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Tytuł:
Zfra Overrides WWOX in Suppressing the Progression of Neurodegeneration.
Autorzy:
Chen YA; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Liu TY; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Wen KY; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Hsu CY; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Sze CI; Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Chang NS; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.; Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung 40402, Taiwan.; Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, New York, NY 10314, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 20; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 20.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Amyloid beta-Peptides*
Neoplasms*/metabolism
Mice ; Animals ; WW Domain-Containing Oxidoreductase/genetics ; WW Domain-Containing Oxidoreductase/metabolism ; Apoptosis ; Signal Transduction/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12.
Autorzy:
Sepulveda J; Department of Pharmacology & Physiology, Georgetown University, Washington, DC, 20007, USA.
Kim JY; Department of Neuroscience, Georgetown University, Washington, DC, 20007, USA.
Binder J; Department of Neuroscience, Georgetown University, Washington, DC, 20007, USA.
Vicini S; Department of Pharmacology & Physiology, Georgetown University, Washington, DC, 20007, USA.
Rebeck GW; Department of Neuroscience, Georgetown University, Washington, DC, 20007, USA. .
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Źródło:
Molecular neurodegeneration [Mol Neurodegener] 2024 Mar 11; Vol. 19 (1), pp. 24. Date of Electronic Publication: 2024 Mar 11.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Amyloid beta-Peptides*/metabolism
Animals ; Mice ; Adenosine Triphosphate/metabolism ; Adenosine Triphosphate/pharmacology ; Apolipoprotein E3/genetics ; Apolipoprotein E3/metabolism ; Apolipoprotein E4/genetics ; Apolipoprotein E4/metabolism ; Brain/metabolism ; Genotype ; Mice, Transgenic ; Microglia/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Blood Markers Show Neural Consequences of LongCOVID-19.
Autorzy:
Tang N; Department of Laboratory Medicine, San Francisco VA Health Care System, San Francisco, CA 94121, USA.
Kido T; Department of Laboratory Medicine, San Francisco VA Health Care System, San Francisco, CA 94121, USA.
Shi J; Department of Neurology, San Francisco VA Health Care System, San Francisco, CA 94121, USA.; Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA.
McCafferty E; Department of Laboratory Medicine, San Francisco VA Health Care System, San Francisco, CA 94121, USA.
Ford JM; Department of Mental Health, San Francisco VA Health Care System, San Francisco, CA 94121, USA.; Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA 94143, USA.
Dal Bon K; Department of Mental Health, San Francisco VA Health Care System, San Francisco, CA 94121, USA.
Pulliam L; Department of Laboratory Medicine, San Francisco VA Health Care System, San Francisco, CA 94121, USA.; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
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Źródło:
Cells [Cells] 2024 Mar 08; Vol. 13 (6). Date of Electronic Publication: 2024 Mar 08.
Typ publikacji:
Journal Article
MeSH Terms:
Amyloid beta-Peptides*
COVID-19*
Humans ; SARS-CoV-2 ; Inflammation ; Neurons
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Polyallylamine Binds to Aβ Amyloid and Inhibits Antibody Recognition.
Autorzy:
Tsuchie Y; Department of Chemistry and Biology, Graduate School of Science and Engineering, Ehime University, 2-5 Bunkyo, Matsuyama 790-8577, Ehime, Japan.
Kusuda S; Department of Chemistry, Faculty of Science, Ehime University, 2-5 Bunkyo, Matsuyama 790-8577, Ehime, Japan.
Kawabe H; Department of Chemistry and Biology, Graduate School of Science and Engineering, Ehime University, 2-5 Bunkyo, Matsuyama 790-8577, Ehime, Japan.
Mori W; Department of Chemistry and Biology, Graduate School of Science and Engineering, Ehime University, 2-5 Bunkyo, Matsuyama 790-8577, Ehime, Japan.
