Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""adenosine"" wg kryterium: Temat


Tytuł :
A Fluorescence Sensor Array Based on Zinc(II)-Carboxyamidoquinolines: Toward Quantitative Detection of ATP*.
Autorzy :
Pushina M; Department of Chemistry, Bowling Green State University, Bowling Green, OH, 43403, USA.
Farshbaf S; Department of Chemistry, Bowling Green State University, Bowling Green, OH, 43403, USA.
Mochida W; Department of Applied Chemistry, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan University, Tokyo, 192-0397, Japan.
Kanakubo M; Department of Applied Chemistry, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan University, Tokyo, 192-0397, Japan.
Nishiyabu R; Department of Applied Chemistry, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan University, Tokyo, 192-0397, Japan.
Kubo Y; Department of Applied Chemistry, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan University, Tokyo, 192-0397, Japan.
Anzenbacher P Jr; Department of Chemistry, Bowling Green State University, Bowling Green, OH, 43403, USA.
Pokaż więcej
Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Aug 05; Vol. 27 (44), pp. 11344-11351. Date of Electronic Publication: 2021 Jun 29.
Typ publikacji :
Journal Article
MeSH Terms :
Adenosine Triphosphate*
Zinc*
Adenosine Diphosphate ; Adenosine Monophosphate ; Fluorescence ; Magnetic Resonance Spectroscopy ; Spectrometry, Fluorescence
Czasopismo naukowe
Tytuł :
Improved in vivo PET imaging of the adenosine A 2A receptor in the brain using [ F]FLUDA, a deuterated radiotracer with high metabolic stability.
Autorzy :
Lai TH; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany. .; Department of Research and Development, ROTOP Pharmaka Ltd., Dresden, Germany. .
Toussaint M; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany. .
Teodoro R; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany.
Dukić-Stefanović S; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany.
Gündel D; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany.
Ludwig FA; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany.
Wenzel B; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany.
Schröder S; Department of Research and Development, ROTOP Pharmaka Ltd., Dresden, Germany.
Sattler B; Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
Moldovan RP; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany.
Falkenburger BH; Department of Neurology, Dresden University Medical Center, Dresden, Germany.
Sabri O; Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
Deuther-Conrad W; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany.
Brust P; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany.
Pokaż więcej
Źródło :
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2021 Aug; Vol. 48 (9), pp. 2727-2736. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Positron-Emission Tomography*
Receptor, Adenosine A2A*/metabolism
Adenosine ; Animals ; Brain/diagnostic imaging ; Brain/metabolism ; Fluorine Radioisotopes ; Mice ; Radiopharmaceuticals ; Rats ; Swine
Czasopismo naukowe
Tytuł :
RNA modification of an RNA modifier prevents self-RNA sensing.
Autorzy :
Snider DL; Department of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, North Carolina, United States of America.
Horner SM; Department of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, North Carolina, United States of America.; Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America.
Pokaż więcej
Źródło :
PLoS biology [PLoS Biol] 2021 Jul 30; Vol. 19 (7), pp. e3001342. Date of Electronic Publication: 2021 Jul 30 (Print Publication: 2021).
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Adenosine Deaminase*/genetics
Adenosine Deaminase*/metabolism
RNA, Double-Stranded*/genetics
Adenosine ; Interferons/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
Insilico analysis of marine indole alkaloids for design of adenosine A2A receptor antagonist.
Autorzy :
Lonikar N; Channabasweshwar Pharmacy College(Degree), Latur, India.; Department of Pharmaceutical Chemistry, Shivlingeshwar College of Pharmacy, Almala, India.
Choudhari P; Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Kolhapur, India.
Bhusnuare O; Channabasweshwar Pharmacy College(Degree), Latur, India.
Pokaż więcej
Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2021 Jul; Vol. 39 (10), pp. 3515-3522. Date of Electronic Publication: 2020 Jun 04.
Typ publikacji :
Journal Article
MeSH Terms :
Adenosine A2 Receptor Antagonists*
Parkinson Disease*
Aged ; Humans ; Indole Alkaloids ; Purinergic P1 Receptor Antagonists ; Receptor, Adenosine A2A
Czasopismo naukowe
Tytuł :
Characterization of polyphosphate kinases for the synthesis of GSH with ATP regeneration from AMP.
