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Wyświetlanie 1-20 z 89523
Tytuł:
Magnetic resonance imaging-based approaches for detecting the efficacy of combining therapy following VEGFR-2 and PD-1 blockade in a colon cancer model.
Autorzy:
Xu X; Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Ma M; Department of Radiology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, 510080, China.
Ye K; Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Zhang D; Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Chen X; Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Wu J; Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Mo X; Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Xiao Z; Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China. .; The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, Jinan University, Guangzhou, 510632, China. .
Shi C; Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China. .; The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, Jinan University, Guangzhou, 510632, China. .
Luo L; Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China. .; The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, Jinan University, Guangzhou, 510632, China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2024 Feb 23; Vol. 22 (1), pp. 198. Date of Electronic Publication: 2024 Feb 23.
Typ publikacji:
Journal Article
MeSH Terms:
Colonic Neoplasms*/diagnostic imaging
Colonic Neoplasms*/drug therapy
Programmed Cell Death 1 Receptor*/antagonists & inhibitors
Immune Checkpoint Inhibitors*/therapeutic use
Animals ; Humans ; Mice ; Diffusion Magnetic Resonance Imaging/methods ; Magnetic Resonance Imaging/methods ; Mice, Inbred C57BL ; Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An AMPK agonist suppresses the progress of colorectal cancer by regulating the polarization of TAM to M1 through inhibition of HIF-1α and mTOR signal pathway.
Autorzy:
Cao Y; Department of Laboratory Medicine, Hangzhou Cancer Hospital, Affiliated Hangzhou Cancer Hospital, Zhejiang University School of Medicine, Shangcheng, China.
Wo M; Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Zhejiang Center for Clinical Laboratory, Gongshu, China.
Xu C; Department of Laboratory Medicine, Affiliated Third Hospital of Zhejiang Traditional Chinese Medicine University, Xihu, Hangzhou, Zhejiang, China.
Fei X; Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Zhejiang Center for Clinical Laboratory, Gongshu, China.
Jin J; Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Zhejiang Center for Clinical Laboratory, Gongshu, China.
Shan Z; Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Zhejiang Center for Clinical Laboratory, Gongshu, China.
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Źródło:
Journal of cancer research and therapeutics [J Cancer Res Ther] 2023 Dec 01; Vol. 19 (6), pp. 1560-1567. Date of Electronic Publication: 2023 Dec 28.
Typ publikacji:
Journal Article
MeSH Terms:
Metformin*/pharmacology
Metformin*/therapeutic use
Signal Transduction*/drug effects
TOR Serine-Threonine Kinases*/antagonists & inhibitors
TOR Serine-Threonine Kinases*/metabolism
Colorectal Neoplasms*/drug therapy
Tumor-Associated Macrophages*/drug effects
Hypoxia-Inducible Factor 1, alpha Subunit/antagonists & inhibitors ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; HCT116 Cells ; Cell Polarity/drug effects ; THP-1 Cells ; AMP-Activated Protein Kinases/antagonists & inhibitors ; AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Gene Knockdown Techniques
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Formaldehyde regulates S -adenosylmethionine biosynthesis and one-carbon metabolism.
Autorzy:
Pham VN; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Bruemmer KJ; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Toh JDW; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Ge EJ; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Tenney L; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Ward CC; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Dingler FA; MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Millington CL; MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Garcia-Prieto CA; Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona, Spain.
Pulos-Holmes MC; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Ingolia NT; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Pontel LB; Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.; Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA), CONICET-Partner Institute of the Max Planck Society, Buenos Aires, Argentina.
Esteller M; Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.; Centro de Investigacion Biomedica en Red Cancer (CIBERONC), Calle Monforte de Lemos, Madrid, Spain.; Institucio Catalana de Recerca i Estudis Avançats (ICREA), Passeig de Lluis Companys, Barcelona, Spain.; Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona, Feixa Llarga, l'Hospitalet de Llobregat, Spain.
Patel KJ; MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Nomura DK; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.; Innovative Genomics Institute, Berkeley, CA 94704, USA.
Chang CJ; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Nov 03; Vol. 382 (6670), pp. eabp9201. Date of Electronic Publication: 2023 Nov 03.
Typ publikacji:
Journal Article
MeSH Terms:
Carbon*/metabolism
Epigenesis, Genetic*/drug effects
S-Adenosylmethionine*/antagonists & inhibitors
S-Adenosylmethionine*/metabolism
Formaldehyde*/metabolism
Formaldehyde*/toxicity
Methionine Adenosyltransferase*/antagonists & inhibitors
Methionine Adenosyltransferase*/genetics
Methionine Adenosyltransferase*/metabolism
Cysteine*/metabolism
Animals ; Mice ; Protein Isoforms/antagonists & inhibitors ; Protein Isoforms/metabolism ; Environmental Exposure ; Humans ; Hep G2 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Ethanolic Extract Propolis-Loaded Niosomes Diminish Phospholipase B1, Biofilm Formation, and Intracellular Replication of Cryptococcus neoformans in Macrophages.