Lindgren M; Department of Chemistry, Faculty of Science, Ehime University, 2-5 Bunkyo, Matsuyama 790-8577, Ehime, Japan.; Department of Physics, Faculty of Natural Sciences, Norwegian University of Science and Technology (NTNU), Gløshaugen, Realfagsbygget, 7490 Trondheim, Norway.
Watanabe Y; Department of Chemistry, Faculty of Science, Ehime University, 2-5 Bunkyo, Matsuyama 790-8577, Ehime, Japan.
Zako T; Department of Chemistry and Biology, Graduate School of Science and Engineering, Ehime University, 2-5 Bunkyo, Matsuyama 790-8577, Ehime, Japan.; Department of Chemistry, Faculty of Science, Ehime University, 2-5 Bunkyo, Matsuyama 790-8577, Ehime, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 07; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 07.
Typ publikacji:
Journal Article
MeSH Terms:
Amyloid beta-Peptides*/metabolism
Amyloid*/metabolism
Polyamines*
Antibodies ; Amyloidogenic Proteins ; Polymers
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Influence of Lipid Electric Charge on the Binding of Aβ(1-42) Amyloid Peptide to Bilayers in the Liquid-Ordered State.
Autorzy:
Ahyayauch H; Departamento de Bioquímica, Instituto Biofisika (CSIC, UPV/EHU), Universidad del País Vasco, 48940 Leioa, Spain.; Institut Supérieur des Professions Infirmières et Techniques de Santé, Rabat 60000, Morocco.; Laboratoire de Biologie et Santé, Unité Neurosciences, Neuroimmunologie et Comportement, Faculty of Sciences, Ibn Tofail University, Kénitra 14000, Morocco.
Masserini ME; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Goñi FM; Departamento de Bioquímica, Instituto Biofisika (CSIC, UPV/EHU), Universidad del País Vasco, 48940 Leioa, Spain.
Alonso A; Departamento de Bioquímica, Instituto Biofisika (CSIC, UPV/EHU), Universidad del País Vasco, 48940 Leioa, Spain.
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Źródło:
Biomolecules [Biomolecules] 2024 Mar 01; Vol. 14 (3). Date of Electronic Publication: 2024 Mar 01.
Typ publikacji:
Journal Article
MeSH Terms:
Amyloid beta-Peptides*/metabolism
Alzheimer Disease*/metabolism
Humans ; Amyloid/chemistry ; Peptide Fragments/metabolism ; Gangliosides
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Diffusion Mediates Molecular Transport through the Perivascular Space in the Brain.
Autorzy:
Tanaka M; Department of Neurology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
Hirayoshi Y; Department of Neurology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
Minatani S; Department of Neurology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
Hasegawa I; Department of Neurology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
Itoh Y; Department of Neurology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 20; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 20.
Typ publikacji:
Journal Article
MeSH Terms:
Dextrans*
Amyloid beta-Peptides*
Fluorescein-5-isothiocyanate/*analogs & derivatives
Animals ; Mice ; Brain ; Diffusion
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Amyloid-β Oligomer-Induced Electrophysiological Mechanisms and Electrical Impedance Changes in Neurons.
Autorzy:
Sun S; Department of Physiology and Pharmacology, Health Science Center, Ningbo University, Ningbo 315211, China.
Ma Q; Department of Physiology and Pharmacology, Health Science Center, Ningbo University, Ningbo 315211, China.
Sheng Q; Department of Physiology and Pharmacology, Health Science Center, Ningbo University, Ningbo 315211, China.
Huang S; Department of Physiology and Pharmacology, Health Science Center, Ningbo University, Ningbo 315211, China.
Wu C; Department of Physiology and Pharmacology, Health Science Center, Ningbo University, Ningbo 315211, China.
Liu J; State Key Laboratory of Superhard Materials, College of Physics, Jilin University, Changchun 130012, China.
Xu J; Department of Physiology and Pharmacology, Health Science Center, Ningbo University, Ningbo 315211, China.
