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Wyszukujesz frazę ""allelic"" wg kryterium: Temat


Tytuł :
Replicate sequencing libraries are important for quantification of allelic imbalance.
Autorzy :
Mendelevich A; Skolkovo Institute of Science and Technology, Moscow, Russia. .; Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA. .
Vinogradova S; Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA.
Gupta S; Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA.; Broad Institute of Harvard and MIT, Cambridge, USA.
Mironov AA; Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Moscow, Russia.; Institute of Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia.
Sunyaev SR; Department of Biomedical Informatics, Harvard Medical School, Boston, USA.; Division of Genetics, Brigham and Women's Hospital, Boston, USA.
Gimelbrant AA; Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA. .; Broad Institute of Harvard and MIT, Cambridge, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 07; Vol. 12 (1), pp. 3370. Date of Electronic Publication: 2021 Jun 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Allelic Imbalance*
Gene Library*
Polymorphism, Single Nucleotide*
RNA/*genetics
Sequence Analysis, RNA/*methods
Transcriptome/*genetics
Algorithms ; Alleles ; Animals ; Female ; Mice, 129 Strain ; Models, Genetic ; RNA/metabolism
Czasopismo naukowe
Tytuł :
Testcrosses are an efficient strategy for identifying cis-regulatory variation: Bayesian analysis of allele-specific expression (BayesASE).
Autorzy :
Miller BR; Genetics Institute, University of Florida, Gainesville, FL 32608, USA.; NYU Langone Health, New York University, New York, NY 10013, USA.
Morse AM; Genetics Institute, University of Florida, Gainesville, FL 32608, USA.; Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32608, USA.
Borgert JE; Genetics Institute, University of Florida, Gainesville, FL 32608, USA.; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27515, USA.
Liu Z; Genetics Institute, University of Florida, Gainesville, FL 32608, USA.; Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32608, USA.
Sinclair K; Genetics Institute, University of Florida, Gainesville, FL 32608, USA.; Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32608, USA.
Gamble G; Genetics Institute, University of Florida, Gainesville, FL 32608, USA.
Zou F; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27515, USA.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27515, USA.
Newman JRB; Genetics Institute, University of Florida, Gainesville, FL 32608, USA.; Department of Pathology, University of Florida, Gainesville, FL 32608 USA.
León-Novelo LG; Department of Biostatistics and Data Science, University of Texas Health Science Center at Houston-University of Texas School of Public Health, Houston, TX 7703, USA.
Marroni F; Department of Agricultural, Food, Environmental and Animal Sciences, University of Udine, Udine, 33100, Italy.
McIntyre LM; Genetics Institute, University of Florida, Gainesville, FL 32608, USA.; Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32608, USA.
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Źródło :
G3 (Bethesda, Md.) [G3 (Bethesda)] 2021 May 07; Vol. 11 (5).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Allelic Imbalance*
Polymorphism, Single Nucleotide*
Alleles ; Bayes Theorem ; Genotype
Czasopismo naukowe
Tytuł :
Improved haplotype inference by exploiting long-range linking and allelic imbalance in RNA-seq datasets.
Autorzy :
Berger E; Computer Science & Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Department of Mathematics, UC Berkeley, Berkeley, CA, 94720, USA.
Yorukoglu D; Computer Science & Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Zhang L; Computer Science & Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Nyquist SK; Computer Science & Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Shalek AK; Computer Science & Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Kellis M; Computer Science & Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Numanagić I; Computer Science & Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. .; Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. .; Department of Computer Science, University of Victoria, Victoria, BC, V8P 5C2, Canada. .
Berger B; Computer Science & Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. .; Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Sep 16; Vol. 11 (1), pp. 4662. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Allelic Imbalance*
Haplotypes*
Sequence Analysis, RNA*/methods
Sequence Analysis, RNA*/statistics & numerical data
Algorithms ; Databases, Genetic ; Diploidy ; Humans ; K562 Cells ; Models, Genetic ; Models, Statistical ; Polymorphism, Single Nucleotide ; Polyploidy ; RNA-Seq
Czasopismo naukowe
Tytuł :
Multiregion exome sequencing of ovarian immature teratomas reveals 2N near-diploid genomes, paucity of somatic mutations, and extensive allelic imbalances shared across mature, immature, and disseminated components.
