Temat: "akt." - OpacWWW - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Knockdown of Kmt2d leads to growth impairment by activating the Akt/β-catenin signaling pathway.
Autorzy:: Shangguan H; Department of Endocrinology, Genetics and Metabolism, Fuzhou Children's Hospital of Fujian Medical University, Fuzhou 350000, China.
Huang X; Department of Endocrinology, Genetics and Metabolism, Fuzhou Children's Hospital of Fujian Medical University, Fuzhou 350000, China.
Lin J; Department of Endocrinology, Genetics and Metabolism, Fuzhou Children's Hospital of Fujian Medical University, Fuzhou 350000, China.
Chen R; Department of Endocrinology, Genetics and Metabolism, Fuzhou Children's Hospital of Fujian Medical University, Fuzhou 350000, China.; Pokaż więcej
Źródło:: G3 (Bethesda, Md.) [G3 (Bethesda)] 2024 Mar 06; Vol. 14 (3).
Typ publikacji:: Journal Article
MeSH Terms:: beta Catenin*/genetics
beta Catenin*/metabolism
Proto-Oncogene Proteins c-akt*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Animals ; Cell Proliferation/genetics ; Chondrocytes/metabolism ; Signal Transduction ; Wnt Signaling Pathway/genetics ; Zebrafish/genetics ; Zebrafish/metabolism

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Skocz do pozycji: 2.

Tytuł:: All Three AKT Isoforms Can Upregulate Oxygen Metabolism and Lactate Production in Human Hepatocellular Carcinoma Cell Lines.
Autorzy:: Tian LY; Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.; Beijing Key Surgical Basic Research Laboratory of Liver Cirrhosis and Liver Cancer, Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing 100044, China.
Smit DJ; Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
Popova NV; Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
Horn S; Research Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Velasquez LN; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Huber S; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Jücker M; Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 11; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 11.
Typ publikacji:: Journal Article
MeSH Terms:: Carcinoma, Hepatocellular*/genetics
Carcinoma, Hepatocellular*/metabolism
Liver Neoplasms*/genetics
Liver Neoplasms*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
Humans ; Cell Line, Tumor ; Lactic Acid/metabolism ; Oxidoreductases ; Oxygen/metabolism ; Phosphatidylinositol 3-Kinases ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Pyruvates

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Skocz do pozycji: 3.

Tytuł:: TRAF6-mediated ubiquitination of AKT in the nucleus is a critical event underlying the desensitization of G protein-coupled receptors.
Autorzy:: Wu C; School of Pharmaceutical Sciences, Guizhou University, Guiyang, 550025, China.
Hu L; School of Pharmaceutical Sciences, Guizhou University, Guiyang, 550025, China.
Liu B; School of Pharmaceutical Sciences, Guizhou University, Guiyang, 550025, China.
Zeng X; School of Pharmaceutical Sciences, Guizhou University, Guiyang, 550025, China.
Ma H; School of Pharmaceutical Sciences, Guizhou University, Guiyang, 550025, China.
Cao Y; Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, China.
Li H; Department of Pharmaceuticals, People's Hospital of Zunyi City Bo Zhou District, Zunyi, 563000, China.
Zhang X; School of Pharmaceutical Sciences, Guizhou University, Guiyang, 550025, China. .; Pokaż więcej
Źródło:: Cell communication and signaling : CCS [Cell Commun Signal] 2024 Apr 02; Vol. 22 (1), pp. 213. Date of Electronic Publication: 2024 Apr 02.
Typ publikacji:: Journal Article
MeSH Terms:: TNF Receptor-Associated Factor 6*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
Receptors, G-Protein-Coupled/metabolism ; Ubiquitination ; Phosphorylation ; Karyopherins

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Skocz do pozycji: 4.

Tytuł:: Selectivity Studies and Free Energy Calculations of AKT Inhibitors.
Autorzy:: Zhong HA; Department of Chemistry, University of Nebraska at Omaha, Omaha, NE 68182, USA.
Goodwin DT; Department of Chemistry, University of Nebraska at Omaha, Omaha, NE 68182, USA.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2024 Mar 10; Vol. 29 (6). Date of Electronic Publication: 2024 Mar 10.
Typ publikacji:: Journal Article
MeSH Terms:: Proto-Oncogene Proteins c-akt*/metabolism
Protein Kinase Inhibitors*/pharmacology
Protein Kinase Inhibitors*/chemistry
Angiogenesis Inhibitors

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Skocz do pozycji: 5.

