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Wyszukujesz frazę ""alternative splicing"" wg kryterium: Temat


Tytuł :
Plant responses to high temperature: a view from pre-mRNA alternative splicing.
Autorzy :
Lin J; College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.
Zhu Z; College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China. .
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Źródło :
Plant molecular biology [Plant Mol Biol] 2021 Apr; Vol. 105 (6), pp. 575-583. Date of Electronic Publication: 2021 Feb 07.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Hot Temperature*
Alternative Splicing/*physiology
RNA Precursors/*genetics
RNA Precursors/*metabolism
Alternative Splicing/genetics ; Arabidopsis/genetics ; Arabidopsis Proteins/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Gene Expression Regulation, Plant ; Plant Development ; Plant Growth Regulators ; RNA Splicing ; RNA, Messenger/metabolism ; Temperature
Czasopismo naukowe
Tytuł :
Hypoxia-induced alternative splicing in human diseases: the pledge, the turn, and the prestige.
Autorzy :
Natua S; Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, 462066, Madhya Pradesh, India.
Ashok C; Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, 462066, Madhya Pradesh, India.
Shukla S; Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, 462066, Madhya Pradesh, India. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Mar; Vol. 78 (6), pp. 2729-2747. Date of Electronic Publication: 2021 Jan 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alternative Splicing*
Hypoxia*
Cardiovascular Diseases/*pathology
Neoplasms/*pathology
Neurodegenerative Diseases/*pathology
Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cardiovascular Diseases/genetics ; Humans ; Neoplasms/genetics ; Neurodegenerative Diseases/genetics ; RNA Precursors/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Identification of cassava alternative splicing-related genes and functional characterization of MeSCL30 involvement in drought stress.
Autorzy :
Weng X; Institute of Bioengineering, Guangdong Academy of Sciences, Guangdong, 510316, China; Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresource, Institute of Tropical Agriculture and Forestry, Hainan University, Haikou, Hainan, 570228, China.
Zhou X; Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresource, Institute of Tropical Agriculture and Forestry, Hainan University, Haikou, Hainan, 570228, China.
Xie S; Key Laboratory of Ministry of Education for Genetics and Germplasm Innovation of Tropical Special Trees and Ornamental Plants, Hainan Key Laboratory for Biology of Tropical Ornamental Plant Germplasm, College of Forestry, Natural Rubber Cooperative Innovation Centre of Hainan Province & Ministry of Education of China, Hainan University, Haikou, China.
Gu J; Institute of Bioengineering, Guangdong Academy of Sciences, Guangdong, 510316, China. Electronic address: .
Wang ZY; Institute of Bioengineering, Guangdong Academy of Sciences, Guangdong, 510316, China; Zhanjiang Sugarcane Research Center, Guangzhou Sugarcane Industry Research Institute, Zhanjiang, Guangdong, 524300, China. Electronic address: .
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Źródło :
Plant physiology and biochemistry : PPB [Plant Physiol Biochem] 2021 Mar; Vol. 160, pp. 130-142. Date of Electronic Publication: 2021 Jan 17.
Typ publikacji :
Journal Article
MeSH Terms :
Alternative Splicing*
Stress, Physiological*
Manihot/*genetics
Plant Proteins/*genetics
Droughts ; Gene Expression Regulation, Plant ; Manihot/physiology ; Plant Proteins/physiology
Czasopismo naukowe
Tytuł :
Alternative splicing and duplication of PI-like genes in maize.
Autorzy :
Qi S; College of Biological Science and Technology, Shenyang Agricultural University, Shenyang, Liaoning 110866, China.
Chen S; College of Biological Science and Technology, Shenyang Agricultural University, Shenyang, Liaoning 110866, China.
Wang W; Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Li W; College of Biological Science and Technology, Shenyang Agricultural University, Shenyang, Liaoning 110866, China.
Xu X; College of Biological Science and Technology, Shenyang Agricultural University, Shenyang, Liaoning 110866, China.
Zhong M; College of Biological Science and Technology, Shenyang Agricultural University, Shenyang, Liaoning 110866, China.
Lin J; College of Biological Science and Technology, Shenyang Agricultural University, Shenyang, Liaoning 110866, China.