Autorzy :
Cui C; Department of Biopharmaceutical Sciences, School of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003, PR China. Electronic address: .
Kong M; Department of Biopharmaceutical Sciences, School of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003, PR China.
Wang Y; Department of Biopharmaceutical Sciences, School of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003, PR China.
Zhou C; Department of Biopharmaceutical Sciences, School of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003, PR China.
Ming H; Department of Biopharmaceutical Sciences, School of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003, PR China. Electronic address: .
Pokaż więcej
Źródło :
Enzyme and microbial technology [Enzyme Microb Technol] 2021 Sep; Vol. 149, pp. 109853. Date of Electronic Publication: 2021 Jun 12.
Typ publikacji :
Journal Article
MeSH Terms :
Adenosine Triphosphate*
Polyphosphates*
Adenosine Monophosphate ; Glutathione ; Phosphotransferases (Phosphate Group Acceptor) ; Regeneration
Czasopismo naukowe
Tytuł :
Convergence of adenosine and GABA signaling for synapse stabilization during development.
Autorzy :
Gomez-Castro F; INSERM UMR-S 1270, Sorbonne Université, Institut du Fer à Moulin, Paris, France.
Zappettini S; Aix Marseille Université, INSERM, INS, Institut de Neurosciences des Systèmes, Marseille, France.
Pressey JC; INSERM UMR-S 1270, Sorbonne Université, Institut du Fer à Moulin, Paris, France.; Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada.
Silva CG; Aix Marseille Université, INSERM, INS, Institut de Neurosciences des Systèmes, Marseille, France.; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Russeau M; INSERM UMR-S 1270, Sorbonne Université, Institut du Fer à Moulin, Paris, France.
Gervasi N; INSERM UMR-S 1270, Sorbonne Université, Institut du Fer à Moulin, Paris, France.; Center for Interdisciplinary Research in Biology, College de France, INSERM U1050, CNRS UMR7241, Labex Memolife, Paris, France.
Figueiredo M; Institute of Pharmacology and Toxicology, University of Zürich, 8057 Zürich, Switzerland.
Montmasson C; INSERM UMR-S 1270, Sorbonne Université, Institut du Fer à Moulin, Paris, France.
Renner M; INSERM UMR-S 1270, Sorbonne Université, Institut du Fer à Moulin, Paris, France.
Canas PM; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Gonçalves FQ; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Alçada-Morais S; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Szabó E; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Rodrigues RJ; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Agostinho P; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.; Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, Portugal.
Tomé AR; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.; Department of Life Sciences, University of Coimbra, 3000-456 Coimbra, Portugal.
Caillol G; Aix Marseille Université, CNRS, INP UMR7051, NeuroCyto, Marseille, France.
Thoumine O; Université Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, Bordeaux, France.
Nicol X; Sorbonne Université, Inserm, CNRS, Institut de la Vision, Paris, France.
Leterrier C; Aix Marseille Université, CNRS, INP UMR7051, NeuroCyto, Marseille, France.
Lujan R; Synaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario, 02008 Albacete, Spain.
Tyagarajan SK; Institute of Pharmacology and Toxicology, University of Zürich, 8057 Zürich, Switzerland.
Cunha RA; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.; Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, Portugal.
Esclapez M; Aix Marseille Université, INSERM, INS, Institut de Neurosciences des Systèmes, Marseille, France.
Bernard C; Aix Marseille Université, INSERM, INS, Institut de Neurosciences des Systèmes, Marseille, France.
Lévi S; INSERM UMR-S 1270, Sorbonne Université, Institut du Fer à Moulin, Paris, France.
Pokaż więcej
Źródło :
Science (New York, N.Y.) [Science] 2021 Nov 05; Vol. 374 (6568), pp. eabk2055. Date of Electronic Publication: 2021 Nov 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
Adenosine/*metabolism
Hippocampus/*growth & development
Neurons/*physiology
Receptor, Adenosine A2A/*metabolism
Synapses/*physiology
gamma-Aminobutyric Acid/*metabolism
Adenosine A2 Receptor Antagonists ; Adenosine Triphosphate/metabolism ; Animals ; Calcium/metabolism ; Cognition ; Cyclic AMP/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Hippocampus/metabolism ; Male ; Membrane Proteins/metabolism ; Mice ; Nerve Tissue Proteins ; Phosphorylation ; Receptor, Adenosine A2A/genetics ; Receptors, GABA-A/metabolism
Czasopismo naukowe
Tytuł :
Binding Characterization of Agonists and Antagonists by MCCS: A Case Study from Adenosine A 2A Receptor.