Tytuł:: PI3K/Akt/mTOR Signaling Pathway as a Target for Colorectal Cancer Treatment.
Autorzy:: Leiphrakpam PD; Graduate Medical Education, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.; Division of Surgical Oncology, Department of Surgery, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Are C; Graduate Medical Education, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.; Division of Surgical Oncology, Department of Surgery, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 09; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 09.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Proto-Oncogene Proteins c-akt*/metabolism
Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/genetics
Colorectal Neoplasms*/metabolism
Humans ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphoinositide-3 Kinase Inhibitors ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism

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Skocz do pozycji: 6.

Tytuł:: Pregnancy-Specific Beta-1-Glycoprotein 1 Increases HTR-8/SVneo Cell Migration through the Orai1/Akt Signaling Pathway.
Autorzy:: Wang Q; Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China.; Department of Obstetrics and Gynaecology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230031, China.; The Fifth Clinical College of Anhui Medical University, Hefei 230032, China.
Fang Y; Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China.; The Fifth Clinical College of Anhui Medical University, Hefei 230032, China.
Li Y; Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China.; The Fifth Clinical College of Anhui Medical University, Hefei 230032, China.
Liu H; Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China.; The Fifth Clinical College of Anhui Medical University, Hefei 230032, China.
Zhu M; Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China.; The Fifth Clinical College of Anhui Medical University, Hefei 230032, China.
Hu X; Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China.; The Fifth Clinical College of Anhui Medical University, Hefei 230032, China.
Zhou J; Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China.; The Fifth Clinical College of Anhui Medical University, Hefei 230032, China.
Deng A; School of Basic Medical Science, Anhui Medical University, Hefei 230032, China.
Shen B; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China.
Chen H; Department of Obstetrics and Gynaecology, Maternal and Child Health Hospital Affiliated to Anhui Medical University, Hefei 230001, China.; The Fifth Clinical College of Anhui Medical University, Hefei 230032, China.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2024 Feb 29; Vol. 14 (3). Date of Electronic Publication: 2024 Feb 29.
Typ publikacji:: Journal Article
MeSH Terms:: Proto-Oncogene Proteins c-akt*/metabolism
Pre-Eclampsia*/metabolism
Phosphatidylethanolamines*
Eosine Yellowish-(YS)/*analogs & derivatives
Female ; Pregnancy ; Humans ; Signal Transduction/physiology ; Transcription Factors ; Cell Movement/physiology ; Glycoproteins ; Cell Proliferation/physiology

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Skocz do pozycji: 7.

Tytuł:: Dihydromyrcenol Modulates Involucrin Expression through the Akt Signaling Pathway.
Autorzy:: Yang S; Department of Food and Nutrition, BK21 FOUR, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.
Kang W; Department of Food and Nutrition, BK21 FOUR, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.
Choi D; Department of Food and Nutrition, BK21 FOUR, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.
Roh J; Department of Food and Nutrition, BK21 FOUR, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.
Park T; Department of Food and Nutrition, BK21 FOUR, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 13; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 13.
Typ publikacji:: Journal Article
MeSH Terms:: Proto-Oncogene Proteins c-akt*/metabolism
Keratinocytes*/metabolism
Octanols*
Protein Precursors*
Monoterpenes*
Humans ; Cell Differentiation/genetics ; Signal Transduction ; RNA, Messenger/metabolism

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Skocz do pozycji: 8.