Yu Y; Yanbian University, Yanji, Jilin 133000, China; Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia 028000, China.
Chen Y; Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia 028000, China.
Li H; College of Biological Science and Technology, Shenyang Agricultural University, Shenyang, Liaoning 110866, China. Electronic address: .
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Źródło :
Gene [Gene] 2021 Feb 15; Vol. 769, pp. 145064. Date of Electronic Publication: 2020 Sep 03.
Typ publikacji :
Journal Article
MeSH Terms :
Alternative Splicing*
Gene Duplication*
Genes, Plant*
MADS Domain Proteins/*genetics
Zea mays/*genetics
Acetates/metabolism ; Cyclopentanes/metabolism ; Evolution, Molecular ; Gene Expression Profiling ; Gene Regulatory Networks ; Gibberellins/metabolism ; Oxylipins/metabolism ; Phylogeny ; Plant Proteins/genetics ; Promoter Regions, Genetic ; Protein Domains ; Sequence Alignment
Czasopismo naukowe
Tytuł :
Restriction of an intron size en route to endothermy.
Autorzy :
Královičová J; University of Southampton, Faculty of Medicine, HDH, Southampton SO16 6YD, UK.; Slovak Academy of Sciences, Centre for Biosciences, 840 05 Bratislava, Slovak Republic.
Borovská I; Slovak Academy of Sciences, Centre for Biosciences, 840 05 Bratislava, Slovak Republic.
Pengelly R; University of Southampton, Faculty of Medicine, HDH, Southampton SO16 6YD, UK.
Lee E; School of Biological Sciences, University of Adelaide, Adelaide 5005, SA, Australia.
Abaffy P; Czech Academy of Sciences, Institute of Biotechnology, 25250 Vestec, Czech Republic.
Šindelka R; Czech Academy of Sciences, Institute of Biotechnology, 25250 Vestec, Czech Republic.
Grutzner F; School of Biological Sciences, University of Adelaide, Adelaide 5005, SA, Australia.
Vořechovský I; University of Southampton, Faculty of Medicine, HDH, Southampton SO16 6YD, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Mar 18; Vol. 49 (5), pp. 2460-2487.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Introns*
Body Temperature Regulation/*genetics
Ketoglutarate Dehydrogenase Complex/*genetics
Animals ; Calcium/metabolism ; Evolution, Molecular ; Exons ; HEK293 Cells ; Humans ; Interspersed Repetitive Sequences ; Ketoglutarate Dehydrogenase Complex/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA Precursors/chemistry ; RNA Precursors/metabolism ; RNA Splice Sites ; RNA Splicing Factors/metabolism ; RNA, Messenger/chemistry ; RNA, Messenger/metabolism ; Spliceosomes/metabolism ; Vertebrates/genetics
Czasopismo naukowe
Tytuł :
Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing.
Autorzy :
Li J; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China.
Liu F; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China.
Lv Y; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China.
Sun K; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China.
Zhao Y; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Innovation Academy for Seed Design, Chinese Academy of Science, Wuhan 430072, PR China.
Reilly J; Department of Life Sciences, Glasgow Caledonian University, Glasgow G4 0BA, Scotland, UK.
Zhang Y; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China.
Tu J; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China.
Yu S; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China.
Liu X; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China.
Qin Y; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China.
Huang Y; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China.
Gao P; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China.
Jia D; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China.
Chen X; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China.
Han Y; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China.
Shu X; Department of Life Sciences, Glasgow Caledonian University, Glasgow G4 0BA, Scotland, UK.
Luo D; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Innovation Academy for Seed Design, Chinese Academy of Science, Wuhan 430072, PR China.
Tang Z; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China.
Liu M; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Feb 26; Vol. 49 (4), pp. 2027-2043.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Neural Stem Cells/*metabolism
Neurogenesis/*genetics
Retina/*embryology
Zebrafish Proteins/*physiology
Animals ; Apoptosis ; CRISPR-Cas Systems ; Cell Survival ; DNA Damage ; DNA Repair ; Exons ; Gene Knockout Techniques ; M Phase Cell Cycle Checkpoints ; Neural Stem Cells/cytology ; Retinal Neurons/cytology ; Retinal Neurons/metabolism ; Spindle Apparatus/ultrastructure ; Tumor Suppressor Protein p53/metabolism ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
Czasopismo naukowe
Tytuł :
Targeted splice sequencing reveals RNA toxicity and therapeutic response in myotonic dystrophy.
