- Tytuł:
-
Clinical features of male patients with alcoholic liver cirrhosis or hepatitis B cirrhosis complicated by abnormal
glucose metabolism - Autorzy:
- Temat:
-
74 had ALC and were
all male
including 54 with abnormalglucose metabolism
the other 213 had HBC
including 97 with abnormalglucose metabolism (69 male patients and 28 female patients). A controlled study was performed for the clinical data of ALC and HBC patients with abnormalglucose metabolism
to investigate the association of patients′ clinical manifestations with the indices for laboratory examination
insulin resistance index
incidence rate of abnormalglucose metabolism
and Child-Pugh class. The t-test was applied for comparison of continuous data between groups
the chi-square test was applied for comparison of categorical data between groups
and the Spearman rank correlation was applied for correlation analysis. ResultsCompared with HBC patients
ALC patients had significantly higher incidence rates of abnormalglucose metabolism (730% vs 32.4%)
hepatogenous diabetes (35.1% vs 14.6%)fasting hypoglycemia (27.0% vs 10.3%)
and impairedglucose tolerance (31.1% vs 14.1%) (χ2=4.371
3.274
4.784
and 1.633all P<0.05 ). The Spearman correlation analysis showed that in ALC and HBC patients
the incidence rate of abnormalglucose metabolism was positively correlated with Child-Pugh class (rs=0.41
P<005). Compared with the HBC patients with abnormalglucose metabolism
the ALC patients with abnormalglucose metabolism had a significantly higher incidence rate of Child-Pugh class A (χ2=7.520
P=0.001)
and a significantly lower incidence rate of Child-Pugh class C (χ2=6.542
P=0.003). There weresignificant differences in the incidence rates of dim complexion
telangiectasia of the face
spider angioma
hepatomegaly
hepatorenal syndrome
malnutrition
ascites
jaundice
hepatic encephalopathy
spontaneous bacterial peritonitis
and upper gastrointestinal bleeding between the ALC and HBC patients with abnormalglucose metabolism (χ2=3.785
2.651
1974
3.316
3.771
5.843
7.251
5.214
5.778
2.966
and 6.312all P<0.05 ). Compared with the HBC patients with abnormalglucose metabolism
the ALC patients with abnormalglucose metabolism had significantly higher levels of aspartate aminotransferase and total bilirubin
a significantly greater mean corpuscular volume
a significantly higherlevel of gamma-glutamyl transpeptidase
and a significantly lowerlevel of albumin (t=4.775
7.887
5.143
6.124
and 5.210all P<0.05 ). There weresignificant differences in thefasting blood glucose level
insulinlevel 2 hours after meal
and insulin resistance index between the ALC and HBC patients with abnormalglucose metabolism (t=2.770
6.331
and 3.770all P<0.05 ). ConclusionThe male patients with ALC or HBC gradually develop abnormalglucose metabolism with the deterioration of liver function
with individual etiology and features of liver cirrhosis
and the manifestations of abnormalglucose metabolism are not obvious. Related examinations should be performed for these male patients with liver cirrhosis of various causes
liver cirrhosis
alcoholic
hepatitis Bglucose metabolism disorders
Diseases of the digestive system. Gastroenterology
RC799-869 - Źródło:
- Linchuang Gandanbing Zazhi, Vol 32, Iss 2, Pp 296-300 (2016)
- Opis pliku:
- electronic resource
- Relacje:
- http://www.lcgdbzz.org/qk_content.asp?id=7148; https://doaj.org/toc/1001-5256
- Dostęp URL:
- https://doaj.org/article/37e26447674149f080d4d5d298945f28  Link otwiera się w nowym oknie
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