Autorzy :
Heskett MB; Department of Molecular & Medical Genetics, Oregon Health & Science University, Portland, OR, USA.
Sanborn JZ; NantOmics, LLC, Culver City, CA, USA.
Boniface C; Department of Molecular & Medical Genetics, Oregon Health & Science University, Portland, OR, USA.
Goode B; Department of Pathology, University of California, San Francisco, CA, USA.
Chapman J; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, CA, USA.
Garg K; Department of Pathology, University of California, San Francisco, CA, USA.
Rabban JT; Department of Pathology, University of California, San Francisco, CA, USA.
Zaloudek C; Department of Pathology, University of California, San Francisco, CA, USA.
Benz SC; NantOmics, LLC, Culver City, CA, USA.
Spellman PT; Department of Molecular & Medical Genetics, Oregon Health & Science University, Portland, OR, USA.
Solomon DA; Department of Pathology, University of California, San Francisco, CA, USA. .
Cho RJ; Department of Dermatology, University of California, San Francisco, CA, USA. .
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Źródło :
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc [Mod Pathol] 2020 Jun; Vol. 33 (6), pp. 1193-1206. Date of Electronic Publication: 2020 Jan 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Allelic Imbalance*
Mutation*
Ovarian Neoplasms/*genetics
Teratoma/*genetics
Adolescent ; Adult ; Alleles ; Child ; Diploidy ; Female ; Humans ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/surgery ; Teratoma/pathology ; Teratoma/surgery ; Whole Exome Sequencing ; Young Adult
Czasopismo naukowe
Tytuł :
Transcriptional bursts explain autosomal random monoallelic expression and affect allelic imbalance.
Autorzy :
Larsson AJM; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Ziegenhain C; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Hagemann-Jensen M; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Reinius B; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Jacob T; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
Dalessandri T; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Hendriks GJ; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Kasper M; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Sandberg R; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2021 Mar 09; Vol. 17 (3), pp. e1008772. Date of Electronic Publication: 2021 Mar 09 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Allelic Imbalance/*genetics
Transcription, Genetic/*genetics
Transcriptome/*genetics
Animals ; Female ; Male ; Mice ; Models, Genetic ; Sequence Analysis, RNA ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
Allele-Specific QTL Fine Mapping with PLASMA.
Autorzy :
Wang AT; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address: .
Shetty A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Cambridge University, Cambridge CB2 1TN, UK.
O'Connor E; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Bell C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Pomerantz MM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Freedman ML; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; The Eli and Edythe L. Broad Institute, Cambridge, MA 02142, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Gusev A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; The Eli and Edythe L. Broad Institute, Cambridge, MA 02142, USA; Brigham & Women's Hospital, Division of Genetics, Boston, MA 02215, USA. Electronic address: .
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Źródło :
American journal of human genetics [Am J Hum Genet] 2020 Feb 06; Vol. 106 (2), pp. 170-187. Date of Electronic Publication: 2020 Jan 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Algorithms*
Allelic Imbalance*
Quantitative Trait Loci*
Biomarkers, Tumor/*genetics
Chromosome Mapping/*methods
Kidney Neoplasms/*genetics
Prostatic Neoplasms/*genetics
Computer Simulation ; Data Interpretation, Statistical ; Humans ; Kidney Neoplasms/pathology ; Linkage Disequilibrium ; Male ; Phenotype ; Polymorphism, Single Nucleotide ; Prostatic Neoplasms/pathology
Czasopismo naukowe
Tytuł :
ISoLDE: a data-driven statistical method for the inference of allelic imbalance in datasets with reciprocal crosses.
Autorzy :
Reynès C; Institut de Génomique Fonctionnelle, IGF, Univ. Montpellier, CNRS, INSERM, 34094 Montpellier, France.; Faculté de Pharmacie, Univ. Montpellier 34093 Montpellier, France.
Kister G; Faculté de Pharmacie, Univ. Montpellier 34093 Montpellier, France.
Rohmer M; Montpellier GenomiX, MGX, Univ. Montpellier, CNRS, INSERM, 34094 Montpellier, France.