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Źródło:
Sensors (Basel, Switzerland) [Sensors (Basel)] 2024 Feb 14; Vol. 24 (4). Date of Electronic Publication: 2024 Feb 14.
Typ publikacji:
Journal Article
MeSH Terms:
Amyloid beta-Peptides*/chemistry
Alzheimer Disease*/pathology
Mice ; Animals ; Electric Impedance ; Neurons/metabolism ; Synapses/metabolism ; Synapses/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer's disease.
Autorzy:
Daily KP; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Badr A; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.; Clinical Pathology Department, College of Medicine, Mansoura University, Mansoura, Egypt.
Eltobgy M; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Estfanous S; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.; Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
Whitham O; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Tan MH; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Carafice C; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Krause K; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.; Max Planck Unit for the Science of Pathogens, Berlin, Germany.
McNamara A; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Hamilton K; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Houle S; Department of Neuroscience, The Ohio State University, Columbus, OH, 43210, USA.
Gupta S; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Gupta GA; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Madhu S; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Fitzgerald J; Department of Neuroscience, The Ohio State University, Columbus, OH, 43210, USA.
Saadey AA; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Laster B; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Yan P; Genomics Shared Resource, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.
Webb A; Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
Zhang X; Center for Biostatistics, Ohio State University, Columbus, OH, USA.
Pietrzak M; Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
Kokiko-Cochran ON; Department of Neuroscience, The Ohio State University, Columbus, OH, 43210, USA.
Ghoneim HE; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA. .; Pelotonia Institute for Immuno-Oncology, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA. .
Amer AO; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA. .
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Feb 08; Vol. 16 (1), pp. 29. Date of Electronic Publication: 2024 Feb 08.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/metabolism
Alzheimer Disease*/pathology
Amyloid beta-Peptides*/metabolism
Caspases, Initiator*/metabolism
Animals ; Humans ; Mice ; Disease Models, Animal ; DNA Methylation ; Inflammation/pathology ; Mice, Transgenic ; Microglia/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion.
Autorzy:
Pagnon de la Vega M; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
Syvänen S; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
Hooley M; UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
Konstantinidis E; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
Meier SR; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
Rokka J; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
Eriksson J; Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Uppsala University, Uppsala, Sweden.; PET Centre, Uppsala University Hospital, Uppsala, Sweden.
Aguilar X; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
Spires-Jones TL; UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
Lannfelt L; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.; BioArctic AB, Stockholm, Sweden.
Nilsson LNG; Department of Pharmacology, University of Oslo and Oslo University Hospital, Oslo, Norway.
Erlandsson A; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
Hultqvist G; Department of Pharmacy, Uppsala University, Uppsala, Sweden.
Ingelsson M; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.; Tanz Centre for Research in Neurodegenerative Diseases, Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Sehlin D; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Feb 05; Vol. 12 (1), pp. 22. Date of Electronic Publication: 2024 Feb 05.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/pathology
Amyloid beta-Peptides*/metabolism
Animals ; Humans ; Mice ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Amyloid Precursor Protein Secretases/metabolism ; Brain/pathology ; Disease Models, Animal ; Gliosis/pathology ; Ligands ; Mice, Transgenic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Presenilin-2 knock-In mice show severe depressive behavior via DVL3 downregulation.
Autorzy:
Yoo SS; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, South Korea.
Lee DW; Ministry of Food and Drug Safety (MFDS), Cheongju, South Korea.; Korea Health Industry Development Institute, Cheongju, South Korea.
Ham HJ; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, South Korea.
Yeo IJ; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, South Korea.
Chang JY; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, South Korea.
Yun J; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, South Korea.
Son DJ; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, South Korea.
Han SB; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, South Korea.
Hong JT; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, South Korea.
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Feb; Vol. 30 (2), pp. e14370. Date of Electronic Publication: 2023 Jul 27.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Amyloid beta-Peptides*/metabolism
Animals ; Mice ; Dishevelled Proteins/metabolism ; Down-Regulation ; Glycogen Synthase Kinase 3 beta ; Hydrocortisone ; Mice, Transgenic ; Presenilin-1/genetics ; Presenilin-2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Palmatine Protects PC12 Cells and Mice from Aβ25-35-Induced Oxidative Stress and Neuroinflammation via the Nrf2/HO-1 Pathway.