Autorzy :
Tanner MK; Medical Scientist Training Program, University of Rochester Medical Center, Rochester, NY 14642, USA.
Tang Z; Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Thornton CA; Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Feb 26; Vol. 49 (4), pp. 2240-2254.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Sequence Analysis, RNA*
Myotonic Dystrophy/*genetics
Myotonic Dystrophy/*therapy
Animals ; DNA-Binding Proteins/genetics ; Exons ; Gene Deletion ; Gene Expression Regulation, Developmental ; Mice ; Muscles/metabolism ; Muscles/physiology ; Myotonic Dystrophy/metabolism ; Oligonucleotides, Antisense ; RNA-Binding Proteins/genetics ; Regeneration ; Transcriptome ; Trinucleotide Repeat Expansion
Czasopismo naukowe
Tytuł :
Identification and analysis of splicing quantitative trait loci across multiple tissues in the human genome.
Autorzy :
Garrido-Martín D; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Catalonia, Spain. .
Borsari B; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Catalonia, Spain.
Calvo M; Section of Statistics, Faculty of Biology, Universitat de Barcelona (UB), Av. Diagonal 643, Barcelona, 08028, Spain.
Reverter F; Section of Statistics, Faculty of Biology, Universitat de Barcelona (UB), Av. Diagonal 643, Barcelona, 08028, Spain.
Guigó R; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Catalonia, Spain. .; Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 01; Vol. 12 (1), pp. 727. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Quantitative Trait Loci*
Genome, Human/*genetics
RNA Splice Sites/*genetics
Binding Sites/genetics ; Datasets as Topic ; Genome-Wide Association Study ; Humans ; Introns/genetics ; Mutation ; RNA-Binding Proteins/metabolism ; RNA-Seq ; Whole Genome Sequencing
Czasopismo naukowe
Tytuł :
Alternative mRNA Processing of Innate Response Pathways in Respiratory Syncytial Virus (RSV) Infection.
Autorzy :
Xu X; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health (SMPH), Madison, WI 53705, USA.
Mann M; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health (SMPH), Madison, WI 53705, USA.
Qiao D; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health (SMPH), Madison, WI 53705, USA.
Brasier AR; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health (SMPH), Madison, WI 53705, USA.; Institute for Clinical and Translational Research (ICTR), University of Wisconsin-Madison, Madison, WI 53705, USA.
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Źródło :
Viruses [Viruses] 2021 Jan 31; Vol. 13 (2). Date of Electronic Publication: 2021 Jan 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Alternative Splicing*
Immunity, Innate*
RNA, Messenger/*genetics
Respiratory Syncytial Virus Infections/*genetics
Respiratory Syncytial Virus Infections/*immunology
Respiratory Syncytial Virus, Human/*physiology
Epithelial Cells/immunology ; Epithelial Cells/virology ; Humans ; RNA Processing, Post-Transcriptional ; RNA, Messenger/immunology ; Respiratory Syncytial Virus Infections/virology ; Respiratory Syncytial Virus, Human/genetics ; Transcription Factor RelA/genetics ; Transcription Factor RelA/immunology
Czasopismo naukowe
Tytuł :
Identification of Sortilin Alternatively Spliced Variants in Mouse 3T3L1 Adipocytes.
Autorzy :
Lui A; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Sparks R; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Patel R; Research Service, James A. Haley Veteran's Hospital, Tampa, FL 33612, USA.
Patel NA; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.; Research Service, James A. Haley Veteran's Hospital, Tampa, FL 33612, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 20; Vol. 22 (3). Date of Electronic Publication: 2021 Jan 20.