Bouschet T; Institut de Génomique Fonctionnelle, IGF, Univ. Montpellier, CNRS, INSERM, 34094 Montpellier, France.
Varrault A; Institut de Génomique Fonctionnelle, IGF, Univ. Montpellier, CNRS, INSERM, 34094 Montpellier, France.
Dubois E; Montpellier GenomiX, MGX, Univ. Montpellier, CNRS, INSERM, 34094 Montpellier, France.
Rialle S; Montpellier GenomiX, MGX, Univ. Montpellier, CNRS, INSERM, 34094 Montpellier, France.
Journot L; Institut de Génomique Fonctionnelle, IGF, Univ. Montpellier, CNRS, INSERM, 34094 Montpellier, France.; Montpellier GenomiX, MGX, Univ. Montpellier, CNRS, INSERM, 34094 Montpellier, France.
Sabatier R; Institut de Génomique Fonctionnelle, IGF, Univ. Montpellier, CNRS, INSERM, 34094 Montpellier, France.; Faculté de Pharmacie, Univ. Montpellier 34093 Montpellier, France.
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Źródło :
Bioinformatics (Oxford, England) [Bioinformatics] 2020 Jan 15; Vol. 36 (2), pp. 504-513.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Allelic Imbalance*
Genomic Imprinting*
Alleles ; Animals ; Genomics ; Mice ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
Leveraging allelic imbalance to refine fine-mapping for eQTL studies.
Autorzy :
Zou J; Computer Science Department, University of California Los Angeles, Los Angeles, California, United States of America.
Hormozdiari F; Genetic Epidemiology and Statistical Genetics Program, Harvard University, Cambridge, Massachusetts, United States of America.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
Jew B; Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, California, United States of America.
Castel SE; New York Genome Center, New York, New York, United States of America.; Department of Systems Biology, Columbia University, New York, New York, United States of America.
Lappalainen T; New York Genome Center, New York, New York, United States of America.; Department of Systems Biology, Columbia University, New York, New York, United States of America.
Ernst J; Computer Science Department, University of California Los Angeles, Los Angeles, California, United States of America.; Department of Biological Chemistry, University of California Los Angeles, Los Angeles, California, United States of America.
Sul JH; Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California, United States of America.
Eskin E; Computer Science Department, University of California Los Angeles, Los Angeles, California, United States of America.; Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America.
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Źródło :
PLoS genetics [PLoS Genet] 2019 Dec 13; Vol. 15 (12), pp. e1008481. Date of Electronic Publication: 2019 Dec 13 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Allelic Imbalance*
Quantitative Trait Loci*
Chromatin/*genetics
Chromosome Mapping/*methods
Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Linkage Disequilibrium ; Multifactorial Inheritance ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł :
Fast effect size shrinkage software for beta-binomial models of allelic imbalance.
Autorzy :
Zitovsky JP; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA.
Love MI; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA.
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Źródło :
F1000Research [F1000Res] 2019 Nov 28; Vol. 8, pp. 2024. Date of Electronic Publication: 2019 Nov 28 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Allelic Imbalance*
Software*
Alleles ; Bayes Theorem ; Models, Statistical
Czasopismo naukowe
Tytuł :
AIJ: joint test for simultaneous detection of imprinting and non-imprinting allelic expression imbalance.
Autorzy :
Chen DP; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Zhang FY; Department of Mathematics and Statistics, Texas Tech University, Texas, USA.
Lin SL; Department of Statistics, The Ohio State University, Ohio, USA.
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Źródło :
Mathematical biosciences and engineering : MBE [Math Biosci Eng] 2019 Oct 10; Vol. 17 (1), pp. 366-386.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Allelic Imbalance*
Epigenesis, Genetic*
Genomic Imprinting*
Animals ; Computer Simulation ; Female ; Gene Expression Regulation ; Genomics ; Heterozygote ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Phenotype ; Polymorphism, Single Nucleotide ; RNA-Seq ; Species Specificity
Czasopismo naukowe
Tytuł :
An alternative miRISC targets a cancer-associated coding sequence mutation in FOXL2.