Autorzy:
Kietrungruang K; Division of Clinical Microbiology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Sookkree S; Division of Clinical Microbiology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Sangboonruang S; Division of Clinical Microbiology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Semakul N; Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.
Poomanee W; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Kitidee K; Center for Research Innovation and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Salaya, Nakhon Pathom 73170, Thailand.
Tragoolpua Y; Natural Extracts and Innovative Products for Alternative Healthcare Research Group, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.; Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.
Tragoolpua K; Division of Clinical Microbiology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.; Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Aug 24; Vol. 28 (17). Date of Electronic Publication: 2023 Aug 24.
Typ publikacji:
Journal Article
MeSH Terms:
Biofilms*/drug effects
Cryptococcus neoformans*/drug effects
Cryptococcus neoformans*/enzymology
Cryptococcus neoformans*/pathogenicity
Fungal Proteins*/antagonists & inhibitors
Lysophospholipase*/antagonists & inhibitors
Macrophages, Alveolar*/microbiology
Propolis*/chemistry
Propolis*/pharmacology
Antifungal Agents*/chemistry
Antifungal Agents*/pharmacology
Humans ; Cell Line, Tumor ; Cryptococcosis/prevention & control ; Cryptococcosis/therapy ; Ethanol/chemistry ; Liposomes ; Lung Diseases, Fungal/prevention & control ; Lung Diseases, Fungal/therapy ; Virulence/drug effects ; Virulence Factors/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Low Molecular Weight Inhibitors Targeting the RNA-Binding Protein HuR.
Autorzy:
Joseph BP; Institute for Neuroscience and Medicine and Institute for Advanced Simulations (INM-9/IAS-5), Computational Biomedicine, Forschungszentrum Jülich, 52425 Jülich, Germany.; Faculty of Mathematics, Computer Science and Natural Sciences, RWTH Aachen University, 52062 Aachen, Germany.
Weber V; Institute for Neuroscience and Medicine and Institute for Advanced Simulations (INM-9/IAS-5), Computational Biomedicine, Forschungszentrum Jülich, 52425 Jülich, Germany.; Faculty of Mathematics, Computer Science and Natural Sciences, RWTH Aachen University, 52062 Aachen, Germany.
Knüpfer L; Institute of Biology, University of Siegen, 57076 Siegen, Germany.
Giorgetti A; Institute for Neuroscience and Medicine and Institute for Advanced Simulations (INM-9/IAS-5), Computational Biomedicine, Forschungszentrum Jülich, 52425 Jülich, Germany.; Department of Biotechnology, University of Verona, 37134 Verona, Italy.
Alfonso-Prieto M; Institute for Neuroscience and Medicine and Institute for Advanced Simulations (INM-9/IAS-5), Computational Biomedicine, Forschungszentrum Jülich, 52425 Jülich, Germany.
Krauß S; Institute of Biology, University of Siegen, 57076 Siegen, Germany.
Carloni P; Institute for Neuroscience and Medicine and Institute for Advanced Simulations (INM-9/IAS-5), Computational Biomedicine, Forschungszentrum Jülich, 52425 Jülich, Germany.; Faculty of Mathematics, Computer Science and Natural Sciences, RWTH Aachen University, 52062 Aachen, Germany.
Rossetti G; Institute for Neuroscience and Medicine and Institute for Advanced Simulations (INM-9/IAS-5), Computational Biomedicine, Forschungszentrum Jülich, 52425 Jülich, Germany.; Jülich Supercomputing Centre (JSC), Forschungszentrum Jülich, 52425 Jülich, Germany.; Department of Neurology, RWTH Aachen University, 44517 Aachen, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 23; Vol. 24 (17). Date of Electronic Publication: 2023 Aug 23.
Typ publikacji:
Journal Article
MeSH Terms:
Benzoates*
Biological Assay*
ELAV-Like Protein 1*/antagonists & inhibitors
Humans ; Cell Nucleus ; Molecular Weight ; RNA-Binding Proteins/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Effect of Xevinapant Combined with Ionizing Radiation on HNSCC and Normal Tissue Cells and the Impact of Xevinapant on Its Targeted Proteins cIAP1 and XIAP.
Autorzy:
Fleischmann J; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-Europäische Metropolregion Nürnberg (CCC ER-EMN), 91054 Erlangen, Germany.