Autorzy :
Cheng J; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, and National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.; Department of Pharmacy, Jiangsu Vocational College of Medicine, Yancheng, Jiangsu 224005, China.
Chen M; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, and National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.
Wang S; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, and National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.
Liang T; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, and National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.
Chen H; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, and National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.
Chen CJ; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, and National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.
Feng Z; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, and National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.
Xie XQ; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, and National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.
Pokaż więcej
Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 May 05; Vol. 12 (9), pp. 1606-1620. Date of Electronic Publication: 2021 Apr 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine A2 Receptor Antagonists*/pharmacology
Receptor, Adenosine A2A*/metabolism
Adenosine ; Adenosine A2 Receptor Agonists/pharmacology ; Ligands ; Protein Binding
Czasopismo naukowe
Tytuł :
The role of the phosphate groups of trinitrophenyl adenosine 5'-triphosphate (TNP-ATP) in allosteric activation of pyruvate carboxylase and the inhibition of acetyl CoA-dependent activation.
Autorzy :
Rattanapornsompong K; Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand.
Sirithanakorn C; Faculty of Medicine, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand; Department of Microbiology, University of Illinois, Urbana, IL, 61801, USA.
Jitrapakdee S; Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand. Electronic address: .
Attwood PV; School of Molecular Sciences, The University of Western Australia, 35 Stirling Highway, Perth, WA, 6009, Australia. Electronic address: .
Pokaż więcej
Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2021 Oct 30; Vol. 711, pp. 109017. Date of Electronic Publication: 2021 Aug 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetyl Coenzyme A/*chemistry
Adenosine Triphosphate/*analogs & derivatives
Allosteric Regulation/*drug effects
Enzyme Activators/*chemistry
Pyruvate Carboxylase/*chemistry
Adenosine Diphosphate/analogs & derivatives ; Adenosine Diphosphate/chemistry ; Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/chemistry ; Adenosine Triphosphate/chemistry ; Animals ; Chickens ; Enzyme Assays ; Kinetics ; Liver/enzymology ; Molecular Structure
Czasopismo naukowe
Tytuł :
CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression.
Autorzy :
Schneider E; Department of Immunology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Winzer R; Department of Immunology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany. .
Rissiek A; Department of Immunology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Ricklefs I; Division of Pediatric Pneumology & Allergology, University Medical Center Schleswig-Holstein, 23538, Lübeck, Germany.; Airway Research Center North, Member of the German Center for Lung Research, Lübeck, Germany.
Meyer-Schwesinger C; Department of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Ricklefs FL; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Bauche A; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Behrends J; Core Facility Fluorescence Cytometry, Research Center Borstel, 23845, Borstel, Germany.
Reimer R; Technology Platform Microscopy and Image Analysis, Heinrich Pette Institute/Leibniz Institute for Experimental Virology, 20251, Hamburg, Germany.
Brenna S; Department of Neurology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Wasielewski H; Department of Immunology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Lauten M; Department of Pediatrics and Adolescent Medicine, University of Lübeck, 23538, Lübeck, Germany.
Rissiek B; Department of Neurology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Puig B; Department of Neurology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Cortesi F; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Magnus T; Department of Neurology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Fliegert R; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Müller CE; Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, 53121, Bonn, Germany.
Gagliani N; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.; Immunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital, Stockholm, Sweden.