Typ publikacji :
Journal Article
MeSH Terms :
Alternative Splicing*
Adaptor Proteins, Vesicular Transport/*genetics
3T3-L1 Cells ; Adaptor Proteins, Vesicular Transport/chemistry ; Adaptor Proteins, Vesicular Transport/metabolism ; Adipocytes/metabolism ; Animals ; Binding Sites ; Glucose/metabolism ; Insulin Resistance ; Intrinsically Disordered Proteins/chemistry ; Mice ; Molecular Dynamics Simulation ; Protein Binding ; Protein Domains
Czasopismo naukowe
Tytuł :
Alternative Splicing of FN (Fibronectin) Regulates the Composition of the Arterial Wall Under Low Flow.
Autorzy :
Murphy PA; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA (P.A.M., N.J., A.M.D.R., S.B., R.O.H.).; UCONN Health, Center for Vascular Biology and Calhoun Cardiology Center, Farmington, CT (P.A.M., S.-A.N., A.K.).
Jailkhani N; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA (P.A.M., N.J., A.M.D.R., S.B., R.O.H.).
Nicholas SA; UCONN Health, Center for Vascular Biology and Calhoun Cardiology Center, Farmington, CT (P.A.M., S.-A.N., A.K.).
Del Rosario AM; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA (P.A.M., N.J., A.M.D.R., S.B., R.O.H.).
Balsbaugh JL; UCONN, Proteomics and Metabolomics Facility, Storrs, CT (J.L.B.).
Begum S; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA (P.A.M., N.J., A.M.D.R., S.B., R.O.H.).; Howard Hughes Medical Institute, Chevy Chase, MD (S.B., R.O.H.).
Kimble A; UCONN Health, Center for Vascular Biology and Calhoun Cardiology Center, Farmington, CT (P.A.M., S.-A.N., A.K.).
Hynes RO; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA (P.A.M., N.J., A.M.D.R., S.B., R.O.H.).; Howard Hughes Medical Institute, Chevy Chase, MD (S.B., R.O.H.).
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Jan; Vol. 41 (1), pp. e18-e32. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Vascular Remodeling*
Carotid Arteries/*metabolism
Carotid Stenosis/*metabolism
Extracellular Matrix/*metabolism
Fibronectins/*metabolism
Animals ; Carotid Arteries/pathology ; Carotid Arteries/physiopathology ; Carotid Stenosis/pathology ; Carotid Stenosis/physiopathology ; Cells, Cultured ; Disease Models, Animal ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/pathology ; Extracellular Matrix/pathology ; Fibronectins/deficiency ; Fibronectins/genetics ; Mechanotransduction, Cellular ; Mice, Knockout ; Protein Isoforms ; Regional Blood Flow ; Stress, Mechanical
Czasopismo naukowe
Tytuł :
Role of promoters in regulating alternative splicing.
Autorzy :
Kolathur KK; Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences (MCOPS), Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, 576104, India. Electronic address: .
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Źródło :
Gene [Gene] 2021 May 25; Vol. 782, pp. 145523. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alternative Splicing*
Promoter Regions, Genetic/*physiology
Animals ; DNA-Binding Proteins/metabolism ; Epigenesis, Genetic ; Humans ; RNA Polymerase II/metabolism
Czasopismo naukowe
Tytuł :
Distant coupling between RNA editing and alternative splicing of the osmosensitive cation channel Tmem63b.
Autorzy :
Wu D; Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Medical School, Nanjing University, Nanjing, China; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing University, Nanjing, China.
Zang YY; Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Medical School, Nanjing University, Nanjing, China; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing University, Nanjing, China.
Shi YY; Department of Orthopaedics, Luhe People's Hospital Affiliated to Yangzhou University, Nanjing, China.
Ye C; Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Medical School, Nanjing University, Nanjing, China; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing University, Nanjing, China.
Cai WM; Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Medical School, Nanjing University, Nanjing, China; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing University, Nanjing, China.
Tang XH; Department of Anesthesiology and Perioperative Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; School of Medicine, Southeast University, Nanjing, China.
Zhao L; Translational Science and Clinical Biomarker, BeiGene (Shanghai) Co., Ltd., Shanghai, China.
Liu Y; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Institute for Advanced Studies, Wuhan University, Wuhan, China.