Hildebrand LS; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-Europäische Metropolregion Nürnberg (CCC ER-EMN), 91054 Erlangen, Germany.
Kuhlmann L; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-Europäische Metropolregion Nürnberg (CCC ER-EMN), 91054 Erlangen, Germany.
Fietkau R; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-Europäische Metropolregion Nürnberg (CCC ER-EMN), 91054 Erlangen, Germany.
Distel LV; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-Europäische Metropolregion Nürnberg (CCC ER-EMN), 91054 Erlangen, Germany.
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Źródło:
Cells [Cells] 2023 Jun 17; Vol. 12 (12). Date of Electronic Publication: 2023 Jun 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*/pharmacology
Head and Neck Neoplasms*/drug therapy
Head and Neck Neoplasms*/radiotherapy
Radiation-Sensitizing Agents*/pharmacology
Squamous Cell Carcinoma of Head and Neck*/drug therapy
Squamous Cell Carcinoma of Head and Neck*/radiotherapy
Inhibitor of Apoptosis Proteins*/antagonists & inhibitors
Inhibitor of Apoptosis Proteins*/metabolism
Humans ; Radiation, Ionizing ; X-Linked Inhibitor of Apoptosis Protein/antagonists & inhibitors ; X-Linked Inhibitor of Apoptosis Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Blocking the Hormone Receptors Modulates NLRP3 in LPS-Primed Breast Cancer Cells.
Autorzy:
Hamza S; Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.
Garanina EE; Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.
Alsaadi M; Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.
Khaiboullina SF; Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.
Tezcan G; Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.; Department of Fundamental Sciences, Faculty of Dentistry, Bursa Uludag University, Bursa 16059, Turkey.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 02; Vol. 24 (5). Date of Electronic Publication: 2023 Mar 02.
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms*/metabolism
Breast Neoplasms*/pathology
NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism
Tamoxifen*/pharmacology
Estrogen Receptor alpha*/antagonists & inhibitors
Estrogen Receptor alpha*/metabolism
Estrogen Antagonists*/pharmacology
Female ; Humans ; Adenosine Triphosphate/metabolism ; Interleukin-8/metabolism ; Lipopolysaccharides ; MCF-7 Cells ; Receptors, Progesterone/antagonists & inhibitors ; Receptor, ErbB-2/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthetic Small Molecule Modulators of Hsp70 and Hsp40 Chaperones as Promising Anticancer Agents.
Autorzy:
Nitzsche B; Institute for Physiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Höpfner M; Institute for Physiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Biersack B; Organische Chemie 1, Universität Bayreuth, Universitätsstrasse 30, 95440 Bayreuth, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 17; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 17.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
HSP40 Heat-Shock Proteins*/antagonists & inhibitors
HSP40 Heat-Shock Proteins*/metabolism
HSP70 Heat-Shock Proteins*/antagonists & inhibitors
HSP70 Heat-Shock Proteins*/metabolism
Molecular Chaperones*/antagonists & inhibitors
Molecular Chaperones*/metabolism
HSP90 Heat-Shock Proteins/antagonists & inhibitors ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Drug Design
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dasatinib ameliorates thioacetamide-induced liver fibrosis: modulation of miR-378 and miR-17 and their linked Wnt/β-catenin and TGF-β/smads pathways.
Autorzy:
Zaafan MA; Faculty of Pharmacy, Pharmacology and Toxicology Department, October University for Modern Sciences and Arts (MSA), Dokki, Egypt.
Abdelhamid AM; Faculty of Pharmacy, Biochemistry Department, October University for Modern Sciences and Arts (MSA), Dokki, Egypt.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 118-124.
Typ publikacji:
Journal Article
MeSH Terms:
Dasatinib/*pharmacology
Liver Cirrhosis/*drug therapy
MicroRNAs/*antagonists & inhibitors
Smad7 Protein/*metabolism
Thioacetamide/*antagonists & inhibitors
Animals ; Dasatinib/chemistry ; Dose-Response Relationship, Drug ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/metabolism ; Male ; Mice ; MicroRNAs/metabolism ; Molecular Structure ; Structure-Activity Relationship ; Transforming Growth Factor beta/antagonists & inhibitors ; Transforming Growth Factor beta/metabolism ; Wnt Signaling Pathway/drug effects ; beta Catenin/antagonists & inhibitors ; beta Catenin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Neurog1-Derived Peptides RMNE1 and DualPep-Shine Penetrate the Skin and Inhibit Melanin Synthesis by Regulating MITF Transcription.
Autorzy:
Song EC; Remedi Co., Ltd., Research Center, Incheon 21990, Republic of Korea.
Park C; Remedi Co., Ltd., Research Center, Incheon 21990, Republic of Korea.