Autorzy:
Wang Y; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Pei H; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Chen W; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Du R; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.; Key Laboratory of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Changchun 130118, China.
Li J; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
He Z; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.; Key Laboratory of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Changchun 130118, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Dec 05; Vol. 28 (24). Date of Electronic Publication: 2023 Dec 05.
Typ publikacji:
Journal Article
MeSH Terms:
Amyloid beta-Peptides*/toxicity
Amyloid beta-Peptides*/metabolism
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Humans ; Rats ; Mice ; Animals ; PC12 Cells ; NF-E2-Related Factor 2/metabolism ; Reactive Oxygen Species/metabolism ; Neuroinflammatory Diseases ; Oxidative Stress
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
M13 phage grafted with peptide motifs as a tool to detect amyloid-β oligomers in brain tissue.
Autorzy:
Martins IM; CEB- Centre of Biological Engineering, University of Minho, 4710-057, Braga, Portugal. .; LABBELS - Associate Laboratory, Braga/Guimarães, Portugal. .; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands. .; Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands. .
Lima A; CEB- Centre of Biological Engineering, University of Minho, 4710-057, Braga, Portugal.; LABBELS - Associate Laboratory, Braga/Guimarães, Portugal.; Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.
de Graaff W; Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.
Cristóvão JS; Biosystems & Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal.; Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal.
Brosens N; Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.
Aronica E; Amsterdam UMC location University of Amsterdam, Department of (Neuro)Pathology, Amsterdam Neuroscience, Amsterdam, the Netherlands.
Kluskens LD; CEB- Centre of Biological Engineering, University of Minho, 4710-057, Braga, Portugal.; LABBELS - Associate Laboratory, Braga/Guimarães, Portugal.
Gomes CM; Biosystems & Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal.; Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal.
Azeredo J; CEB- Centre of Biological Engineering, University of Minho, 4710-057, Braga, Portugal.; LABBELS - Associate Laboratory, Braga/Guimarães, Portugal.
Kessels HW; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands. .; Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands. .
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Źródło:
Communications biology [Commun Biol] 2024 Jan 27; Vol. 7 (1), pp. 134. Date of Electronic Publication: 2024 Jan 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyloid beta-Peptides*/metabolism
Alzheimer Disease*
Humans ; Mice ; Animals ; Amyloid beta-Protein Precursor/metabolism ; Bacteriophage M13/metabolism ; Mice, Transgenic ; Brain/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Influence of Physiological Variables and Comorbidities on Plasma Aβ40, Aβ42, and p-tau181 Levels in Cognitively Unimpaired Individuals.
Autorzy:
Martínez-Dubarbie F; Neurology Service, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.; Institute for Research Marqués de Valdecilla (IDIVAL), 39011 Santander, Spain.
Guerra-Ruiz A; Biochemistry and Clinical Analysis Department, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.
López-García S; Neurology Service, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.; Institute for Research Marqués de Valdecilla (IDIVAL), 39011 Santander, Spain.
Irure-Ventura J; Institute for Research Marqués de Valdecilla (IDIVAL), 39011 Santander, Spain.; Immunology Department, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.
Lage C; Neurology Service, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.; Institute for Research Marqués de Valdecilla (IDIVAL), 39011 Santander, Spain.; Atlantic Fellow for Equity in Brain Health, Global Brain Health Institute, University of California, San Francisco, CA 94143, USA.
Fernández-Matarrubia M; Neurology Service, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.; Institute for Research Marqués de Valdecilla (IDIVAL), 39011 Santander, Spain.
Pozueta-Cantudo A; Neurology Service, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.; Institute for Research Marqués de Valdecilla (IDIVAL), 39011 Santander, Spain.