Autorzy :
Shin E; School of Pharmacy, Chung-Ang University, Seoul, Korea.
Jin H; Department of Life Science, Chung-Ang University, Seoul, Korea.
Suh DS; Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Luo Y; School of Pharmacy, Chung-Ang University, Seoul, Korea.
Ha HJ; School of Pharmacy, Chung-Ang University, Seoul, Korea.
Kim TH; Department of Pathology, Bundang CHA Hospital, CHA University, Seongnam, Korea.
Hahn Y; Department of Life Science, Chung-Ang University, Seoul, Korea.
Hyun S; Department of Life Science, Chung-Ang University, Seoul, Korea.
Lee K; Department of Life Science, Chung-Ang University, Seoul, Korea.
Bae J; School of Pharmacy, Chung-Ang University, Seoul, Korea.
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Źródło :
The EMBO journal [EMBO J] 2020 Dec 15; Vol. 39 (24), pp. e104719. Date of Electronic Publication: 2020 Nov 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Open Reading Frames*
Forkhead Box Protein L2/*genetics
Forkhead Box Protein L2/*metabolism
Granulosa Cell Tumor/*genetics
MicroRNAs/*metabolism
Allelic Imbalance ; Animals ; Apoptosis ; Argonaute Proteins/genetics ; Argonaute Proteins/metabolism ; Cell Death/physiology ; DEAD-box RNA Helicases/genetics ; DEAD-box RNA Helicases/metabolism ; Gene Expression Regulation, Neoplastic ; Gene Knockout Techniques ; Granulosa Cell Tumor/pathology ; HEK293 Cells ; Humans ; Mice ; Mice, Knockout ; MicroRNAs/genetics ; Mutation, Missense ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; RNA, Messenger/metabolism ; Transcriptome
Czasopismo naukowe
Tytuł :
Precise detection of genomic imbalances at single-cell resolution reveals intra-patient heterogeneity in Hodgkin's lymphoma.
Autorzy :
Mangano C; Menarini Silicon Biosystems S.p.A, Bologna, Italy.
Ferrarini A; Menarini Silicon Biosystems S.p.A, Bologna, Italy.
Forcato C; Menarini Silicon Biosystems S.p.A, Bologna, Italy.
Garonzi M; Menarini Silicon Biosystems S.p.A, Bologna, Italy.
Tononi P; Menarini Silicon Biosystems S.p.A, Bologna, Italy.
Lanzellotto R; Menarini Silicon Biosystems S.p.A, Bologna, Italy.
Raspadori A; Menarini Silicon Biosystems S.p.A, Bologna, Italy.
Bolognesi C; Menarini Silicon Biosystems S.p.A, Bologna, Italy.
Buson G; Menarini Silicon Biosystems S.p.A, Bologna, Italy.
Medoro G; Menarini Silicon Biosystems S.p.A, Bologna, Italy.
Hummel M; Charité - Universitätsmedizin Berlin, Institut für Pathologie, Berlin, Germany.
Fontana F; Menarini Silicon Biosystems S.p.A, Bologna, Italy.
Manaresi N; Menarini Silicon Biosystems S.p.A, Bologna, Italy. .
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Źródło :
Blood cancer journal [Blood Cancer J] 2019 Nov 21; Vol. 9 (12), pp. 92. Date of Electronic Publication: 2019 Nov 21.
Typ publikacji :
Letter
MeSH Terms :
Allelic Imbalance*
Biomarkers, Tumor*
Genomics*/methods
Precision Medicine*/methods
Hodgkin Disease/*diagnosis
Hodgkin Disease/*genetics
DNA Copy Number Variations ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genetic Testing ; Humans ; Single-Cell Analysis
Opinia redakcyjna
Tytuł :
Identification of somatic mutations in single cell DNA-seq using a spatial model of allelic imbalance.
Autorzy :
Luquette LJ; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Bohrson CL; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Sherman MA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Park PJ; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. .; Ludwig Center at Harvard, Boston, MA, USA. .