Gan Z; Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Medical School, Nanjing University, Nanjing, China; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing University, Nanjing, China.
Chen GQ; Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Medical School, Nanjing University, Nanjing, China; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing University, Nanjing, China; Institute for Brain Sciences, Nanjing University, Nanjing, China.
Xu Y; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing University, Nanjing, China; Institute for Brain Sciences, Nanjing University, Nanjing, China.
Yang JJ; Department of Anesthesiology and Perioperative Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address: .
Shi YS; Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Medical School, Nanjing University, Nanjing, China; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing University, Nanjing, China; Institute for Brain Sciences, Nanjing University, Nanjing, China; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing, China. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Dec 25; Vol. 295 (52), pp. 18199-18212. Date of Electronic Publication: 2020 Oct 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Exons*
RNA Editing*
Adenosine Deaminase/*physiology
Brain/*metabolism
Calcium Channels/*genetics
RNA Precursors/*genetics
RNA-Binding Proteins/*physiology
Animals ; Calcium Channels/metabolism ; Female ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Titration of SF3B1 Activity Reveals Distinct Effects on the Transcriptome and Cell Physiology.
Autorzy :
Kim Guisbert KS; Department of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, FL 32937, USA.
Mossiah I; Department of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, FL 32937, USA.
Guisbert E; Department of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, FL 32937, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 17; Vol. 21 (24). Date of Electronic Publication: 2020 Dec 17.
Typ publikacji :
Journal Article
MeSH Terms :
Alternative Splicing*
Cell Physiological Phenomena*
Gene Expression Regulation/*drug effects
Phosphoproteins/*metabolism
RNA Splicing Factors/*metabolism
RNA, Messenger/*metabolism
Sequence Analysis, RNA/*methods
Transcriptome/*drug effects
Epoxy Compounds/pharmacology ; HEK293 Cells ; Humans ; Macrolides/pharmacology ; Nonsense Mediated mRNA Decay ; Phosphoproteins/genetics ; RNA Splicing Factors/genetics ; RNA, Messenger/genetics
Czasopismo naukowe
Tytuł :
Perspective in Alternative Splicing Coupled to Nonsense-Mediated mRNA Decay.
Autorzy :
García-Moreno JF; Department of Human Genetics, Instituto Nacional de Saúde Doutor Ricardo Jorge, 1649-016 Lisboa, Portugal.; Faculty of Science, BioISI-Biosystems and Integrative Sciences Institute, University of Lisboa, 1749-016 Lisboa, Portugal.
Romão L; Department of Human Genetics, Instituto Nacional de Saúde Doutor Ricardo Jorge, 1649-016 Lisboa, Portugal.; Faculty of Science, BioISI-Biosystems and Integrative Sciences Institute, University of Lisboa, 1749-016 Lisboa, Portugal.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 10; Vol. 21 (24). Date of Electronic Publication: 2020 Dec 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alternative Splicing*
Nonsense Mediated mRNA Decay*
Animals ; Gene Expression Regulation, Developmental ; Humans ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
Viral-induced alternative splicing of host genes promotes influenza replication.
Autorzy :
Thompson MG; Biochemistry and Molecular Biophysics Graduate Group, University of Pennsylvania, Philadelphia, United States.; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, United States.
Dittmar M; Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Mallory MJ; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, United States.
Bhat P; Department of Cell Biology, UT Southwestern Medical Center, Dallas, United States.
Ferretti MB; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, United States.; Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Fontoura BM; Department of Cell Biology, UT Southwestern Medical Center, Dallas, United States.
Cherry S; Biochemistry and Molecular Biophysics Graduate Group, University of Pennsylvania, Philadelphia, United States.; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, United States.; Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Lynch KW; Biochemistry and Molecular Biophysics Graduate Group, University of Pennsylvania, Philadelphia, United States.; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, United States.