Tytuł:: Sex-based differences in growth-related IGF1 signaling in response to PAPP-A2 deficiency: comparative effects of rhGH, rhIGF1 and rhPAPP-A2 treatments.
Autorzy:: Fernández-Arjona MDM; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Avenida Carlos Haya 82, Málaga, 29010, Spain.; Servicio de Neurología, Hospital Regional Universitario de Málaga, Málaga, 29010, Spain.
Navarro JA; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Avenida Carlos Haya 82, Málaga, 29010, Spain.; UGC Salud Mental, Hospital Regional Universitario de Málaga, Málaga, 29010, Spain.
López-Gambero AJ; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Avenida Carlos Haya 82, Málaga, 29010, Spain.; University of Bordeaux, INSERM, Neurocentre Magendie, U1215, Bordeaux, 33000, France.
de Ceglia M; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Avenida Carlos Haya 82, Málaga, 29010, Spain.; UGC Salud Mental, Hospital Regional Universitario de Málaga, Málaga, 29010, Spain.
Rodríguez M; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Avenida Carlos Haya 82, Málaga, 29010, Spain.; Departamento de Anatomía Humana, Medicina Legal e Historia de la Ciencia. Facultad de Medicina, Universidad de Málaga, Bulevar Louis Pasteur 32, Málaga, 29071, Spain.
Rubio L; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Avenida Carlos Haya 82, Málaga, 29010, Spain.; Departamento de Anatomía Humana, Medicina Legal e Historia de la Ciencia. Facultad de Medicina, Universidad de Málaga, Bulevar Louis Pasteur 32, Málaga, 29071, Spain.
Rodríguez de Fonseca F; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Avenida Carlos Haya 82, Málaga, 29010, Spain.; Servicio de Neurología, Hospital Regional Universitario de Málaga, Málaga, 29010, Spain.
Barrios V; Departments of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Avenida Menéndez Pelayo 65, Madrid, 28009, Spain.; La Princesa Research Institute, Madrid, 28009, Spain.; Centro de Investigación Biomédica en Red Fisiología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, 28029, Spain.
Chowen JA; Departments of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Avenida Menéndez Pelayo 65, Madrid, 28009, Spain.; La Princesa Research Institute, Madrid, 28009, Spain.; Centro de Investigación Biomédica en Red Fisiología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, 28029, Spain.; IMDEA Food Institute, CEI UAM & CSIC, Madrid, 28049, Spain.
Argente J; Departments of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Avenida Menéndez Pelayo 65, Madrid, 28009, Spain. .; La Princesa Research Institute, Madrid, 28009, Spain. .; Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, 28049, Spain. .; Centro de Investigación Biomédica en Red Fisiología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, 28029, Spain. .; IMDEA Food Institute, CEI UAM & CSIC, Madrid, 28049, Spain. .
Rivera P; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Avenida Carlos Haya 82, Málaga, 29010, Spain. .; UGC Salud Mental, Hospital Regional Universitario de Málaga, Málaga, 29010, Spain. .
Suárez J; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Avenida Carlos Haya 82, Málaga, 29010, Spain. .; Departamento de Anatomía Humana, Medicina Legal e Historia de la Ciencia. Facultad de Medicina, Universidad de Málaga, Bulevar Louis Pasteur 32, Málaga, 29071, Spain. .; Pokaż więcej
Źródło:: Biology of sex differences [Biol Sex Differ] 2024 Apr 08; Vol. 15 (1), pp. 34. Date of Electronic Publication: 2024 Apr 08.
Typ publikacji:: Journal Article
MeSH Terms:: Pregnancy-Associated Plasma Protein-A*/genetics
Pregnancy-Associated Plasma Protein-A*/metabolism
Proto-Oncogene Proteins c-akt*
Piperazines*
Humans ; Male ; Child ; Mice ; Female ; Animals ; Growth Disorders/metabolism

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Skocz do pozycji: 9.

Tytuł:: Substrate preference of protein kinase B isoforms can vary depending on the cell line.
Autorzy:: Palma MS; Department of Chemistry and Biochemistry, California State University Long Beach, Long Beach, California, United States of America.
Perez SR; Department of Chemistry and Biochemistry, California State University Long Beach, Long Beach, California, United States of America.
Husain A; Department of Chemistry and Biochemistry, California State University Long Beach, Long Beach, California, United States of America.
Bhandari D; Department of Chemistry and Biochemistry, California State University Long Beach, Long Beach, California, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2024 Mar 19; Vol. 19 (3), pp. e0298322. Date of Electronic Publication: 2024 Mar 19 (Print Publication: 2024).
Typ publikacji:: Journal Article
MeSH Terms:: Proto-Oncogene Proteins c-akt*/metabolism
Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Cell Line

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Skocz do pozycji: 10.