Shin Y; Remedi Co., Ltd., Research Center, Incheon 21990, Republic of Korea.
Kim WK; Remedi Co., Ltd., Research Center, Incheon 21990, Republic of Korea.
Kim SB; College of Pharmacy, Sahmyook University, Seoul 01795, Republic of Korea.
Cho S; Remedi Co., Ltd., Research Center, Incheon 21990, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 24; Vol. 24 (7). Date of Electronic Publication: 2023 Mar 24.
Typ publikacji:
Journal Article
MeSH Terms:
Melanins*/antagonists & inhibitors
Skin Pigmentation*/drug effects
Microphthalmia-Associated Transcription Factor*/genetics
Transcription, Genetic*/drug effects
Cell-Penetrating Peptides*/chemistry
Cell-Penetrating Peptides*/pharmacology
Skin Lightening Preparations*/chemistry
Skin Lightening Preparations*/pharmacology
Nerve Tissue Proteins*/chemistry
Nerve Tissue Proteins*/pharmacology
Basic Helix-Loop-Helix Transcription Factors*/chemistry
Basic Helix-Loop-Helix Transcription Factors*/pharmacology
Melanocytes*/drug effects
Melanocytes*/metabolism
alpha-MSH/antagonists & inhibitors ; alpha-MSH/metabolism ; Humans ; Melanoma, Experimental ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Epidermis/drug effects ; Epidermis/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
ETC-159, an Upstream Wnt inhibitor, Induces Tumour Necrosis via Modulation of Angiogenesis in Osteosarcoma.
Autorzy:
Chua K; Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore 169857, Singapore.; Department of Orthopaedic Surgery, Singapore General Hospital, Singapore 169608, Singapore.; Programme in Musculoskeletal Sciences Academic Clinical Program, SingHealth/Duke-NUS, Singapore 169857, Singapore.
Sim AYL; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Level 3 NUH Main Building, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
Yeo EYM; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Level 3 NUH Main Building, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
Bin Masroni MS; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Level 3 NUH Main Building, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
Naw WW; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Level 3 NUH Main Building, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
Leong SM; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Level 3 NUH Main Building, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
Lee KW; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, MD10, 4 Medical Drive, Singapore 117594, Singapore.
Lim HJ; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Level 3 NUH Main Building, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
Virshup DM; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore 169857, Singapore.
Lee VKM; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Level 3 NUH Main Building, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 01; Vol. 24 (5). Date of Electronic Publication: 2023 Mar 01.
Typ publikacji:
Journal Article
MeSH Terms:
Acyltransferases*/antagonists & inhibitors
Bone Neoplasms*/blood supply
Bone Neoplasms*/drug therapy
Osteosarcoma*/blood supply
Osteosarcoma*/drug therapy
Wnt Signaling Pathway*/drug effects
Neovascularization, Pathologic*/drug therapy
Animals ; Humans ; Mice ; beta Catenin/metabolism ; Carcinogenesis/genetics ; Cell Line, Tumor ; Cell Proliferation ; Membrane Proteins/antagonists & inhibitors ; Necrosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Discovery of the 3-Amino-1,2,4-triazine-Based Library as Selective PDK1 Inhibitors with Therapeutic Potential in Highly Aggressive Pancreatic Ductal Adenocarcinoma.
Autorzy:
Carbone D; Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123 Palermo, Italy.
De Franco M; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy.
Pecoraro C; Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123 Palermo, Italy.
Bassani D; Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy.
Pavan M; Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy.
Cascioferro S; Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123 Palermo, Italy.
Parrino B; Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123 Palermo, Italy.
Cirrincione G; Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123 Palermo, Italy.
Dall'Acqua S; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy.
Moro S; Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy.
Gandin V; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy.
Diana P; Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123 Palermo, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 12; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 12.
Typ publikacji:
Journal Article
MeSH Terms:
Adenocarcinoma*/drug therapy
Adenocarcinoma*/metabolism
Pancreatic Neoplasms*/drug therapy
Pancreatic Neoplasms*/metabolism
Pyruvate Dehydrogenase Acetyl-Transferring Kinase*/antagonists & inhibitors
Small Molecule Libraries*/chemistry
Small Molecule Libraries*/pharmacology
Humans ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Protein Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins p21(ras)/drug effects ; Proto-Oncogene Proteins p21(ras)/metabolism ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/therapeutic use ; Pancreatic Neoplasms
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The argument for near-term human disempowerment through AI
Autorzy:
Dung, LeonardAff1, IDs00146024019302_cor1
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Źródło:
AI & SOCIETY: Journal of Knowledge, Culture and Communication. :1-14
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 89523

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