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Źródło :
Nature communications [Nat Commun] 2019 Aug 29; Vol. 10 (1), pp. 3908. Date of Electronic Publication: 2019 Aug 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Allelic Imbalance*
Base Sequence*
Models, Genetic*
Mutation*
Single-Cell Analysis/*methods
Algorithms ; Chromosomes, Human, X ; Gene Frequency ; Genes, Neoplasm ; Genotype ; Humans ; Male ; Neoplasms/genetics ; Polymorphism, Single Nucleotide ; Whole Genome Sequencing
Czasopismo naukowe
Tytuł :
Recessive gene disruptions in autism spectrum disorder.
Autorzy :
Doan RN; Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Lim ET; Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
De Rubeis S; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Betancur C; Neuroscience Paris Seine, Institut de Biologie Paris Seine, Sorbonne Université, INSERM, CNRS, Paris, France.
Cutler DJ; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
Chiocchetti AG; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Autism Research and Intervention Center of Excellence, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
Overman LM; Human Developmental Biology Resource, Institute of Genetic Medicine, Newcastle University, International Centre for Life, Newcastle-upon-Tyne, UK.
Soucy A; Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Goetze S; Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Freitag CM; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Autism Research and Intervention Center of Excellence, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
Daly MJ; Harvard Medical School, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Walsh CA; Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA.
Buxbaum JD; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yu TW; Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA. .; Harvard Medical School, Boston, MA, USA. .; The Broad Institute of MIT and Harvard, Cambridge, MA, USA. .
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Corporate Authors :
Autism Sequencing Consortium
Źródło :
Nature genetics [Nat Genet] 2019 Jul; Vol. 51 (7), pp. 1092-1098. Date of Electronic Publication: 2019 Jun 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Allelic Imbalance*
Genetic Predisposition to Disease*
Mutation, Missense*
Autism Spectrum Disorder/*genetics
Genes, Recessive/*genetics
Case-Control Studies ; Cohort Studies ; Female ; Genome, Human ; Humans ; Male ; Whole Exome Sequencing
Czasopismo naukowe
Tytuł :
Directional allelic imbalance profiling and visualization from multi-sample data with RECUR.
Autorzy :
Jakubek YA; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
San Lucas FA; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Scheet P; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
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Źródło :
Bioinformatics (Oxford, England) [Bioinformatics] 2019 Jul 01; Vol. 35 (13), pp. 2300-2302.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Allelic Imbalance*
Alleles ; DNA Copy Number Variations ; Haplotypes ; Humans ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł :
Role of Allelic Imbalance in Predicting Hepatocellular Carcinoma (HCC) Recurrence Risk After Liver Transplant.
Autorzy :
Pagano D; Department for Treatment and Study of Abdominal Diseases and Abdominal Transplantation, Mediterranean Institute for Transplantation and High Specialization Therapies (IRCCS-ISMETT), Palermo, Italy.
Barbera F; Department of Laboratory Medicine and Advanced Biotechnologies, Mediterranean Institute for Transplantation and High Specialization Therapies (IRCCS-ISMETT), Palermo, Italy.
Conaldi PG; Department of Laboratory Medicine and Advanced Biotechnologies, Mediterranean Institute for Transplantation and High Specialization Therapies (IRCCS-ISMETT), Palermo, Italy.; Ri.MED Foundation, Palermo, Italy.
Seidita A; Department for Treatment and Study of Abdominal Diseases and Abdominal Transplantation, Mediterranean Institute for Transplantation and High Specialization Therapies (IRCCS-ISMETT), Palermo, Italy.
Di Francesco F; Department for Treatment and Study of Abdominal Diseases and Abdominal Transplantation, Mediterranean Institute for Transplantation and High Specialization Therapies (IRCCS-ISMETT), Palermo, Italy.
Di Carlo D; Department for Treatment and Study of Abdominal Diseases and Abdominal Transplantation, Mediterranean Institute for Transplantation and High Specialization Therapies (IRCCS-ISMETT), Palermo, Italy.
Bàrbara M; Department for Treatment and Study of Abdominal Diseases and Abdominal Transplantation, Mediterranean Institute for Transplantation and High Specialization Therapies (IRCCS-ISMETT), Palermo, Italy.
