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Tytuł :
High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.
Autorzy :
Chen X; Department of Anesthesiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Qi J; Department of Anesthesiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Wu Q; Department of Anesthesiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Jiang H; Department of Anesthesiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Wang J; Department of Anesthesiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Chen W; Department of Anesthesiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Mao A; Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Zhu M; Department of Anesthesiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
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Źródło :
Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2020 May 26; Vol. 52 (5), pp. 506-516.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidant Response Elements*
Down-Regulation/*drug effects
Gene Expression Regulation, Enzymologic/*drug effects
Glucose/*pharmacology
Histone-Lysine N-Methyltransferase/*biosynthesis
Human Umbilical Vein Endothelial Cells/*metabolism
Kelch-Like ECH-Associated Protein 1/*metabolism
NF-E2-Related Factor 2/*metabolism
Signal Transduction/*drug effects
Histone-Lysine N-Methyltransferase/genetics ; Human Umbilical Vein Endothelial Cells/pathology ; Humans ; Hyperglycemia/genetics ; Hyperglycemia/metabolism ; Hyperglycemia/pathology ; Kelch-Like ECH-Associated Protein 1/genetics ; NF-E2-Related Factor 2/genetics ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Ginsenoside Rb1 regulates neuronal injury and Keap1-Nrf2/ARE signaling pathway in cerebral infarction rats.
Autorzy :
Yang JE; Department of Rehabilitation, Affiliated Foshan Gaoming Hospital of Guangdong Medical University, Guangdong Province, P.R. China.
Jia N; Department of Rehabilitation, Affiliated Foshan Gaoming Hospital of Guangdong Medical University, Guangdong Province, P.R. China.
Wang D; Department of Rehabilitative Medicine, Affiliated Hospital of Chengdu University, Sichuan Province, P.R. China.
He Y; Department of Rehabilitative Medicine, Affiliated Hospital of Chengdu University, Sichuan Province, P.R. China.
Dong L; Department of Rehabilitative Medicine, Affiliated Hospital of Chengdu University, Sichuan Province, P.R. China.
Yang AG; Department of Rehabilitative Medicine, Affiliated Hospital of Chengdu University, Sichuan Province, P.R. China.
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Źródło :
Journal of biological regulators and homeostatic agents [J Biol Regul Homeost Agents] 2020 May-Jun; Vol. 34 (3), pp. 1091-1095.
Typ publikacji :
Letter
MeSH Terms :
Antioxidant Response Elements*
Signal Transduction*
Cerebral Infarction/*drug therapy
Ginsenosides/*pharmacology
Kelch-Like ECH-Associated Protein 1/*genetics
NF-E2-Related Factor 2/*genetics
Animals ; Kelch-Like ECH-Associated Protein 1/metabolism ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress ; Rats
Opinia redakcyjna
Tytuł :
Keap1/Nrf2/ARE signaling unfolds therapeutic targets for redox imbalanced-mediated diseases and diabetic nephropathy.
Autorzy :
Adelusi TI; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.
Du L; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.
Hao M; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.
Zhou X; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.
Xuan Q; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.
Apu C; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.
Sun Y; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.
Lu Q; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.
Yin X; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Mar; Vol. 123, pp. 109732. Date of Electronic Publication: 2020 Jan 13.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antioxidant Response Elements/*physiology
Diabetic Nephropathies/*drug therapy
Diabetic Nephropathies/*metabolism
Kelch-Like ECH-Associated Protein 1/*metabolism
NF-E2-Related Factor 2/*metabolism
Signal Transduction/*drug effects
Antioxidant Response Elements/genetics ; Humans ; Kelch-Like ECH-Associated Protein 1/genetics ; NF-E2-Related Factor 2/genetics ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
Nrf2/ARE pathway activation is involved in negatively regulating heat-induced apoptosis in non-small cell lung cancer cells.
Autorzy :
Xie W; Department of Oncology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
Tan B; Department of Oncology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
Yang Z; Department of Oncology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
Yu X; Department of Oncology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
Chen L; Department of Respiratory, Chongqing Three Gorges Central Hospital, Chongqing 404000, China.