Tytuł:: Oxyresveratrol Improves Cognitive Impairments and Episodic-like Memory through Modulating Neuroinflammation and PI3K-Akt Signaling Pathway in LPS-Induced Mice.
Autorzy:: Yin G; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.; Byhealth Co., Ltd., Guangzhou 510030, China.
Pan C; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
Liu H; Jihua Laboratory, Foshan 528061, China.
Dong C; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
Chang X; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
Zhou W; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
Wang S; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
Du Z; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.; Foshan Allan Conney Biotechnology Co., Ltd., Foshan 523281, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2024 Mar 13; Vol. 29 (6). Date of Electronic Publication: 2024 Mar 13.
Typ publikacji:: Journal Article
MeSH Terms:: Proto-Oncogene Proteins c-akt*/metabolism
Cognitive Dysfunction*/drug therapy
Cognitive Dysfunction*/metabolism
Plant Extracts*
Stilbenes*
Mice ; Animals ; Inflammation/metabolism ; Lipopolysaccharides/adverse effects ; Lipopolysaccharides/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Neuroinflammatory Diseases ; Signal Transduction ; Microglia/metabolism

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Skocz do pozycji: 11.

Tytuł:: SP140 inhibitor suppressing TRIM22 expression regulates glioma progress through PI3K/AKT signaling pathway.
Autorzy:: Li X; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China.; Department of Neurosurgery, Xinghua People's Hospital, Xinghua, China.
Li G; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China.; Department of Neurosurgery, Hefei First People's Hospital, Hefei, China.
Li L; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Gao B; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Niu X; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China.; Department of Neurosurgery, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, China.
Wang Y; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China.; Department of Neurosurgery, Yancheng Third People's Hospital, Yancheng, China.
Wang Z; Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, China.; Pokaż więcej
Źródło:: Brain and behavior [Brain Behav] 2024 Mar; Vol. 14 (3), pp. e3465.
Typ publikacji:: Journal Article
MeSH Terms:: Proto-Oncogene Proteins c-akt*/metabolism
Glioma*/drug therapy
Glioma*/genetics
Humans ; Phosphatidylinositol 3-Kinases/metabolism ; Cell Proliferation ; Signal Transduction ; Tripartite Motif Proteins/genetics ; Tripartite Motif Proteins/pharmacology ; Repressor Proteins/metabolism ; Minor Histocompatibility Antigens/pharmacology ; Transcription Factors ; Antigens, Nuclear/metabolism ; Antigens, Nuclear/pharmacology

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Skocz do pozycji: 12.

Tytuł:: Phosphorylation of PP2Ac by PKC is a key regulatory step in the PP2A-switch-dependent AKT dephosphorylation that leads to apoptosis.
Autorzy:: Nadel G; Department of Immunology and Regenerative Biology, the Weizmann Institute of Science, Rehovot, Israel.
Yao Z; Department of Immunology and Regenerative Biology, the Weizmann Institute of Science, Rehovot, Israel.
Hacohen-Lev-Ran A; Department of Immunology and Regenerative Biology, the Weizmann Institute of Science, Rehovot, Israel.
Wainstein E; Department of Immunology and Regenerative Biology, the Weizmann Institute of Science, Rehovot, Israel.
Maik-Rachline G; Department of Immunology and Regenerative Biology, the Weizmann Institute of Science, Rehovot, Israel.
Ziv T; Smoler Proteomic Center, Technion-Israel Institute of Technology, Haifa, Israel.
Naor Z; Department of Biochemistry and Molecular Biology, Tel Aviv University, Tel Aviv, Israel.
Admon A; Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel.
Seger R; Department of Immunology and Regenerative Biology, the Weizmann Institute of Science, Rehovot, Israel. .; Pokaż więcej
Źródło:: Cell communication and signaling : CCS [Cell Commun Signal] 2024 Feb 28; Vol. 22 (1), pp. 154. Date of Electronic Publication: 2024 Feb 28.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Signal Transduction*
Proto-Oncogene Proteins c-akt*/metabolism
Phosphorylation ; Phosphatidylinositol 3-Kinases/metabolism ; Apoptosis

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Skocz do pozycji: 13.

