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Wyświetlanie 1-1 z 1
Tytuł:
Clinical features of male patients with alcoholic liver cirrhosis or hepatitis B cirrhosis complicated by abnormal glucose metabolism
Autorzy:
CHEN Qidan
WAN Yu
Pokaż więcej
Temat:
74 had ALC and were all male
including 54 with abnormal glucose metabolism
the other 213 had HBC
including 97 with abnormal glucose metabolism (69 male patients and 28 female patients). A controlled study was performed for the clinical data of ALC and HBC patients with abnormal glucose metabolism
to investigate the association of patients′ clinical manifestations with the indices for laboratory examination
insulin resistance index
incidence rate of abnormal glucose metabolism
and Child-Pugh class. The t-test was applied for comparison of continuous data between groups
the chi-square test was applied for comparison of categorical data between groups
and the Spearman rank correlation was applied for correlation analysis. ResultsCompared with HBC patients
ALC patients had significantly higher incidence rates of abnormal glucose metabolism (730% vs 32.4%)
hepatogenous diabetes (35.1% vs 14.6%)
fasting hypoglycemia (27.0% vs 10.3%)
and impaired glucose tolerance (31.1% vs 14.1%) (χ2=4.371
3.274
4.784
and 1.633
all P<0.05). The Spearman correlation analysis showed that in ALC and HBC patients
the incidence rate of abnormal glucose metabolism was positively correlated with Child-Pugh class (rs=0.41
P<005). Compared with the HBC patients with abnormal glucose metabolism
the ALC patients with abnormal glucose metabolism had a significantly higher incidence rate of Child-Pugh class A (χ2=7.520
P=0.001)
and a significantly lower incidence rate of Child-Pugh class C (χ2=6.542
P=0.003). There were significant differences in the incidence rates of dim complexion
telangiectasia of the face
spider angioma
hepatomegaly
hepatorenal syndrome
malnutrition
ascites
jaundice
hepatic encephalopathy
spontaneous bacterial peritonitis
and upper gastrointestinal bleeding between the ALC and HBC patients with abnormal glucose metabolism (χ2=3.785
2.651
1974
3.316
3.771
5.843
7.251
5.214
5.778
2.966
and 6.312
all P<0.05). Compared with the HBC patients with abnormal glucose metabolism
the ALC patients with abnormal glucose metabolism had significantly higher levels of aspartate aminotransferase and total bilirubin
a significantly greater mean corpuscular volume
a significantly higher level of gamma-glutamyl transpeptidase
and a significantly lower level of albumin (t=4.775
7.887
5.143
6.124
and 5.210
all P<0.05). There were significant differences in the fasting blood glucose level
insulin level 2 hours after meal
and insulin resistance index between the ALC and HBC patients with abnormal glucose metabolism (t=2.770
6.331
and 3.770
all P<0.05). ConclusionThe male patients with ALC or HBC gradually develop abnormal glucose metabolism with the deterioration of liver function
with individual etiology and features of liver cirrhosis
and the manifestations of abnormal glucose metabolism are not obvious. Related examinations should be performed for these male patients with liver cirrhosis of various causes
liver cirrhosis
alcoholic
hepatitis B
glucose metabolism disorders
Diseases of the digestive system. Gastroenterology
RC799-869
Źródło:
Linchuang Gandanbing Zazhi, Vol 32, Iss 2, Pp 296-300 (2016)
Opis pliku:
electronic resource
Relacje:
http://www.lcgdbzz.org/qk_content.asp?id=7148; https://doaj.org/toc/1001-5256
Dostęp URL:
https://doaj.org/article/37e26447674149f080d4d5d298945f28  Link otwiera się w nowym oknie
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