Tuzzolino F; Research Office, Mediterranean Institute for Transplantation and High Specialization Therapies (IRCCS-ISMETT), Palermo, Italy.
Luca A; Department of Diagnostic and Therapeutic Services, Mediterranean Institute for Transplantation and High Specialization Therapies (IRCCS-ISMETT), Palermo, Italy.
Gruttadauria S; Department for Treatment and Study of Abdominal Diseases and Abdominal Transplantation, Mediterranean Institute for Transplantation and High Specialization Therapies (IRCCS-ISMETT), Palermo, Italy.
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Źródło :
Annals of transplantation [Ann Transplant] 2019 Apr 24; Vol. 24, pp. 223-233. Date of Electronic Publication: 2019 Apr 24.
Typ publikacji :
Journal Article
MeSH Terms :
Allelic Imbalance*
Liver Transplantation*
Carcinoma, Hepatocellular/*pathology
Liver Neoplasms/*pathology
Neoplasm Recurrence, Local/*pathology
Aged ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/surgery ; Female ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/surgery ; Male ; Middle Aged ; Neoplasm Recurrence, Local/genetics ; Prognosis ; Retrospective Studies ; Risk Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Analysis of allele-specific expression of seven candidate genes involved in lipid metabolism in pig skeletal muscle and fat tissues reveals allelic imbalance of ACACA, LEP, SCD, and TNF.
Autorzy :
Stachowiak M; Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60-637, Poznan, Poland. .
Flisikowski K; Chair of Livestock Biotechnology, Technical University of Munich, Liesel-Beckmannstr. 1, 85354, Freising, Germany.
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Źródło :
Journal of applied genetics [J Appl Genet] 2019 Feb; Vol. 60 (1), pp. 97-101. Date of Electronic Publication: 2019 Jan 26.
Typ publikacji :
Journal Article
MeSH Terms :
Allelic Imbalance*
Genes*
Polymorphism, Genetic*
Adipose Tissue/*metabolism
Lipid Metabolism/*genetics
Muscle, Skeletal/*metabolism
Swine/*genetics
Acetyl-CoA Carboxylase/genetics ; Alleles ; Animals ; Leptin/genetics ; Stearoyl-CoA Desaturase/genetics ; Tumor Necrosis Factor-alpha/genetics
Czasopismo naukowe
Tytuł :
A Four-gene Decision Tree Signature Classification of Triple-negative Breast Cancer: Implications for Targeted Therapeutics.
Autorzy :
Quist J; Cancer Bioinformatics, Cancer Centre at Guy's Hospital, King's College London, London, United Kingdom.; Breast Cancer Now Research Unit, Cancer Centre at Guy's Hospital, King's College London, London, United Kingdom.; School of Cancer and Pharmaceutical Sciences, Cancer Research UK King's Health Partners Centre, King's College London, London, United Kingdom.
Mirza H; Cancer Bioinformatics, Cancer Centre at Guy's Hospital, King's College London, London, United Kingdom.; Breast Cancer Now Research Unit, Cancer Centre at Guy's Hospital, King's College London, London, United Kingdom.; School of Cancer and Pharmaceutical Sciences, Cancer Research UK King's Health Partners Centre, King's College London, London, United Kingdom.
Cheang MCU; Clinical Trials and Statistics Unit (ICR-CTSU), The Institute of Cancer Research, Surrey, United Kingdom.; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.
Telli ML; Department of Medicine, Stanford University School of Medicine, Stanford, California.
O'Shaughnessy JA; Baylor University Medical Center, Texas Oncology, US Oncology, Dallas, Texas.
Lord CJ; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, United Kingdom.
Tutt ANJ; Breast Cancer Now Research Unit, Cancer Centre at Guy's Hospital, King's College London, London, United Kingdom.; School of Cancer and Pharmaceutical Sciences, Cancer Research UK King's Health Partners Centre, King's College London, London, United Kingdom.; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.
Grigoriadis A; Cancer Bioinformatics, Cancer Centre at Guy's Hospital, King's College London, London, United Kingdom. .; Breast Cancer Now Research Unit, Cancer Centre at Guy's Hospital, King's College London, London, United Kingdom.; School of Cancer and Pharmaceutical Sciences, Cancer Research UK King's Health Partners Centre, King's College London, London, United Kingdom.