Tytuł:: Combined inhibition of HER2 and VEGFR synergistically improves therapeutic efficacy via PI3K-AKT pathway in advanced ovarian cancer.
Autorzy:: Li W; Department of Pathology, First Affiliated Hospital, Gannan Medical University, Ganzhou, 341000, China.; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases (Ministry of Education), Gannan Medical University, 1 Hexie Road, Rongjiang New District, Ganzhou, 341000, China.
Zhang K; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases (Ministry of Education), Gannan Medical University, 1 Hexie Road, Rongjiang New District, Ganzhou, 341000, China.; School of Basic Medicine, Gannan Medical University, Ganzhou, 341000, China.
Wang W; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases (Ministry of Education), Gannan Medical University, 1 Hexie Road, Rongjiang New District, Ganzhou, 341000, China.; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Liu Y; Department of Gynaecology and Obstetrics, Ganzhou People's Hospital (The Affiliated Ganzhou Hospital of Nanchang University), Ganzhou, 341000, China.
Huang J; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases (Ministry of Education), Gannan Medical University, 1 Hexie Road, Rongjiang New District, Ganzhou, 341000, China.; School of Basic Medicine, Gannan Medical University, Ganzhou, 341000, China.
Zheng M; Department of Pathology, First Affiliated Hospital, Gannan Medical University, Ganzhou, 341000, China.; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases (Ministry of Education), Gannan Medical University, 1 Hexie Road, Rongjiang New District, Ganzhou, 341000, China.
Li L; Department of Pathology, First Affiliated Hospital, Gannan Medical University, Ganzhou, 341000, China.; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases (Ministry of Education), Gannan Medical University, 1 Hexie Road, Rongjiang New District, Ganzhou, 341000, China.
Zhang X; Department of Pathology, First Affiliated Hospital, Gannan Medical University, Ganzhou, 341000, China.; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases (Ministry of Education), Gannan Medical University, 1 Hexie Road, Rongjiang New District, Ganzhou, 341000, China.
Xu M; Department of Gynaecology and Obstetrics, Ganzhou People's Hospital (The Affiliated Ganzhou Hospital of Nanchang University), Ganzhou, 341000, China. .
Chen G; Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Tongji University, Shanghai, 200092, China. .
Wang L; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases (Ministry of Education), Gannan Medical University, 1 Hexie Road, Rongjiang New District, Ganzhou, 341000, China. .; School of Basic Medicine, Gannan Medical University, Ganzhou, 341000, China. .
Zhang S; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases (Ministry of Education), Gannan Medical University, 1 Hexie Road, Rongjiang New District, Ganzhou, 341000, China. .; School of Basic Medicine, Gannan Medical University, Ganzhou, 341000, China. .; Pokaż więcej
Źródło:: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2024 Feb 26; Vol. 43 (1), pp. 56. Date of Electronic Publication: 2024 Feb 26.
Typ publikacji:: Journal Article
MeSH Terms:: Proto-Oncogene Proteins c-akt*/metabolism
Ovarian Neoplasms*/drug therapy
Ovarian Neoplasms*/genetics
Ovarian Neoplasms*/metabolism
Humans ; Female ; Phosphatidylinositol 3-Kinases/metabolism ; Carcinoma, Ovarian Epithelial ; Cell Proliferation ; Cell Line, Tumor

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Skocz do pozycji: 14.

Tytuł:: Cai's prescription inhibits granulosa cell apoptosis through ARHGAP4 on poor ovarian responders.
Autorzy:: Wang Z; Department of Integrated Traditional Chinese and Western Medicine, Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai, 200040, China. .
Liu D; Prenatal Diagnosis Center, Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai, 200040, China.
Nie Y; Department of Integrated Traditional Chinese and Western Medicine, Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai, 200040, China.
Zhang Q; Department of Integrated Traditional Chinese and Western Medicine, Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai, 200040, China. .; Pokaż więcej
Źródło:: Journal of ovarian research [J Ovarian Res] 2024 Feb 14; Vol. 17 (1), pp. 40. Date of Electronic Publication: 2024 Feb 14.
Typ publikacji:: Journal Article
MeSH Terms:: Proto-Oncogene Proteins c-akt*/metabolism
Phosphatidylinositol 3-Kinases*/metabolism
Female ; Humans ; Ovary/diagnostic imaging ; Granulosa Cells/metabolism ; Apoptosis

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Skocz do pozycji: 15.