Ran D; Respiratory Department of the Elderly, Chongqing Public Health Medical Center, Chongqing 400036, China.
Xu Q; Pulmonary And Critical Care Medicine Ward, Eastern Hospital, Sichuan Provincial Medical Sciences Academy & Sichuan Provincial People's Hospital, Chengdu 610100, China.
Zhou X; Department of Respiratory Medicine, the First Affiliated Hospital of Hainan Medical University, Haikou 570102, China.
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Źródło :
Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2020 Apr 20; Vol. 52 (4), pp. 439-445.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidant Response Elements*
Apoptosis*
Carcinoma, Non-Small-Cell Lung/*metabolism
Lung Neoplasms/*metabolism
NF-E2-Related Factor 2/*metabolism
Neoplasm Proteins/*metabolism
A549 Cells ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/therapy ; Heat-Shock Response ; Humans ; Hyperthermia, Induced ; Lung Neoplasms/pathology ; Lung Neoplasms/therapy ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Exploring the correlation between deltamethrin stress and Keap1-Nrf2-ARE pathway from Drosophila melanogaster RNASeq data.
Autorzy :
Liu Y; Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China.
Ge M; Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China.
Zhang T; Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China.
Chen L; Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China.
Xing Y; Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China.
Liu L; Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China.
Li F; Institute of Plant Protection, Guizhou Academy of Agricultural Sciences, Guiyang 550009, China.
Cheng L; Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China. Electronic address: .
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Źródło :
Genomics [Genomics] 2020 Mar; Vol. 112 (2), pp. 1300-1308. Date of Electronic Publication: 2019 Jul 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antioxidant Response Elements*
Stress, Physiological*
Drosophila Proteins/*metabolism
Kelch-Like ECH-Associated Protein 1/*metabolism
Animals ; Apoptosis ; Cell Line ; Drosophila Proteins/genetics ; Drosophila melanogaster ; Insecticides/toxicity ; Kelch-Like ECH-Associated Protein 1/genetics ; Nitriles/toxicity ; Pyrethrins/toxicity ; RNA-Seq
Czasopismo naukowe
Tytuł :
A bacterial metabolite induces Nrf2-mediated anti-oxidative responses in gingival epithelial cells by activating the MAPK signaling pathway.
Autorzy :
Yokoji-Takeuchi M; Research Unit for Oral-Systemic Connection, Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; Division of Periodontology, Department of Oral Biological Science, Niigata University Faculty of Dentistry, Niigata, Japan.
Takahashi N; Division of Periodontology, Department of Oral Biological Science, Niigata University Faculty of Dentistry, Niigata, Japan. Electronic address: .
Yamada-Hara M; Division of Periodontology, Department of Oral Biological Science, Niigata University Faculty of Dentistry, Niigata, Japan; Research Center for Advanced Oral Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Sulijaya B; Research Unit for Oral-Systemic Connection, Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; Division of Periodontology, Department of Oral Biological Science, Niigata University Faculty of Dentistry, Niigata, Japan; Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
Tsuzuno T; Research Unit for Oral-Systemic Connection, Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; Division of Periodontology, Department of Oral Biological Science, Niigata University Faculty of Dentistry, Niigata, Japan.
Aoki-Nonaka Y; Division of Periodontology, Department of Oral Biological Science, Niigata University Faculty of Dentistry, Niigata, Japan.
Tabeta K; Division of Periodontology, Department of Oral Biological Science, Niigata University Faculty of Dentistry, Niigata, Japan.
Kishino S; Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Ogawa J; Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Yamazaki K; Research Unit for Oral-Systemic Connection, Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. Electronic address: .
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Źródło :
Archives of oral biology [Arch Oral Biol] 2020 Feb; Vol. 110, pp. 104602. Date of Electronic Publication: 2019 Nov 05.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidant Response Elements*
Gingiva*/cytology
Gingiva*/metabolism
Linoleic Acids*/pharmacology
NF-E2-Related Factor 2*
Oxidative Stress*
Signal Transduction*
Antioxidants ; Epithelial Cells ; Humans ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Reactive Oxygen Species
Czasopismo naukowe
Tytuł :
Context-Dependent Regulation of Nrf2/ARE Axis on Vascular Cell Function during Hyperglycemic Condition.