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Źródło :
ELife [Elife] 2020 Dec 03; Vol. 9. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Alternative Splicing*
Virus Replication*
Cell Nucleus/*virology
Epithelial Cells/*virology
Influenza A virus/*growth & development
Lung/*virology
A549 Cells ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Epithelial Cells/metabolism ; Heterogeneous-Nuclear Ribonucleoprotein K/genetics ; Heterogeneous-Nuclear Ribonucleoprotein K/metabolism ; Host-Pathogen Interactions ; Humans ; Influenza A virus/genetics ; Influenza A virus/pathogenicity ; Lung/metabolism
Czasopismo naukowe
Tytuł :
Characterization of the rat Acetylcholinesterase readthrough (AChE-R) splice variant: Implications for toxicological studies.
Autorzy :
Padhi BK; Hazard Identification Division, Environmental Health Science and Research Bureau, HECSB, Health Canada, Ottawa, ON, Canada. Electronic address: .
Pelletier G; Hazard Identification Division, Environmental Health Science and Research Bureau, HECSB, Health Canada, Ottawa, ON, Canada.
Singh M; Hazard Identification Division, Environmental Health Science and Research Bureau, HECSB, Health Canada, Ottawa, ON, Canada.
Kulkarni S; Existing Substances Risk Assessment Bureau, HECSB, Health Canada, Ottawa, ON, Canada.
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Nov 19; Vol. 532 (4), pp. 528-534. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Acetylcholinesterase/*genetics
Acetylcholinesterase/metabolism ; Animals ; Cells, Cultured ; Chlorpyrifos/toxicity ; Cholinesterase Inhibitors/toxicity ; Exons ; GPI-Linked Proteins/genetics ; GPI-Linked Proteins/metabolism ; Gene Expression Regulation ; Insecticides/toxicity ; Introns ; PC12 Cells ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Rats
Czasopismo naukowe
Tytuł :
Revised Exon Structure of l-DOPA Decarboxylase ( DDC ) Reveals Novel Splice Variants Associated with Colorectal Cancer Progression.
Autorzy :
Artemaki PI; Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, 15701 Athens, Greece.
Papatsirou M; Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, 15701 Athens, Greece.
Boti MA; Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, 15701 Athens, Greece.
Adamopoulos PG; Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, 15701 Athens, Greece.
Christodoulou S; Fourth Surgery Department, National and Kapodistrian University of Athens, University General Hospital 'Attikon', 12462 Athens, Greece.
Vassilacopoulou D; Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, 15701 Athens, Greece.
Scorilas A; Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, 15701 Athens, Greece.
Kontos CK; Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, 15701 Athens, Greece.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 13; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :
Journal Article
MeSH Terms :
Alternative Splicing*
Aromatic-L-Amino-Acid Decarboxylases*/biosynthesis
Aromatic-L-Amino-Acid Decarboxylases*/genetics
Colorectal Neoplasms*/enzymology
Colorectal Neoplasms*/genetics
Exons*
Gene Expression Regulation, Enzymologic*
Gene Expression Regulation, Neoplastic*
Neoplasm Proteins*/biosynthesis
Neoplasm Proteins*/genetics
Cell Line, Tumor ; Disease Progression ; HEK293 Cells ; Humans ; Isoenzymes/biosynthesis ; Isoenzymes/genetics ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Novel alternative splicing variants of Klf4 display different capacities for self-renewal and pluripotency in mouse embryonic stem cells.
Autorzy :
Yang Y; Experimental Center of Basic Medicine, College of Basic Medical Sciences, Army Medical University, Chongqing, 400038, China; Laboratory of Stem Cell & Developmental Biology, Department of Histology and Embryology, Army Medical University, Chongqing, 400038, China.
Xiong J; Experimental Center of Basic Medicine, College of Basic Medical Sciences, Army Medical University, Chongqing, 400038, China; Laboratory of Stem Cell & Developmental Biology, Department of Histology and Embryology, Army Medical University, Chongqing, 400038, China.
Wang J; Laboratory of Stem Cell & Developmental Biology, Department of Histology and Embryology, Army Medical University, Chongqing, 400038, China.
Ruan Y; Laboratory of Stem Cell & Developmental Biology, Department of Histology and Embryology, Army Medical University, Chongqing, 400038, China.
Zhang J; Laboratory of Stem Cell & Developmental Biology, Department of Histology and Embryology, Army Medical University, Chongqing, 400038, China.