García-Martínez M; Neurology Service, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.; Institute for Research Marqués de Valdecilla (IDIVAL), 39011 Santander, Spain.
Corrales-Pardo A; Neurology Service, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.; Institute for Research Marqués de Valdecilla (IDIVAL), 39011 Santander, Spain.; Health Sciences Department, Universidad Europea del Atlántico, 39011 Santander, Spain.
Bravo M; Neurology Service, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.; Institute for Research Marqués de Valdecilla (IDIVAL), 39011 Santander, Spain.
Martín-Arroyo J; Neurology Service, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.
Infante J; Neurology Service, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.; Institute for Research Marqués de Valdecilla (IDIVAL), 39011 Santander, Spain.; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28220 Madrid, Spain.; Medicine and Psychiatry Department, University of Cantabria, 39011 Santander, Spain.
López-Hoyos M; Institute for Research Marqués de Valdecilla (IDIVAL), 39011 Santander, Spain.; Immunology Department, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.; Molecular Biology Department, University of Cantabria, 39011 Santander, Spain.
García-Unzueta MT; Institute for Research Marqués de Valdecilla (IDIVAL), 39011 Santander, Spain.; Biochemistry and Clinical Analysis Department, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.
Sánchez-Juan P; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28220 Madrid, Spain.; CIEN Foundation, Queen Sofia Foundation Alzheimer Center, 28220 Madrid, Spain.
Rodríguez-Rodríguez E; Neurology Service, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.; Institute for Research Marqués de Valdecilla (IDIVAL), 39011 Santander, Spain.; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28220 Madrid, Spain.; Medicine and Psychiatry Department, University of Cantabria, 39011 Santander, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 25; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 25.
Typ publikacji:
Journal Article
MeSH Terms:
Amyloid beta-Peptides*/cerebrospinal fluid
Alzheimer Disease*/diagnosis
Humans ; Comorbidity ; Biomarkers ; tau Proteins/cerebrospinal fluid ; Peptide Fragments
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Definition of a Threshold for the Plasma Aβ42/Aβ40 Ratio Measured by Single-Molecule Array to Predict the Amyloid Status of Individuals without Dementia.
Autorzy:
Colmant L; Institute of Neuroscience, UCLouvain, 1200 Brussels, Belgium.; Neurology Department, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium.; Institute of Information and Communication Technologies, Electronics and Applied Mathematics, UCLouvain, 1348 Louvain-la-Neuve, Belgium.
Boyer E; Institute of Neuroscience, UCLouvain, 1200 Brussels, Belgium.; Neurology Department, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium.
Gerard T; Institute of Neuroscience, UCLouvain, 1200 Brussels, Belgium.; Neurology Department, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium.
Sleegers K; Complex Genetics of Alzheimer's Disease Group, VIB-UAntwerp Center for Molecular Neurology, University of Antwerp, 2000 Antwerpen, Belgium.
Lhommel R; Neurology Department, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium.
Ivanoiu A; Institute of Neuroscience, UCLouvain, 1200 Brussels, Belgium.; Neurology Department, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium.
Lefèvre P; Institute of Neuroscience, UCLouvain, 1200 Brussels, Belgium.; Institute of Information and Communication Technologies, Electronics and Applied Mathematics, UCLouvain, 1348 Louvain-la-Neuve, Belgium.
Kienlen-Campard P; Institute of Neuroscience, UCLouvain, 1200 Brussels, Belgium.
Hanseeuw B; Institute of Neuroscience, UCLouvain, 1200 Brussels, Belgium.; Neurology Department, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium.; WELBIO Department, WEL Research Institute, Avenue Pasteur, 6, 1300 Wavre, Belgium.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 18; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 18.