Autorzy :
Ramprasath T; Department of Molecular Biology, School of Biological Sciences, Madurai Kamaraj University, Madurai 625021, Tamil Nadu, India.
Freddy AJ; Department of Zoology, Madras Christian College, Chennai 600 059, Tamil Nadu, India.
Velmurugan G; Chemomicrobiomics Laboratory, KMCH Research Foundation, Kovai Medical Center & Hospital, Coimbatore 641 014, Tamil Nadu, India.
Tomar D; Center for Translational Medicine, Temple University, Philadelphia 19140, United States.
Rekha B; Department of Molecular Biology, School of Biological Sciences, Madurai Kamaraj University, Madurai 625021, Tamil Nadu, India.
Suvekbala V; Department of Biomedical Sciences & Technology, Noorul Islam Centre for Higher Education, Kumaracoil, Thucklay, Tamilnadu 629180, India.
Ramasamy S; Department of Molecular Biology, School of Biological Sciences, Madurai Kamaraj University, Madurai 625021, Tamil Nadu, India.
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Źródło :
Current diabetes reviews [Curr Diabetes Rev] 2020; Vol. 16 (8), pp. 797-806.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antioxidant Response Elements/*genetics
Diabetes Mellitus, Type 2/*genetics
Endothelial Cells/*metabolism
Hyperglycemia/*genetics
Myocytes, Smooth Muscle/*metabolism
NF-E2-Related Factor 2/*genetics
Animals ; Antioxidant Response Elements/physiology ; Antioxidants/metabolism ; Diabetes Complications/genetics ; Diabetes Complications/metabolism ; Diabetes Complications/physiopathology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/physiopathology ; Diabetic Angiopathies/genetics ; Diabetic Angiopathies/metabolism ; Diabetic Angiopathies/physiopathology ; Epigenesis, Genetic ; Gene Expression Regulation/genetics ; Gene Expression Regulation/physiology ; Humans ; Hyperglycemia/metabolism ; Kelch-Like ECH-Associated Protein 1/genetics ; Kelch-Like ECH-Associated Protein 1/metabolism ; NF-E2-Related Factor 2/metabolism ; Oxidation-Reduction ; Oxidative Stress/genetics ; Oxidative Stress/physiology ; Phosphotransferases/genetics ; Phosphotransferases/metabolism ; Reactive Oxygen Species/adverse effects ; Reactive Oxygen Species/metabolism ; Signal Transduction/genetics ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Astragaloside IV Protects Against Oxidative Stress in Calf Small Intestine Epithelial Cells via NFE2L2-Antioxidant Response Element Signaling.
Autorzy :
Wang Y; Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Sangyuan Road, Number 8, Jinan 250100, China.; Shandong Key Laboratory of Animal Disease Control and Breeding, Sangyuan Road, Number 8, Jinan 250100, China.; College of Life Sciences, Shandong Normal University, East Wenhua Road Number 88, Jinan 250014, China.
Jiang F; Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Sangyuan Road, Number 8, Jinan 250100, China.; Shandong Key Laboratory of Animal Disease Control and Breeding, Sangyuan Road, Number 8, Jinan 250100, China.
Cheng H; Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Sangyuan Road, Number 8, Jinan 250100, China.; Shandong Key Laboratory of Animal Disease Control and Breeding, Sangyuan Road, Number 8, Jinan 250100, China.
Tan X; Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Sangyuan Road, Number 8, Jinan 250100, China.; Shandong Key Laboratory of Animal Disease Control and Breeding, Sangyuan Road, Number 8, Jinan 250100, China.
Liu Y; Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Sangyuan Road, Number 8, Jinan 250100, China.; Shandong Key Laboratory of Animal Disease Control and Breeding, Sangyuan Road, Number 8, Jinan 250100, China.