Tolosa E; Department of Immunology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2021 Oct 08; Vol. 12 (1), pp. 5911. Date of Electronic Publication: 2021 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunosuppression*
5'-Nucleotidase/*metabolism
Adenosine/*metabolism
CD8-Positive T-Lymphocytes/*metabolism
Extracellular Vesicles/*metabolism
GPI-Linked Proteins/*metabolism
5'-Nucleotidase/genetics ; Adenosine Triphosphate ; Animals ; Autoimmunity ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Proliferation ; Extracellular Vesicles/immunology ; Humans ; Inflammation ; Lymphocyte Activation ; Mice ; T-Lymphocytes ; T-Lymphocytes, Regulatory/immunology
Czasopismo naukowe
Tytuł :
CD39-mediated ATP-adenosine signalling promotes hepatic stellate cell activation and alcoholic liver disease.
Autorzy :
Shuai C; Institute for Liver Diseases of Anhui Medical University, Hefei, China; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, China.
Xia GQ; Institute for Liver Diseases of Anhui Medical University, Hefei, China; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, China.
Yuan F; Institute for Liver Diseases of Anhui Medical University, Hefei, China; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, China.
Wang S; Department of Pharmacy, Yijishan Affiliated Hospital of Wannan Medical College, Wuhu, 241001, Anhui Province, China.
Lv XW; Institute for Liver Diseases of Anhui Medical University, Hefei, China; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, China. Electronic address: .
Pokaż więcej
Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 Aug 15; Vol. 905, pp. 174198. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article
MeSH Terms :
Adenosine/*metabolism
Adenosine Triphosphate/*metabolism
Antigens, CD/*metabolism
Apyrase/*metabolism
Hepatic Stellate Cells/*metabolism
Liver Diseases, Alcoholic/*etiology
Liver Diseases, Alcoholic/*metabolism
Signal Transduction/*drug effects
5'-Nucleotidase/genetics ; 5'-Nucleotidase/metabolism ; Acetaldehyde/toxicity ; Animals ; Antigens, CD/genetics ; Apyrase/antagonists & inhibitors ; Apyrase/genetics ; Carbon Tetrachloride/toxicity ; Colchicine/pharmacology ; Cytokines/metabolism ; Disease Models, Animal ; Ethanol/toxicity ; Gene Knockdown Techniques ; Humans ; Liver Diseases, Alcoholic/pathology ; Mice, Inbred C57BL ; Primary Cell Culture ; Rats ; Receptor, Adenosine A2A/metabolism ; Receptor, Adenosine A2B/metabolism ; Smad3 Protein/metabolism ; Transforming Growth Factor beta/metabolism ; Tungsten Compounds/pharmacology
Czasopismo naukowe
Tytuł :
Discovery of novel dual adenosine A1/A2A receptor antagonists using deep learning, pharmacophore modeling and molecular docking.
Autorzy :
Wang M; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
Hou S; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
Wei Y; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
Li D; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
Lin J; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.; Biodesign Center, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.; Platform of Pharmaceutical Intelligence, Tianjin International Joint Academy of Biomedicine, Tianjin, China.
Pokaż więcej
Źródło :
PLoS computational biology [PLoS Comput Biol] 2021 Mar 19; Vol. 17 (3), pp. e1008821. Date of Electronic Publication: 2021 Mar 19 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine A1 Receptor Antagonists*
Adenosine A2 Receptor Antagonists*
Deep Learning*
Drug Discovery/*methods
Humans ; Molecular Docking Simulation ; Parkinson Disease ; Protein Binding ; Receptor, Adenosine A2A/chemistry ; Receptor, Adenosine A2A/genetics ; Receptor, Adenosine A2A/metabolism
Czasopismo naukowe
Tytuł :
Cellular Uptake and Intracellular Phosphorylation of GS-441524: Implications for Its Effectiveness against COVID-19.
Autorzy :
Rasmussen HB; Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, DK-4000 Roskilde, Denmark.; Department of Science and Environment, Roskilde University Center, DK-4000 Roskilde, Denmark.
Jürgens G; Clinical Pharmacology Unit, Zealand University Hospital, DK-4000 Roskilde, Denmark.
Thomsen R; Section of Forensic Chemistry, Department of Forensic Medicine, Faculty of Health Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark.
Taboureau O; INSERM U1133, CNRS UMR 8251, Université de Paris, F-75013 Paris, France.
Zeth K; Department of Science and Environment, Roskilde University Center, DK-4000 Roskilde, Denmark.
Hansen PE; Department of Science and Environment, Roskilde University Center, DK-4000 Roskilde, Denmark.
