resende C; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Silva MM; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Tezini GCSV; Ribeirão Preto Medical School, Universidade de São Paulo, Riberão Preto, São Paulo, Brazil.
Melo MB; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Souza-Neto FP; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Silva KSC; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Jesus ICG; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Santos AK; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
de Oliveira M; Ribeirão Preto Medical School, Universidade de São Paulo, Riberão Preto, São Paulo, Brazil.
Szawka RE; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Salgado HC; Ribeirão Preto Medical School, Universidade de São Paulo, Riberão Preto, São Paulo, Brazil.
Prado MAM; Robarts Research Institute, Department of Physiology and Pharmacology and Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada.
Poletini MO; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Guatimosim S; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2021 Apr 01; Vol. 320 (4), pp. C602-C612. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ventricular Function, Left*/drug effects
Ventricular Remodeling*/drug effects
Acetylcholine/*metabolism
Cholinergic Fibers/*metabolism
Estrogens/*deficiency
Heart/*innervation
Hypertrophy, Left Ventricular/*metabolism
Myocytes, Cardiac/*metabolism
Ventricular Dysfunction, Left/*metabolism
Vesicular Acetylcholine Transport Proteins/*metabolism
Animals ; Estradiol/pharmacology ; Estrogen Replacement Therapy ; Female ; Heart Rate ; Hypertrophy, Left Ventricular/pathology ; Hypertrophy, Left Ventricular/physiopathology ; Hypertrophy, Left Ventricular/prevention & control ; Mice, Inbred C57BL ; Mice, Transgenic ; Myocardial Contraction ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/pathology ; Ovariectomy ; Signal Transduction ; Ventricular Dysfunction, Left/pathology ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Dysfunction, Left/prevention & control ; Vesicular Acetylcholine Transport Proteins/genetics
Czasopismo naukowe
Tytuł :
Engineered Conotoxin Differentially Blocks and Discriminates Rat and Human α7 Nicotinic Acetylcholine Receptors.
Autorzy :
Wang S; Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China.
Zhu X; Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China.; Medical School, Guangxi University, Nanning 530004, China.
Zhangsun M; Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China.
Wu Y; Medical School, Guangxi University, Nanning 530004, China.
Yu J; Medical School, Guangxi University, Nanning 530004, China.
Harvey PJ; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia.
Kaas Q; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia.
Zhangsun D; Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China.; Medical School, Guangxi University, Nanning 530004, China.
Craik DJ; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia.
Luo S; Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China.; Medical School, Guangxi University, Nanning 530004, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 May 13; Vol. 64 (9), pp. 5620-5631. Date of Electronic Publication: 2021 Apr 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Conotoxins/*chemistry
alpha7 Nicotinic Acetylcholine Receptor/*metabolism
Amino Acid Sequence ; Animals ; Binding Sites ; Conotoxins/chemical synthesis ; Conotoxins/metabolism ; Humans ; Inhibitory Concentration 50 ; Isomerism ; Ligands ; Molecular Dynamics Simulation ; Mutagenesis ; Oocytes/metabolism ; Rats ; Sequence Alignment ; Species Specificity ; Xenopus/metabolism ; alpha7 Nicotinic Acetylcholine Receptor/antagonists & inhibitors ; alpha7 Nicotinic Acetylcholine Receptor/genetics
Czasopismo naukowe
Tytuł :
Cholinergic Modulation of Neuroinflammation: Focus on α7 Nicotinic Receptor.
Autorzy :
Piovesana R; Département de Neurosciences, Université de Montréal, Montréal, QC H3C 3J7, Canada.; Groupe de Recherche sur le Système Nerveux Central, Université de Montréal, Montréal, QC H3C 3J7, Canada.
Salazar Intriago MS; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza, University of Rome, 00185 Rome, Italy.
Dini L; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza, University of Rome, 00185 Rome, Italy.
Tata AM; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza, University of Rome, 00185 Rome, Italy.; Research Centre of Neurobiology 'Daniel Bovet', Sapienza, University of Rome, 00185 Rome, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 06; Vol. 22 (9). Date of Electronic Publication: 2021 May 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Brain/*pathology
Cholinergic Agents/*metabolism
Inflammation/*metabolism
Inflammation/*pathology
alpha7 Nicotinic Acetylcholine Receptor/*metabolism
Animals ; Humans ; Neuroglia/metabolism ; Neuroglia/pathology ; Signal Transduction ; alpha7 Nicotinic Acetylcholine Receptor/chemistry
Czasopismo naukowe
Tytuł :
Nicotine facilitates pancreatic fibrosis by promoting activation of pancreatic stellate cells via α7nAChR-mediated JAK2/STAT3 signaling pathway in rats.
Autorzy :
Li Z; Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Lu D; Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Jin T; Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Liu X; Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Hao J; Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Oct 01; Vol. 349, pp. 84-91. Date of Electronic Publication: 2021 Jun 18.
Typ publikacji :
Journal Article
MeSH Terms :
Janus Kinase 2/*metabolism
Nicotine/*toxicity
Nicotinic Agonists/*toxicity
Pancreatic Stellate Cells/*drug effects
Pancreatitis, Chronic/*chemically induced
STAT3 Transcription Factor/*metabolism
alpha7 Nicotinic Acetylcholine Receptor/*agonists
Animals ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Extracellular Matrix/drug effects ; Extracellular Matrix/metabolism ; Extracellular Matrix/pathology ; Fibrosis ; Male ; Pancreatic Stellate Cells/enzymology ; Pancreatic Stellate Cells/pathology ; Pancreatitis, Chronic/enzymology ; Pancreatitis, Chronic/pathology ; Rats, Wistar ; Signal Transduction ; alpha7 Nicotinic Acetylcholine Receptor/metabolism
Czasopismo naukowe
Tytuł :
Expression levels of the α7 nicotinic acetylcholine receptor in the brains of patients with Alzheimer's disease and their effect on synaptic proteins in SH-SY5Y cells.
Autorzy :
Ren JM; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China.
Zhang SL; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China.
Wang XL; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China.
Guan ZZ; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China.
Qi XL; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2020 Sep; Vol. 22 (3), pp. 2063-2075. Date of Electronic Publication: 2020 Jun 18.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*metabolism
Amyloid beta-Peptides/*metabolism
Brain/*metabolism
alpha7 Nicotinic Acetylcholine Receptor/*genetics
alpha7 Nicotinic Acetylcholine Receptor/*metabolism
Acetylcholine/metabolism ; Acetylcholinesterase/metabolism ; Aged ; Aged, 80 and over ; Alzheimer Disease/genetics ; Case-Control Studies ; Disks Large Homolog 4 Protein/genetics ; Disks Large Homolog 4 Protein/metabolism ; Female ; Humans ; Male ; Synaptophysin/genetics ; Synaptophysin/metabolism ; Synaptosomal-Associated Protein 25/genetics ; Synaptosomal-Associated Protein 25/metabolism ; Up-Regulation
Czasopismo naukowe

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