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Źródło :
Molecular cancer therapeutics [Mol Cancer Ther] 2019 Jan; Vol. 18 (1), pp. 204-212. Date of Electronic Publication: 2018 Oct 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Allelic Imbalance*
Gene Expression Profiling/*methods
Genomics/*methods
Platinum/*pharmacology
Triple Negative Breast Neoplasms/*classification
Apoptosis Regulatory Proteins/genetics ; Bayes Theorem ; Cell Line, Tumor ; Cell Survival/drug effects ; Clinical Trials, Phase II as Topic ; DNA Repair Enzymes/genetics ; Decision Trees ; Exodeoxyribonucleases/genetics ; Female ; Forkhead Box Protein M1/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Molecular Targeted Therapy ; Platinum/therapeutic use ; Transcription Factors/genetics ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/genetics
Czasopismo naukowe
Tytuł :
Allele-specific epigenome maps reveal sequence-dependent stochastic switching at regulatory loci.
Autorzy :
Onuchic V; Molecular and Human Genetics Department, Baylor College of Medicine, Houston, TX, USA.; Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX, USA.; Epigenome Center, Baylor College of Medicine, Houston, TX, USA.; NIH Roadmap Epigenomics Project.
Lurie E; Molecular and Human Genetics Department, Baylor College of Medicine, Houston, TX, USA.; Epigenome Center, Baylor College of Medicine, Houston, TX, USA.; NIH Roadmap Epigenomics Project.
Carrero I; Molecular and Human Genetics Department, Baylor College of Medicine, Houston, TX, USA.; Epigenome Center, Baylor College of Medicine, Houston, TX, USA.
Pawliczek P; Molecular and Human Genetics Department, Baylor College of Medicine, Houston, TX, USA.; Epigenome Center, Baylor College of Medicine, Houston, TX, USA.
Patel RY; Molecular and Human Genetics Department, Baylor College of Medicine, Houston, TX, USA.; Epigenome Center, Baylor College of Medicine, Houston, TX, USA.
Rozowsky J; Program in Computational Biology and Bioinformatics, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.; Department of Computer Science, Yale University, New Haven, CT, USA.
Galeev T; Program in Computational Biology and Bioinformatics, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.; Department of Computer Science, Yale University, New Haven, CT, USA.
Huang Z; Molecular and Human Genetics Department, Baylor College of Medicine, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Altshuler RC; NIH Roadmap Epigenomics Project.; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA, USA.
Zhang Z; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA, USA.
Harris RA; Molecular and Human Genetics Department, Baylor College of Medicine, Houston, TX, USA.; Epigenome Center, Baylor College of Medicine, Houston, TX, USA.; NIH Roadmap Epigenomics Project.
Coarfa C; Molecular and Human Genetics Department, Baylor College of Medicine, Houston, TX, USA.; Epigenome Center, Baylor College of Medicine, Houston, TX, USA.; NIH Roadmap Epigenomics Project.
Ashmore L; Molecular and Human Genetics Department, Baylor College of Medicine, Houston, TX, USA.; Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX, USA.; Epigenome Center, Baylor College of Medicine, Houston, TX, USA.
Bertol JW; Center for Craniofacial Research, Department of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center at Houston, Houston, TX, USA.
Fakhouri WD; Center for Craniofacial Research, Department of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center at Houston, Houston, TX, USA.
Yu F; Molecular and Human Genetics Department, Baylor College of Medicine, Houston, TX, USA.; Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Kellis M; NIH Roadmap Epigenomics Project.; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA, USA.
Gerstein M; Program in Computational Biology and Bioinformatics, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.; Department of Computer Science, Yale University, New Haven, CT, USA.
Milosavljevic A; Molecular and Human Genetics Department, Baylor College of Medicine, Houston, TX, USA. .; Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX, USA.; Epigenome Center, Baylor College of Medicine, Houston, TX, USA.; NIH Roadmap Epigenomics Project.