Hansen PR; Department of Cardiology, Herlev and Gentofte Hospital, DK-2900 Hellerup, Denmark.
Pokaż więcej
Źródło :
Viruses [Viruses] 2021 Jul 14; Vol. 13 (7). Date of Electronic Publication: 2021 Jul 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Adenosine/*analogs & derivatives
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
SARS-CoV-2/*drug effects
Adenosine/pharmacokinetics ; Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/pharmacology ; Alanine/analogs & derivatives ; Alanine/pharmacology ; Animals ; Humans ; Phosphorylation ; Prodrugs
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Activation of central adenosine A2B receptors mediate brain ghrelin-induced improvement of intestinal barrier function through the vagus nerve in rats.
Autorzy :
Ishioh M; Division of Metabolism, Systemic Bioscience, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Japan; Department of General Medicine, Asahikawa Medical University, Japan.
Nozu T; Department of Regional Medicine and Education, Asahikawa Medical University, Japan.
Igarashi S; Division of Metabolism, Systemic Bioscience, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Japan.
Tanabe H; Division of Metabolism, Systemic Bioscience, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Japan.
Kumei S; Department of General Medicine, Asahikawa Medical University, Japan.
Ohhira M; Department of General Medicine, Asahikawa Medical University, Japan.
Takakusaki K; Division of Neuroscience, Department of Physiology, Asahikawa Medical University, Japan.
Okumura T; Division of Metabolism, Systemic Bioscience, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Japan; Department of General Medicine, Asahikawa Medical University, Japan. Electronic address: .
Pokaż więcej
Źródło :
Experimental neurology [Exp Neurol] 2021 Jul; Vol. 341, pp. 113708. Date of Electronic Publication: 2021 Mar 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*metabolism
Ghrelin/*metabolism
Intestinal Mucosa/*metabolism
Receptor, Adenosine A2B/*metabolism
Vagus Nerve/*metabolism
Adenosine A2 Receptor Agonists/administration & dosage ; Adenosine A2 Receptor Antagonists/administration & dosage ; Animals ; Brain/drug effects ; Ghrelin/administration & dosage ; Humans ; Injections, Subcutaneous ; Intestinal Mucosa/drug effects ; Male ; Permeability/drug effects ; Rats ; Rats, Sprague-Dawley ; Vagus Nerve/drug effects
Czasopismo naukowe
Tytuł :
Sequence and functional differences in the ATPase domains of CHD3 and SNF2H promise potential for selective regulability and drugability.
Autorzy :
Hoffmeister H; Department of Biochemistry, Genetics and Microbiology, Biochemistry III, University of Regensburg, Germany.
Fuchs A; Department of Biochemistry, Genetics and Microbiology, Biochemistry III, University of Regensburg, Germany.
Komives E; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.
Groebner-Ferreira R; Department of Biochemistry, Genetics and Microbiology, Biochemistry III, University of Regensburg, Germany.
Strobl L; Department of Biochemistry, Genetics and Microbiology, Biochemistry III, University of Regensburg, Germany.
Nazet J; Department of Biochemistry II, University of Regensburg, Germany.
Heizinger L; Department of Biochemistry II, University of Regensburg, Germany.
Merkl R; Department of Biochemistry II, University of Regensburg, Germany.
Dove S; Department of Pharmaceutical and Medical Chemistry II, University of Regensburg, Germany.
Längst G; Department of Biochemistry, Genetics and Microbiology, Biochemistry III, University of Regensburg, Germany.
Pokaż więcej
Źródło :
The FEBS journal [FEBS J] 2021 Jul; Vol. 288 (13), pp. 4000-4023. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine Triphosphatases/*metabolism
Adenosine Triphosphate/*metabolism
Chromosomal Proteins, Non-Histone/*metabolism
DNA Helicases/*metabolism
Mi-2 Nucleosome Remodeling and Deacetylase Complex/*metabolism
Adenosine Diphosphate/metabolism ; Adenosine Triphosphatases/chemistry ; Adenosine Triphosphatases/genetics ; Amino Acid Sequence ; Binding, Competitive ; Chromatin/genetics ; Chromatin/metabolism ; Chromatin Assembly and Disassembly ; Chromosomal Proteins, Non-Histone/chemistry ; Chromosomal Proteins, Non-Histone/genetics ; DNA Helicases/chemistry ; DNA Helicases/genetics ; Humans ; Hydrolysis ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/chemistry ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/genetics ; Mutation ; Nucleosomes/genetics ; Nucleosomes/metabolism ; Protein Binding ; Protein Domains ; Sequence Homology, Amino Acid ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Adenosine A 2A Receptor Occupancy by Long-Term Istradefylline Administration in Parkinson's Disease.