Tian Y; Laboratory of Stem Cell & Developmental Biology, Department of Histology and Embryology, Army Medical University, Chongqing, 400038, China.
Wang J; Laboratory of Stem Cell & Developmental Biology, Department of Histology and Embryology, Army Medical University, Chongqing, 400038, China.
Liu L; Laboratory of Stem Cell & Developmental Biology, Department of Histology and Embryology, Army Medical University, Chongqing, 400038, China.
Cheng Y; Laboratory of Stem Cell & Developmental Biology, Department of Histology and Embryology, Army Medical University, Chongqing, 400038, China.
Wang X; Laboratory of Stem Cell & Developmental Biology, Department of Histology and Embryology, Army Medical University, Chongqing, 400038, China.
Xu Y; Southwest Hospital/southwest Eye Hospital, The First Hospital Affiliated to Army Medical University, Chongqing, 400038, China.
Wang J; Laboratory of Stem Cell & Developmental Biology, Department of Histology and Embryology, Army Medical University, Chongqing, 400038, China.
Yu M; Laboratory of Stem Cell & Developmental Biology, Department of Histology and Embryology, Army Medical University, Chongqing, 400038, China.
Zhao B; Laboratory of Stem Cell & Developmental Biology, Department of Histology and Embryology, Army Medical University, Chongqing, 400038, China.
Zhang Y; Laboratory of Stem Cell & Developmental Biology, Department of Histology and Embryology, Army Medical University, Chongqing, 400038, China.
Li H; Experimental Center of Basic Medicine, College of Basic Medical Sciences, Army Medical University, Chongqing, 400038, China; Department of Histology and Embryology, Army Medical University, Chongqing, 400038, China. Electronic address: .
Jian R; Laboratory of Stem Cell & Developmental Biology, Department of Histology and Embryology, Army Medical University, Chongqing, 400038, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Nov 12; Vol. 532 (3), pp. 377-384. Date of Electronic Publication: 2020 Aug 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Cell Self Renewal/*genetics
Cell Self Renewal/*physiology
Kruppel-Like Transcription Factors/*genetics
Kruppel-Like Transcription Factors/*physiology
Mouse Embryonic Stem Cells/*cytology
Mouse Embryonic Stem Cells/*physiology
Animals ; Base Sequence ; Cell Differentiation/genetics ; Cell Differentiation/physiology ; Cell Line ; Codon, Nonsense ; Mice ; Models, Biological ; Poly A/genetics ; Protein Isoforms/genetics ; Protein Isoforms/physiology
Czasopismo naukowe
Tytuł :
Identification of Dominant Transcripts in Oxidative Stress Response by a Full-Length Transcriptome Analysis.
Autorzy :
Otsuki A; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Medical Biochemistry, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Okamura Y; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan.
Aoki Y; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Graduate School of Information Sciences, Tohoku University, Sendai, Japan.
Ishida N; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Kumada K; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Minegishi N; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Katsuoka F; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Medical Biochemistry, Graduate School of Medicine, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan.
Kinoshita K; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan.; Graduate School of Information Sciences, Tohoku University, Sendai, Japan.
Yamamoto M; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan .; Department of Medical Biochemistry, Graduate School of Medicine, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan.
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Źródło :
Molecular and cellular biology [Mol Cell Biol] 2021 Jan 25; Vol. 41 (2). Date of Electronic Publication: 2021 Jan 25 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Transcriptome*
Kelch-Like ECH-Associated Protein 1/*genetics
NF-E2-Related Factor 2/*genetics
RNA, Messenger/*genetics
Cell Line, Transformed ; Cell Nucleus/drug effects ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Gene Expression Profiling ; High-Throughput Nucleotide Sequencing ; Humans ; Kelch-Like ECH-Associated Protein 1/chemistry ; Kelch-Like ECH-Associated Protein 1/metabolism ; Lymphocytes/cytology ; Lymphocytes/drug effects ; Lymphocytes/metabolism ; Maleates/pharmacology ; Models, Molecular ; NF-E2-Related Factor 2/chemistry ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Protein Structure, Secondary ; RNA, Messenger/classification ; RNA, Messenger/metabolism
Czasopismo naukowe

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