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Źródło :
Science (New York, N.Y.) [Science] 2018 Sep 28; Vol. 361 (6409). Date of Electronic Publication: 2018 Aug 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Allelic Imbalance*
DNA Methylation*
Epigenesis, Genetic*
Genome, Human*
Polymorphism, Single Nucleotide*
Disease/*genetics
Alleles ; Binding Sites ; CpG Islands ; Gene Regulatory Networks ; Genetic Loci ; Genome-Wide Association Study ; Humans ; Sequence Analysis, DNA ; Sulfites/chemistry ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Contribution of allelic imbalance to colorectal cancer.
Autorzy :
Palin K; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Pitkänen E; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Turunen M; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Sahu B; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Pihlajamaa P; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Kivioja T; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Kaasinen E; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.; Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles väg 2, SE-17165, Stockholm, Sweden.
Välimäki N; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Hänninen UA; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Cajuso T; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Aavikko M; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Tuupanen S; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Kilpivaara O; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
van den Berg L; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Kondelin J; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Tanskanen T; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Katainen R; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Grau M; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Rauanheimo H; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Plaketti RM; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Taira A; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Sulo P; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Hartonen T; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Dave K; Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles väg 2, SE-17165, Stockholm, Sweden.
Schmierer B; Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles väg 2, SE-17165, Stockholm, Sweden.
Botla S; Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles väg 2, SE-17165, Stockholm, Sweden.
Sokolova M; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Vähärautio A; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Gladysz K; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.
Ongen H; Genetic Medicine and Development, University of Geneva Medical School-CMU, 1 Rue Michel-Servet, 1211, Geneva, Switzerland.
Dermitzakis E; Genetic Medicine and Development, University of Geneva Medical School-CMU, 1 Rue Michel-Servet, 1211, Geneva, Switzerland.
Bramsen JB; Department of Molecular Medicine, Aarhus University Hospital, DK8200, Aarhus N, Denmark.
Ørntoft TF; Department of Molecular Medicine, Aarhus University Hospital, DK8200, Aarhus N, Denmark.
Andersen CL; Department of Molecular Medicine, Aarhus University Hospital, DK8200, Aarhus N, Denmark.
Ristimäki A; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland.; Department of Pathology, HUSLAB and Haartman Institute, Helsinki University Central Hospital, Haartmaninkatu 3, FI-00290, Helsinki, Finland.
Lepistö A; Department of Gastrointestinal Surgery, Helsinki University Hospital, University of Helsinki, Haartmaninkatu 4, FI-00290, Helsinki, Finland.
Renkonen-Sinisalo L; Department of Gastrointestinal Surgery, Helsinki University Hospital, University of Helsinki, Haartmaninkatu 4, FI-00290, Helsinki, Finland.
Mecklin JP; Department of Surgery, Jyväskylä Central Hospital, Keskussairaalantie 19, FI-40620, Jyväskylä, Finland.; Department of Health Sciences, Faculty of Sport and Health Sciences, University of Jyväskylä, PO Box 35, FI-40014, Jyväskylä, Finland.
Taipale J; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland. .; Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles väg 2, SE-17165, Stockholm, Sweden. .; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, UK. .
Aaltonen LA; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland. .; Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FI-00014, Helsinki, Finland. .; Department of Biosciences and Nutrition, Karolinska Institutet, SE-17177, Stockholm, Sweden. .
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Źródło :
Nature communications [Nat Commun] 2018 Sep 10; Vol. 9 (1), pp. 3664. Date of Electronic Publication: 2018 Sep 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Allelic Imbalance*
Genetic Predisposition to Disease*
Colorectal Neoplasms/*genetics
CRISPR-Cas Systems ; Chromosome Aberrations ; Chromosomes, Human, Pair 8 ; Colorectal Neoplasms/pathology ; DNA Copy Number Variations ; Denmark ; Gene Expression Profiling ; Genomics ; Genotype ; Humans ; Loss of Heterozygosity ; Microsatellite Repeats ; Phenotype ; Point Mutation ; Proto-Oncogene Proteins p21(ras)/genetics ; RNA, Small Interfering/genetics ; Transcription Factors/genetics ; Tumor Suppressor Protein p53/genetics ; Whole Genome Sequencing
Czasopismo naukowe

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