Autorzy :
Ishibashi K; Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.; Department of Neurology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Miura Y; Department of Neurology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Wagatsuma K; Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Toyohara J; Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Ishiwata K; Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.; Institute of Cyclotron and Drug Discovery Research, Southern Tohoku Research Institute for Neuroscience, Koriyama, Japan.; Department of Biofunctional Imaging, Fukushima Medical University, Fukushima, Japan.
Ishii K; Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Pokaż więcej
Źródło :
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2021 Jan; Vol. 36 (1), pp. 268-269. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Parkinson Disease*/drug therapy
Receptor, Adenosine A2A*
Adenosine ; Adenosine A2 Receptor Antagonists ; Antiparkinson Agents ; Humans ; Purines
Raport
Tytuł :
Sepsis expands a CD39 plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity.
Autorzy :
Nascimento DC; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil; Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil; CNRS, UMR7355, Orleans, 45071, France. Electronic address: .
Viacava PR; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil; Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil.
Ferreira RG; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil; Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil.
Damaceno MA; Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil.
Piñeros AR; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil; Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil.
Melo PH; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil; Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil.
Donate PB; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil; Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil.
Toller-Kawahisa JE; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil; Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil.
Zoppi D; Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil.
Veras FP; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil; Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil.
Peres RS; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil; Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil.
Menezes-Silva L; Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil.
Caetité D; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil; Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil.
Oliveira AER; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil.
Castro ÍMS; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil.
Kauffenstein G; UMR INSERM 1260, Regenerative NanoMedicine, University of Strasbourg, Strasbourg 60026, France.
Nakaya HI; Hospital Israelita Albert Einstein, São Paulo, 05620-900, Brazil.
Borges MC; Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil.
Zamboni DS; Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil; Department of Cell Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil.
Fonseca DM; Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil.
Paschoal JAR; Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil.
Cunha TM; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil; Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil.
Quesniaux V; CNRS, UMR7355, Orleans, 45071, France; Experimental and Molecular Immunology and Neurogenetics, University of Orleans, Orleans 45071, France.
Linden J; Division of Nephrology, Center for Immunity, Inflammation and Regenerative Medicine University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
Cunha FQ; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil; Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil.
Ryffel B; CNRS, UMR7355, Orleans, 45071, France; Experimental and Molecular Immunology and Neurogenetics, University of Orleans, Orleans 45071, France.
Alves-Filho JC; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil; Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil. Electronic address: .
Pokaż więcej
Źródło :
Immunity [Immunity] 2021 Sep 14; Vol. 54 (9), pp. 2024-2041.e8. Date of Electronic Publication: 2021 Sep 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine/*immunology
Antigens, CD/*immunology
Apyrase/*immunology
Immune Tolerance/*immunology
Macrophages/*immunology
Plasma Cells/*immunology
Sepsis/*immunology
Adenosine/metabolism ; Animals ; Antigens, CD/metabolism ; Apyrase/metabolism ; Cellular Reprogramming/immunology ; Macrophages/metabolism ; Mice ; Plasma Cells/metabolism ; Receptor, Adenosine A2A/immunology ; Receptor, Adenosine A2A/metabolism ; Sepsis/metabolism
Czasopismo naukowe
Tytuł :
A 2A Adenosine Receptor as a Potential Biomarker and a Possible Therapeutic Target in Alzheimer's Disease.
Autorzy :
Gessi S; Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Poloni TE; Department of Neurology & Neuropathology, Golgi-Cenci Foundation, 20081 Abbiategrasso, Italy.
Negro G; Department of Neurology & Neuropathology, Golgi-Cenci Foundation, 20081 Abbiategrasso, Italy.; Department of Neurology, School of Medicine and Surgery, University of Milano-Bicocca, 20126 Monza, Italy.