Tytuł:: Lineage-specific intolerance to oncogenic drivers restricts histological transformation.
Autorzy:: Gardner EE; Meyer Cancer Center, Weill Cornell Medicine, New York, NY.
Earlie EM; Meyer Cancer Center, Weill Cornell Medicine, New York, NY.; Department of Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine, New York, NY.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY.
Li K; Meyer Cancer Center, Weill Cornell Medicine, New York, NY.
Thomas J; Meyer Cancer Center, Weill Cornell Medicine, New York, NY.
Hubisz MJ; Meyer Cancer Center, Weill Cornell Medicine, New York, NY.; Department of Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine, New York, NY.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY.; Bioinformatics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY.
Stein BD; Meyer Cancer Center, Weill Cornell Medicine, New York, NY.; Department of Medicine, Weill Cornell Medicine, New York, NY.
Zhang C; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY.
Cantley LC; Meyer Cancer Center, Weill Cornell Medicine, New York, NY.; Department of Medicine, Weill Cornell Medicine, New York, NY.
Laughney AM; Meyer Cancer Center, Weill Cornell Medicine, New York, NY.; Department of Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine, New York, NY.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY.
Varmus H; Meyer Cancer Center, Weill Cornell Medicine, New York, NY.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2024 Feb 09; Vol. 383 (6683), pp. eadj1415. Date of Electronic Publication: 2024 Feb 09.
Typ publikacji:: Journal Article
MeSH Terms:: Adenocarcinoma of Lung*/genetics
Adenocarcinoma of Lung*/pathology
Adenocarcinoma of Lung*/therapy
Lung Neoplasms*/genetics
Lung Neoplasms*/pathology
Lung Neoplasms*/therapy
Small Cell Lung Carcinoma*/genetics
Small Cell Lung Carcinoma*/pathology
Small Cell Lung Carcinoma*/therapy
Proto-Oncogene Proteins c-myc*/genetics
Proto-Oncogene Proteins c-akt*/genetics
Humans ; Epithelial Cells/pathology ; Lung/pathology ; Oncogenes ; Cell Lineage ; Molecular Targeted Therapy

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Skocz do pozycji: 16.

Tytuł:: Age-Dependent Activation of Purinergic Transmission Contributes to the Development of Epileptogenesis in ADSHE Model Rats.
Autorzy:: Fukuyama K; Department of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.
Motomura E; Department of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.
Okada M; Department of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2024 Feb 08; Vol. 14 (2). Date of Electronic Publication: 2024 Feb 08.
Typ publikacji:: Journal Article
MeSH Terms:: Connexin 43*/genetics
Connexin 43*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
Rats ; Animals ; Astrocytes/metabolism ; Seizures/metabolism ; Adenosine Triphosphate/metabolism

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Tytuł:: The Schwann cell-specific G-protein Gαo (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve system.
Autorzy:: Xu J; Jiangsu Key Laboratory of Neuroregeneration, Co-Innovation Center of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, JS, 226001, People's Republic of China.
Peng Q; Jiangsu Key Laboratory of Neuroregeneration, Co-Innovation Center of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, JS, 226001, People's Republic of China.
Cai J; Jiangsu Key Laboratory of Neuroregeneration, Co-Innovation Center of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, JS, 226001, People's Republic of China.
Shangguan J; Jiangsu Key Laboratory of Neuroregeneration, Co-Innovation Center of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, JS, 226001, People's Republic of China.
Su W; Jiangsu Key Laboratory of Neuroregeneration, Co-Innovation Center of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, JS, 226001, People's Republic of China.
Chen G; Jiangsu Key Laboratory of Neuroregeneration, Co-Innovation Center of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, JS, 226001, People's Republic of China.
Sun H; Jiangsu Key Laboratory of Neuroregeneration, Co-Innovation Center of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, JS, 226001, People's Republic of China.
Zhu C; Jiangsu Key Laboratory of Neuroregeneration, Co-Innovation Center of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, JS, 226001, People's Republic of China. .
Gu Y; Jiangsu Key Laboratory of Neuroregeneration, Co-Innovation Center of Neuroregeneration, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, JS, 226001, People's Republic of China. .; Pokaż więcej
Źródło:: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Feb 08; Vol. 12 (1), pp. 24. Date of Electronic Publication: 2024 Feb 08.
Typ publikacji:: Journal Article
MeSH Terms:: Phosphatidylinositol 3-Kinases*
Proto-Oncogene Proteins c-akt*/metabolism
Animals ; Mice ; GTP-Binding Proteins ; Mammals/metabolism ; Myelin Sheath/metabolism ; Peripheral Nervous System/metabolism ; Schwann Cells

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Skocz do pozycji: 18.