Typ publikacji:
Journal Article
MeSH Terms:
Amyloid beta-Peptides*
Alzheimer Disease*/diagnosis
Humans ; Amyloidogenic Proteins ; Positron-Emission Tomography ; Brain ; Plaque, Amyloid
Czasopismo naukowe
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Tytuł:
Age-Dependent and Aβ-Induced Dynamic Changes in the Subcellular Localization of HMGB1 in Neurons and Microglia in the Brains of an Animal Model of Alzheimer's Disease.
Autorzy:
Seol SI; Department of Anatomy, Inha University School of Medicine, Incheon 22212, Republic of Korea.
Davaanyam D; Department of Anatomy, Inha University School of Medicine, Incheon 22212, Republic of Korea.
Oh SA; Department of Anatomy, Inha University School of Medicine, Incheon 22212, Republic of Korea.
Lee EH; Department of Brain and Cognitive Sciences, Scranton College, Ewha Womans University, Seoul 03760, Republic of Korea.
Han PL; Department of Brain and Cognitive Sciences, Scranton College, Ewha Womans University, Seoul 03760, Republic of Korea.; Department of Chemistry and Nano Science, College of Natural Science, Ewha Womans University, Seoul 03760, Republic of Korea.
Kim SW; Department of Biomedical Sciences, Inha University School of Medicine, Inchon 22212, Republic of Korea.
Lee JK; Department of Anatomy, Inha University School of Medicine, Incheon 22212, Republic of Korea.
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Źródło:
Cells [Cells] 2024 Jan 18; Vol. 13 (2). Date of Electronic Publication: 2024 Jan 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*
Amyloid beta-Peptides*
HMGB1 Protein*
Aged ; Animals ; Humans ; Mice ; Alarmins ; Brain ; Microglia ; Neurons ; Disease Models, Animal
Czasopismo naukowe
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Tytuł:
Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid β aggregates in vivo in a mouse model of Alzheimer's disease.
Autorzy:
Calvo-Rodriguez M; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114, 16Th St, Charlestown, MA, 02129, USA.; Present address: Foundational Neuroscience Center, AbbVie Inc, Cambridge, MA, USA.
Kharitonova EK; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114, 16Th St, Charlestown, MA, 02129, USA.
Snyder AC; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114, 16Th St, Charlestown, MA, 02129, USA.
Hou SS; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114, 16Th St, Charlestown, MA, 02129, USA.
Sanchez-Mico MV; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114, 16Th St, Charlestown, MA, 02129, USA.
Das S; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114, 16Th St, Charlestown, MA, 02129, USA.
Fan Z; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114, 16Th St, Charlestown, MA, 02129, USA.
Shirani H; Department of Physics, Chemistry and Biology, Linköping University, 581 83, Linköping, Sweden.
Nilsson KPR; Department of Physics, Chemistry and Biology, Linköping University, 581 83, Linköping, Sweden.
Serrano-Pozo A; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114, 16Th St, Charlestown, MA, 02129, USA.
Bacskai BJ; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114, 16Th St, Charlestown, MA, 02129, USA. .
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Źródło:
Molecular neurodegeneration [Mol Neurodegener] 2024 Jan 18; Vol. 19 (1), pp. 6. Date of Electronic Publication: 2024 Jan 18.
Typ publikacji:
Journal Article
MeSH Terms:
Amyloid beta-Peptides*/metabolism
Alzheimer Disease*/metabolism
Mice ; Animals ; Oxidative Stress/physiology ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Oxidation-Reduction ; Mitochondria/metabolism ; Disease Models, Animal
Czasopismo naukowe
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Tytuł:
Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state.
Autorzy:
Bhalla M; Center for Cognition and Sociality, Life Science Institute (LSI), Institute for Basic Science (IBS), 55, Expo-ro, Yuseong-gu, Daejeon, 34126, Republic of Korea.; IBS School, University of Science and Technology (UST), 217 Gajeong-ro, Yuseong-gu, Daejeon, 34113, Republic of Korea.
Lee CJ; Center for Cognition and Sociality, Life Science Institute (LSI), Institute for Basic Science (IBS), 55, Expo-ro, Yuseong-gu, Daejeon, 34126, Republic of Korea. .; IBS School, University of Science and Technology (UST), 217 Gajeong-ro, Yuseong-gu, Daejeon, 34113, Republic of Korea. .
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Źródło:
Molecular brain [Mol Brain] 2024 Jan 12; Vol. 17 (1), pp. 3. Date of Electronic Publication: 2024 Jan 12.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/pathology
Amyloid beta-Peptides*/metabolism
Animals ; Humans ; Mice ; Amyloid beta-Protein Precursor/metabolism ; Astrocytes/metabolism ; Brain/metabolism ; Disease Models, Animal ; gamma-Aminobutyric Acid/metabolism ; Mice, Transgenic ; Plaque, Amyloid/complications ; Ornithine Decarboxylase
Czasopismo naukowe
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Tytuł:
Updates on Aβ Processing by Hsp90, BRICHOS, and Newly Reported Distinctive Chaperones.
Autorzy:
Iqbal M; Department of Pharmaceutical Sciences, USF-Health Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USA.
Lewis SL; Department of Pharmaceutical Sciences, USF-Health Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USA.
Padhye S; Department of Pharmaceutical Sciences, USF-Health Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USA.
Jinwal UK; Department of Pharmaceutical Sciences, USF-Health Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USA.
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Źródło:
Biomolecules [Biomolecules] 2023 Dec 22; Vol. 14 (1). Date of Electronic Publication: 2023 Dec 22.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Alzheimer Disease*
HSP90 Heat-Shock Proteins*/metabolism
Neurodegenerative Diseases*
Amyloid beta-Peptides*/metabolism
Humans ; Heat-Shock Proteins ; Molecular Chaperones
Czasopismo naukowe
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Tytuł:
Immunotherapies for Alzheimer's disease.
Autorzy:
Golde TE; Department of Pharmacology and Chemical Biology, Department of Neurology, Center for Neurodegenerative Disease, Goizueta Institute Emory Brain Health, Emory University School of Medicine, Atlanta, GA, USA.
Levey AI; Department of Pharmacology and Chemical Biology, Department of Neurology, Center for Neurodegenerative Disease, Goizueta Institute Emory Brain Health, Emory University School of Medicine, Atlanta, GA, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Dec 15; Vol. 382 (6676), pp. 1242-1244. Date of Electronic Publication: 2023 Dec 14.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/therapy
Amyloid beta-Peptides*/immunology
Antibodies, Monoclonal, Humanized*/therapeutic use
Humans ; Immunotherapy ; Clinical Trials as Topic
Czasopismo naukowe
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Tytuł:
Few-shot prediction of amyloid β accumulation from mainly unpaired data on biomarker candidates.
Autorzy:
Yada Y; Laboratory of Data-driven Biology, Graduate School of Integrated Sciences for Life, Hiroshima University, Kagamiyama, Higashi-hiroshima, Hiroshima, 739-8526, Japan. .
Naoki H; Laboratory of Data-driven Biology, Graduate School of Integrated Sciences for Life, Hiroshima University, Kagamiyama, Higashi-hiroshima, Hiroshima, 739-8526, Japan. .; Kansei-Brain Informatics Group, Center for Brain, Mind and Kansei Sciences Research (BMK Center), Hiroshima University, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. .; Laboratory of Theoretical Biology, Graduate School of Biostudies, Kyoto University, Yoshidakonoecho, Sakyo, Kyoto, 606-8315, Japan. .; Theoretical Biology Research Group, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki, Aichi, 444-8787, Japan. .
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Źródło:
NPJ systems biology and applications [NPJ Syst Biol Appl] 2023 Nov 23; Vol. 9 (1), pp. 59. Date of Electronic Publication: 2023 Nov 23.
Typ publikacji:
Journal Article
MeSH Terms:
Amyloid beta-Peptides*/metabolism
Alzheimer Disease*/genetics
Mice ; Animals ; Brain/metabolism ; Biomarkers
Czasopismo naukowe
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