Wei C; Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Sangyuan Road, Number 8, Jinan 250100, China.; Shandong Key Laboratory of Animal Disease Control and Breeding, Sangyuan Road, Number 8, Jinan 250100, China.
Song E; Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Sangyuan Road, Number 8, Jinan 250100, China.; Shandong Key Laboratory of Animal Disease Control and Breeding, Sangyuan Road, Number 8, Jinan 250100, China.; College of Life Sciences, Shandong Normal University, East Wenhua Road Number 88, Jinan 250014, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 Dec 05; Vol. 20 (24). Date of Electronic Publication: 2019 Dec 05.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidant Response Elements*
Epithelial Cells/*metabolism
Intestine, Small/*metabolism
NF-E2-Related Factor 2/*metabolism
Oxidative Stress/*drug effects
Saponins/*pharmacology
Signal Transduction/*drug effects
Triterpenes/*pharmacology
Animals ; Cattle ; Hydrogen Peroxide/metabolism
Czasopismo naukowe
Tytuł :
New insights into organ-specific oxidative stress mechanisms using a novel biosensor zebrafish.
Autorzy :
Mourabit S; Biosciences, College of Life and Environmental Sciences, University of Exeter, UK. Electronic address: .
Fitzgerald JA; Biosciences, College of Life and Environmental Sciences, University of Exeter, UK.
Ellis RP; Biosciences, College of Life and Environmental Sciences, University of Exeter, UK.
Takesono A; Biosciences, College of Life and Environmental Sciences, University of Exeter, UK.
Porteus CS; Biosciences, College of Life and Environmental Sciences, University of Exeter, UK.
Trznadel M; Biosciences, College of Life and Environmental Sciences, University of Exeter, UK.
Metz J; Biosciences, College of Life and Environmental Sciences, University of Exeter, UK.
Winter MJ; Biosciences, College of Life and Environmental Sciences, University of Exeter, UK.
Kudoh T; Biosciences, College of Life and Environmental Sciences, University of Exeter, UK.
Tyler CR; Biosciences, College of Life and Environmental Sciences, University of Exeter, UK. Electronic address: .
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Źródło :
Environment international [Environ Int] 2019 Dec; Vol. 133 (Pt A), pp. 105138. Date of Electronic Publication: 2019 Oct 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biosensing Techniques*
Antioxidant Response Elements/*physiology
Oxidative Stress/*physiology
Water Pollutants, Chemical/*toxicity
Zebrafish/*metabolism
Animals ; Animals, Genetically Modified ; Antioxidant Response Elements/genetics ; Antioxidants ; Biomarkers ; Gene Expression Regulation/drug effects ; Humans ; Reactive Oxygen Species ; Water Pollutants, Chemical/chemistry ; Zebrafish/genetics
Czasopismo naukowe
Tytuł :
HPLC Analysis and Antioxidant Evaluation of Acteoside-Rich Osmanthus fragrans Extracts.
Autorzy :
Lee, Sung-Ho (AUTHOR)
Seo, Seong-Wook (AUTHOR)
Song, Seung-Yub (AUTHOR)
Oh, Deuk-Sil (AUTHOR)
Shim, Jung-Hyun (AUTHOR)
Yoon, Goo (AUTHOR)
Choi, Ye-Yong (AUTHOR)
Kim, Do-Kyung (AUTHOR)
Kim, Jae-Sung (AUTHOR)
Yoon, In-Soo (AUTHOR)
Cho, Seung-Sik (AUTHOR)
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Źródło :
Journal of Food Quality. 9/2/2020, p1-6. 6p.
Czasopismo naukowe
Tytuł :
Characterization of the Oxidative Stress in Renal Ischemia/Reperfusion-Induced Cardiorenal Syndrome Type 3.
Autorzy :
Caio-Silva, Wellington (AUTHOR)
da Silva Dias, Danielle (AUTHOR)
Junho, Carolina Victoria Cruz (AUTHOR)
Panico, Karine (AUTHOR)
Neres-Santos, Raquel Silva (AUTHOR)
Pelegrino, Milena Trevisan (AUTHOR)
Pieretti, Joana Claudio (AUTHOR)
Seabra, Amedea Barozzi (AUTHOR)
De Angelis, Kátia (AUTHOR)
Carneiro-Ramos, Marcela Sorelli (AUTHOR)
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Źródło :
BioMed Research International. 10/9/2020, p1-11. 11p.
Czasopismo naukowe
Tytuł :
비자 및 초두구 추출물의 코스메슈티칼 특성 및 이를 포함한 마스크팩 제형특성.
Autorzy :
소순영
전용진
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Alternatywny tytuł :
Cosmeceutical Properties of Extracts of Torreya nucifera and Alpinia henryi and Formulation Characteristics of Mask Pack Containing Extracts of These.
Źródło :
Journal of the Korea Academia-Industrial Cooperation Society. 2020, Vol. 21 Issue 8, p36-43. 8p.
Czasopismo naukowe
Tytuł :
Berberine ameliorates CCl4‑induced liver injury in rats through regulation of the Nrf2‑Keap1‑ARE and p53 signaling pathways.
Autorzy :
Han CY; College of Animal Science and Technology, Anhui Agricultural University, Hefei, Anhui 230036, P.R. China.
Sun TT; College of Animal Science and Technology, Anhui Agricultural University, Hefei, Anhui 230036, P.R. China.
Xv GP; College of Animal Science and Technology, Anhui Agricultural University, Hefei, Anhui 230036, P.R. China.
Wang SS; College of Animal Science and Technology, Anhui Agricultural University, Hefei, Anhui 230036, P.R. China.
Gu JG; Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing 100081, P.R. China.
Liu CY; College of Animal Science and Technology, Anhui Agricultural University, Hefei, Anhui 230036, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2019 Oct; Vol. 20 (4), pp. 3095-3102. Date of Electronic Publication: 2019 Aug 06.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidant Response Elements*
Berberine/*pharmacology
Carbon Tetrachloride/*toxicity
Chemical and Drug Induced Liver Injury/*drug therapy
Gene Expression Regulation/*drug effects
Kelch-Like ECH-Associated Protein 1/*biosynthesis
NF-E2-Related Factor 2/*biosynthesis
Signal Transduction/*drug effects
Tumor Suppressor Protein p53/*biosynthesis
Animals ; Apoptosis/drug effects ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Liver/metabolism ; Liver/pathology ; Male ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis.
Autorzy :
Li AL; Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhua Xi Road, Jinan, 250012, People's Republic of China.
Shen T; Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhua Xi Road, Jinan, 250012, People's Republic of China.
Wang T; Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhua Xi Road, Jinan, 250012, People's Republic of China.
Zhou MX; Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhua Xi Road, Jinan, 250012, People's Republic of China.
Wang B; Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhua Xi Road, Jinan, 250012, People's Republic of China.
Song JT; Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhua Xi Road, Jinan, 250012, People's Republic of China.
Zhang PL; Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhua Xi Road, Jinan, 250012, People's Republic of China.
Wang XL; The Second Hospital of Shandong University, No. 247 Bei-Yuan Street, Jinan, 250033, People's Republic of China.
Ren DM; Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhua Xi Road, Jinan, 250012, People's Republic of China.
Lou HX; Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhua Xi Road, Jinan, 250012, People's Republic of China.
Wang XN; Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhua Xi Road, Jinan, 250012, People's Republic of China. Electronic address: .
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Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2019 Sep; Vol. 141, pp. 21-33. Date of Electronic Publication: 2019 Jun 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antioxidant Response Elements*
Oxidative Stress*
Diterpenes/*pharmacology
Kelch-Like ECH-Associated Protein 1/*metabolism
NF-E2-Related Factor 2/*metabolism
Animals ; Antioxidants/pharmacology ; Carcinoma, Hepatocellular/metabolism ; Cell Line, Tumor ; Cell Survival ; Homeostasis ; Liver Neoplasms/metabolism ; Mice ; Molecular Docking Simulation ; Oxidation-Reduction ; Oxygen/chemistry ; Tobacco Smoke Pollution ; Zebrafish
Czasopismo naukowe

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