Tytuł:: Targeting PI3K/AKT/mTOR and MAPK Signaling Pathways in Gastric Cancer.
Autorzy:: Morgos DT; Discipline of Anatomy, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Stefani C; Department I of Family Medicine and Clinical Base, 'Dr. Carol Davila' Central Military Emergency University Hospital, 010825 Bucharest, Romania.
Miricescu D; Discipline of Biochemistry, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Greabu M; Discipline of Biochemistry, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Stanciu S; Department of Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, Central Military Emergency University Hospital, 010825 Bucharest, Romania.
Nica S; Emergency Discipline, University Hospital of Bucharest, 050098 Bucharest, Romania.
Stanescu-Spinu II; Discipline of Physiology, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Balan DG; Discipline of Physiology, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Balcangiu-Stroescu AE; Discipline of Physiology, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Coculescu EC; Discipline of Oral Pathology, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Georgescu DE; Department of General Surgery, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 50474 Bucharest, Romania.; Department of General Surgery, 'Dr. Ion Cantacuzino' Clinical Hospital, 020475 Bucharest, Romania.
Nica RI; Central Military Emergency University Hospital 'Dr. Carol Davila', 010825 Bucharest, Romania.; Discipline of General Surgery, Faculty of Midwifery and Nursing, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 03; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 03.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Proto-Oncogene Proteins c-akt*/metabolism
Stomach Neoplasms*/etiology
Stomach Neoplasms*/genetics
Humans ; Phosphatidylinositol 3-Kinase/metabolism ; Sirolimus ; Phosphatidylinositol 3-Kinases/metabolism ; TOR Serine-Threonine Kinases/metabolism ; MAP Kinase Signaling System

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Skocz do pozycji: 19.

Tytuł:: Systems genetics analysis reveals the common genetic basis for pain sensitivity and cognitive function.
Autorzy:: Xu F; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, China.
Chen A; The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Pan S; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, China.
Wu Y; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, China.
He H; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, China.
Han Z; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, China.
Lu L; University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Orgil BO; University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Chi X; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, China.
Yang C; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, China.
Jia S; Department of Anesthesiology, YanTai Affiliated Hospital of BinZhou Medical University, Yantai, China.
Yu C; The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Mi J; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, China.; Pokaż więcej
Źródło:: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Feb; Vol. 30 (2), pp. e14557.
Typ publikacji:: Journal Article
MeSH Terms:: Phosphatidylinositol 3-Kinases*
Proto-Oncogene Proteins c-akt*
Mice ; Animals ; Mice, Inbred C57BL ; Bayes Theorem ; Pain Threshold ; Cognition

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Skocz do pozycji: 20.

Tytuł:: Lactate administration induces skeletal muscle synthesis by influencing Akt/mTOR and MuRF1 in non-trained mice but not in trained mice.
Autorzy:: Kyun S; Department of Sports Medicine and Science in Graduated School, Konkuk University, Seoul, Korea.
Kim J; Department of Sports Medicine and Science in Graduated School, Konkuk University, Seoul, Korea.; Physical Activity and Performance Institute (PAPI), Konkuk University, Seoul, Korea.
Hwang D; Department of Sports Medicine and Science in Graduated School, Konkuk University, Seoul, Korea.
Jang I; Department of Sports Medicine and Science in Graduated School, Konkuk University, Seoul, Korea.
Park HY; Department of Sports Medicine and Science in Graduated School, Konkuk University, Seoul, Korea.; Physical Activity and Performance Institute (PAPI), Konkuk University, Seoul, Korea.
Lim K; Department of Sports Medicine and Science in Graduated School, Konkuk University, Seoul, Korea.; Physical Activity and Performance Institute (PAPI), Konkuk University, Seoul, Korea.; Department of Physical Education, Konkuk University, Seoul, Korea.; Pokaż więcej
Źródło:: Physiological reports [Physiol Rep] 2024 Feb; Vol. 12 (4), pp. e15952.
Typ publikacji:: Journal Article
MeSH Terms:: Lactic Acid*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
Mice ; Animals ; Oxygen Consumption ; Oxygen/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Muscle, Skeletal/metabolism ; Mice, Inbred Strains ; Mammals/metabolism

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