Varani K; Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Pasquini S; Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Vincenzi F; Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Borea PA; Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Merighi S; Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Pokaż więcej
Źródło :
Cells [Cells] 2021 Sep 07; Vol. 10 (9). Date of Electronic Publication: 2021 Sep 07.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alzheimer Disease/*genetics
Receptor, Adenosine A2A/*physiology
Adenosine/metabolism ; Alzheimer Disease/metabolism ; Alzheimer Disease/therapy ; Biomarkers/metabolism ; Brain/metabolism ; Cerebral Cortex/metabolism ; Entorhinal Cortex/metabolism ; Glutamic Acid/metabolism ; Hippocampus/metabolism ; Humans ; Neuronal Plasticity/physiology ; Receptor, Adenosine A2A/genetics ; Receptor, Adenosine A2A/metabolism ; Receptors, N-Methyl-D-Aspartate
Czasopismo naukowe
Tytuł :
Adenosine Triggers Larval Settlement and Metamorphosis in the Mussel Mytilopsis sallei through the ADK-AMPK-FoxO Pathway.
Autorzy :
He J; State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, China.; Key Laboratory of Marine Environmental Corrosion and Bio-Fouling, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
Wu Z; State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, China.
Chen L; State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, China.
Dai Q; State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, China.
Hao H; State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, China.
Su P; State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, China.
Ke C; State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, China.; State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361102, China.
Feng D; State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, China.
Pokaż więcej
Źródło :
ACS chemical biology [ACS Chem Biol] 2021 Aug 20; Vol. 16 (8), pp. 1390-1400. Date of Electronic Publication: 2021 Jul 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine/*analogs & derivatives
Adenosine/*pharmacology
Bivalvia/*drug effects
Larva/*drug effects
Metamorphosis, Biological/*drug effects
Signal Transduction/*drug effects
AMP-Activated Protein Kinases/metabolism ; Adenosine/metabolism ; Adenosine Kinase/metabolism ; Amino Acid Sequence ; Animals ; Forkhead Transcription Factors/metabolism ; Photoaffinity Labels/metabolism ; Photoaffinity Labels/pharmacology ; Transcriptome/drug effects
Czasopismo naukowe
Tytuł :
Identification of V6.51L as a selectivity hotspot in stereoselective A 2B adenosine receptor antagonist recognition.
Autorzy :
Wang X; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.
Jespers W; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.; Department of Cell and Molecular Biology and Science for Life Laboratory, Uppsala University, Box 596, 751 24, Biomedical CenterUppsala, Sweden.
Prieto-Díaz R; Centro Singular de Investigación en Química Biolóxica Y Materiais Moleculares (CIQUS), Santiago de Compostela, Spain.; Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Majellaro M; Centro Singular de Investigación en Química Biolóxica Y Materiais Moleculares (CIQUS), Santiago de Compostela, Spain.; Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
IJzerman AP; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.
van Westen GJP; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.
Sotelo E; Centro Singular de Investigación en Química Biolóxica Y Materiais Moleculares (CIQUS), Santiago de Compostela, Spain. .; Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain. .
Heitman LH; Department of Cell and Molecular Biology and Science for Life Laboratory, Uppsala University, Box 596, 751 24, Biomedical CenterUppsala, Sweden. .; Oncode Institute, Leiden, The Netherlands. .
Gutiérrez-de-Terán H; Department of Cell and Molecular Biology and Science for Life Laboratory, Uppsala University, Box 596, 751 24, Biomedical CenterUppsala, Sweden. .
Pokaż więcej
Źródło :
Scientific reports [Sci Rep] 2021 Jul 08; Vol. 11 (1), pp. 14171. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Substitution*
Purinergic P1 Receptor Antagonists/*pharmacology
Receptor, Adenosine A2B/*chemistry
Receptor, Adenosine A2B/*metabolism
Amino Acid Sequence ; Chromatography, High Pressure Liquid ; HEK293 Cells ; Humans ; Ligands ; Models, Molecular ; Receptor, Adenosine A2A/chemistry ; Receptor, Adenosine A2A/metabolism ; Stereoisomerism ; Thermodynamics
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies