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Tytuł :
Development of Androgen-Antagonistic Coumarinamides with a Unique Aromatic Folded Pharmacophore.
Autorzy :
Koga H; Department of Chemistry, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan.
Negishi M; Department of Chemistry, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan.
Kinoshita M; Department of Chemistry, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan.
Fujii S; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Mori S; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Ishigami-Yuasa M; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Kawachi E; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Kagechika H; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Tanatani A; Department of Chemistry, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan.; Institute of Human Life Innovation, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Aug 04; Vol. 21 (15). Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :
Journal Article
MeSH Terms :
Androgens/*genetics
Prostatic Neoplasms/*drug therapy
Prostatic Neoplasms, Castration-Resistant/*drug therapy
Receptors, Androgen/*genetics
Androgen Receptor Antagonists/chemistry ; Androgen Receptor Antagonists/pharmacology ; Androgens/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Coumarins/chemistry ; Coumarins/pharmacology ; Flutamide/analogs & derivatives ; Flutamide/chemistry ; Flutamide/pharmacology ; Humans ; Male ; Molecular Structure ; Mutation ; Nonsteroidal Anti-Androgens/chemistry ; Nonsteroidal Anti-Androgens/pharmacology ; Prostate-Specific Antigen/genetics ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms, Castration-Resistant/genetics ; Prostatic Neoplasms, Castration-Resistant/pathology ; Receptors, Androgen/drug effects
Czasopismo naukowe
Tytuł :
Electrochemically Enabled One-Pot Multistep Synthesis of C19 Androgen Steroids.
Autorzy :
Sommer F; Institute of Chemistry, University of Graz, Heinrichstrasse 28, 8010, Graz, Austria.; Center for Continuous Flow Synthesis and Processing (CC FLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010, Graz, Austria.
Kappe CO; Institute of Chemistry, University of Graz, Heinrichstrasse 28, 8010, Graz, Austria.; Center for Continuous Flow Synthesis and Processing (CC FLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010, Graz, Austria.
Cantillo D; Institute of Chemistry, University of Graz, Heinrichstrasse 28, 8010, Graz, Austria.; Center for Continuous Flow Synthesis and Processing (CC FLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010, Graz, Austria.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Apr 01; Vol. 27 (19), pp. 6044-6049. Date of Electronic Publication: 2021 Mar 04.
Typ publikacji :
Journal Article
MeSH Terms :
Androgens*
Androstanes*
Hydrogenation ; Steroids
Czasopismo naukowe
Tytuł :
Exposure of androgen mimicking environmental chemicals enhances proliferation of prostate cancer (LNCaP) cells by inducing AR expression and epigenetic modifications.
Autorzy :
Singh VK; Food, Drug and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh, 226001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Pal R; Unit of Oncology and Molecular Pathology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Srivastava P; Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, 201313, India.
Misra G; Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, 201313, India.
Shukla Y; Food, Drug and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh, 226001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Sharma PK; Food, Drug and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh, 226001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. Electronic address: .
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Źródło :
Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2021 Mar 01; Vol. 272, pp. 116397. Date of Electronic Publication: 2021 Jan 02.
Typ publikacji :
Journal Article
MeSH Terms :
Androgens*
Prostatic Neoplasms*/genetics
Androgen Antagonists ; Cell Line, Tumor ; Cell Proliferation ; Epigenesis, Genetic ; Humans ; Male ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism
Czasopismo naukowe
Tytuł :
Novel use of coactivators to enhance sensitivity of SEAP-based reporter assay system for visual monitoring and quantitation of androgens and antiandrogens in water.
Autorzy :
Dagar G; Amity Institute of Biotechnology, Amity University, Gurgaon 122413, India.
Bagchi G; Amity Institute of Biotechnology, Amity University, Gurgaon 122413, India. Electronic address: .
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Źródło :
The Science of the total environment [Sci Total Environ] 2021 Jun 01; Vol. 771, pp. 144514. Date of Electronic Publication: 2021 Jan 23.
Typ publikacji :
Journal Article
MeSH Terms :
Androgen Antagonists*/toxicity
Androgens*
Animals ; Bacterial Proteins ; Biological Assay ; Endopeptidases ; Genes, Reporter ; Humans ; Male ; Water
Czasopismo naukowe
Tytuł :
Binary and multi-class classification for androgen receptor agonists, antagonists and binders.
Autorzy :
Piir G; University of Tartu, Institute of Chemistry, Ravila 14A, Tartu, 50411, Estonia.
Sild S; University of Tartu, Institute of Chemistry, Ravila 14A, Tartu, 50411, Estonia.
Maran U; University of Tartu, Institute of Chemistry, Ravila 14A, Tartu, 50411, Estonia. Electronic address: .
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Źródło :
Chemosphere [Chemosphere] 2021 Jan; Vol. 262, pp. 128313. Date of Electronic Publication: 2020 Sep 11.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Chemical*
Androgen Receptor Antagonists/*classification
Androgens/*classification
Receptors, Androgen/*metabolism
Androgen Receptor Antagonists/chemistry ; Androgen Receptor Antagonists/pharmacology ; Androgens/chemistry ; Androgens/pharmacology ; Humans ; Machine Learning ; Protein Binding ; Quantitative Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Androgen Reduces Mitochondrial Respiration in Mouse Brown Adipocytes: A Model for Disordered Energy Balance in Polycystic Ovary Syndrome.
Autorzy :
Lerner A; Institute of Reproductive and Developmental Biology, Imperial College London, London SW7 2AZ, UK.
Kewada D; Institute of Reproductive and Developmental Biology, Imperial College London, London SW7 2AZ, UK.
Ahmed A; Institute of Reproductive and Developmental Biology, Imperial College London, London SW7 2AZ, UK.
Hardy K; Institute of Reproductive and Developmental Biology, Imperial College London, London SW7 2AZ, UK.
Christian M; School of Science & Technology, Nottingham Trent University, Nottingham NG1 4FQ, UK.
Franks S; Institute of Reproductive and Developmental Biology, Imperial College London, London SW7 2AZ, UK.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 29; Vol. 22 (1). Date of Electronic Publication: 2020 Dec 29.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Respiration*/drug effects
Adipocytes, Brown/*metabolism
Androgens/*metabolism
Mitochondria/*metabolism
Adipocytes, Brown/cytology ; Adipocytes, Brown/drug effects ; Adipogenesis/genetics ; Adipokines/genetics ; Adipokines/metabolism ; Androgens/pharmacology ; Animals ; Cell Differentiation/genetics ; Disease Susceptibility ; Energy Metabolism ; Female ; Gene Expression ; Metabolic Networks and Pathways ; Mice ; Mitochondria/drug effects ; Polycystic Ovary Syndrome/etiology ; Polycystic Ovary Syndrome/metabolism ; Receptors, Androgen/metabolism ; Thermogenesis/genetics
Czasopismo naukowe
Tytuł :
Crosstalk between Androgen-ZIP9 Signaling and Notch Pathway in Rodent Sertoli Cells.
Autorzy :
Kamińska A; Department of Endocrinology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, 30-387 Kraków, Poland.
Marek S; Department of Endocrinology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, 30-387 Kraków, Poland.
Pardyak L; Department of Endocrinology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, 30-387 Kraków, Poland.; Center of Experimental and Innovative Medicine, University of Agriculture in Krakow, 30-248 Kraków, Poland.
Brzoskwinia M; Department of Endocrinology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, 30-387 Kraków, Poland.
Bilinska B; Department of Endocrinology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, 30-387 Kraków, Poland.
Hejmej A; Department of Endocrinology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, 30-387 Kraków, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 05; Vol. 21 (21). Date of Electronic Publication: 2020 Nov 05.
Typ publikacji :
Journal Article
MeSH Terms :
Androgens/*metabolism
Cation Transport Proteins/*physiology
Receptors, Notch/*metabolism
Sertoli Cells/*metabolism
Androgens/pharmacology ; Androgens/physiology ; Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cells, Cultured ; Male ; Mice ; Rats ; Receptor Cross-Talk/drug effects ; Receptor Cross-Talk/physiology ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Sertoli Cells/drug effects ; Sertoli Cells/physiology ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Transcription Factor HES-1/genetics ; Transcription Factor HES-1/metabolism
Czasopismo naukowe
Tytuł :
A Genetically Encoded Bioluminescence Intracellular Nanosensor for Androgen Receptor Activation Monitoring in 3D Cell Models.
Autorzy :
Calabretta MM; Department of Chemistry 'Giacomo Ciamician', University of Bologna, 40126 Bologna, Italy.; Center for Applied Biomedical Research (CRBA), University of Bologna, 40126 Bologna, Italy.
Lopreside A; Department of Chemistry 'Giacomo Ciamician', University of Bologna, 40126 Bologna, Italy.; Center for Applied Biomedical Research (CRBA), University of Bologna, 40126 Bologna, Italy.
Montali L; Department of Chemistry 'Giacomo Ciamician', University of Bologna, 40126 Bologna, Italy.; Center for Applied Biomedical Research (CRBA), University of Bologna, 40126 Bologna, Italy.
Cevenini L; Department of Chemistry 'Giacomo Ciamician', University of Bologna, 40126 Bologna, Italy.
Roda A; Department of Chemistry 'Giacomo Ciamician', University of Bologna, 40126 Bologna, Italy.; Istituto Nazionale di Biostrutture e Biosistemi (INBB), 00136 Rome, Italy.
Michelini E; Department of Chemistry 'Giacomo Ciamician', University of Bologna, 40126 Bologna, Italy.; Center for Applied Biomedical Research (CRBA), University of Bologna, 40126 Bologna, Italy.; Istituto Nazionale di Biostrutture e Biosistemi (INBB), 00136 Rome, Italy.; Health Sciences and Technologies-Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, Ozzano dell'Emilia, 40064 Bologna, Italy.
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Źródło :
Sensors (Basel, Switzerland) [Sensors (Basel)] 2021 Jan 29; Vol. 21 (3). Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article
MeSH Terms :
Androgens*
Luminescent Measurements*
Nanotechnology*
Receptors, Androgen*/genetics
Genes, Reporter ; HEK293 Cells ; Humans ; Luciferases/genetics
Czasopismo naukowe
Tytuł :
Occurrence and distribution of natural and synthetic progestins, androgens, and estrogens in soils from agricultural production areas in China.
Autorzy :
Yang X; College of Natural Resources and Environment, Joint Institute for Environment & Education, South China Agricultural University, Guangzhou 510642, PR China; Key Laboratory of Southern Farmland Pollution Prevention and Control, Ministry of Agriculture and Rural Affairs, Hunan Division GRG Metrology and Test, Changsha 410000, PR China.
He X; College of Natural Resources and Environment, Joint Institute for Environment & Education, South China Agricultural University, Guangzhou 510642, PR China.
Lin H; College of Natural Resources and Environment, Joint Institute for Environment & Education, South China Agricultural University, Guangzhou 510642, PR China.
Lin X; College of Natural Resources and Environment, Joint Institute for Environment & Education, South China Agricultural University, Guangzhou 510642, PR China.
Mo J; College of Natural Resources and Environment, Joint Institute for Environment & Education, South China Agricultural University, Guangzhou 510642, PR China.
Chen C; College of Natural Resources and Environment, Joint Institute for Environment & Education, South China Agricultural University, Guangzhou 510642, PR China.
Dai X; College of Natural Resources and Environment, Joint Institute for Environment & Education, South China Agricultural University, Guangzhou 510642, PR China.
Liao D; Jiangmen Agricultural Technology Service Center, Jiangmen 529000, PR China.
Gao C; Jiangmen Agricultural and Rural Bureau, Jiangmen 529000, PR China.
Li Y; College of Natural Resources and Environment, Joint Institute for Environment & Education, South China Agricultural University, Guangzhou 510642, PR China. Electronic address: .
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Źródło :
The Science of the total environment [Sci Total Environ] 2021 Jan 10; Vol. 751, pp. 141766. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article
MeSH Terms :
Androgens*/analysis
Soil Pollutants*/analysis
Animals ; Carbon ; China ; Environmental Monitoring ; Estrogens/analysis ; Progesterone Congeners ; Progestins/analysis ; Soil ; Swine
Czasopismo naukowe
Tytuł :
Gender Susceptibility to COVID-19 Mortality: Androgens as the Usual Suspects?
Autorzy :
Vahedian-Azimi A; Trauma Research Center, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Pourhoseingholi MA; Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. .
Saberi M; Medicine, Quran and Hadith Research Center & Department of Community Medicine, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Behnam B; Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.; Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Sahebkar A; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. .; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. .; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland. .; Halal Research Center of IRI, FDA, Tehran, Iran. .
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Źródło :
Advances in experimental medicine and biology [Adv Exp Med Biol] 2021; Vol. 1321, pp. 261-264.
Typ publikacji :
Journal Article
MeSH Terms :
Androgens*
COVID-19*
Aged ; Female ; Humans ; Iran/epidemiology ; Male ; Middle Aged ; SARS-CoV-2 ; Sex Factors
Czasopismo naukowe
Tytuł :
Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormones.
Autorzy :
Viveiros A; Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.
Rasmuson J; Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Vu J; Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Mulvagh SL; Division of Cardiology, Dalhousie University, Halifax, Canada.; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Yip CYY; Heart and Stroke Foundation of Canada, Toronto, Canada.
Norris CM; Division of Cardiology, Dalhousie University, Halifax, Canada.; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.; Faculty of Nursing, University of Alberta, Edmonton, Canada.
Oudit GY; Division of Cardiology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
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Źródło :
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2021 Jan 01; Vol. 320 (1), pp. H296-H304. Date of Electronic Publication: 2020 Dec 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Adaptive Immunity/*immunology
Androgens/*immunology
Angiotensin-Converting Enzyme 2/*genetics
COVID-19/*immunology
Estrogens/*immunology
Immunity, Innate/*immunology
Receptors, Coronavirus/*genetics
ADAM17 Protein/metabolism ; Adaptive Immunity/genetics ; Androgens/metabolism ; Angiotensin-Converting Enzyme 2/metabolism ; COVID-19/genetics ; COVID-19/metabolism ; COVID-19/mortality ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/immunology ; Estrogens/metabolism ; Female ; Genes, X-Linked/genetics ; Genes, X-Linked/immunology ; Humans ; Immunity, Innate/genetics ; Male ; Promoter Regions, Genetic ; Receptors, Coronavirus/metabolism ; Renin-Angiotensin System/genetics ; Renin-Angiotensin System/immunology ; Response Elements/genetics ; SARS-CoV-2/metabolism ; Severity of Illness Index ; Sex Characteristics ; Sex Factors ; X Chromosome Inactivation
Czasopismo naukowe
Tytuł :
An assessment of the estrogenic and androgenic properties of tetra- and hexachloronaphthalene by YES/YAS in vitro assays.
Autorzy :
Stragierowicz J; Department of Toxicology, Medical University of Lodz, Muszynskiego 1, 90-151, Lodz, Poland.
Stypuła-Trębas S; Department of Pharmacology and Toxicology, National Veterinary Research Institute, Al. Partyzantow 57, 24-100, Pulawy, Poland.
Radko L; Department of Pharmacology and Toxicology, National Veterinary Research Institute, Al. Partyzantow 57, 24-100, Pulawy, Poland.
Posyniak A; Department of Pharmacology and Toxicology, National Veterinary Research Institute, Al. Partyzantow 57, 24-100, Pulawy, Poland.
Nasiadek M; Department of Toxicology, Medical University of Lodz, Muszynskiego 1, 90-151, Lodz, Poland.
Klimczak M; Department of Toxicology, Medical University of Lodz, Muszynskiego 1, 90-151, Lodz, Poland.
Kilanowicz A; Department of Toxicology, Medical University of Lodz, Muszynskiego 1, 90-151, Lodz, Poland. Electronic address: .
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Źródło :
Chemosphere [Chemosphere] 2021 Jan; Vol. 263, pp. 128006. Date of Electronic Publication: 2020 Aug 18.
Typ publikacji :
Journal Article
MeSH Terms :
Androgens*
Endocrine Disruptors*/toxicity
Estrogens ; Naphthalenes
Czasopismo naukowe
Tytuł :
Trials and tribulations of testosterone therapy in women: Importance of adhering to the evidence.
Autorzy :
Kling JM; Associate Professor of Medicine and Interim Chair and Associate Chair for Research in Women's Health Internal Medicine, Associate Chair of Equity, Inclusion and Diversity, Department of Medicine, Mayo Clinic Arizona, Scottsdale .
Parish SJ; Professor of Medicine in Clinical Psychiatry and Professor of Clinical Medicine, Weill Cornell Medical College, Department of Psychiatry and Department of Medicine, New York, NY.
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Źródło :
Cleveland Clinic journal of medicine [Cleve Clin J Med] 2020 Dec 31; Vol. 88 (1), pp. 44-46. Date of Electronic Publication: 2020 Dec 31.
Typ publikacji :
Editorial; Comment
MeSH Terms :
Androgens*
Testosterone*
Dehydroepiandrosterone ; Female ; Humans ; Postmenopause
Opinia redakcyjna
Tytuł :
Reproductive events and respective faecal androgen metabolite concentrations in captive male roan antelope (Hippotragus equinus).
Autorzy :
Kamgang VW; Mammal Research Institute, University of Pretoria, Pretoria, Gauteng, South Africa.
Bennett NC; Mammal Research Institute, University of Pretoria, Pretoria, Gauteng, South Africa.
Hart DW; Department of Zoology and Entomology, University of Pretoria, Pretoria, Gauteng, South Africa.
van der Goot AC; Lapalala Wilderness Nature Reserve, Melkrevier, Limpopo, South Africa.
Ganswindt A; Mammal Research Institute, University of Pretoria, Pretoria, Gauteng, South Africa.
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Źródło :
PloS one [PLoS One] 2020 Dec 17; Vol. 15 (12), pp. e0243277. Date of Electronic Publication: 2020 Dec 17 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Androgens/*metabolism
Antelopes/*physiology
Androgens/analysis ; Animals ; Feces/chemistry ; Female ; Male ; Reproduction ; Seasons
Czasopismo naukowe
Tytuł :
Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.
Autorzy :
Samuel RM; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA.
Majd H; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA.
Richter MN; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA.
Ghazizadeh Z; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Yale School of Medicine, New Haven, CT 06510, USA.
Zekavat SM; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Program of Computational Biology & Bioinformatics, Yale University, New Haven, CT 06510, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.
Navickas A; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.
Ramirez JT; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA.
Asgharian H; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.
Simoneau CR; Gladstone Institutes, San Francisco, CA 94158, USA.
Bonser LR; Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Koh KD; Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Garcia-Knight M; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Tassetto M; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Sunshine S; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.
Farahvashi S; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA.
Kalantari A; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA.
Liu W; Program of Computational Biology & Bioinformatics, Yale University, New Haven, CT 06510, USA.
Andino R; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Zhao H; Program of Computational Biology & Bioinformatics, Yale University, New Haven, CT 06510, USA; Department of Biostatistics, Yale School of Public Health, New Haven, CT 06510, USA.
Natarajan P; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Erle DJ; Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Ott M; Gladstone Institutes, San Francisco, CA 94158, USA; Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
Goodarzi H; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA; Department of Urology, University of California, San Francisco, CA 94158, USA; Bakar Computational Health Sciences Institute, University of California, San Francisco, CA 94158, USA. Electronic address: .
Fattahi F; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA; Program in Craniofacial Biology, University of California, San Francisco, CA 94110, USA. Electronic address: .
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Źródło :
Cell stem cell [Cell Stem Cell] 2020 Dec 03; Vol. 27 (6), pp. 876-889.e12. Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Patient Acuity*
Signal Transduction*
Androgens/*metabolism
Angiotensin-Converting Enzyme 2/*metabolism
COVID-19/*metabolism
Receptors, Coronavirus/*metabolism
Adult ; Androgen Antagonists ; Androgens/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Animals ; Antiviral Agents/therapeutic use ; COVID-19/complications ; COVID-19/drug therapy ; Cells, Cultured ; Chlorocebus aethiops ; Drug Evaluation, Preclinical ; Female ; Humans ; Male ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Organoids/drug effects ; Organoids/virology ; Risk Factors ; Sex Factors ; Vero Cells
Czasopismo naukowe
Tytuł :
Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality.
Autorzy :
Brandi ML; Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy. Electronic address: .
Giustina A; Institute of Endocrine and Metabolic Sciences, San Raffaele Vita-Salute University and Division of Endocrinology IRCS San Raffaele Hospital, Milan, Italy.
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Źródło :
Trends in endocrinology and metabolism: TEM [Trends Endocrinol Metab] 2020 Dec; Vol. 31 (12), pp. 918-927. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Sex Factors*
Androgens/*metabolism
COVID-19/*mortality
Estrogens/*metabolism
Age Factors ; Androgens/immunology ; Angiotensin-Converting Enzyme 2/metabolism ; COVID-19/immunology ; COVID-19/metabolism ; COVID-19/physiopathology ; Comorbidity ; Diabetes Mellitus, Type 2/epidemiology ; Estrogen Replacement Therapy ; Estrogens/immunology ; Estrogens/therapeutic use ; Female ; Hormone Replacement Therapy ; Humans ; Hypertension/epidemiology ; Male ; Myocardial Ischemia/epidemiology ; Obesity/epidemiology ; Postmenopause/metabolism ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Renal Insufficiency/epidemiology ; Sex Distribution ; Vitamin D Deficiency/epidemiology
Czasopismo naukowe
Tytuł :
Male balding as a major risk factor for severe COVID-19: A possible role for targeting androgens and transmembrane protease serine 2 to protect vulnerable individuals.
Autorzy :
Wambier CG; Department of Dermatology, Alpert Medical School of Brown University, Providence, Rhode Island. Electronic address: .
McCoy J; Applied Biology, Inc, Irvine, California.
Goren A; Applied Biology, Inc, Irvine, California.
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Źródło :
Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2020 Dec; Vol. 83 (6), pp. e401-e402. Date of Electronic Publication: 2020 Sep 11.
Typ publikacji :
Letter; Comment
MeSH Terms :
Androgens*
Coronavirus Infections*
Pandemics*
Pneumonia, Viral*
Betacoronavirus ; COVID-19 ; Humans ; Male ; Risk Factors ; SARS-CoV-2 ; Serine
Opinia redakcyjna
Tytuł :
Improved protocol for efficacious in vitro androgenesis and development of doubled haploids in temperate japonica rice.
Autorzy :
Sakina A; Division of Plant Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Srinagar, J&K, India.
Mir S; Division of Plant Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Srinagar, J&K, India.
Najeeb S; Mountain Research Centre for Field Crops, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Srinagar, J&K, India.
Zargar SM; Division of Plant Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Srinagar, J&K, India.
Nehvi FA; Division of Plant Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Srinagar, J&K, India.
Rather ZA; Division of Floriculture and Landscaping, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Srinagar, J&K, India.
Salgotra RK; School of Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, Srinagar, J&K, India.
Shikari AB; Division of Plant Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Srinagar, J&K, India.
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Źródło :
PloS one [PLoS One] 2020 Nov 02; Vol. 15 (11), pp. e0241292. Date of Electronic Publication: 2020 Nov 02 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Androgens/*genetics
Kinetin/*genetics
Oryza/*genetics
Plant Growth Regulators/*pharmacology
2,4-Dichlorophenoxyacetic Acid/metabolism ; Androgens/metabolism ; Culture Media ; Haploidy ; In Vitro Techniques ; Oryza/growth & development ; Plant Growth Regulators/metabolism ; Plant Leaves/genetics ; Plant Leaves/growth & development ; Purines/metabolism
Czasopismo naukowe
Tytuł :
[Research progress in the correlation between androgen imprinting of the brain and androgen insensitive syndrome].
Autorzy :
Zhang S; Department of Urology, Dalian Children's Hospital, Dalian 116012, China.
Tang DX; Department of Pediatric Urological Surgery, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou 310003, China.
Fu JF; Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou 310052, China.
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Źródło :
Zhonghua er ke za zhi = Chinese journal of pediatrics [Zhonghua Er Ke Za Zhi] 2020 Nov 02; Vol. 58 (11), pp. 957-960.
Typ publikacji :
Journal Article
MeSH Terms :
Androgen-Insensitivity Syndrome*
Androgens*/physiology
Brain*/physiology
Humans ; Male ; Molecular Imprinting
Czasopismo naukowe
Tytuł :
Global consensus statement on testosterone therapy for women: an Australian perspective.
Autorzy :
Jang C; Mater Health Services, Brisbane, QLD.; University of Queensland, Brisbane, QLD.
Boyle JA; Monash Centre for Health Research and Implementation, Monash University, Melbourne, VIC.; Monash Health, Melbourne, VIC.
Vincent A; Monash Centre for Health Research and Implementation, Monash University, Melbourne, VIC.; Monash Health, Melbourne, VIC.
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Źródło :
The Medical journal of Australia [Med J Aust] 2020 Nov; Vol. 213 (10), pp. 449-452.e1. Date of Electronic Publication: 2020 Nov 01.
Typ publikacji :
Consensus Development Conference; Journal Article
MeSH Terms :
Androgens/*therapeutic use
Sexual Dysfunction, Physiological/*drug therapy
Testosterone/*therapeutic use
Adult ; Aged ; Androgens/blood ; Australia/epidemiology ; Female ; Humans ; Middle Aged ; Postmenopause ; Sexual Dysfunction, Physiological/blood ; Sexual Dysfunction, Physiological/diagnosis ; Sexual Dysfunction, Physiological/epidemiology ; Testosterone/blood
Czasopismo naukowe

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